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Regulation of Ncbe in the Choroid Plexus of Mice after Hemorrhage-Induced Hydrocephalus
FASEB J. 2022 May;36 Suppl 1. doi: 10.1096/fasebj.2022.36.S1.R3405.ABSTRACTThe choroid plexus (CP) is a small tissue located inside brain ventricles. It is responsible for the production of most of the cerebrospinal fluid (CSF); approximately 500 mL of CSF per day in the adult human [1, 2]. CSF production occurs as a net result of transcellular movement of salt and water, carried out by various cellular transporters. Ncbe is a sodium-coupled bicarbonate transporter located in the basolateral membrane of the choroid plexus epithelial (CPE) cells. It transports Na+ and HCO3 - into the cell in exchange for Cl- . Ncbe is the m...
Source: Pharmacological Reviews - May 13, 2022 Category: Drugs & Pharmacology Authors: Laura Ø Johnsen Kathrine A Friis Laura B Ry ø Jacob G Mikkelsen Thomas B Lindhardt Rasmus W Knopper Brian Hansen Jeppe Praetorius Helle H Damkier Source Type: research

Astragaloside IV attenuates ferroptosis after subarachnoid hemorrhage via Nrf2/HO-1 signaling pathway
Subarachnoid hemorrhage (SAH) is a severe type of stroke featuring exceptionally high rate of morbidity and mortality due to the lack of effective management. Ferroptosis can be defined as a novel iron-dependent programmed cell death in contrast to classical apoptosis and necrosis. Astragaloside IV (AS-IV) is an active ingredient extracted from Astragalus membranaceus with established therapeutic effect on CNS diseases. However, the exact role of ferroptosis in Astragaloside IV-mediated neuroprotection after SAH is yet to be demonstrated. In the present study, the SAH model of SD male rats with endovascular perforation was...
Source: Frontiers in Pharmacology - August 19, 2022 Category: Drugs & Pharmacology Source Type: research

Activation of HIF-1α/VEGF-A pathway by deferoxamine ameliorates retinal hypoxia in a rat subarachnoid hemorrhage model
Conclusions Our findings suggest that modulating the application of deferoxamine may offer therapeutic approaches to alleviate retinal complications after SAH.
Source: NeuroReport - October 6, 2022 Category: Neurology Tags: Degeneration and Repair Source Type: research

Deferoxamine Prevents Neonatal Posthemorrhagic Hydrocephalus Through Choroid Plexus-Mediated Iron Clearance
AbstractPosthemorrhagic hydrocephalus occurs in up to 30% of infants with high-grade intraventricular hemorrhage and is associated with the worst neurocognitive outcomes in preterm infants. The mechanisms of posthemorrhagic hydrocephalus after intraventricular hemorrhage are unknown; however, CSF levels of iron metabolic pathway proteins including hemoglobin have been implicated in its pathogenesis. Here, we develop an animal model of intraventricular hemorrhage using intraventricular injection of hemoglobin at post-natal day 4 that results in acute and chronic  hydrocephalus, pathologic choroid plexus iron accumulation, ...
Source: Translational Stroke Research - October 29, 2022 Category: Neurology Source Type: research

Taurine attenuates neuronal ferroptosis by regulating GABA < sub > B < /sub > /AKT/GSK3 β/β-catenin pathway after subarachnoid hemorrhage
Free Radic Biol Med. 2022 Nov 16:S0891-5849(22)00965-0. doi: 10.1016/j.freeradbiomed.2022.11.003. Online ahead of print.ABSTRACTFerroptosis, characterized by lipid peroxidation and intracellular iron accumulation, has been reported to be involving in the pathophysiological of early brain injury (EBI) after subarachnoid hemorrhage (SAH). Although taurine reportedly yields neuroprotective effects in multiple central neurological diseases and can attenuated neuron damage after stroke, its role in EBI after SAH remains unclear. The present study indicated that taurine levels in cerebrospinal fluid were significantly reduced in...
Source: Free Radical Biology and Medicine - November 19, 2022 Category: Biology Authors: Chengli Liu Peibang He Yujia Guo Qi Tian Jianfeng Wang Guijun Wang Zhan Zhang Mingchang Li Source Type: research

Autophagy regulates inflammation in intracerebral hemorrhage: Enemy or friend?
In conclusion, the mutual regulation of autophagy and inflammation in ICH is worth exploring. The control of inflammation by autophagy will hopefully prove to be an essential treatment target for ICH.PMID:36726453 | PMC:PMC9884704 | DOI:10.3389/fncel.2022.1036313
Source: Cancer Control - February 2, 2023 Category: Cancer & Oncology Authors: Kaijing Fu Weilin Xu Cameron Lenahan Yong Mo Jing Wen Teng Deng Qianrong Huang Fangzhou Guo Ligen Mo Jun Yan Source Type: research

Emerging role of miRNAs in the regulation of ferroptosis
Front Mol Biosci. 2023 Feb 15;10:1115996. doi: 10.3389/fmolb.2023.1115996. eCollection 2023.ABSTRACTFerroptosis is a kind of cell death which has distinctive features differentiating it from autophagy, necrosis and apoptosis. This iron-dependent form of cell death is described by an increase in lipid reactive oxygen species, shrinkage of mitochondria and decrease in mitochondrial cristae. Ferroptosis is involved in the initiation and progression of many diseases and is regarded as a hotspot of investigations on treatment of disorders. Recent studies have shown that microRNAs partake in the regulation of ferroptosis. The im...
Source: Atherosclerosis - March 6, 2023 Category: Cardiology Authors: Reza Mahmoudi-Lamouki Sepideh Kadkhoda Bashdar Mahmud Hussen Soudeh Ghafouri-Fard Source Type: research

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