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Risks of neurological and psychiatric sequelae 2 years after hospitalisation or intensive care admission with COVID-19 compared to admissions for other causes
Brain Behav Immun. 2023 May 30:S0889-1591(23)00132-0. doi: 10.1016/j.bbi.2023.05.014. Online ahead of print.ABSTRACTThe association between COVID-19 and subsequent neurological and psychiatric disorders is well established. However, two important questions remain unanswered. First, what are the risks in those admitted to intensive care unit (ICU) with COVID-19? Admission to ICU is itself associated with neurological and psychiatric sequelae and it is not clear whether COVID-19 further increases those risks or changes their profile. Second, what are the trajectories of neurological and psychiatric risks in patients admitted...
Source: Brain, Behavior, and Immunity - June 1, 2023 Category: Neurology Authors: Harriet Ley Zuzanna Skorniewska Paul J Harrison Maxime Taquet Source Type: research

COVID-19 Continuous-EEG Case Series: A Descriptive Study
Conclusions: In this observational case series of 16 patients with COVID-19 who were monitored with continuous video-EEG, most patients experienced a nonspecific encephalopathy. Clinical seizures and electrographic status epilepticus were the second most commonly observed neurological problem.
Source: Journal of Clinical Neurophysiology - November 1, 2022 Category: Neurology Tags: Original Research Source Type: research

Stroke-like presentation of autoimmune chorea with positive anti-Yo and anti-MOG antibodies: a case report
AbstractWith the in-depth study of autoimmune encephalitis, more and more antibody combinations and clinical manifestations appear in our sights, enriching the spectrum of autoimmune encephalitis. Here, we report a case of a 58-year-old male patient with sudden involuntary movement of the left limb. The brain MRI was normal. CSF analysis showed slightly elevated protein (548.38  mg/L) and normal cell count(1.00 10^6/L). No tumors were detected by the whole-body PET-CT. Positive anti-Yo and anti-MOG antibodies were found in the blood. So we considered the diagnosis of autoimmune chorea with positive anti-Yo and anti-MOG a...
Source: Neurological Sciences - October 25, 2022 Category: Neurology Source Type: research

Cytokine storm and neuropathological alterations in patients with neurological manifestations of COVID-19
Curr Alzheimer Res. 2022 Sep 8. doi: 10.2174/1567205019666220908084559. Online ahead of print.ABSTRACTThe COVID-19 pandemic is caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2), a respiratory pathogen with neuroinvasive potential. Neurological COVID-19 manifestations include loss of smell and taste, headache, dizziness, stroke, and potentially fatal encephalitis. Several studies found elevated proinflammatory cytokines such as TNF-α, IFN-γ, IL-6 IL-8, IL-10 IL-16, IL-17A, and IL-18 in severely and critically ill COVID-19 patients, which may persist even after apparent recovery from infection. Bioma...
Source: Current Alzheimer Research - September 12, 2022 Category: Neurology Authors: Christos Tsagkaris Muhammad Bilal Irem Aktar Youssef Aboufandi Ahmet Tas Abdullahi Tunde Aborode Tarun Kumar Suvvari Shoaib Ahmad Anastasiia Shkodina Rachana Phadke Marwa S Emhamed Atif Amin Baig Athanasios Alexiou Ghulam Md Ashraf Mohammad Amjad Kamal Source Type: research

Case report: Acute vestibular syndrome and cerebellitis in anti-Yo paraneoplastic syndrome
We report three patients evaluated over the past decade with an acute AVS along with subtle downbeat nystagmus (DBN), followed by dysarthria and progressive truncal and limb ataxia, as well as increasing DBN intensity.MethodsAll patients underwent neurologic examination, video-oculography, MRI, serum cancer markers, spinal fluid examination, paraneoplastic panel testing, and oncologic workup. With a consolidated diagnosis of cancer/paraneoplastic syndrome, we treated with plasma exchange (PLEX), high-dose steroids, surgery, and oncologic investigation. We additionally provided oncotherapy in one out of three patients.Resul...
Source: Frontiers in Neurology - August 26, 2022 Category: Neurology Source Type: research

Late-onset seizures and epilepsy: Electroclinical features suggestive of autoimmune etiology
ConclusionOur study shows that high-frequency focal seizures with autonomic manifestations should raise the suspicion of AE in the elderly with new-onset seizures. It also highlights the relevant contribution of AEEG, which might reduce the diagnostic delay and provide useful clues to recognize AE.
Source: Frontiers in Neurology - August 12, 2022 Category: Neurology Source Type: research

Arterial Spin Labeling Imaging Characteristics of Anti-leucine-rich Glioma-Inactivated 1 Encephalitis: A Qualitative and Quantitative Analysis
DiscussionIn this preliminary study of six patients, we demonstrate an ASL hyperperfusion pattern, with a possible predilection for the right mesial temporal lobe on both qualitative and quantitative assessments in patients with seropositive LGI1. Larger scale studies are necessary to further characterize the strength of these associations.
Source: Frontiers in Neurology - July 28, 2022 Category: Neurology Source Type: research

The spectrum of Neuro-COVID: A study of a comprehensively investigated large cohort from India
Conclusion: Stroke and encephalopathy constitute the most common neurological manifestations. The absence of preceding COVID-19 symptoms in nearly half the cases is striking. Poor outcome was seen in nearly 50% despite early recognition and management.
Source: Annals of Indian Academy of Neurology - May 25, 2022 Category: Neurology Authors: Seena Vengalil Rohan Mahale N Chakradhar Swathi Alluri PR Sagar Navanith VH Ganaraja KR Haripriya Holla Venkappayya Vikram Ajay Asranna Pooja Mailankody Doniparthi V Seshagiri H Manoj Cheerla VN Maturu CR Vaddepally Raghavendra Kenchaiah PR Srijithesh Jay Source Type: research

Post-varicella neurological complications: A preliminary observation from a tertiary care centre of Eastern India
Conclusion: Chickenpox is a common viral disease and most patients recover without any complication. Although rare, neurological complications following acute varicella infection may have myriad presentations ranging from lower motor neuron facial palsy to life-threatening encephalitis. Compared to other studies, varicella encephalitis and ataxia were not so common in our study group. Response to therapy was uniformly good except in the patients presenting with ataxia. Response was particularly good to central and peripheral demyelinating disorders.
Source: Annals of Indian Academy of Neurology - May 25, 2022 Category: Neurology Authors: Subhadeep Gupta Atanu Biswas Atanu Chandra Biman Kanti Ray Arpan Dutta Alak Pandit Source Type: research

Outcome of neurocritical disorders, a multicenter prospective cross ‐sectional study
ConclusionThis study identified that near two-thirds of the patients required mechanical ventilation. Delayed admission was observed due to causes distributed between the medical side and patient side. The majority of patients were discharged from ICU with partial recovery.
Source: Brain and Behavior - February 23, 2022 Category: Neurology Authors: Khalid Mohamed Ali, Mahmoud Hussien Salih, Hiba Hassan AbuGabal, Mohammed Eltahier Abdalla Omer, Ammar ElTahir Ahmed, Khabab Abbasher Hussien Mohamed Ahmed Tags: ORIGINAL ARTICLE Source Type: research

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