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Cryptogenic Subtype Predicts Reduced Survival Among Cancer Patients With Ischemic Stroke Clinical Sciences
Conclusions— Cryptogenic stroke is independently associated with reduced survival in patients with active cancer and ischemic stroke.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Navi, B. B., Singer, S., Merkler, A. E., Cheng, N. T., Stone, J. B., Kamel, H., Iadecola, C., Elkind, M. S. V., DeAngelis, L. M. Tags: Arterial thrombosis, Thrombophilia, Acute Cerebral Infarction, Embolic stroke, Pathology of Stroke Clinical Sciences Source Type: research

Association of Cancer Cell Type and Extracellular Vesicles With Coagulopathy in Patients With Lung Cancer and Stroke Brief Report
Conclusions—Our findings indicate that cancer cell type is associated with circulating EV levels and coagulopathy in patients with lung cancer and stroke.
Source: Stroke - April 23, 2018 Category: Neurology Authors: Jong-Won Chung, Yeon Hee Cho, Myung-Ju Ahn, Mi Ji Lee, Gyeong-Moon Kim, Chin-Sang Chung, Oh Young Bang Tags: Biomarkers, Mechanisms, Translational Studies, Cerebrovascular Disease/Stroke, Thrombosis Brief Reports Source Type: research

Recurrent thromboembolic events after ischemic stroke in patients with cancer
Conclusions: Patients with acute ischemic stroke in the setting of active cancer (especially adenocarcinoma) face a substantial short-term risk of recurrent ischemic stroke and other types of thromboembolism.
Source: Neurology - June 30, 2014 Category: Neurology Authors: Navi, B. B., Singer, S., Merkler, A. E., Cheng, N. T., Stone, J. B., Kamel, H., Iadecola, C., Elkind, M. S. V., DeAngelis, L. M. Tags: All Cerebrovascular disease/Stroke, All Oncology, Cohort studies, Infarction ARTICLE Source Type: research

Warfarin-Resistant Deep Vein Thrombosis during the Treatment of Acute Ischemic Stroke in Lung Adenocarcinoma
A 66-year-old man with acute ischemic stroke in the setting of lung adenocarcinoma developed acute-onset deep vein thrombosis (DVT) of the lower limbs after changing to warfarin from a heparin combination. The diagnosis of warfarin-resistant DVT was established based on the laboratory data and clinical evaluation. Heparin administration resulted in good control of thrombin regulation. Cancer patients are at high risk of venous thromboembolism, and the combination of these 2 conditions is known as Trousseau's syndrome.
Source: Journal of Stroke and Cerebrovascular Diseases - June 21, 2016 Category: Neurology Authors: Hiroyuki Naito, Shiro Aoki, Naoko Sumi, Kazuhide Ochi, Naohisa Hosomi, Hirofumi Maruyama, Masayasu Matsumoto Tags: Case Studies Source Type: research

Stroke and cancer
Rev Neurol (Paris). 2023 Apr 4:S0035-3787(23)00891-3. doi: 10.1016/j.neurol.2023.03.009. Online ahead of print.ABSTRACTAssociation between stroke and cancer is well-established and has led to a growing literature over the past decades. Risk of ischemic and hemorrhagic stroke is increased among patients with newly diagnosed cancer and 5-10% of stroke patients bear an active cancer. All cancers are concerned, but hematological malignancy in childhood and adenocarcinoma from lung, digestive tract and pancreas in adults are most usually identified. Unique stroke mechanisms are dominated by hypercoagulation, a condition that ma...
Source: Revue Neurologique - April 6, 2023 Category: Neurology Authors: M Zuber Source Type: research

A Case of Perioperative Stroke Caused by Tumour Embolus. (P6.244)
CONCLUSIONS: Tumour embolism has previously been described with primary and secondary lung neoplasms, as well as cardiac tumours. Although rare, this should be considered as a potential cause of perioperative stroke in patients after cancer surgery.Study Supported by: Non-applicable.Disclosure: Dr. Hughes has nothing to disclose. Dr. Hunter has nothing to disclose. Dr. Campbell has nothing to disclose. Dr. Brady has nothing to disclose. Dr. Herron has nothing to disclose. Dr. Smyth has nothing to disclose. Dr. Rennie has nothing to disclose. Dr. Hunt has received personal compensation for activities with Eisai Inc., UCB Ph...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Hughes, S., Hunter, A., Campbell, J., Brady, A., Herron, B., Smyth, G., Rennie, I., Hunt, S. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

Cancer-related Stroke due to Mural Thrombus in the Extracranial Carotid Artery.
Authors: Ando D, Kobayashi J, Kuroda H, Aoki M Abstract A 41-year-old man was admitted to our hospital because of a cancer-related stroke (CRS) caused by a thrombus of the extracranial carotid artery. He had undergone neoadjuvant radiochemotherapy for metastatic colorectal adenocarcinoma. The serum D-dimer values were within the normal range. We treated him with intravenous unfractionated heparin followed by warfarin. There were no recurrent stroke events over six months. The leading cause of a CRS is an embolism caused by hypercoagulopathy, mainly represented by non-bacterial thrombotic endocarditis. However, it w...
Source: Internal Medicine - June 4, 2016 Category: Internal Medicine Tags: Intern Med Source Type: research

The resolution of carotid arterial thrombus by oral anticoagulation after IV thrombolysis for chemotherapy-induced stroke: A case report
Rationale: Cancer-related stroke has been regarded as an emerging subtype of ischemic event. Acute treatment for this subtype may include the antiplatelet agents, anticoagulants, or endovascular intervention. Patient concerns: A 63-year-old woman with sudden-onset right hemiparesis and conscious change was sent to our emergency department. The patient had underlying sigmoid adenocarcinoma and received chemotherapy FOLFIRI (FOL, folinic acid; F, fluorouracil; and IRI, irinotecan) with targeted therapy cetuximab following lower anterior resection since the diagnosis was made. Diagnoses: Brain magnetic resonance angio...
Source: Medicine - August 28, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

An Unusual Cause Of Recurrent Ischemic Stroke: Trousseau's Syndrome From Gastric Cancer (P4.231)
CONCLUSIONS: Trousseau’s Syndrome must be considered in those presenting with recurrent strokes with an otherwise negative embolic work up especially in the elderly and those with cancer risk factors. It must prompt the clinician to look for an associated malignancy.Disclosure: Dr. JADEJA has nothing to disclose. Dr. Johnson has nothing to disclose. Dr. Soetanto has nothing to disclose. Dr. Nalleballe has nothing to disclose. Dr. DeNiro has nothing to disclose. Dr. Qureshi has nothing to disclose. Dr. Graber has received personal compensation for activities with Stemedica Inc., Novocure Inc., and Biogen Idec.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Jadeja, N., Johnson, J., Soetanto, A., Nalleballe, K., DeNiro, L., Qureshi, I., Graber, J. Tags: Neuro-oncology: Paraneoplastic Disorders Source Type: research

Ischemic stroke in cancer patients treated with direct oral anticoagulants for venous thromboembolism
Direct oral anticoagulants (DOACs) are at least as efficacious as conventional anticoagulation therapy for the initial and long-term treatment of cancer patients with venous thromboembolism (VTE). Whether DOACs are non-inferior to low-molecular-weight heparin for the management of cancer patients with VTE is under investigation. In addition, the efficacy of DOACs for the treatment of cancer patients with arterial thrombosis (e.g., ischemic stroke) remains unclear. Herein, we report on two cancer patients admitted to our hospital with Stage IV gastric adenocarcinoma who were being treated with DOACs due to a history of VTE ...
Source: Thrombosis Research - March 31, 2017 Category: Hematology Authors: Yasufumi Gon, Manabu Sakaguchi, Junji Takasugi, Hideki Mochizuki Tags: Letter to the Editors-in-Chief Source Type: research

Right Hemispheric Acute Ischemic Stroke Secondary To Right Common Carotid Artery Free Floating Thrombus Due To Hypercoagulable State In An Otherwise Healthy 48-Year-Old Woman. (P6.263)
Conclusions: Due to the high association between malignancy and hypercoagulable state, further work up needs to be warranted in the evaluation of a patient with FFT. To our knowledge this is the first case report of symptomatic FFT treated with an oral direct factor-Xa inhibitor. Further randomized clinical trials are required to assess the best therapeutic approach of this condition.Disclosure: Dr. Orjuela has nothing to disclose. Dr. Gill has nothing to disclose. Dr. Vlahovic has nothing to disclose. Dr. Morales-Vidal has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Orjuela, K., Gill, R., Vlahovic, L., Morales-Vidal, S. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

Concomitant AngioVac thrombectomy and patent foramen ovale closure in a patient with a large right atrial thrombus and recent paradoxical embolic stroke.
Abstract A 59-year-old male with a history of gallbladder adenocarcinoma receiving chemotherapy and on therapeutic anticoagulation for portal vein thrombosis presented to the emergency department via ambulance after being found unresponsive and in cardiac arrest. Initial workup upon return of spontaneous circulation revealed a large right atrial mass, patent foramen ovale (PFO), and bilateral acute cortical infarctions. This constellation of findings were concerning for PFO-related paradoxical embolic strokes. Given the risk of recurrent paradoxical embolic events and the absolute contraindication to thrombolysis ...
Source: Diagnostic and Interventional Radiology : The Turkish Society of Radiology - February 18, 2021 Category: Radiology Authors: Callese TE, Yang EH, Levi D, Srinivasa RN, Moriarty JM Tags: Diagn Interv Radiol Source Type: research

Middle cerebral artery infarction in a cancer patient: a fatal case of Trousseau's syndrome.
This report describes a young, previously healthy man diagnosed to have an acute middle cerebral arterial ischaemic stroke and lower-limb deep vein thrombosis, who subsequently succumbed to pulmonary arterial embolism. During the course of his illness, he was diagnosed to have a malignant pleural effusion secondary to an occult adenocarcinoma. This report highlights the need for a high degree of suspicion for occult malignancy and non-bacterial thrombotic endocarditis in young (<60 years old) ischaemic stroke patients with no identifiable conventional cardiovascular risks. In selected patients, transoesophageal echocard...
Source: Hong Kong Med J - February 1, 2014 Category: Journals (General) Authors: Woo PY, Chan DT, Cheung TC, Zhu XL, Poon WS Tags: Hong Kong Med J Source Type: research

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