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Total 44 results found since Jan 2013.
Impact of gallstone disease on the risk of stroke and coronary artery disease: evidence from prospective observational studies and genetic analyses
Despite epidemiological evidence associating gallstone disease (GSD) with cardiovascular disease (CVD), a dilemma remains on the role of cholecystectomy in modifying the risk of CVD. We aimed to characterize t...
Source: BMC Medicine - September 13, 2023 Category: Internal Medicine Authors: Li Zhang, Wenqiang Zhang, Lin He, Huijie Cui, Yutong Wang, Xueyao Wu, Xunying Zhao, Peijing Yan, Chao Yang, Changfeng Xiao, Mingshuang Tang, Lin Chen, Chenghan Xiao, Yanqiu Zou, Yunjie Liu, Yanfang Yang & hellip; Tags: Research article Source Type: research
Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients
CONCLUSIONS: Among statin-intolerant patients, treatment with bempedoic acid was associated with a lower risk of major adverse cardiovascular events (death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, or coronary revascularization). (Funded by Esperion Therapeutics; CLEAR Outcomes ClinicalTrials.gov number, NCT02993406.).PMID:36876740 | DOI:10.1056/NEJMoa2215024
Source: Atherosclerosis - March 6, 2023 Category: Cardiology Authors: Steven E Nissen A Michael Lincoff Danielle Brennan Kausik K Ray Denise Mason John J P Kastelein Paul D Thompson Peter Libby Leslie Cho Jorge Plutzky Harold E Bays Patrick M Moriarty Venu Menon Diederick E Grobbee Michael J Louie Chien-Feng Chen Na Li LeAn Source Type: research
Sickle Cell Trait and Risks for Common Diseases: Evidence from the UK Biobank
Sickle cell disease is an autosomal recessive disease caused by the inheritance of two pathogenic mutations of the hemoglobin subunit beta gene (HBB) (usually Glu6Val, though other pathogenic mutations exist).1 The altered hemoglobin makes red blood cells prone to being crescent-shaped, which can cause vaso-occlusion and result in numerous serious complications and comorbidities including: vaso-occlusive crisis, acute chest syndrome, infections, pulmonary hypertension, stroke, pulmonary embolism, renal failure, retinopathy, splenic sequestration, priapism, cholelithiasis, and osteonecrosis.
Source: The American Journal of Medicine - April 21, 2022 Category: General Medicine Authors: Joseph Hulsizer, W. Kyle Resurreccion, Zhuqing Shi, Jun Wei, Skylar Ladson-Gary, S. Lilly Zheng, Brian T. Helfand, Liana Billings, Michael S. Caplan, Jianfeng Xu Source Type: research
Causal relationship from coffee consumption to diseases and mortality: a review of observational and Mendelian randomization studies including cardiometabolic diseases, cancer, gallstones and other diseases
ConclusionHigh coffee consumption is associated with low risk of mortality, cardiometabolic diseases, some cancers and gallstones in observational studies, with no evidence to support causality from Mendelian randomization studies for most diseases except gallstones.
Source: European Journal of Nutrition - February 27, 2022 Category: Nutrition Source Type: research
Multimorbidity patterns and association with mortality in 0.5 million Chinese adults
CONCLUSION: Cardiometabolic multimorbidity and respiratory multimorbidity posed the highest threat on mortality risk and deserved particular attention in Chinese adults.PMID:35191418 | DOI:10.1097/CM9.0000000000001985
Source: Cancer Control - February 22, 2022 Category: Cancer & Oncology Authors: Junning Fan Zhijia Sun Canqing Yu Yu Guo Pei Pei Ling Yang Yiping Chen Huaidong Du Dianjianyi Sun Yuanjie Pang Jun Zhang Simon Gilbert Daniel Avery Junshi Chen Zhengming Chen Jun Lyu Liming Li China Kadoorie Biobank Collaborative Group Source Type: research
Causal relationship from coffee consumption to diseases and mortality: a review of observational and Mendelian randomization studies including cardiometabolic diseases, cancer, gallstones and other diseases
ConclusionHigh coffee consumption is associated with low risk of mortality, cardiometabolic diseases, some cancers and gallstones in observational studies, with no evidence to support causality from Mendelian randomization studies for most diseases except gallstones.
Source: European Journal of Nutrition - February 18, 2022 Category: Nutrition Source Type: research
Variations and characteristics of the various clinical phenotypes in a cohort of Nigerian sickle cell patients
CONCLUSION: The prevalence of SLU, AVN, priapism, nephropathy and the other complications of SCD show some variations from other studies. This variation in the clinical parameters across different clinical phenotypes indicates an interplay between age, genetic and environmental factors.PMID:34493173 | DOI:10.1080/16078454.2021.1972242
Source: Hematology - September 8, 2021 Category: Hematology Authors: Augustine Duru Anazoeze Jude Madu Helen Okoye Charles Nonyelu Onochie Obodo Kelechi Okereke Kenechi Madu Source Type: research
