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Condition: Hypertension
Procedure: Cardiac Catheterization

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Total 178 results found since Jan 2013.

Effects of sotatercept on haemodynamics and right heart function: analysis of the STELLAR trial
Conclusion In pre-treated patients with PAH, sotatercept demonstrated substantial improvements in PA pressures, PA compliance, PA–RV coupling and right heart function.
Source: European Respiratory Journal - September 21, 2023 Category: Respiratory Medicine Authors: Souza, R., Badesch, D. B., Ghofrani, H. A., Gibbs, J. S. R., Gomberg-Maitland, M., McLaughlin, V. V., Preston, I. R., Waxman, A. B., Grünig, E., Kopec, G., Meyer, G., Olsson, K. M., Rosenkranz, S., Lin, J., Johnson-Levonas, A. O., de Oliveira Pena Tags: Original Articles: Pulmonary vascular disease Source Type: research

Effects of sotatercept on haemodynamics and right heart function: analysis of STELLAR trial
CONCLUSION: In pre-treated patients with PAH, sotatercept demonstrated substantial improvements in PA pressures, PA compliance, PA-RV coupling and right heart function.PMID:37696565 | DOI:10.1183/13993003.01107-2023
Source: Respiratory Care - September 11, 2023 Category: Respiratory Medicine Authors: Rogerio Souza David B Badesch H Ardeschir Ghofrani J Simon R Gibbs Mardi Gomberg-Maitland Vallerie V McLaughlin Ioana R Preston Aaron B Waxman Ekkehard Gr ünig Grzegorz Kope ć Gisela Meyer Karen M Olsson Stephan Rosenkranz Jianxin Lin Amy O Johnson-Levo Source Type: research

Echocardiographic pressure –strain loop‐derived stroke work of the right ventricle: validation against the gold standard
ConclusionsIntegrated echo measurement of pressure –strain loop-derived SW correlates with PV loop-based assessment of RV SW. Wasted work correlates with invasive measures of load-independent RV function. Given the methodological and anatomical challenges of RV work assessment, evolution of this approach by incorporating more elaborated echo analy sis data and an RV reference curve might improve its reliability to mirror invasively assessed RV SW.
Source: ESC Heart Failure - July 7, 2023 Category: Cardiology Authors: Manuel J. Richter, Philipp Douschan, Federico Fortuni, Henning Gall, Hossein A. Ghofrani, Stanislav Keranov, Nils Kremer, Steffen D. Kriechbaum, Zvonimir A. Rako, Andreas J. Rieth, Bruno Brito Rocha, Werner Seeger, Daniel Zedler, Selin Yildiz Tags: Short Communication Source Type: research

Adrenomedullin peptides and precursor levels in relation to haemodynamics and prognosis after heart transplantation
ConclusionsElevated plasma levels of ADM may be a marker of pressure/volume overload in HF patients with PH, as well as long-term prognosis after HT. In line with previous studies, our findings additionally confirm that ADM may be a marker of venous congestion in HF. Further studies are encouraged to establish a deeper understanding of the properties of ADM and its relationship with HF and PH, in order to potentially facilitate clinical management of HF and associated PH.
Source: ESC Heart Failure - May 29, 2023 Category: Cardiology Authors: Abdulla Ahmed, Kriss Kania, Hebba Abdul Rahim, Salaheldin Ahmed, G öran Rådegran Tags: Original Article Source Type: research

Inflammation May Be the Culprit Behind Our Deadliest Diseases
In the early days of my medical residency, I met a man whom we’ll call Jason. He arrived to our emergency room on a holiday, nonchalant yet amiable, and complained of mild chest pain. Jason was tall and trim, with a strong South Boston accent and fingertips still faintly stained from his last home-improvement project. He was only 45 years old, but he looked much younger. He didn’t smoke, barely drank alcohol, and his cholesterol levels had always been normal. No one in his family had a history of heart disease. He asked us if we could work quickly—he wanted to be home for dinner with his daughters. [time-...
Source: TIME: Health - April 11, 2023 Category: Consumer Health News Authors: Shilpa Ravella Tags: Uncategorized freelance health Source Type: news

Acute beat blockade improves right ventricular diastolic filling in pulmonary arterial hypertension: a rodent CMR and clinical human pressure-volume study
Conclusions: Esmolol improves RV diastolic filling in PAH at rest and during low-grade exercise, preserving SV and CO, with energetically favourable effects on contractile efficiency.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Samaranayake, C., Niglas, M., Kempny, A., Baxan, N., Ashek, A., Pinguel, J., Dimopoulos, K., Price, L. C., Wort, S. J., Zhao, L., Mccabe, C. Tags: 13.01 - Pulmonary hypertension Source Type: research

Adaptive versus maladaptive right ventricular remodelling
AbstractRight ventricular (RV) function and its adaptation to increased afterload [RV –pulmonary arterial (PA) coupling] are crucial in various types of pulmonary hypertension, determining symptomatology and outcome. In the course of disease progression and increasing afterload, the right ventricle undergoes adaptive remodelling to maintain right-sided cardiac output by increasing contractility. Exhaustion of compensatory RV remodelling (RV–PA uncoupling) finally leads to maladaptation and increase of cardiac volumes, resulting in heart failure. The gold-standard measurement of RV–PA coupling is the ratio of contract...
Source: ESC Heart Failure - November 24, 2022 Category: Cardiology Authors: Zvonimir A. Rako, Nils Kremer, Athiththan Yogeswaran, Manuel J. Richter, Khodr Tello Tags: Review Source Type: research

Elevated plasma WIF ‐1 levels are associated with worse prognosis in heart failure with pulmonary hypertension
ConclusionsThe present study demonstrated that LHF-PH patients have higher plasma WIF-1 levels than healthy controls, suggesting that plasma WIF-1 may be a potential future prognostic biomarker in LHF-PH. Its prognostic capability could be further refined by including it in a multi-marker panel. Further studies are needed to establish the potential role of WIF-1 in LHF-PH pathophysiology in larger cohorts to determine its clinical applicability.
Source: ESC Heart Failure - September 9, 2022 Category: Cardiology Authors: Kriss Kania, Abdulla Ahmed, Salaheldin Ahmed, G öran Rådegran Tags: Original Article Source Type: research

How we do it: evaluation of dyspnea and exercise intolerance after acute pulmonary embolism
Chest. 2022 Jul 2:S0012-3692(22)01215-6. doi: 10.1016/j.chest.2022.06.036. Online ahead of print.ABSTRACTLong-term dyspnea and exercise intolerance are common clinical problems after acute PE. Unfortunately, no single test can distinguish among the range of potential pathological outcomes after PE. We illustrate a stepwise approach to post-PE evaluation that uses a hierarchical series of clinically validated diagnostic tests. The algorithm is represented by the acronym SEARCH, which stands for symptom screening, exercise testing, arterial perfusion, resting echocardiography, confirmatory chest imaging and (right) heart cat...
Source: Chest - July 6, 2022 Category: Respiratory Medicine Authors: Timothy A Morris Timothy M Fernandes Richard Channick Source Type: research

Blunted cardiovascular effects of beta-blockers in patients with cirrhosis: Relation to severity?
ConclusionWe found the effect of beta-blockade on cardiac index in patients with advanced cirrhosis to be less potent than in patients with early cirrhosis, indicating that underlying cirrhotic cardiomyopathy increases, and the cardiac compensatory reserve becomes more compromised, with disease progression. The differential effects of beta-blockade in the left atrium may be used to predict the effect of beta-blockers on portal pressure, but further studies are needed to investigate this possibility.
Source: PLoS One - June 28, 2022 Category: Biomedical Science Authors: Puria Nabilou Source Type: research

Clinical value of echocardiography in evaluating hemodynamics and right ventricular function in patients with chronic thromboembolic pulmonary hypertension after balloon pulmonary angioplasty
CONCLUSIONS: The findings show that a single BPA procedure significantly improves RV volume load and reduces the pulmonary blood pressure in CTEPH patients in the short-term. However, BPA does not improve RV systolic function 24 hours after the procedure. The results indicate that evaluation of RV structural and function with echocardiography is an effective approach for non-invasive monitoring of patient status after BPA.PMID:35693626 | PMC:PMC9186241 | DOI:10.21037/jtd-21-1536
Source: Journal of Thoracic Disease - June 13, 2022 Category: Respiratory Medicine Authors: Jiaxin Chen Shangwei Ding Chenkai Zhang Rifei Li Wenliang Guo Chen Hong Qing Tang Source Type: research