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Source: Stroke
Condition: Thrombosis

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Total 230 results found since Jan 2013.

Alteplase Reduces Downstream Microvascular Thrombosis and Improves the Benefit of Large Artery Recanalization in Stroke Basic Sciences
Conclusions— Our data demonstrate that DMT is an early phenomenon initiated before recanalization. We further show that alteplase-dependent maintenance of downstream perfusion during MCAO improves acute ischemic stroke outcome through a fibrinogen-dependent platelet aggregation reduction. Our results indicate that early targeting of DMT represents a therapeutic strategy to improve the benefit of large artery recanalization in acute ischemic stroke.
Source: Stroke - October 26, 2015 Category: Neurology Authors: Desilles, J.-P., Loyau, S., Syvannarath, V., Gonzalez-Valcarcel, J., Cantier, M., Louedec, L., Lapergue, B., Amarenco, P., Ajzenberg, N., Jandrot-Perrus, M., Michel, J.-B., Ho-Tin-Noe, B., Mazighi, M. Tags: Fibrinolysis, Fibrinogen/fibrin, Acute Cerebral Infarction, Brain Circulation and Metabolism, Thrombolysis Basic Sciences Source Type: research

Early Loss of Immediate Reperfusion While Stent Retriever in Place Predicts Successful Final Reperfusion in Acute Ischemic Stroke Patients Brief Reports
Conclusions— ELOIR during the embedding period after deployment of stent retrievers is associated with successful final reperfusion, likely because of greater thrombus engagement with the stent retriever. ELOIR may be a useful finding to guide duration of embedding time in clinical practice and design of novel stent retrievers.
Source: Stroke - October 26, 2015 Category: Neurology Authors: Okawa, M., Tateshima, S., Liebeskind, D., Rao, N., Jahan, R., Gonzalez, N., Szeder, V., Ali, L., Kim, D., Saver, J., Duckwiler, G. Tags: Acute Cerebral Infarction, Acute Stroke Syndromes, Embolic stroke Brief Reports Source Type: research

Association Between Anemia and Cerebral Venous Thrombosis: Case-Control Study Clinical Sciences
Conclusion— Our data suggest that anemia is a risk factor for CVT.
Source: Stroke - September 28, 2015 Category: Neurology Authors: Coutinho, J. M., Zuurbier, S. M., Gaartman, A. E., Dikstaal, A. A., Stam, J., Middeldorp, S., Cannegieter, S. C. Tags: Thrombosis risk factors, Cerebral Venous Thrombosis Clinical Sciences Source Type: research

Cross-National Key Performance Measures of the Quality of Acute Stroke Care in Western Europe Clinical Sciences
Conclusions— On the basis of experience of quality registers in Europe, we have proposed a common set of performance measures that will facilitate the international comparison of acute stroke care quality.
Source: Stroke - September 28, 2015 Category: Neurology Authors: Norrving, B., Bray, B. D., Asplund, K., Heuschmann, P., Langhorne, P., Rudd, A. G., Wagner, M., Wiedmann, S., Wolfe, C. D. A., for the European Implementation Score Collaboration Tags: Health policy and outcome research Clinical Sciences Source Type: research

Cavernous Sinus Thrombosis in Children: Imaging Characteristics and Clinical Outcomes Brief Reports
Conclusions— CAN and infarcts were common in this modest cohort of children with CST. Despite the high incidence of CAN and infarction, outcomes were often favorable. Although this is the largest cohort of childhood CST reported to date, large multicenter cohorts are needed to confirm our findings and determine the preferred therapeutic strategies for childhood CST.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Press, C. A., Lindsay, A., Stence, N. V., Fenton, L. Z., Bernard, T. J., Mirsky, D. M. Tags: Computerized tomography and Magnetic Resonance Imaging, Anticoagulants, Antiplatelets Brief Reports Source Type: research

Altered Fibrin Clot Properties in Patients With Cerebral Venous Sinus Thrombosis: Association With the Risk of Recurrence Brief Reports
Conclusions— CVST is associated with the formation of more compact plasma fibrin clots and resistance to fibrinolysis, which may predispose to the recurrence.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Siudut, J., Świat, M., Undas, A. Tags: Fibrinolysis, Fibrinogen/fibrin, Cerebral Venous Thrombosis Brief Reports Source Type: research

Prognostic Significance of Short-Term Blood Pressure Variability in Acute Stroke: Systematic Review Clinical Sciences
Conclusions— This systematic review and meta-analysis suggest that greater systolic BPV, measured early from ischemic stroke or intracerebral hemorrhage onset, is associated with poor longer-term functional outcome. Future prospective studies should investigate how best to measure and define BPV in acute stroke, as well as to determine its prognostic significance.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Manning, L. S., Rothwell, P. M., Potter, J. F., Robinson, T. G. Tags: Cerebrovascular disease/stroke, Acute Cerebral Hemorrhage, Acute Cerebral Infarction, Acute Stroke Syndromes Clinical Sciences Source Type: research

Recurrent Stroke: The Value of the CHA2DS2VASc Score and the Essen Stroke Risk Score in a Nationwide Stroke Cohort Clinical Sciences
Conclusions— In this cohort of non–atrial fibrillation patients with incident ischemic stroke, increasing CHA2DS2VASc score and Essen Stroke Risk Score was associated with increasing risk of recurrent stroke, death, and cardiovascular events. Their discriminatory performance was modest and further refinements are required for clinical application.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Andersen, S. D., Gorst-Rasmussen, A., Lip, G. Y. H., Bach, F. W., Larsen, T. B. Tags: Risk Factors, Acute Cerebral Infarction Clinical Sciences Source Type: research

Younger Stroke Patients With Large Pretreatment Diffusion-Weighted Imaging Lesions May Benefit From Endovascular Treatment Clinical Sciences
Conclusions— There was a growing risk for poor outcome and symptomatic intracerebral hemorrhage with increasing pretreatment DWI lesion volumes. Nevertheless, favorable outcome was achieved in every third patient with DWI lesions >70 mL after successful endovascular reperfusion, whereas after poor or failed reperfusion, outcome was favorable in only every 12th patient. Therefore, endovascular treatment might be considered in patients with large DWI lesions, especially in younger patients.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Gilgen, M. D., Klimek, D., Liesirova, K. T., Meisterernst, J., Klinger-Gratz, P. P., Schroth, G., Mordasini, P., Hsieh, K., Slotboom, J., Heldner, M. R., Broeg-Morvay, A., Mono, M.-L., Fischer, U., Mattle, H. P., Arnold, M., Gralla, J., El-Koussy, M., Jun Tags: Acute Cerebral Infarction, Thrombolysis, Other Stroke Treatment - Medical Clinical Sciences Source Type: research

Residual Risk of Stroke and Death in Anticoagulated Patients According to the Type of Atrial Fibrillation: AMADEUS Trial Clinical Sciences
Conclusions— The risk of cardiovascular death, stroke, or systemic embolism is higher in anticoagulated patients with permanent AF than in those with nonpermanent AF, regardless of preexisting heart failure.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Senoo, K., Lip, G. Y. H., Lane, D. A., Buller, H. R., Kotecha, D. Tags: Thrombosis risk factors Clinical Sciences Source Type: research

White Matter Lesions Double the Risk of Post-Thrombolytic Intracerebral Hemorrhage Clinical Sciences
Conclusions— WMLs visible on computed tomography are associated with a more than doubled risk of sICH in patients treated with intravenous thrombolysis for acute ischemic stroke.
Source: Stroke - July 27, 2015 Category: Neurology Authors: Curtze, S., Haapaniemi, E., Melkas, S., Mustanoja, S., Putaala, J., Sairanen, T., Sibolt, G., Tiainen, M., Tatlisumak, T., Strbian, D. Tags: Computerized tomography and Magnetic Resonance Imaging, Thrombolysis Clinical Sciences Source Type: research

Duration of Diabetes Mellitus and Risk of Thromboembolism and Bleeding in Atrial Fibrillation: Nationwide Cohort Study Clinical Sciences
Conclusions— In patients with atrial fibrillation, longer duration of diabetes mellitus was associated with a higher risk of thromboembolism, but not with a higher risk of anticoagulant-related bleeding. Considering the critical balance between preventing thromboembolism and avoiding bleeding, longer duration of diabetes mellitus may favor initiation of anticoagulant therapy.
Source: Stroke - July 27, 2015 Category: Neurology Authors: Overvad, T. F., Skjoth, F., Lip, G. Y. H., Lane, D. A., Albertsen, I. E., Rasmussen, L. H., Larsen, T. B. Tags: Thrombosis risk factors, Type 1 diabetes, Type 2 diabetes, Embolic stroke, Anticoagulants Clinical Sciences Source Type: research

Retrobulbar Spot Sign Predicts Thrombolytic Treatment Effects and Etiology in Central Retinal Artery Occlusion Brief Reports
Conclusions— Transbulbar ultrasound is valuable for initial diagnosis and diagnostic workup of CRAO. In the light of inconsistent results of previous thrombolysis trials, ultrasound may identify patients more likely to benefit from thrombolytic treatment.
Source: Stroke - July 27, 2015 Category: Neurology Authors: Nedelmann, M., Graef, M., Weinand, F., Wassill, K.-H., Kaps, M., Lorenz, B., Tanislav, C. Tags: Clinical Studies, Doppler ultrasound, Transcranial Doppler etc., Thrombolysis Brief Reports Source Type: research

Homocysteine, Ischemic Stroke, and Coronary Heart Disease in Hypertensive Patients: A Population-Based, Prospective Cohort Study Clinical Sciences
Conclusions— Hyperhomocysteinemia in Chinese hypertensive patients is significantly associated with IS risk but not coronary heart disease susceptibility, and folic acid supplementation can efficiently reduce tHcy levels.
Source: Stroke - June 22, 2015 Category: Neurology Authors: Han, L., Wu, Q., Wang, C., Hao, Y., Zhao, J., Zhang, L., Fan, R., Liu, Y., Li, R., Chen, Z., Zhang, T., Chen, S., Ma, J., Liu, S., Peng, X., Duan, S. Tags: Myocardial cardiomyopathy disease, Valvular heart disease, Clinical Studies, Acute Cerebral Hemorrhage, Cerebral Venous Thrombosis Clinical Sciences Source Type: research

Effect Size Estimates for the ESCAPE Trial: Proportional Odds Regression Versus Other Statistical Methods Clinical Sciences
Conclusions— The mRS distribution for both treatment and control groups influences the power of the investigated statistical models to assess treatment efficacy. A careful evaluation of the expected outcome distribution across the mRS scale is required to determine the best choice of primary analysis.
Source: Stroke - June 22, 2015 Category: Neurology Authors: Sajobi, T. T., Zhang, Y., Menon, B. K., Goyal, M., Demchuk, A. M., Broderick, J. P., Hill, M. D. Tags: Thrombolysis, Other Stroke Treatment - Surgical Clinical Sciences Source Type: research