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Specialty: Hematology
Condition: Thrombosis

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Total 1625 results found since Jan 2013.

The thrombus proteome in stroke reveals a key role of the innate immune system and new insights associated with its aetiology, severity and prognosis
CONCLUSIONS: The use of the SWATH-MS in thrombi from IS patients has provided new insights of pathways and players involved in its aetiology, severity and prognosis. The prominent role of the innate immune system identified might pave the way for the development of new biomarkers and therapeutic approaches in this disease.PMID:37100394 | DOI:10.1016/j.jtha.2023.04.015
Source: Thrombosis and Haemostasis - April 26, 2023 Category: Hematology Authors: Chary Lopez-Pedrera Rafael Oteros Alejandro Ib áñez-Costa Mar ía Luque-Tévar Laura Mu ñoz-Barrera Nuria Barbarroja Eduardo Chicano-G álvez Juan Marta-Enguita Josune Orbe Francisco Velasco Carlos Perez-S ánchez Source Type: research

Stroke and dyslipidaemia in Africa: a meta-analysis of case-control studies
Conclusion: Although not particularly substantial, there is an association between dyslipidaemia and stroke in Africa.
Source: Journal of Thrombosis and Thrombolysis - May 6, 2023 Category: Hematology Source Type: research

Lack of secondary microthrombosis after thrombin‐induced stroke in mice and non‐human primates
ConclusionsOur data demonstrates that secondary microthrombosis does not occur after thrombin‐induced stroke. In view of that, the pathophysiological roles of hematologic players promoting or protecting from secondary microthrombosis (such as Factor XII, von Willebrand Factor, T‐cells…) deserve to be reevaluated in non‐TMVO stroke models.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - December 16, 2013 Category: Hematology Authors: Maxime Gauberti, Sara Martinez Lizarrondo, Cyrille Orset, Denis Vivien Tags: Brief Report ‐ Vascular Biology Source Type: research

Circulating desphospho-uncarboxylated matrix Gla protein and the risk of coronary heart disease and stroke.
CONCLUSION: The average follow-up was 11.5 years. Dp-ucMGP concentrations were not associated with CHD risk with a HR per SD of 1.00 (95% CI: 0.93-1.07) and a HR Q4 vs Q1 of 0.94 (95% CI: 0.79-1.13) after adjustment for cardiovascular risk factors. Dp-ucMGP was not associated with stroke risk (HRSD 0.98;95% CI: 0.90-1.08 and a HR Q4 vs Q1 of 1.09;95% CI: 0.78-1.51). This study could not confirm that high dp-ucMGP concentrations, reflecting a poor vitamin K status, are associated with increased CHD or stroke risk in the general population. This article is protected by copyright. All rights reserved. PMID: 24826813 [Pub...
Source: Thrombosis and Haemostasis - May 15, 2014 Category: Hematology Authors: Dalmeijer GW, van der Schouw YT, Magdeleyns EJ, Vermeer C, Verschuren WM, Boer JM, Beulens JW Tags: J Thromb Haemost Source Type: research

Differential impact of unrecognised brain infarction on stroke outcome in non-valvular atrial fibrillation.
This study enrolled 631 patients with NVAF having no clinical stroke history. UBIs were categorised into three types as territorial, lacunar, or subcortical. We collected stroke severity, functional outcome at three months, and the total volume of UBIs and acute infarction lesions. We investigated the association between clinical outcome and the type or volume of UBI, using a linear mixed model and logistic regression analysis. UBIs were detected in 285 (45.2 %) patients; territorial UBIs were observed in 24.4 % of patients (154/631), lacunar UBIs in 25 % (158/631), and subcortical UBIs in 15.7 % (99/631). Although...
Source: Thrombosis and Haemostasis - September 18, 2014 Category: Hematology Authors: Song TJ, Kim J, Lee HS, Nam CM, Nam HS, Kim EH, Lee KJ, Song D, Heo JH, Kim YD Tags: Thromb Haemost Source Type: research

Pretreatment with rivaroxaban attenuates stroke severity in rats by a dual antithrombotic and anti-inflammatory mechanism.
This study examined whether prestroke anticoagulation with rivaroxaban, a novel direct factor Xa inhibitor, influences stroke severity, thrombin-mediated intracerebral thrombus formation and pro-inflammatory processes in a rat model of brain ischaemia/reperfusion injury. Male Wistar rats were anticoagulated with rivaroxaban and subjected to 90 minutes of transient middle cerebral artery occlusion. Infarct size, functional outcome and the occurrence of intracranial haemorrhage (ICH) were assessed until day 7. Thrombin generation was determined by measuring the amount of thrombin/antithrombin complex. Intracerebral thrombus ...
Source: Thrombosis and Haemostasis - October 22, 2015 Category: Hematology Authors: Dittmeier M, Kraft P, Schuhmann MK, Fluri F, Kleinschnitz C Tags: Thromb Haemost Source Type: research

The VWF-GPIb axis in ischaemic stroke: lessons from animal models.
Abstract Stroke is a leading cause of death and long-term disability worldwide. Ischaemic stroke is caused by a blood clot that obstructs cerebral blood flow. Current treatment mainly consists of achieving fast reperfusion, either via pharmacological thrombolysis using tissue plasminogen activator or via endovascular thrombectomy. Unfortunately, reperfusion therapy is only available to a limited group of patients and reperfusion injury can further aggravate brain damage. Hence, there is an urgent need for better understanding of ischaemic stroke pathophysiology in order to develop novel therapeutic strategies. In ...
Source: Thrombosis and Haemostasis - March 30, 2016 Category: Hematology Authors: Denorme F, De Meyer SF Tags: Thromb Haemost Source Type: research

Spotlight on unmet needs in stroke prevention: The PIONEER AF-PCI, NAVIGATE ESUS and GALILEO trials.
This article focuses on three randomised controlled trials (RCTs) that are investigating the utility of rivaroxaban, a direct, oral, factor Xa inhibitor, in additional areas of stroke prevention where data for anticoagulants are lacking: oPen-label, randomized, controlled, multicentre study explorIng twO treatmeNt stratEgiEs of Rivaroxaban and a dose-adjusted oral vitamin K antagonist treatment (PIONEER AF-PCI); New Approach riVaroxoban Inhibition of factor Xa in a Global trial vs Aspirin to prevenT Embolism in Embolic Stroke of Undetermined Source (NAVIGATE ESUS); and Global study comparing a rivAroxaban-based antithrombo...
Source: Thrombosis and Haemostasis - September 13, 2016 Category: Hematology Authors: Hemmrich M, Peterson ED, Thomitzek K, Weitz JI Tags: Thromb Haemost Source Type: research

Associations of coagulation factors IX and XI levels with incident coronary heart disease and ischemic stroke: the REGARDS study
ConclusionsHigher FIX antigen was associated with incident CHD in blacks but not whites. FIX levels may increase CHD risk among blacks.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - April 10, 2017 Category: Hematology Authors: N.C. Olson, M. Cushman, S.E. Judd, B.M. Kissela, M.M. Safford, G. Howard, N.A. Zakai Tags: Original Article ‐ Coagulation Source Type: research

The C-reactive protein gene polymorphism predicts the risk of thromboembolic stroke in atrial fibrillation: a more than 10-year prospective follow-up study.
CONCLUSION: The CRP gene triallelic polymorphism and the CRP level are associated with the risk of incident thromboembolic stroke in patients with AF. This article is protected by copyright. All rights reserved. PMID: 28498565 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - May 12, 2017 Category: Hematology Authors: Chang SN, Lai LP, Chiang FT, Lin JL, Hwang JJ, Tsai CT Tags: J Thromb Haemost Source Type: research

Hematocrit and Stroke: A Forgotten and Neglected Link?
Semin Thromb Hemost DOI: 10.1055/s-0037-1602663Stroke is considered among the most common causes of mortality and disability, leading to dramatic socioeconomic consequences. From a pathophysiologic perspective, enhanced blood viscosity due to increased hematocrit might be associated with stroke through impaired cerebral blood perfusion. This association has remained rather neglected during previous decades, but newly emerged as an epicenter of scientific interest due to the unexpected elevation of stroke rates with sodium-glucose cotransporter-2 inhibitors, a new class of hypoglycemic drugs with otherwise dramatic cardiova...
Source: Seminars in Thrombosis and Hemostasis - June 13, 2017 Category: Hematology Authors: Stavropoulos, Konstantinos Imprialos, Konstantinos P. Bouloukou, Sofia Boutari, Chrysoula Doumas, Michael Tags: Review Article Source Type: research

N-terminal pro-B-type natriuretic peptide and the risk of stroke among patients hospitalized with acute heart failure: an APEX trial substudy
ConclusionsBaseline NT-proBNP concentration was associated with short-term stroke among patients hospitalized with acute HF. Stroke risk assessment models should consider incorporation of NT-proBNP measurement.
Source: Journal of Thrombosis and Thrombolysis - September 13, 2017 Category: Hematology Source Type: research

Number of ischemic strokes potentially eligible for revascularization treatments in an Italian Comprehensive Stroke Center: a modeling study
AbstractTo rationally plan acute services, the proportion of ischemic strokes that may be eligible for revascularization treatments should be estimated. We aimed to estimate the proportion of patients directly admitted to an Italian Comprehensive Stroke Center who may be eligible for intravenous thrombolysis (IVT), combined IVT and endovascular thrombectomy (ET), or direct ET according to the current guidelines. We conducted a retrospective analysis based on data prospectively collected from 876 consecutive adult ischemic stroke patients who were directly admitted to the Stroke Unit of the University Hospital of Verona wit...
Source: Journal of Thrombosis and Thrombolysis - July 14, 2018 Category: Hematology Source Type: research

Introduction of direct oral anticoagulant within 7  days of stroke onset: a nomogram to predict the probability of 3-month modified Rankin Scale score  & gt;  2
AbstractIn clinical practice, direct oral anticoagulants (DOACs) are often started earlier ( ≤ 7 days) than in randomized clinical trials after stroke. We aimed to develop a nomogram model incorporating time of DOAC introduction ≤ 7 days of stroke onset in combination with different degrees of stroke radiological/neurological severity at the time of treatment to predict the prob ability of unfavorable outcome. We conducted a multicenter prospective study including 344 patients who started DOAC 1–7 days after atrial fibrillation-related stroke onset. Computed tomography scan 24–36 h after stroke onset was ...
Source: Journal of Thrombosis and Thrombolysis - September 10, 2018 Category: Hematology Source Type: research

Stroke Severity in Patients on Non-Vitamin K Antagonist Oral Anticoagulants with a Standard or Insufficient Dose.
CONCLUSION:  Use of warfarin with a therapeutic intensity or standard-dosed NOACs was associated with a relatively mild stroke in the patients with NVAF. PMID: 30453351 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - November 19, 2018 Category: Hematology Authors: Jung YH, Choi HY, Lee KY, Cheon K, Han SW, Park JH, Cho HJ, Park HJ, Nam HS, Heo JH, Lee HS, Kim YD Tags: Thromb Haemost Source Type: research