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Condition: Hyperactivity
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Total 310 results found since Jan 2013.
Carotid dysfunction in senescent female mice is mediated by increased α < sub > 1A < /sub > -adrenoceptor activity and COX-derived vasoconstrictor prostanoids
In conclusion, senescence intensifies vasoconstriction mediated by a1A-adrenergic signaling in the carotid of female mice by mechanisms involving increased iCa+2 and release of cyclooxygenase-derived prostanoids.PMID:36705993 | DOI:10.1152/ajpheart.00495.2022
Source: American Journal of Physiology. Heart and Circulatory Physiology - January 27, 2023 Category: Physiology Authors: Tiago J Costa Paula R Barros Diego A Duarte J úlio A Silva-Neto Sara Cristina Hott Thamyris Santos-Silva Claudio M Costa-Neto Felipe V Gomes Eliana H Akamine Cameron G McCarthy Francesc Jim énez-Altayó Ana Paula Dantas Rita C Tostes Source Type: research
Escin alleviates stress-induced intestinal dysfunction to protect brain injury by regulating the gut-brain axis in ischemic stroke rats
Int Immunopharmacol. 2023 Jan 4;115:109659. doi: 10.1016/j.intimp.2022.109659. Online ahead of print.ABSTRACTHyperactivity of HPA axis results in intestinal dysfunction, which may play a role in brain injury caused by ischemic stroke (IS). Escin shows a neuroprotective effect but it may not penetrate blood brain barrier (BBB). Previous work in our laboratory showed that escin ameliorated intestinal injury in animals. The aim of this study is to investigate whether escin attenuates brain injury by improving intestinal dysfunction in middle cerebral artery occlusion (MCAO) rats, to mimic IS. MCAO rats and lipopolysaccharides...
Source: International Immunopharmacology - January 6, 2023 Category: Allergy & Immunology Authors: Min Li Shengguang Wang Ce Zhang Chenglin Chi Rongxia Liu Tian Wang Fenghua Fu Source Type: research
Risk of Major Cardiovascular and Cerebrovascular Events in Users of Lisdexamfetamine and Other Medications for Attention-Deficit/Hyperactivity Disorder in Denmark and Sweden: A Population-Based Cohort Study
ConclusionOur findings suggest little to no increased risk of cardiovascular and cerebrovascular events in patients treated with LDX compared with patients previously treated with other ADHD medications.
Source: Neurology and Therapy - October 23, 2022 Category: Neurology Source Type: research
Mutant Phosphodiesterase 3A Protects From Hypertension-Induced Cardiac Damage
CONCLUSIONS: Although in vascular smooth muscle, PDE3A mutations cause hypertension, they confer protection against hypertension-induced cardiac damage in hearts. Nonselective PDE3A inhibition is a final, short-term option in heart failure treatment to increase cardiac cAMP and improve contractility. Our data argue that mimicking the effect of PDE3A mutations in the heart rather than nonselective PDE3 inhibition is cardioprotective in the long term. Our findings could facilitate the search for new treatments to prevent hypertension-induced cardiac damage.PMID:36259389 | DOI:10.1161/CIRCULATIONAHA.122.060210
Source: Circulation - October 19, 2022 Category: Cardiology Authors: Maria Ercu Michael B M ücke Tamara Pallien Lajos Mark ó Anastasiia Sholokh Carolin Sch ächterle Atakan Aydin Alexa Kidd Stephan Walter Yasmin Esmati Brandon J McMurray Daniella F Lato Daniele Yumi Sunaga-Franze Philip H Dierks Barbara Isabel Montesinos Source Type: research
Attention-deficit/hyperactivity disorder as a risk factor for cardiovascular diseases: a nationwide population-based cohort study
World Psychiatry. 2022 Oct;21(3):452-459. doi: 10.1002/wps.21020.ABSTRACTAccumulating evidence suggests a higher risk for cardiovascular diseases among individuals with mental disorders, but very little is known about the risk for overall and specific groups of cardiovascular diseases in people with attention-deficit/hyperactivity disorder (ADHD). To fill this knowledge gap, we investigated the prospective associations between ADHD and a wide range of cardiovascular diseases in adults. In a nationwide population-based cohort study, we identified 5,389,519 adults born between 1941 and 1983, without pre-existing cardiovascul...
Source: World Psychiatry - September 8, 2022 Category: Psychiatry Authors: Lin Li Zheng Chang Jiangwei Sun Miguel Garcia-Argibay Ebba Du Rietz Maja Dobrosavljevic Isabell Brikell Tomas Jernberg Marco Solmi Samuele Cortese Henrik Larsson Source Type: research
