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E-224 Bilateral external carotid artery sacrifice in massive refractory hemorrhage of the pharynx: a case report
This report suggests that bilateral ECA embolization may be safe in acute settings. In this report, the bleeding did not respond to conservative or surgical management and ECA embolization was used as a life-saving procedure in order to stop massive bleeding. Bilateral external carotid artery embolization is rarely employed because of the high risk of facial necrosis. Additionally, ECAs are also assumed to serve as potential blood reservoirs, particularly in the case of ICA occlusion where the ipsilateral ECA can significantly contribute to intracranial blood flow via collaterals. However, in this report, no complications ...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Esmaeil, S., Eltatawy, A., Hossein Abbasi, M., Mowla, A., Grossman, A., Prestigiacomo, C., Shirani, P. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

The relationship between malignant tumors and ischemic stroke: II. Chronology of diagnoses and treatment of strokes
Orv Hetil. 2022 Jan 9;163(2):43-51. doi: 10.1556/650.2022.32329. Print 2022 Jan 9.ABSTRACTÖsszefoglaló. A malignus daganatok és a stroke együttesen gyakran fordulnak elő a stroke tradicionális rizikófaktoraival (magas vérnyomás, hyperlipidaemia, cukorbetegség, elhízás, dohányzás) rendelkező betegekben. Az elmúlt évtized kutatási eredményei alátámasztották, hogy a rosszindulatú daganatban szenvedő betegekben szignifikánsan nagyobb a stroke kockázata. A malignus daganatokhoz társuló stroke a leggyakrabban a malignus daganat diagnózisát követő fél-egy év során jelentkezik. A kapcsolat a más...
Source: Orvosi Hetilap - January 9, 2022 Category: General Medicine Authors: N óra Hajnóczky D ániel Bereczki Source Type: research

Janssen to Present the Strength and Promise of its Hematologic Malignancies Portfolio and Pipeline at ASH 2021
RARITAN, N.J., November 4, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that more than 45 company-sponsored abstracts, including 11 oral presentations, plus more than 35 investigator-initiated studies will be featured at the American Society of Hematology (ASH) Annual Meeting and Exposition. ASH is taking place at the Georgia World Congress Center in Atlanta and virtually from December 11-14, 2021.“We are committed to advancing the science and treatment of hematologic malignancies and look forward to presenting the latest research from our robust portfolio and pipeline during ASH...
Source: Johnson and Johnson - November 5, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Carotid Sparing Conformal Radiotherapy for Early Larynx Cancer
Parallel opposed lateral (POL) portals have been adopted as the mainstay radiation therapy technique for early-stage carcinoma of the glottis. Although the use of POL has been associated with excellent control rates and tolerability, the partial inclusion of carotid arteries (CAs) in the high dose regions of the fields has been shown to lead to an increased long-term risk of carotid stenosis and hemorrhagic stroke. Many researchers have proposed the utilization of three-dimension conformal therapy (3DCRT) or Intensity-modulated radiation therapy (IMRT) as viable carotid-sparing techniques via reductions to the mean and max...
Source: International Journal of Radiation Oncology * Biology * Physics - March 12, 2020 Category: Radiology Authors: N.S. Kalman, J. Laher, B. Zholendz Tags: Toxicity, Quality of Life, Survivorship, Costs of Care Source Type: research

One-year prognosis of non-traumatic cortical subarachnoid haemorrhage: a prospective series of 34 patients
ConclusionsThe most frequent causes of cSAH in our series were cerebral amyloid angiopathy, ischaemic stroke, and vasculitis. This type of haemorrhage has a worse prognosis than other non-aneurysmal cSAH. There are numerous possible causes, and prognosis depends on the aetiology. In elderly patients, intracranial haemorrhage is frequently associated with cognitive impairment.ResumenIntroducciónLas hemorragias subaracnoideas corticales (HSAc) tienen numerosas etiologías. No hay estudios prospectivos que indiquen su evolución a largo plazo. El objetivo de este trabajo es describir las características clínicas y etiológ...
Source: Neurologia - November 5, 2019 Category: Neurology Source Type: research

A Genetic Variant of miR-34a Contributes to Susceptibility of Ischemic Stroke Among Chinese Population
This study was supported by National Natural Science Foundation of China (Nos. 81560552, 81260234), Natural Science Foundation of Guangxi Zhuang Autonomous Region (CN) (2017JJA180826), Innovation Project of Guangxi Graduate Education (CN) (201601009) and Key Laboratory Open Project Fund of Guangxi Zhuang Autonomous Region (CN) (kfkt20160064). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementary Material for this article can be fou...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Chemoprevention of Barrett ’s Esophagus and Esophageal Adenocarcinoma
AbstractBarrett ’s esophagus is common in Western countries, but progression to esophageal adenocarcinoma is uncommon. Chemoprevention therefore needs to consider whether benefits outweigh risks given an otherwise healthy population. This will depend on the particular population at risk and the relative safety of a potential preventive agent. Most evidence regarding the potential benefit of chemoprevention of Barrett’s esophagus and prevention of progression to esophageal adenocarcinoma is based on observational studies such as case–control and cohort studies. Given the potential benefits and relatively low risks, pa...
Source: Digestive Diseases and Sciences - June 12, 2018 Category: Gastroenterology Source Type: research

ConnectViz : Accelerated Approach for Brain Structural Connectivity Using Delaunay Triangulation
This study proposes an accelerated approach for brain connectomic visualization based on graph theory paradigm using compute unified device architecture, extending the previously proposed SurLens Visualization and computer aided hepatocellular carcinoma frameworks. The accelerated brain structural connectivity framework was evaluated with stripped brain datasets from the Department of Surgery, University of North Carolina, Chapel Hill, USA. Significantly, our proposed framework is able to generate and extract points and edges of datasets, displays nodes and edges in the datasets in form of a network and clearly maps data v...
Source: Interdisciplinary Sciences, Computational Life Sciences - January 14, 2016 Category: Bioinformatics Source Type: research

Metastatic chromophobe renal cell carcinoma to the brain
This report documents an unusual case of a patient with a chromophobe renal cell carcinoma presenting with a brain metastasis. A 58-year-old man presented with stroke-like symptomatology, including expressive aphasia, right side facial weakness, headaches and vomiting. CT imaging demonstrated a 4.7cm left frontal lobe hemorrhagic mass. He underwent surgery with excision of the mass, which was marked by sheets of large cells with lightly eosinophilic to clear cytoplasm. PAX8 staining was positive and a diagnosis of clear cell carcinoma of probably renal origin was rendered. Subsequently, CT imaging of the abdomen revealed a...
Source: Journal of Clinical Neuroscience - November 17, 2015 Category: Neuroscience Source Type: research

Neuron-Specific Enolase as a Biomarker: Biochemical and Clinical Aspects.
Authors: Isgrò MA, Bottoni P, Scatena R Abstract Neuron-specific enolase (NSE) is known to be a cell specific isoenzyme of the glycolytic enzyme enolase. In vertebrate organisms three isozymes of enolase, expressed by different genes, are present: enolase α is ubiquitous; enolase β is muscle-specific and enolase γ is neuron-specific. The expression of NSE, which occurs as γγ- and αγ-dimer, is a late event in neural differentiation, thus making it a useful index of neural maturation.NSE is a highly specific marker for neurons and peripheral neuroendocrine cells. As a result of the findings of NSE in specific...
Source: Advances in Experimental Medicine and Biology - November 6, 2015 Category: Research Tags: Adv Exp Med Biol Source Type: research

Summary: International Kidney Cancer Symposium
Conclusions:  Ideal ischemia time is 20-25 minutes or less improves short and long term renal function.  >25 minutes carried 5 year risk of new onset stage 4 CKD No differences on GFR for cold vs. warm ischemia times Preoperative GFR and the percent of kidney preserved was a better predictor of post op GFR.  No ischemia preserves renal function better than warm. Longer cold ischemia times were equivalent to shorter warm ischemia times. Quality and quantity of the remaining kidney is associated with ultimate renal function. Robotics in RCC Surgery Gennady Bratslavsky, MD The...
Source: Kidney Cancer Association - December 15, 2011 Category: Urology & Nephrology Source Type: news