Stroke RSS Page 15

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Condition: Thrombosis
Drug: Activase

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Total 351 results found since Jan 2013.

Influence of recent direct-to-EVT trials on practical decision-making for the treatment of acute ischemic stroke patients
CONCLUSION: In light of the recent direct-to-EVT trials, a sizeable proportion of stroke physicians appears to be rethinking IVT treatment strategies of EVT-eligible mothership patients with AIS due to LVO in specific situations.PMID:34787489 | DOI:10.1177/15910199211057984
Source: Interventional Neuroradiology - November 17, 2021 Category: Radiology Authors: Rosalie McDonough Johanna Ospel Nima Kashani Manon Kappelhof Jianmin Liu Pengfei Yang Charles Majoie Yvo Roos Mayank Goyal Source Type: research

Emerging agents for the treatment and prevention of stroke: progress in clinical trials
Expert Opin Investig Drugs. 2021 Sep 24. doi: 10.1080/13543784.2021.1985463. Online ahead of print.ABSTRACTINTRODUCTION: Recent years have witnessed unprecedented progress in stroke care, but unmet needs persist regarding the efficacy of acute treatment and secondary prevention. Novel approaches are being tested to enhance the efficacy of thrombolysis or provide neuroprotection in non-thrombolized patients.AREAS COVERED: The current review highlights pharmaceutical agents under evaluation in clinical trials concerning the acute, subacute, and chronic phase post-stroke. We examine the evidence in favor of tenecteplase as an...
Source: Expert Opinion on Investigational Drugs - September 24, 2021 Category: Drugs & Pharmacology Authors: Apostolos Safouris Georgios Magoufis Georgios Tsivgoulis Source Type: research

Reduced-dose intravenous thrombolysis for acute intermediate high-risk pulmonary embolism: Rationale and design of the PEITHO-3 trial
Thromb Haemost. 2021 Sep 24. doi: 10.1055/a-1653-4699. Online ahead of print.ABSTRACTIntermediate high-risk pulmonary embolism (PE) is characterised by right ventricular (RV) dysfunction and elevated circulating cardiac troponin levels despite apparent haemodynamic stability at presentation. In these patients, full-dose systemic thrombolysis reduced the risk of haemodynamic decompensation or death but increased the risk of life-threatening bleeding. Reduced-dose thrombolysis may be capable of improving safety while maintaining reperfusion efficacy. The Pulmonary Embolism International Trial (PEITHO)-3 study (EudraCT 2018-0...
Source: Thrombosis and Haemostasis - September 24, 2021 Category: Hematology Authors: Olivier Sanchez Anais Charles-Nelson Walter Ageno Stefano Barco Harald Binder Gilles Chatellier Daniel Duerschmied Klaus Empen Melanie Ferreira Philippe Girard Menno V Huisman David Jim énez Sandrine Katsahian Matija Kozak Mareike Lankeit Nicolas Menevea Source Type: research

Effect of Apixaban Pretreatment on Alteplase-Induced Thrombolysis: An In Vitro Study
Benefit of thrombolytic therapy in patients with acute stroke, who are on anticoagulant treatment, is not well addressed. The aim of this study was to investigate whether apixaban can modify the thrombolytic efficacy of alteplase in vitro. Static and flow models and two variants of red blood cell (RBC) dominant clots, with and without apixaban, were used. Clots were prepared from the blood of healthy human donors and subsequently exposed to alteplase treatment. Apixaban and alteplase were used in clinically relevant concentrations. Clot lysis in the static model was determined both by clot weight and spectrophotometric det...
Source: Frontiers in Pharmacology - September 15, 2021 Category: Drugs & Pharmacology Source Type: research

Fucoidan-functionalized polysaccharide submicroparticles loaded with alteplase for efficient targeted thrombolytic therapy
Biomaterials. 2021 Aug 30;277:121102. doi: 10.1016/j.biomaterials.2021.121102. Online ahead of print.ABSTRACTIntravenous administration of fibrinolytic drugs is the standard treatment of acute thrombotic diseases. However, current fibrinolytics exhibit limited clinical efficacy because of their short plasma half-lives and might trigger hemorrhagic transformations. Therefore, it is mandatory to develop innovative nanomedicine-based solutions for more efficient and safer thrombolysis with biocompatible and biodegradable thrombus-targeted nanocarrier. Herein, fucoidan-functionalized hydrogel polysaccharide submicroparticles w...
Source: Biomaterials - September 5, 2021 Category: Materials Science Authors: Alina Zenych Charl ène Jacqmarcq Rachida Aid Louise Fournier Laura M Forero Ramirez Fr édéric Chaubet Thomas Bonnard Denis Vivien Didier Letourneur C édric Chauvierre Source Type: research

Familiarization with Contact Aspiration using Non-Penetrating of the Thrombus (CANP) Technique as the Initial Procedure for Acute Ischemic Stroke
Thrombectomy, along with intravenous alteplase, had been the standard medical care to achieve rapid and complete reperfusion for acute ischemic stroke.1 Many devices and techniques had been developed and devised, respectively, to achieve rapid and complete reperfusion. Thrombectomy includes stent retriever thrombectomy, with or without aspiration assistance, and contact aspiration (CA), mainly a direct aspiration first-pass technique (ADAPT). Kang et al. reported CA using a catheter with an inner diameter (I.D.) of 0.041 in.
Source: Journal of Stroke and Cerebrovascular Diseases - September 3, 2021 Category: Neurology Authors: Hiroaki Neki, Takehiro Katano, Takuma Maeda, Aoto Shibata, Hiroyuki Komine, Yuichiro Kikkawa Source Type: research

P-042 Initial experience with tenecteplase as the intravenous thrombolytic of choice before mechanical thrombectomy for large vessel occlusion acute ischemic stroke
ConclusionIntravenous TNK in patients with LVOAIS is feasible, safe and effective. In our cohort from ‘real world’ patients, TNK was associated with lower need for MT, high recanalization rates and shorter hospitalization.Disclosures U. Ugur: None. S. Platko: None. D. Peters: None. F. Bensabeur: None. J. Terry: None. B. Ludwig: None. E. Cheng-Ching: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Ugur, U., Platko, S., Peters, D., Bensabeur, F., Terry, J., Ludwig, B., Cheng-Ching, E. Tags: Oral poster abstracts Source Type: research

Maximum intravenous Alteplase dose for obese stroke patients is not associated with greater likelihood of worse outcomes
We examined differences between patients treated with WBD vs. MD.
Source: Thrombosis Research - June 6, 2021 Category: Hematology Authors: Kaushik Ravipati, Roboan Guillen, Starlie Belnap, Anshul Saxena, Emir Veledar, Amy K. Starosciak, Felipe De Los Rios La Rosa Source Type: research

Factors that Influence Door-to-Needle Administration for Acute Stroke Patients in the Emergency Department
CONCLUSION: Although many factors can influence door-to-needle times in the ED, we did not find National Institutes of Health Stroke Scale score on arrival and time of day to be significant factors. Patients arriving to the ED by personal vehicle will have a significant delay in IV alteplase administration, therefore emphasizing the importance of using emergency medical services. Perhaps more importantly, collaborative efforts including the addition of a specialized stroke nurse significantly decreased time to IV alteplase administration for AIS patients. With this dedicated role, accelerated triage and more effective mana...
Source: Journal of Neuroscience Nursing - May 18, 2021 Category: Neuroscience Tags: Articles Source Type: research

Impact of intravenous alteplase on sub-angiographic emboli in high-resolution diffusion-weighted imaging following successful thrombectomy
ConclusionsIntravenous alteplase neither affects the number nor volume of sub-angiographic DWI-PE after successful endovascular reperfusion. In the light of currently running randomized trials, further studies are warranted to validate these findings.Key Points• Thrombus microfragmentation during endovascular stroke treatment may cause peripheral emboli that are only detectable on diffusion-weighted imaging and may directly compromise treatment effects.• In this prospective study, the application of intravenous alteplase did not influence the occurrence of peripheral emboli detected on high-resolution diffusion-weighte...
Source: European Radiology - May 8, 2021 Category: Radiology Source Type: research

Safety and efficacy of intravenous thrombolytic treatment in wake ‐up stroke: Experiences from a single center
ConclusionsOur study demonstrated that in patients who awaken with stroke symptoms, intravenous thrombolytic treatment is a safe procedure that may lead to favorable outcomes. Further studies should be performed to increase the size of the group of patients with wake ‐up strokes who can be treated with reperfusion therapy.
Source: Brain and Behavior - May 3, 2021 Category: Neurology Authors: Adam Wi śniewski Tags: ORIGINAL RESEARCH Source Type: research

Intravenous abciximab as a rescue therapy for immediate reocclusion after successful mechanical thrombectomy in acute ischemic stroke patients
Conclusions - Our results underscore a key role for platelet aggregation and the potential of Glycoprotein IIb/IIIa antagonists as a rescue therapy in post-MT immediate reocclusion.PMID:33840346 | DOI:10.1080/09537104.2021.1894326
Source: Platelets - April 12, 2021 Category: Hematology Authors: Fran çois Delvoye Stephane Loyau Julien Labreuche Guillaume Taylor Benjamin Maier Michel Piotin Raphael Blanc Simon Escalard Lucas Di Meglio Malek Ben Maacha Hocine Redjem Stanislas Smajda Gabriele Ciccio Sol ène Hébert Candice Sabben Martine Jandrot-P Source Type: research

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