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Identification of Secondary Prevention Patients Eligible for PCSK9 Inhibitors Therapy According to the Routine Clinical Practice in Spain
ConclusionUp to 82% of patients with atherosclerotic CV disease do not achieve LDL-C levels recommended by the 2019 ESC/EAS guidelines despite being on optimized oral LLT therapy. In 17.9% of these patients LDL-C levels exceed 100  mg/dL, being eligible for PCSK9i in Spain.
Source: Advances in Therapy - December 16, 2022 Category: Drugs & Pharmacology Source Type: research

Long-Term Abnormalities of Lipid Profile After a Single Episode of Sepsis
Conclusions: Our study suggests that persistent derangements of lipid profile components for up to two years after sepsis may be associated with altered risk of atherosclerosis-related events among sepsis survivors.PMID:34869619 | PMC:PMC8634493 | DOI:10.3389/fcvm.2021.674248
Source: Atherosclerosis - December 6, 2021 Category: Cardiology Authors: Nicholas Felici Da Liu Josh Maret Mariana Restrepo Yuliya Borovskiy Jihane Hajj Wesley Chung Krzysztof Laudanski Source Type: research

Cardiovascular Event Rates in Statin-Treated Korean Patients with Cardiovascular Disease: Estimates from a Real-World Population Using Electronic Medical Record Data
ConclusionBy analyzing EMR data representing routine practice in Korea, we found that patients with very high-risk ASCVD were at substantial risk of further cardiovascular events in 3  years. Given the observed risk of recurrent events with suboptimal lipid management by statin, additional treatment to control LDL-C might be necessary to reduce the burden of further cardiovascular events for very high-risk ASCVD patients.
Source: Cardiovascular Drugs and Therapy - October 8, 2021 Category: Cardiology Source Type: research

Low Risk of Neurological Recurrence while Awaiting Carotid Endarterectomy: Results From a Danish Multicentre Study
CONCLUSION: In symptomatic carotid artery stenosis patients awaiting CEA, very few NRs occurred within 14 days. Institution of immediate BMT in specialised TIA/stroke units followed by early, but not necessarily urgent, CEA is a reasonable course of action in patients with high grade symptomatic carotid artery stenosis.PMID:34127375 | DOI:10.1016/j.ejvs.2021.04.016
Source: PubMed: Eur J Vasc Endovasc ... - June 15, 2021 Category: Surgery Authors: Martin Lawaetz Benjamin Sandholt Emilie N Eilersen Christian Petersen Katrine T ørslev Dmitriy Shilenok Kim C Houlind Henrik Sillesen Saeid Shahidi Lisbet K Rathenborg Jonas Eiberg Source Type: research

Treatment patterns and low-density lipoprotein cholesterol (LDL-C) goal attainment among patients receiving high- or moderate-intensity statins
ConclusionsMajority of ASCVD patients had LDL-C  ≥ 70 mg/dL while on moderate-/high-intensity statins. Despite low LDL-C goal attainment, few patients changed their treatment regimens.
Source: Clinical Research in Cardiology - December 22, 2017 Category: Cardiology Source Type: research

Economic evaluation of ezetimibe treatment in combination with statin therapy in the United States.
CONCLUSIONS: Compared with statin monotherapy, ezetimibe with statin therapy was cost-effective for secondary prevention of CHD and stroke and for primary prevention of these conditions in patients whose LDL-C level is ≥ 100 mg/dL and in patients with diabetes, taking into account a 90% cost reduction for ezetimibe. PMID: 28426345 [PubMed - as supplied by publisher]
Source: Journal of Medical Economics - April 22, 2017 Category: Health Management Tags: J Med Econ Source Type: research

Safety and Effectiveness of Statins for Prevention of Recurrent Myocardial Infarction in 12 156 Typical Older Patients: A Quasi-Experimental Study
Conclusions: Estimates of statin effectiveness for the prevention of recurrent myocardial infarction in patients aged 60–79 years were similar to trial results, but more evidence is needed in the older group. There may be an excess of falls and fractures in very old patients, which deserves further investigation.
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Ble, A., Hughes, P. M., Delgado, J., Masoli, J. A., Bowman, K., Zirk-Sadowski, J., Mujica Mota, R. E., Henley, W. E., Melzer, D. Tags: Research Article Source Type: research

LDL and Systolic Blood Pressure Are Associated with Coated-Platelet Levels in Patients with Asymptomatic Carotid Atherosclerosis (P1.235)
Conclusions: In asymptomatic patients with carotid atherosclerosis, higher LDL and lower SBP were associated with increased coated-platelet levels. The relationship between LDL and coated-platelet levels is consistent with the recognized role of hypercholesterolemia in cardiovascular disease. The significance of the association between lower SBP and higher coated-platelet levels is less clear. These findings should be confirmed in prospective studies. Supported by grants from the American Heart Association and Clinical Science Research & Development Service (CX000340).Disclosure: Dr. Kirkpatrick has nothing to disclose...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Kirkpatrick, A., Nguyen, N., Vincent, A., Guthery, L., Mathews, E., Malatinszky, G., Donna-Ferreira, F., Dale, G., Prodan, C. Tags: Carotid Disease Source Type: research

Retrospective case review of missed opportunities for primary prevention of stroke and TIA in primary care: protocol paper
This study will investigate: (1) the proportion of strokes/TIAs with prior missed opportunities for prevention in primary care; (2) the influence of patient characteristics on missed prevention opportunities and (3) how the proportion of missed prevention opportunities has changed over time. Methods and analysis A retrospective case review will identify first-ever stroke and patients with TIA between 2000 and 2013 using anonymised electronic medical records extracted from the health improvement network (THIN) database. Four categories of missed opportunities for stroke/TIA prevention will be sought: untreated high blood p...
Source: BMJ Open - November 11, 2014 Category: Journals (General) Authors: Moran, G. M., Calvert, M., Feltham, M. G., Marshall, T. Tags: Open access, Cardiovascular medicine, Epidemiology, General practice / Family practice, Global health Protocol Source Type: research

Relationship between early postoperative C-reactive protein elevation and long-term postoperative major adverse cardiovascular and cerebral events in patients undergoing off-pump coronary artery bypass graft surgery: a retrospective study
Conclusions Postoperative CRP elevation was associated with long-term postoperative MACCE in OPCAB patients. This was mitigated by postoperative statin medication. Furthermore, postoperative CRP elevation was associated with intraoperative parameters reflecting hypoperfusion and inflammation.
Source: British Journal of Anaesthesia - August 18, 2014 Category: Anesthesiology Authors: Min, J. J., Nam, K., Kim, T. K., Kim, H. J., Seo, J. H., Hwang, H. Y., Kim, K. B., Murkin, J. M., Hong, D. M., Jeon, Y. Tags: Cardiovascular Source Type: research

Central Hemodynamics Are Associated With Cardiovascular Disease and Albuminuria in Type 1 Diabetes.
CONCLUSIONS: In type 1 diabetes patients, increased CASP and CPP and decreased CADP and SEVR were independently associated with history of CVD and albuminuria. Furthermore, SEVR predicted mortality and ESRD during follow-up. Future studies are needed to determine whether targeting central hemodynamics improves outcome. PMID: 24627444 [PubMed - as supplied by publisher]
Source: American Journal of Hypertension - March 13, 2014 Category: Cardiology Authors: Theilade S, Hansen TW, Rossing P Tags: Am J Hypertens Source Type: research