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Sickle Mice Are Sensitive to Hypoxia/Ischemia-Induced Stroke but Respond to Tissue-Type Plasminogen Activator Treatment Basic Sciences
Conclusions—Sickle mice are sensitive to hypoxia/ischemia-induced cerebral infarct but benefit from thrombolytic treatment. An increased resistive index in carotid arteries may be an early marker of sickle cell vasculopathy.
Source: Stroke - November 27, 2017 Category: Neurology Authors: Yu-Yo Sun, Jolly Lee, Henry Huang, Mary B. Wagner, Clinton H. Joiner, David R. Archer, Chia-Yi Kuan Tags: Animal Models of Human Disease, Basic Science Research Original Contributions Source Type: research

IJERPH, Vol. 17, Pages 618: Risk Factors Associated with Outcomes of Recombinant Tissue Plasminogen Activator Therapy in Patients with Acute Ischemic Stroke
eng Tsong-Hai Lee Ischemic stroke is the most common type of stroke, and early interventional treatment is associated with favorable outcomes. In the guidelines, thrombolytic therapy using recombinant tissue-type plasminogen activator (rt-PA) is recommended for eligible patients with acute ischemic stroke. However, the risk of hemorrhagic complications limits the use of rt-PA, and the risk factors for poor treatment outcomes need to be identified. To identify the risk factors associated with in-hospital poor outcomes in patients treated with rt-PA, we analyzed the electronic medical records of patients who were diagn...
Source: International Journal of Environmental Research and Public Health - January 17, 2020 Category: Environmental Health Authors: Yi-Ju Tseng Ru-Fang Hu Shin-Tyng Lee Yu-Li Lin Chien-Lung Hsu Shih-Wei Lin Chia-Wei Liou Jiann-Der Lee Tsung-I Peng Tsong-Hai Lee Tags: Article Source Type: research

Long-term outcomes of percutaneous left atrial appendage closure for the prevention of stroke in patients with atrial fibrillation: Asia-Pacific experience
CONCLUSION: This long-term follow-up study shows that percutaneous closure of LAA is a safe and technically feasible procedure with satisfactory outcomes in Asia. The procedure success rate, efficacy and adverse event were similar to those reported in the Caucasian populations.PMID:34799213 | DOI:10.1016/j.jfma.2021.10.010
Source: J Formos Med Assoc - November 20, 2021 Category: General Medicine Authors: Fu-Chun Chiu Pang-Shuo Huang Jien-Jiun Chen Juey-Jen Hwang Chia-Ti Tsai Source Type: research

Obstructive sleep apnea and the risk of ischemic stroke in patients with atrial fibrillation
Atrial fibrillation (AF) is associated with significant morbidity and mortality. Prevention of thromboembolism with oral anticoagulant agents is an important treatment for patients with AF. CHADS2 and CHA2DS2-VASc score has been widely used as the initial approach to assess future stroke risk among AF patients. Obstructive sleep apnea (OSA) is a common breathing disorder associated with substantial cardiovascular morbidity and mortality. It has been reported as an independent risk factor for ischemic stroke [1–4].
Source: International Journal of Cardiology - December 2, 2014 Category: Cardiology Authors: Chun-Chin Chang, Chun-Chih Chiu, Chia-Hung Chiang, Chin-Chou Huang, Wan-Leong Chan, Po-Hsun Huang, Yu-Chun Chen, Tzeng-Ji Chen, Chia-Min Chung, Shing-Jong Lin, Jaw-Wen Chen, Hsin-Bang Leu Tags: Letter to the Editor Source Type: research

Stroke propensity in the Th3+/ mouse model of β-thalassemia intermedia
Neurobiol Dis. 2022 Jun 23:105802. doi: 10.1016/j.nbd.2022.105802. Online ahead of print.ABSTRACTβ-thalassemia is associated with multiple hematological and cerebrovascular symptoms linked to a hypercoagulable state that has not been fully replicated in animal models for the development of stroke treatments. Herein we compared the physiological properties and responses to transient cerebral hypoxia-ischemia (tHI) between six-month-old wildtype and heterozygous Th3/+ mice, a model of non-transfusion-dependent β-thalassemia intermedia (β-TI). We found that Th3/+ mice developed microcytic anemia, splenomegaly, higher plate...
Source: Neurobiology of Disease - June 26, 2022 Category: Neurology Authors: Yu-Yo Sun Hui-Wen Yao Hong-Ru Chen Ching-Wen Chen Melissa M Kinkaid Chia-Yi Kuan Source Type: research

Long-Term Effectiveness of Cilostazol in Patients with Hemodialysis with Peripheral Artery Disease
CONCLUSION: Continuous treatment of cilostazol in patients with HD with PAD significantly decreases the risk of ED visits, hemorrhagic stroke, and cardiovascular events and improves ED visit-free and cardiovascular event-free rates during long-term follow-up.PMID:36216573 | DOI:10.5551/jat.63404
Source: Journal of Atherosclerosis and Thrombosis - October 10, 2022 Category: Cardiology Authors: Chung-Kuan Wu Chia-Hsun Lin Noi Yar Zih-Kai Kao Ya-Bei Yang Yun-Yi Chen Source Type: research

Novel oral anticoagulant vs. warfarin in elderly atrial fibrillation patients with normal, mid ‐range, and reduced left ventricular ejection fraction
ConclusionsIn elderly AF patients ≥65 years, using NOAC was associated with lower IS/SE compared with warfarin in normal and mid‐range LVEF but not in reduced LVEF. Using NOACs was associated with lower death compared with warfarin in normal LVEF.
Source: ESC Heart Failure - July 15, 2020 Category: Cardiology Authors: Victor Chien ‐Chia Wu, Chun‐Li Wang, Cheng‐Hung Lee, Yu‐Ling Chen, Hui‐Tzu Tu, Michael Wu, Chang‐Fu Kuo, Shao‐Wei Chen, Yu‐Tung Huang, Ming‐Shien Wen, Shang‐Hung Chang Tags: Original Research Article Source Type: research

Long-term outcomes of left atrial appendage occlusion in patients with atrial fibrillation and end stage renal disease
CONCLUSIONS: Long-term outcomes of LAAO therapy may be less favorable in patients with AF undergoing dialysis, possibly because of the poor condition of patients with ESRD.PMID:37394333 | DOI:10.1016/j.jfma.2023.06.016
Source: J Formos Med Assoc - July 2, 2023 Category: General Medicine Authors: Sheng-Nan Chang Chin-Feng Tsai Ting-Tse Lin Fu-Chun Chiu Jung-Cheng Hsu Su-Kiat Chua Hsiao-Liang Cheng Li-Ting Ho Pang-Shuo Huang Jien-Jiun Chen Cho-Kai Wu Yi-Chih Wang Juey-Jen Hwang Chia-Ti Tsai Source Type: research

Thromboinflammatory Functions of Platelets in Ischemia –Reperfusion Injury and Its Dysregulation in Diabetes
Semin Thromb Hemost DOI: 10.1055/s-0037-1613694Ischemia–reperfusion (IR) injury is a common complication of a variety of cardiovascular diseases, including ischemic stroke and myocardial infarction (MI). While timely re-establishment of blood flow in a thrombosed artery is the primary goal of acute therapy in these diseases, paradoxically, reperfusion of ischemic tissue can cause widespread microvascular dysfunction that significantly exacerbates organ damage. Reperfusion injury is associated with activation of the humoral and cellular components of the hemostatic and innate immune systems and also with excessive reactiv...
Source: Seminars in Thrombosis and Hemostasis - January 2, 2018 Category: Hematology Authors: Maiocchi, Sophie Alwis, Imala Wu, Mike Chia Lun Yuan, Yuping Jackson, Shaun P. Tags: Review Article Source Type: research

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