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Condition: Headache
Drug: Topamax

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Total 19 results found since Jan 2013.

Migraine Prophylaxis, Ischemic Depolarizations, and Stroke Outcomes in Mice Basic Sciences
Conclusions— These data underscore the importance of hyperexcitability as a mechanism for increased stroke risk in migraineurs, and suggest that migraine prophylaxis may not only prevent migraine attacks but also protect migraineurs against ischemic injury.
Source: Stroke - December 22, 2014 Category: Neurology Authors: Eikermann-Haerter, K., Lee, J. H., Yalcin, N., Yu, E. S., Daneshmand, A., Wei, Y., Zheng, Y., Can, A., Sengul, B., Ferrari, M. D., van den Maagdenberg, A. M. J. M., Ayata, C. Tags: Neuroprotectors Basic Sciences Source Type: research

Acute Stroke in Young Women Taking Phentermine (P01.249)
CONCLUSIONS: We present here two patients with mild underlying cerebrovascular risk factors who presented with acute stroke after taking diet pills containing phentermine. The public should be aware of the possible association between stroke and phentermine. More long-term outcomes research is necessary to understand the safety of phentermine-containing diet pills. Patients with cerebrovascular risk factors should be cautious about using Phentermine containing diet pills.Disclosure: Dr. Smit has nothing to disclose. Dr. Cutting has received personal compensation for activities with F1000. Dr. Conners has nothing to disclos...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Smit, L., Cutting, S., Conners, J., Lee, V., Song, S. Tags: P01 Cerebrovascular Disease I Source Type: research

Heat stroke related to the use of topiramate. The importance of prevention.
We present the case of a patient who developed heat stroke due to physical exercise while under topiramate treatment. PMID: 24290155 [PubMed - as supplied by publisher]
Source: Anales de Pediatria - November 27, 2013 Category: Pediatrics Authors: Rosich Del Cacho M, Pareja Grande J, Martínez Jiménez MD, Latorre Latorre JF, Bejarano Ramírez N, López-Menchero Oliva C Tags: An Pediatr (Barc) Source Type: research

Writing Tremor Secondary to Ischemic Stroke: A Report on a Case With a Remarkable Response to Topiramate
Conclusions: Primary WT pathophysiology is not well known, and secondary WT as a result of stroke is even less considered. Although patients with essential tremor benefit with TPM and WT could be a variant of essential tremor, we used TPM with our patient and there was a marked benefit.
Source: Clinical Neuropharmacology - March 1, 2015 Category: Neurology Tags: Case Reports Source Type: research

Recurrent headaches: a case of neurological Behçet's disease.
Abstract A 48-year-old black male, of Nigerian heritage, presented with a 24-hour history of frontal headache of gradual onset. The headache characteristic was migranous, being described as throbbing in nature and located to the right frontal area with associated blurring of vision. Although similar to prior frequent headaches, there was now increasing unsteadiness on walking. Diagnosed 10 years earlier with Behçet's disease, the initial presentation was with oral and genital ulceration. Recurrent episodes of headache caused by neurological flare-ups resulted in a stroke at the age of 46 years. This previous stro...
Source: British Journal of Hospital Medicine - October 9, 2013 Category: Internal Medicine Authors: M Ismail A, W Dubrey S, C Patel M Tags: Br J Hosp Med (Lond) Source Type: research

Episodic Aphasia After Subdural Hemorrhage Due to Cortical Spreading Depression: A Case Report (P2.124)
CONCLUSION:CSD can be difficult to detect due to its brief and focal pathology. EEG should be done to exclude seizure and MRI/MRA to exclude stroke. CSD should be considered with a focal deficit with brief episodes when all other tests are negative. Better knowledge of the pathophysiolgy of CSD and its possible manifestations may facilitate a better way to diagnose as well as treatment to prevent CSD from causing permanent damage.Disclosure: Dr. Grayson has nothing to disclose. Dr. Shah has nothing to disclose. Dr. Patel has nothing to disclose. Dr. Forteza has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Grayson, J., Shah, N., Patel, S., Forteza, A. Tags: Cerebrovascular Disease and Interventional Neurology: Behavioral, Cognitive, and Miscellaneous Source Type: research

Status Epilepticus in Patients with SMART (P5.012)
CONCLUSIONS We describe three patients with SMART presenting with SE. Our cases raise the concern that SMART is not necessarily a migraine phenomenon but can be a form of focal SE associated with stroke-like symptoms. In patients with radiographic suspicion of SMART we suggest a low threshold for vEEG monitoring and aggressive anti-epileptic management.Disclosure: Dr. Fan has nothing to disclose. Dr. Gabriel has nothing to disclose. Dr. Gerard has nothing to disclose. Dr. Schuele has received personal compensation for activities with Sunovion and Eisai as a speaker.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Fan, P., Gabriel, H., Gerard, E., Schuele, S. Tags: Neuromuscular Disease and Epilepsy ePoster Session Source Type: research

Childhood and Adolescent Migraine Prevention (CHAMP) Study: A Double‐Blinded, Placebo‐Controlled, Comparative Effectiveness Study of Amitriptyline, Topiramate, and Placebo in the Prevention of Childhood and Adolescent Migraine
ConclusionsThe goal of the CHAMP study is to obtain level 1 evidence for the effectiveness of amitriptyline and topiramate in the prevention of migraine in children and adolescents. If this study proves to be positive, it will provide information to the practicing physician as how to best prevent migraine in children and adolescents and subsequently improve the disability and outcomes.
Source: Headache: The Journal of Head and Face Pain - April 17, 2013 Category: Neurology Authors: Andrew D. Hershey, Scott W. Powers, Christopher S. Coffey, Dixie D. Eklund, Leigh Ann Chamberlin, Leslie L. Korbee, Tags: Protocols Source Type: research

Childhood and Adolescent Migraine Prevention (CHAMP) Study: A Double-Blinded, Placebo-Controlled, Comparative Effectiveness Study of Amitriptyline, Topiramate, and Placebo in the Prevention of Childhood and Adolescent Migraine.
CONCLUSIONS: The goal of the CHAMP study is to obtain level 1 evidence for the effectiveness of amitriptyline and topiramate in the prevention of migraine in children and adolescents. If this study proves to be positive, it will provide information to the practicing physician as how to best prevent migraine in children and adolescents and subsequently improve the disability and outcomes. PMID: 23594025 [PubMed - in process]
Source: Headache - May 1, 2013 Category: Neurology Authors: Hershey AD, Powers SW, Coffey CS, Eklund DD, Chamberlin LA, Korbee LL, CHAMP Study Group Tags: Headache Source Type: research

Managing migraine and other headache syndromes in those over 50
Abstract: Migraine in an older person may appear with sensory or motor phenomena (“late-life migraine accompaniments”), so that it may be confused with transient ischemic attack or stroke. An older patient may have cervicogenic headache in addition to migraine. Medication overuse headache is just as much of a problem in older patients as it is in younger ones. Abdominal migraine without headache can be seen in older adults as a migraine equivalent, just as it can occur in children. The most effective drugs for migraine prophylaxis in young people (divalproex, topiramate, metoprolol and propranolol) are similarly effect...
Source: Maturitas - May 1, 2013 Category: Primary Care Authors: Brett Dees, Rhonda Coleman-Jackson, Linda A. Hershey Tags: Reviews Source Type: research

Mitochondrial Dysfunction in Migraine
Migraine is the most frequent type of headache in children. In the 1980s, scientists first hypothesized a connection between migraine and mitochondrial (mt) disorders. More recent studies have suggested that at least some subtypes of migraine may be related to a mt defect. Different types of evidence support a relationship between mitochondria (mt) and migraine: (1) Biochemical evidence: Abnormal mt function translates into high intracellular penetration of Ca2+, excessive production of free radicals, and deficient oxidative phosphorylation, which ultimately causes energy failure in neurons and astrocytes, thus triggering ...
Source: Seminars in Pediatric Neurology - September 1, 2013 Category: Neurology Authors: William R. Yorns, H. Huntley Hardison Source Type: research

Effect of Percutaneous Closure of Patent Foramen Ovale on Post-Procedural Arrhythmias
Atrial arrhythmias after percutaneous patent foramen ovale (PFO) closure, including atrial fibrillation (AF), has been consistently reported in different series suggesting a causal link between mechanical closure of PFO and the new onset of post-procedural arrhythmias (1,2,3). We have systematically assessed the effect of percutaneous PFO closure upon the development of post-procedural arrhythmias in 221 consecutive patients (144 women; mean age 48 ± 13 years) undergoing percutaneous PFO closure. At clinical evaluation, no patient had symptoms indicative or suggestive of arrhythmias. Indications for closure were the prese...
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - December 16, 2013 Category: Cardiology Source Type: research

An Unusual Case of Episodic SUNCT Responding to High Doses of Topiramate
We report a case of episodic SUNCT with symptoms suggestive of brainstem stroke that completely resolved spontaneously for which no underlying structural cause was found. The onset of first attack occurred during orgasm, and the patient responded to a high dose of topiramate.
Source: Headache: The Journal of Head and Face Pain - September 1, 2014 Category: Neurology Authors: Modar Khalil, Farooq Maniyar, Fayyaz Ahmed Tags: Brief Communication Source Type: research

An Unusual Case of Episodic SUNCT Responding to High Doses of Topiramate.
We report a case of episodic SUNCT with symptoms suggestive of brainstem stroke that completely resolved spontaneously for which no underlying structural cause was found. The onset of first attack occurred during orgasm, and the patient responded to a high dose of topiramate. PMID: 25250729 [PubMed - as supplied by publisher]
Source: Headache - September 24, 2014 Category: Neurology Authors: Khalil M, Maniyar F, Ahmed F Tags: Headache Source Type: research