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Total 8092 results found since Jan 2013.
CYP2C19 Loss-of-Function Variants Associated with Long-term Ischemic Stroke Events During Clopidogrel Treatment in the Chinese Population
This study aims to determine whether CYP2C19 loss-of-function (LoF) variants were associated with long-term ischemic stroke risk in Chinese primary care patients treated with clopidogrel. Patients treated with clopidogrel were ascertained from a Chinese Electronic Medical Record linked with biobank for a retrospective cohort study. Their medical information was examined for the period from January 2018 to December 2021. Two CYP2C19 major loss of function variants (*2:rs4244285, *3: rs4986893) were genotyped. The clinical outcome was ischemic stroke event. Cox regression analysis was used to evaluate the association between...
Source: Clinical Pharmacology and Therapeutics - August 22, 2023 Category: Drugs & Pharmacology Authors: Peng Wu Ziqing Liu Zijian Tian Benrui Wu Jian Shao Qian Li Zhaoxu Geng Ying Pan Ke Lu Qiang Wang Tao Xu Kaixin Zhou Source Type: research
Evaluation of Large-Scale Proteomics for Prediction of Cardiovascular Events
CONCLUSIONS AND RELEVANCE: A protein risk score was significantly associated with ASCVD events in primary and secondary event populations. When added to clinical risk factors, the protein risk score and polygenic risk score both provided statistically significant but modest improvement in discrimination.PMID:37606673 | DOI:10.1001/jama.2023.13258
Source: Atherosclerosis - August 22, 2023 Category: Cardiology Authors: Hannes Helgason Thjodbjorg Eiriksdottir Magnus O Ulfarsson Abhishek Choudhary Sigrun H Lund Erna V Ivarsdottir Grimur Hjorleifsson Eldjarn Gudmundur Einarsson Egil Ferkingstad Kristjan H S Moore Narimon Honarpour Thomas Liu Huei Wang Thomas Hucko Marc S S Source Type: research
Vertebrobasilar Artery Calcification as a Risk Factor for the Development of Stroke: Case-Control Study From a Tertiary Care Center, Southern India
Conclusion The presence of higher grades of calcifications in the vertebrobasilar arteries is a major risk factor for stroke. Hence, its presence in asymptomatic individuals needs to be taken as a warning sign for the development of stroke.PMID:37605701 | PMC:PMC10440145 | DOI:10.7759/cureus.42196
Source: Atherosclerosis - August 22, 2023 Category: Cardiology Authors: Kibballi M Adarsh H Pavithra Valiyapalathingal Abdul Rasheed Source Type: research
Distinctive metabolic remodeling in TYMP deficiency beyond mitochondrial dysfunction
This study aimed to elucidate the characteristic metabolic alterations and associated homeostatic regulation caused by TYMP deficiency. The pathogenicity of novel TYMP variants was evaluated in terms of clinical features, genetic analysis, and structural instability. We analyzed plasma samples from three patients with MNGIE; three patients with m.3243A > G mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS); and four healthy controls (HC) using both targeted and untargeted metabolomics techniques. Transcriptomics analysis and bioenergetic studies were performed on skin fibroblasts from partic...
Source: Molecular Medicine - August 21, 2023 Category: Molecular Biology Authors: Jixiang Du Chao Zhang Fuchen Liu Xihan Liu Dongdong Wang Dandan Zhao Guanghou Shui Yuying Zhao Chuanzhu Yan Source Type: research
Association of remnant cholesterol with intracranial atherosclerosis in community-based population: The ARIC study
CONCLUSIONS: Elevated levels of remnant-C were connected to ICAD independent of LDL-C and traditional risk factors. The mechanisms of remnant-C association with ICAD probably offer insight into preventive risk-factor of ischemic stroke.PMID:37604080 | DOI:10.1016/j.jstrokecerebrovasdis.2023.107293
Source: Atherosclerosis - August 21, 2023 Category: Cardiology Authors: Peng Zhang Ziheng Zhang Daojing Li Rongrong Han Hongfang Li Jinfeng Ma Peng Xu Ziyou Qi Lixia Liu Aimei Zhang Source Type: research
Distinctive metabolic remodeling in TYMP deficiency beyond mitochondrial dysfunction
This study aimed to elucidate the characteristic metabolic alterations and associated homeostatic regulation caused by TYMP deficiency. The pathogenicity of novel TYMP variants was evaluated in terms of clinical features, genetic analysis, and structural instability. We analyzed plasma samples from three patients with MNGIE; three patients with m.3243A > G mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS); and four healthy controls (HC) using both targeted and untargeted metabolomics techniques. Transcriptomics analysis and bioenergetic studies were performed on skin fibroblasts from partic...
Source: Molecular Medicine - August 21, 2023 Category: Molecular Biology Authors: Jixiang Du Chao Zhang Fuchen Liu Xihan Liu Dongdong Wang Dandan Zhao Guanghou Shui Yuying Zhao Chuanzhu Yan Source Type: research
Associations of polygenic inheritance of physical activity with aerobic fitness, cardiometabolic risk factors and diseases: the HUNT study
AbstractPhysical activity (PA), aerobic fitness, and cardiometabolic diseases (CMD) are highly heritable multifactorial phenotypes. Shared genetic factors may underlie the associations between higher levels of PA and better aerobic fitness and a lower risk for CMDs. We aimed to study how PA genotype associates with self-reported PA, aerobic fitness, cardiometabolic risk factors and diseases. PA genotype, which combined variation in over one million of gene variants, was composed using the SBayesR polygenic scoring methodology. First, we constructed a polygenic risk score for PA in the Tr øndelag Health Study (N = 47,1...
Source: European Journal of Epidemiology - August 21, 2023 Category: Epidemiology Source Type: research
Development and validation of a dementia risk score in the UK Biobank and Whitehall II cohorts
Background
Current dementia risk scores have had limited success in consistently identifying at-risk individuals across different ages and geographical locations.
Objective
We aimed to develop and validate a novel dementia risk score for a midlife UK population, using two cohorts: the UK Biobank, and UK Whitehall II study.
Methods
We divided the UK Biobank cohort into a training (n=176 611, 80%) and test sample (n=44 151, 20%) and used the Whitehall II cohort (n=2934) for external validation. We used the Cox LASSO regression to select the strongest predictors of incident dementia from 28 candidate predictors and then dev...
Source: Evidence-Based Mental Health - August 21, 2023 Category: Psychiatry & Psychology Authors: Anatürk, M., Patel, R., Ebmeier, K. P., Georgiopoulos, G., Newby, D., Topiwala, A., de Lange, A.-M. G., Cole, J. H., Jansen, M. G., Singh-Manoux, A., Kivimäki, M., Suri, S. Tags: Open access, Press releases Old age psychiatry Source Type: research
Associations of polygenic inheritance of physical activity with aerobic fitness, cardiometabolic risk factors and diseases: the HUNT study
AbstractPhysical activity (PA), aerobic fitness, and cardiometabolic diseases (CMD) are highly heritable multifactorial phenotypes. Shared genetic factors may underlie the associations between higher levels of PA and better aerobic fitness and a lower risk for CMDs. We aimed to study how PA genotype associates with self-reported PA, aerobic fitness, cardiometabolic risk factors and diseases. PA genotype, which combined variation in over one million of gene variants, was composed using the SBayesR polygenic scoring methodology. First, we constructed a polygenic risk score for PA in the Tr øndelag Health Study (N = 47,1...
Source: European Journal of Epidemiology - August 21, 2023 Category: Epidemiology Source Type: research
Distinctive metabolic remodeling in TYMP deficiency beyond mitochondrial dysfunction
This study aimed to elucidate the characteristic metabolic alterations and associated homeostatic regulation caused by TYMP deficiency. The pathogenicity of novel TYMP variants was evaluated in terms of clinical features, genetic analysis, and structural instability. We analyzed plasma samples from three patients with MNGIE; three patients with m.3243A > G mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS); and four healthy controls (HC) using both targeted and untargeted metabolomics techniques. Transcriptomics analysis and bioenergetic studies were performed on skin fibroblasts from ...
Source: Journal of Molecular Medicine - August 21, 2023 Category: Molecular Biology Source Type: research
Association of remnant cholesterol with intracranial atherosclerosis in community-based population: The ARIC study
Intracranial atherosclerotic stenosis (ICAS) is one of the main prevalent causes of ischemic stroke globally.1,2 However, even with aggressive medical management, the annual rate of stroke recurrence remains high among individuals with multiple risk factors and severe stenosis.2 Moreover, ICAS has been connected to an elevated risk of mild cognitive impairment and dementia3, which confers an extra necessity for the identification of risk factors associated with ICAS.
Source: Journal of Stroke and Cerebrovascular Diseases - August 19, 2023 Category: Neurology Authors: Peng Zhang, Ziheng Zhang, Daojing Li, Rongrong Han, Hongfang Li, Jinfeng Ma, Peng Xu, Ziyou Qi, Lixia Liu, Aimei Zhang Source Type: research
Paying more attention to arterial hypertension, dyslipidaemia, women and the rural environment in our ongoing fight against cardiovascular diseases and their risk factors
CONCLUSION: In Senegal, we need to pay more attention to arterial hypertension, dyslipidaemia, women and the rural environment in our ongoing fight against cardiovascular diseases and their risk factors.PMID:37594257 | DOI:10.5830/CVJA-2023-033
Source: Cardiovascular Journal of Africa - August 18, 2023 Category: Cardiology Authors: P êngd-Wendé Habib Boussé Traore Jean Augustin Di égane Tine Oumar Bassoum Abdoul Kane Adama Faye Source Type: research
