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Cardiovascular and metabolic risk of antipsychotics in children and young adults: a multinational self-controlled case series study
CONCLUSIONS: Long-term exposure to antipsychotics was associated with an increased risk of metabolic events but did not trigger cardiovascular events in children and young adults.PMID:34751642 | PMC:PMC8546502 | DOI:10.1017/S2045796021000494
Source: Epidemiology and Psychiatric Sciences - November 9, 2021 Category: Psychiatry Authors: Kenneth K C Man Shih-Chieh Shao Yu-Chuan Chang Mei-Hung Chi Han Eol Jeong Swu-Jane Lin Chien-Chou Su Ju-Young Shin Kirstie H Wong Ian C K Wong Yea-Huei Kao Yang Yen-Kuang Yang Edward Chia-Cheng Lai Source Type: research

Major adverse cardiovascular and limb events in patients with diabetes treated with GLP-1 receptor agonists vs DPP-4 inhibitors
Conclusions/interpretationIn individuals with diabetes, the use of GLP1RAs was associated with significantly lower risks of major adverse limb events when compared with the use of DPP4is. The reduction in risk was driven largely by reduced rate of amputations. Moreover, treatment with GLP1RAs was also associated with lower risks of cardiovascular death, non-fatal stroke, non-fatal myocardial infarction and death from any cause. However, some unexplored confounding factors may exist in this observation study and future large-scale randomised controlled trials are needed.Graphical abstract
Source: Diabetologia - August 24, 2021 Category: Endocrinology Source Type: research

Telmisartan use and risk of dementia in type 2 diabetes patients with hypertension: A population-based cohort study
by Chi-Hung Liu, Pi-Shan Sung, Yan-Rong Li, Wen-Kuan Huang, Tay-Wey Lee, Chin-Chang Huang, Tsong-Hai Lee, Tien-Hsing Chen, Yi-Chia Wei BackgroundAngiotensin receptor blockers (ARBs) may have protective effects against dementia occurrence in patients with hypertension (HTN). However, whether telmisartan, an ARB with peroxisome proliferator-activated receptor γ (PPAR-γ)–modulating effects, has additional benefits compared to other ARBs remains unclear. Methods and findingsBetween 1997 and 2013, 2,166,944 type 2 diabetes mellitus (T2DM) patients were identified from the National Health Insurance Research Database of Taiwa...
Source: PLoS Medicine - July 19, 2021 Category: Internal Medicine Authors: Chi-Hung Liu Source Type: research

IJERPH, Vol. 18, Pages 7540: Relationship of Multimorbidity, Obesity Status, and Grip Strength among Older Adults in Taiwan
Conclusion: Older adults who have two, rather than one or greater than three chronic diseases, have significantly lower GSs than those who are healthy. Stroke and CKD for males, and hypertension and diabetes for females, are important chronic diseases that are significantly associated with GS. Furthermore, being overweight may be a protective factor for GS in older adults of both sexes.
Source: International Journal of Environmental Research and Public Health - July 15, 2021 Category: Environmental Health Authors: Ming-Hsun Lin Chun-Yung Chang Der-Min Wu Chieh-Hua Lu Che-Chun Kuo Nain-Feng Chu Tags: Article Source Type: research

Correlation between Immune-Inflammatory Markers and Clinical Features in Patients with Acute Ischemic Stroke
CONCLUSIONS: Immune-inflammatory markers dynamically increased from symptom onset of acute ischemic stroke in patients eligible for thrombolytic therapy. Higher levels of immune-inflammatory markers suggest more in-hospital complications and unfavorable short-term outcomes.PMID:34018169
Source: Acta Neurologica Taiwanica - May 21, 2021 Category: Neurology Authors: Yu-Wei Chu Pei-Ya Chen Shinn-Kuang Lin Source Type: research

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