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Poststroke Depression: An Update
J Neuropsychiatry Clin Neurosci. 2023 Aug 10:0. doi: 10.1176/appi.neuropsych.21090231. Online ahead of print.ABSTRACTThe presence of neuropsychiatric disorders after stroke has been recognized for more than 100 years, but controlled systematic studies did not begin until the 1970s. The most clinically important advances, however, have been in the treatment and prevention of poststroke depression (PSD). Recent meta-analyses of randomized controlled trials (RCTs) for the treatment of PSD have demonstrated the efficacy of antidepressants. Similarly, RCTs for the prevention of PSD have shown that antidepressants significantly ...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - August 10, 2023 Category: Psychiatry Authors: Robert G Robinson Ricardo E Jorge Sergio E Starkstein Source Type: research

A systematic review and evaluation of post-stroke depression clinical practice guidelines
Post-stroke depression is a depressive mood disorder that follows a cerebrovascular accident and is a burden on stroke patients. Its management is included in clinical practice guidelines focused on stroke, and the recommended treatment is selective serotonin reuptake inhibitors in conjunction with psychotherapy. Clinical practice guidelines are recommendations used to standardize best medical practice, but there is no current evaluation of guidelines containing post stroke depression recommendations.
Source: Journal of Stroke and Cerebrovascular Diseases - August 10, 2023 Category: Neurology Authors: James Graham Cross, Brandon R. May, Peter Q.M. Mai, Elizabeth Anderson, Connor Welsh, Shaeker Chandran, Kevin T. Chorath, Shelby Herr, Daniel Gonzalez Source Type: research

Train-your-brain program to reduce depression, anxiety, and stress in stroke survivors: a pilot community-based cognitive intervention study
DiscussionThe TYB program provided group support and validation, resulting in improved mood and reduced stress among stroke survivors. Cultural collectivism played a significant role in fostering group cohesion. However, the program’s limited focus on caregivers and timing of assessments during the December holidays may have affected the outcomes. The TYB program demonstrated feasibility and potential effectiveness in alleviating psychological distress and enhancing cognitive function among stroke survivors. Future research should explore long-term effects, larger sample sizes, and non-English-speaking populations to enh...
Source: Frontiers in Neurology - August 10, 2023 Category: Neurology Source Type: research

Machine learning models of plasma proteomic data predict mood in chronic stroke and tie it to aberrant peripheral immune responses
Brain Behav Immun. 2023 Aug 7:S0889-1591(23)00225-8. doi: 10.1016/j.bbi.2023.08.002. Online ahead of print.ABSTRACTPost-stroke depression is common, long-lasting and associated with severe morbidity and death, but mechanisms are not well-understood. We used a broad proteomics panel and developed a machine learning algorithm to determine whether plasma protein data can predict mood in people with chronic stroke, and to identify proteins and pathways associated with mood. We used Olink to measure 1,196 plasma proteins in 85 participants aged 25 and older who were between 5 months and 9 years after ischemic stroke. Mood was a...
Source: Brain, Behavior, and Immunity - August 9, 2023 Category: Neurology Authors: Neda H Bidoki Kristy A Zera Huda Nassar Lauren L Drag Michael Mlynash Elizabeth Osborn Muhith Musabbir Da Eun K Kim Maria Paula Mendez Maarten G Lansberg Nima Aghaeepour Marion S Buckwalter Source Type: research

Integrative-interpersonal dynamic therapy for poststroke depression (INID): study protocol of a randomised controlled pilot trial
Introduction Depression is the most frequent psychiatric disorder following stroke, affecting about one-third of stroke survivors. Patients experience poorer recovery, lower quality of life and higher mortality compared with stroke survivors without depression. Despite these well-known malign consequences, poststroke depression (PSD) is regarded underdiagnosed and undertreated. Evidence of beneficial effects of psychotherapy to treat PSD remains scarce and inconclusive and is limited by heterogeneity in design, content and timing of the intervention. This pilot study aims to assess the feasibility of a newly developed inte...
Source: BMJ Open - August 8, 2023 Category: General Medicine Authors: Volz, M., Mundiyanapurath, S., Schauenburg, H., Meuth, S. G., Wild, B., Werheid, K., Barber, J. P., Schäfer, R., Beerbaum, L., Dinger, U. Tags: Open access, Rehabilitation medicine Source Type: research

The key roles of reactive oxygen species in microglial inflammatory activation: Regulation by endogenous antioxidant system and exogenous sulfur-containing compounds
Eur J Pharmacol. 2023 Aug 5:175966. doi: 10.1016/j.ejphar.2023.175966. Online ahead of print.ABSTRACTAberrant innate immunity in the brain has been implicated in the pathogenesis of several central nervous system (CNS) disorders, including Alzheimer's disease, Huntington's disease, Parkinson's disease, stroke, amyotrophic lateral sclerosis, and depression. Except for extraparenchymal CNS-associated macrophages, which predominantly afford protection against peripheral invading pathogens, it has been reported that microglia, a population of macrophage-like cells governing CNS immune defense in nearly all neurological disease...
Source: European Journal of Pharmacology - August 7, 2023 Category: Drugs & Pharmacology Authors: Hua Fan Qianqian Bai Yang Yang Xiaofei Shi Ganqin Du Junqiang Yan Jian Shi Dongmei Wang Source Type: research

Iran Quality of Care in Medicine Program (IQCAMP): Design and Outcomes
CONCLUSION: The IQCAMP study was the first healthcare utilization, cost, and quality survey in Iran with a longitudinal data collection to represent the pattern, quantity, and quality of medical care provided for high-burden conditions.PMID:37543935 | DOI:10.34172/aim.2023.21
Source: Archives of Iranian Medicine - August 6, 2023 Category: Middle East Health Authors: Saeid Shahraz Sarvenaz Shahin Yosef Farzi Mitra Modirian Nazila Shahbal Mehrdad Azmin Farnam Mohebi Mohammadreza Naderian Masoume Amin-Esmaeili Naser Ahmadi Shahedeh Seyfi Hossein Zokaei Roya Samadi Bahram Mohajer Roya Sherafat-Kazemzadeh Abbas Balouchi B Source Type: research