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Specialty: Hematology
Condition: Thrombosis

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Total 1625 results found since Jan 2013.

Characteristics and comparisons of acute stroke in “recovered & quot; to “active COVID-19 and “pre-pandemic” in Qatar database
AbstractUnderstanding the relationship of COVID-19 to stroke is important. We compare characteristics of pre-pandemic stroke (PPS), cases in acute COVID infection (CS) and in patients who have recovered from COVID-19 infection (RCS). We interrogated the Qatar stroke database for all stroke admissions between Jan 2020 and Feb 2021 (PPS) to CS and RCS to determine how COVID-19 affected ischemic stroke sub-types, clinical course, and outcomes prior to, during and post-pandemic peak. There were 3264 cases admitted (pre-pandemic: 3111, stroke in COVID-19: 60 and recovered COVID-19 stroke: 93). Patients with CS were significantl...
Source: Journal of Thrombosis and Thrombolysis - March 4, 2022 Category: Hematology Source Type: research

The potential role of micro-RNA 125b-5p level in predicting outcome from thrombolytic therapy in patients with acute ischemic stroke
AbstractSeveral studies highlighted a significant role of specific miRNA as diagnostic and prognostic biomarkers for acute ischemic stroke. The aim of this work was to study micro-RNA 125b-5p level in patients with acute ischemic stroke in relation to stroke etiology, risk factors, severity and outcome. This case –control study was conducted on 40 patients with acute ischemic stroke eligible for receiving rt-PA and 40 age and sex matched healthy controls, Patients were submitted to neurological and radiological assessment. Functional outcome after 3 months was assessed using the modified Rankin Scale (mRS ). Plasma micr...
Source: Journal of Thrombosis and Thrombolysis - June 8, 2023 Category: Hematology Source Type: research

Ischemic Stroke in Cancer: Mechanisms, Biomarkers, and Implications for Treatment
Semin Thromb Hemost DOI: 10.1055/s-0043-1771270Ischemic stroke is an important cause of morbidity and mortality in cancer patients. The underlying mechanisms linking cancer and stroke are not completely understood. Long-standing and more recent evidence suggests that cancer-associated prothrombotic states, along with treatment-related vascular toxicity, such as with chemotherapy and immunotherapy, contribute to an increased risk of ischemic stroke in cancer patients. Novel biomarkers, including coagulation, platelet and endothelial markers, cell-free DNA, and extracellular vesicles are being investigated for their potentia...
Source: Seminars in Thrombosis and Hemostasis - July 28, 2023 Category: Hematology Authors: Costamagna, Gianluca Navi, Babak B. Beyeler, Morin Hottinger, Andreas F. Alberio, Lorenzo Michel, Patrik Tags: Review Article Source Type: research

Retinal vein and artery occlusions:a risk factor for stroke in atrial fibrillation
ConclusionA history of retinal arterial or retinal venous occlusion is associated with an increased risk of stroke/TE/TIA in patients with atrial fibrillation. Thus, prior retinal vascular occlusion may be considered a previous thromboembolic event when evaluating stroke risk in patients with atrial fibrillation.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - May 11, 2013 Category: Hematology Authors: Christine Benn Christiansen, Gregory YH Lip, Morten Lamberts, Gunnar Gislason, Christian Torp‐Pedersen, Jonas Bjerring Olesen Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research

proMetalloproteinase-10 is associated with brain damage and clinical outcome in acute ischemic stroke.
CONCLUSIONS: Increased serum proMMP-10 after acute ischemic stroke, associated with TNFα, is a new marker of brain damage and poor outcome. This article is protected by copyright. All rights reserved. PMID: 23742289 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - June 7, 2013 Category: Hematology Authors: Rodríguez JA, Sobrino T, Orbe J, Purroy A, Martínez-Vila E, Castillo J, Páramo JA Tags: J Thromb Haemost Source Type: research

Female sex as an independent risk factor for stroke in atrial fibrillation: Possible mechanisms.
The objective of this review is to describe the potential mechanisms behind the increased risk of stroke in AF associated with female sex. PMID: 24305974 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - December 5, 2013 Category: Hematology Authors: Cove CL, Albert CM, Andreoti F, Badimon L, Van Gelder IC, Hylek EM Tags: Thromb Haemost Source Type: research

Lack of secondary microthrombosis after thrombin-induced stroke in mice and non-human primates.
CONCLUSIONS: Our data demonstrates that secondary microthrombosis does not occur after thrombin-induced stroke. In view of that, the pathophysiological roles of hematologic players promoting or protecting from secondary microthrombosis (such as Factor XII, von Willebrand Factor, T-cells…) deserve to be reevaluated in non-TMVO stroke models. This article is protected by copyright. All rights reserved. PMID: 24354644 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - December 16, 2013 Category: Hematology Authors: Gauberti M, de Lizarrondo SM, Orset C, Vivien D Tags: J Thromb Haemost Source Type: research

Determinants of premature familial arterial thrombosis in patients with juvenile ischaemic stroke. The Italian Project on Stroke in Young Adults (IPSYS).
In conclusion, young IS patients with FH of premature arterial thrombosis exhibit a distinct risk-factor profile, an underlying procoagulant state and have worse vascular prognosis than those with no FH of juvenile thrombotic events. PMID: 25413729 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - November 20, 2014 Category: Hematology Authors: Pezzini A, Grassi M, Lodigiani C, Patella R, Gandolfo C, Zini A, DeLodovici ML, Paciaroni M, Del Sette M, Toriello A, Musolino R, Calabrò RS, Bovi P, Adami A, Silvestrelli G, Sessa M, Cavallini A, Marcheselli S, Bonifati DM, Checcarelli N, Tancredi L, Ch Tags: Thromb Haemost Source Type: research

Neutrophil to Lymphocyte Ratio (NLR) and Risk of First Episode Stroke in Patients with Atrial Fibrillation: A Cohort Study
ConclusionsNLR is directly associated with the risk of stroke in patients with atrial fibrillation. Future studies are needed to replicate these findings.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - May 18, 2015 Category: Hematology Authors: Walid Saliba, Ofra Barnett‐Griness, Mazen Elias, Gad Rennert Tags: Original Article ‐ Cardiovascular Medicine Source Type: research

D-dimer for prediction of long-term outcome in cryptogenic stroke patients with patent foramen ovale.
Abstract Patent foramen ovale (PFO) is a potential cause of cryptogenic stroke, given the possibility of paradoxical embolism from venous to systemic circulation. D-dimer level is used to screen venous thrombosis. We investigated the risk of embolism and mortality according to the presence of PFO and D-dimer levels in cryptogenic stroke patients. A total of 570 first-ever cryptogenic stroke patients who underwent transesophageal echocardiography were included in this study. D-dimer was assessed using latex agglutination assay during admission. The association of long-term outcomes with the presence of PFO and D-di...
Source: Thrombosis and Haemostasis - May 21, 2015 Category: Hematology Authors: Kim YD, Song D, Nam HS, Lee K, Yoo J, Hong GR, Lee HS, Nam CM, Heo JH Tags: Thromb Haemost Source Type: research

Neutrophil to lymphocyte ratio and risk of a first episode of stroke in patients with atrial fibrillation: a cohort study
ConclusionsThe neutrophil to lymphocyte ratio is directly associated with the risk of stroke in patients with atrial fibrillation. Future studies are needed to replicate these findings.
Source: Journal of Thrombosis and Haemostasis - September 14, 2015 Category: Hematology Authors: W. Saliba, O. Barnett‐Griness, M. Elias, G. Rennert Tags: In Focus Source Type: research

The role of CHADS2 and CHA2DS2‐VASc scores in the prediction of stroke in individuals without atrial fibrillation: a population‐based study
ConclusionsCHADS2 and CHA2DS2‐VASc scores have a relatively high performance for stroke/TIA prediction in individuals without AF which is comparable to their performance in patients with AF.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - February 29, 2016 Category: Hematology Authors: Walid Saliba, Naomi Gronich, Ofra Barnett‐Griness, Gad Rennert Tags: Original Article Source Type: research

Hematological disorders: a commonly unrecognized cause of acute stroke.
Authors: Arboix A, Jiménez C, Massons J, Parra O, Besses C Abstract INTRODUCTION: Hematological disorders account for about 1.3% of all causes of acute stroke. This systematized review presents updated information on the implications of this category of heterogeneous diseases as a cause of stroke. AREAS COVERED: The most relevant aspects of the relationship between stroke and hematological disorders are reported. A high index of suspicion is needed in young stroke patients, patients with recurrent stroke of undetermined cause, and in patients with prior history of venous thrombosis to identify a potential hema...
Source: Expert Review of Hematology - July 3, 2016 Category: Hematology Tags: Expert Rev Hematol Source Type: research

Whole exome sequencing analysis reveals TRPV3 as a risk factor for cardioembolic stroke.
In conclusion, new strategies using exome sequence data have revealed TRPV3 as a new gene associated with cardioembolic stroke. This strategy among others might be useful in finding new genes associated with complex genetic diseases. PMID: 27604134 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - September 7, 2016 Category: Hematology Authors: Carrera C, Jiménez-Conde J, Derdak S, Rabionet K, Vives-Bauzá C, Soriano-Tárrega C, Giralt-Steinhauer E, Mola M, Diaz-Navarro RM, Tur S, Muiño E, Gallego-Fabrega C, Beltran S, Roquer J, Ruiz A, Sotolongo-Grau O, Krupinski J, Lee JM, Cruchaga C, Delgad Tags: Thromb Haemost Source Type: research

Clinical recovery and health-related quality of life in ischaemic stroke survivors receiving thrombolytic treatment: a 1-year follow-up study
AbstractThe aims of this study were to examine prospectively the course of neurological and functional recovery and health related quality of life (HRQoL) in ischaemic stroke patients after intravenous thrombolysis, to assess the 1-year outcome and to determine the early predictors. A group of 53 consecutive patients were assessed at admission to the acute stroke unit (T0), before their discharge (T1), and at 3 (T2) and 12 (T3) months after hospital discharge. The National Institutes of Health Stroke Scale (NIHSS), the Barthel Index (BI) and the Stroke Specific Quality of Life Scale (SSQoL) were used to evaluate stroke sev...
Source: Journal of Thrombosis and Thrombolysis - December 31, 2016 Category: Hematology Source Type: research