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Is Intra-Arterial Thrombolysis Beneficial for M2 Occlusions? Subgroup Analysis of the PROACT-II Trial Brief Reports
Conclusions— Intra-arterial thrombolysis may lead to a 3-fold increase in the rate of early reperfusion of solitary M2 occlusions and could potentially double the chance of a favorable functional outcome at 90 days. Clinical Trial Registration— This trial was not registered because enrollment began before July 1, 2005.
Source: Stroke - December 24, 2012 Category: Neurology Authors: Rahme, R., Abruzzo, T. A., Martin, R. H., Tomsick, T. A., Ringer, A. J., Furlan, A. J., Carrozzella, J. A., Khatri, P. Tags: Clinical Studies, Emergency treatment of Stroke, Thrombolysis Brief Reports Source Type: research

Density of Thrombus on Admission CT Predicts Revascularization Efficacy in Large Vessel Occlusion Acute Ischemic Stroke Brief Reports
Conclusions— Thrombi with lower HU on NECT appear to be more resistant to pharmacological lysis and mechanical thrombectomy. Measuring thrombus density on admission NECT provides a rapid method to analyze clot composition, a potentially useful discriminator in selecting the most appropriate reperfusion strategy for an individual patient.
Source: Stroke - December 24, 2012 Category: Neurology Authors: Moftakhar, P., English, J. D., Cooke, D. L., Kim, W. T., Stout, C., Smith, W. S., Dowd, C. F., Higashida, R. T., Halbach, V. V., Hetts, S. W. Tags: Acute Cerebral Infarction, Angiography, Computerized tomography and Magnetic Resonance Imaging Brief Reports Source Type: research

Venous Thromboembolism Risk in Ischemic Stroke Patients Receiving Extended-Duration Enoxaparin Prophylaxis: Results From the EXCLAIM Study Brief Reports
Conclusion— Extended-duration thromboprophylaxis with enoxaparin was associated with reduced venous thromboembolism risk and increased major bleeding in the subgroup of patients with ischemic stroke in the EXCLAIM study. Clinical Trial Registration Information— URL: http://clinicaltrials.gov. Unique Identifier: NCT00077753.
Source: Stroke - December 24, 2012 Category: Neurology Authors: Turpie, A. G. G., Hull, R. D., Schellong, S. M., Tapson, V. F., Monreal, M., Samama, M.-M., Chen, M., Yusen, R. D., for the EXCLAIM Investigators Tags: Cerebrovascular disease/stroke, Deep vein thrombosis, Anticoagulants Brief Reports Source Type: research

Early Insulin Glycemic Control Combined With tPA Thrombolysis Reduces Acute Brain Tissue Damages in a Focal Embolic Stroke Model of Diabetic Rats Brief Reports
Conclusions— Early insulin glycemic control may be beneficial in combination with tPA thrombolysis for ischemic stroke with diabetes mellitus or poststroke hyperglycemia.
Source: Stroke - December 24, 2012 Category: Neurology Authors: Fan, X., Ning, M., Lo, E. H., Wang, X. Tags: Animal models of human disease, Type 1 diabetes, Acute Cerebral Infarction, Embolic stroke, Emergency treatment of Stroke, Thrombolysis Brief Reports Source Type: research

Toward the Neurovascular Unit A Journey in Clinical Translation: 2012 Thomas Willis Lecture Special Report
The Nobel laureate Max Delbrück often said that it is the crossover between disciplines where advances are possible in science. This certainly has been true for our understanding of the vascular biology of the central nervous system in the setting of ischemic stroke. The ability to cross the boundaries of hemostasis, neurology, hematology, and neuroscience has facilitated our research direction to define the relation of the microvasculature to neuron function. Work begun with the clinical scientific exploration of the contributions of arterial thrombosis to the acute injury processes initiated by focal cerebral ischem...
Source: Stroke - December 24, 2012 Category: Neurology Authors: del Zoppo, G. J. Tags: Special Report Source Type: research

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