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Condition: Ischemic Stroke
Procedure: Perfusion

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Total 2383 results found since Jan 2013.

The role of fetal-type posterior cerebral artery in mediating occipital and thalamic perfusion: An arterial spin labeling MRI study
This study investigates the relationship between the presence of fPCA and arterial spin labeling (ASL) hyperperfusion patterns in the medial occipital cortex and thalami.
Source: Journal of Medical Imaging and Radiation Sciences - September 15, 2023 Category: Radiology Authors: Emilian Kalchev Tags: Clinical Perspectives Source Type: research

Post-reperfusion hyperperfusion after endovascular stroke treatment: a prospective comparative study of TCD versus MRI
Conclusions TCD is a reliable bedside tool to identify post-reperfusion hyperperfusion, correlates well with perfusion MRI, and indicates risk of reperfusion injury after MT.
Source: Journal of NeuroInterventional Surgery - September 15, 2023 Category: Neurosurgery Authors: Kneihsl, M., Hinteregger, N., Nistl, O., Deutschmann, H., Horner, S., Poltrum, B., Fandler-Höfler, S., Hatab, I., Haidegger, M., Pinter, D., Pichler, A., Willeit, K., Knoflach, M., Enzinger, C., Gattringer, T. Tags: Ischemic stroke Source Type: research

Selecting stroke patients for thrombectomy: is CTA+ASPECTS enough?
Since 2014, a series of randomised controlled trails (RCTs) have demonstrated the benefit of endovascular thrombectomy (EVT) on functional outcome for the participants who had acute ischaemic stroke (AIS) with occlusion of a proximal intracranial artery in the anterior circulation. The characteristics of the people enrolled in these RCTs have been used to define recommended criteria to select patients for thrombectomy in clinical practice. The initial group of RCTs largely enrolled participants early after AIS (mostly under 6 hours) who had National Institutes of Health stroke scale scores ≥6 (range 0–42 with lowe...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 14, 2023 Category: Neurosurgery Authors: Powers, W. Tags: Editorial commentaries Source Type: research

Clot-based time attenuation curve as a novel imaging predictor of mechanical thrombectomy functional outcome in acute ischemia stroke
ConclusionsThrombus TAC on CTP were found to be a promising new imaging biomarker to predict the outcomes of MT in AIS.Clinical relevance statementThis study revealed that clot-based time attenuation curve based on admission perfusion CT could reflect the permeability and composition of thrombus and, also, provide valuable information to predict the clinical outcomes of mechanical thrombectomy in patients with acute ischemia stroke.Key Points• Two time-attenuation curves distributions achieved strong correlations (|r|= 0.627, p <  0.001) with histopathological results.• The unimodal time-attenuation curve was ...
Source: European Radiology - September 14, 2023 Category: Radiology Source Type: research

CT Perfusion Does Not Modify the Effect of Reperfusion in Patients with Acute Ischemic Stroke Undergoing Endovascular Treatment in the ESCAPE-NA1 Trial INTERVENTIONAL
CONCLUSIONS: CTP did not modify the effect of near-complete reperfusion on clinical outcomes. Thus, CTP cannot explain why some patients with near-complete reperfusion have poor clinical outcomes.
Source: American Journal of Neuroradiology - September 11, 2023 Category: Radiology Authors: Rex, N. B., McDonough, R. V., Ospel, J. M., Kashani, N., Sehgal, A., Fladt, J. C., McTaggart, R. A., Nogueira, R., Menon, B., Demchuk, A. M., Tymianski, M., Hill, M. D., Goyal, M., on behalf of the ESCAPE-NA1 Investigators Tags: INTERVENTIONAL Source Type: research

Association of Ferroptosis with Severity and Outcomes in Acute Ischemic Stroke Patients Undergoing Endovascular Thrombectomy: A Case-control Study
AbstractFerroptosis, an iron-dependent form of cell death, is characterized by intracellular accumulation of iron and reactive oxygen species-induced lipid peroxidation. Animal experiments have shown the important roles of ferroptosis in ischemic stroke, but the evidence in human stroke is insufficient. This prospective study evaluated the associations between plasma ferroptosis biomarkers at hyperacute stage and long-term outcomes in patients with acute ischemic stroke undergoing endovascular thrombectomy (EVT). The plasma samples were collected immediately before and after EVT (T1 and T2) and at 24  h (T3) for the 126 s...
Source: Molecular Neurobiology - September 7, 2023 Category: Neurology Source Type: research

Prognostic Value of Venous Outflow Profiles on Multiphase CT Angiography for the Patients with Acute Ischemic Stroke After Endovascular Thrombectomy
This study supports that favorable peak venous VO profiles on mCTA might be a promising biomarker in predicting the good outcome in patients with AIS after EVT.
Source: Translational Stroke Research - September 5, 2023 Category: Neurology Source Type: research

Blood Pressure Management After Successful Thrombectomy
Despite the success of endovascular therapy (EVT) in acute ischemic stroke due to large vessel occlusion, opportunities to further optimize clinical outcomes remain. One such avenue is to reduce hemorrhagic transformation in the infarcted tissue bed after successful reperfusion, which has been shown to be associated with worsened clinical outcomes. Because higher cerebral perfusion pressures may foster hemorrhagic transformation, it has been hypothesized that lowering systemic blood pressure (BP) after successful reperfusion could decrease cerebral hemorrhagic complications. Reducing systemic BP may also lead to a decrease...
Source: JAMA - September 5, 2023 Category: General Medicine Source Type: research

Association of Ferroptosis with Severity and Outcomes in Acute Ischemic Stroke Patients Undergoing Endovascular Thrombectomy: A Case-control Study
AbstractFerroptosis, an iron-dependent form of cell death, is characterized by intracellular accumulation of iron and reactive oxygen species-induced lipid peroxidation. Animal experiments have shown the important roles of ferroptosis in ischemic stroke, but the evidence in human stroke is insufficient. This prospective study evaluated the associations between plasma ferroptosis biomarkers at hyperacute stage and long-term outcomes in patients with acute ischemic stroke undergoing endovascular thrombectomy (EVT). The plasma samples were collected immediately before and after EVT (T1 and T2) and at 24  h (T3) for the 126 s...
Source: Molecular Neurobiology - September 1, 2023 Category: Neurology Source Type: research

Persistent perfusion abnormalities at day 1 correspond to different clinical trajectories after stroke
Conclusion ASL hypoperfusion within the infarct and the surrounding tissue was associated with poor outcome. A more comprehensive view of the mechanisms in the hypoperfused surrounding tissue could help to design new therapeutic approaches during and after reperfusion therapies.
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Rosso, C., Belkacem, S., Amor-Sahli, M., Clarencon, F., Leger, A., Baronnet, F., Dormont, D., Alamowitch, S., Lehericy, S., Samson, Y. Tags: Ischemic stroke Source Type: research

Augmentation of perfusion with simultaneous vasodilator and inotropic agents in experimental acute middle cerebral artery occlusion: a pilot study
Conclusion Results suggest that perfusion can be augmented in ischemic stroke with norepinephrine and hydralazine. Perfusion augmentation depends on degree of collateralization and territory in question, with some evidence of vascular steal.
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Liu, M., Saadat, N., Jeong, Y. I., Roth, S., Niekrasz, M., Carroll, T., Christoforidis, G. A. Tags: Ischemic stroke Source Type: research

Contrast conservation measures during the global iohexol contrast shortage crisis did not affect stroke thrombectomy outcomes
Conclusions Modifying stroke workflow to adapt to the current global shortage in iohexol is feasible. Using diluted iohexol (50% contrast mixed with 50% heparinized saline) did not affect MT outcomes.
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Almallouhi, E., Sattur, M., Lajthia, O., Kicielinski, K. P., Holmstedt, C., Lena, J. R., Al Kasab, S., Spiotta, A. M. Tags: Ischemic stroke Source Type: research

Quantitative assessment of collateral time on perfusion computed tomography in acute ischemic stroke patients
ConclusionOur results indicate that perfusion computed tomography can accurately quantify the collateral time after acute ischemic stroke.
Source: Frontiers in Neurology - August 24, 2023 Category: Neurology Source Type: research

O05/57 Validation of a novel multiphase CTA perfusion tool compared to CTP in patients with suspected acute ischemic stroke
Conclusion mCTAp shows similar performance compared to CTP in assisting readers to detect ischemia and its side/location, requiring less radiation exposure, acquisition time and contrast-dose compared to additional-CTP, but mainly as it relates to proximal vessel occlusions.Disclosure of InterestDr. Menon holds patents on systems of triage in acute stroke, for LVO detection and for mCTAp, and stock ownership in Circle Cardiovascular Inc. Dr. Bala has nothing to declare. Dr. Duszynski is an employee of, and holds stock options for Circle Cardiovascular Imaging Inc. Dr. Nayem Pinky, Dr. Golan and Luis A Souto Maior Neto are ...
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Benali, F., Zhang, J., Pinky, N., Bala, F., Alhabli, I., Golan, R., Neto, S., Elebute, I., Duszynski, C., Qiu, W., Menon, B. Tags: 2.2 ISCHEMIC - Imaging Source Type: research

O09/90 Thrombectomy in ischemic stroke patients with large core but minor or absent ischemic changes on non-enhanced computed tomography
ConclusionIn patients with ASPECTS≥6, core volumes did not significantly modify the treatment effect of recanalization. Reperfusion and higher core volume were significantly associated with core overestimation which may explain the treatment effect of MT for patients with large ischemic core but minor ischemic changes on NECT.Abstract O09/90 Figure 1Abstract O09/90 Figure 2Disclosure of InterestNA.
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Broocks, G., Kniep, H., Bechstein, M., Paula Hanning, U. M., Kemmling, A., Fiehler, J., Meyer, L. Tags: 2.3 ISCHEMIC - Treatment Source Type: research