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Condition: Dementia
Procedure: MRI Scan

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Total 250 results found since Jan 2013.

Obstructive Sleep Apnea as a Risk Factor for Cerebral White Matter Change in a Middle-Aged and Older General Population
Conclusions:Moderate to severe OSA is an independent risk factor for WMC in middle-aged and older individuals. Thus, early recognition and treatment of OSA could reduce the risk of stroke and vascular dementia.Citation:Kim H; Yun CH; Thomas RJ; Lee SH; Seo HS; Cho ER; Lee SK; Yoon DW; Suh S; Shin C. Obstructive sleep apnea as a risk factor for cerebral white matter change in a middle-aged and older general population. SLEEP 2013;36(5):709-715.
Source: Sleep - May 4, 2013 Category: Sleep Medicine Source Type: research

Perceived Stress Is Associated With Subclinical Cerebrovascular Disease in Older Adults.
CONCLUSIONS: Greater perceived stress was significantly and independently associated with cerebral infarction and lower brain volume assessed 5 years later in this elderly cohort. PMID: 23567443 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - April 10, 2013 Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research

Course and etiology of dysexecutive MCI in a community sample.
CONCLUSIONS: dMCI appears to follow a different course, and is less associated with Alzheimer's disease and more associated with stroke than aMCI. PMID: 23452959 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - March 9, 2013 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Course and etiology of dysexecutive MCI in a community sample
Conclusions: dMCI appears to follow a different course, and is less associated with Alzheimer's disease and more associated with stroke than aMCI.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - March 1, 2013 Category: Geriatrics Authors: Edward D. Huey, Jennifer J. Manly, Ming-X. Tang, Nicole Schupf, Adam M. Brickman, Masood Manoochehri, Jesse Mez, Charles DeCarli, Davangere P. Devanand, Richard Mayeux Tags: Featured Articles Source Type: research

Leukoaraiosis on Magnetic Resonance Imaging Correlates With Worse Outcomes After Spontaneous Intracerebral Hemorrhage Clinical Sciences
Conclusions— Increased LA is an independent predictor of worse functional outcomes in patients after spontaneous ICH. The pathophysiology associating LA with worse outcomes requires further study. These data may improve prognostication and selection for clinical trials.
Source: Stroke - February 25, 2013 Category: Neurology Authors: Caprio, F. Z., Maas, M. B., Rosenberg, N. F., Kosteva, A. R., Bernstein, R. A., Alberts, M. J., Prabhakaran, S., Naidech, A. M. Tags: Acute Cerebral Hemorrhage, Computerized tomography and Magnetic Resonance Imaging, Intracerebral Hemorrhage, Risk Factors for Stroke Clinical Sciences Source Type: research

Association of Parental Stroke With Brain Injury and Cognitive Measures in Offspring: The Framingham Heart Study Brief Reports
Conclusions— Parental stroke by age 65 years is associated with increased vascular brain injury and lower memory in offspring equivalent to 3 and 7 years of brain aging, respectively. This may be partly attributed to inheritance of vascular risk factors.
Source: Stroke - February 25, 2013 Category: Neurology Authors: Weinstein, G., Beiser, A. S., Au, R., DeCarli, C., Wolf, P. A., Seshadri, S. Tags: Cerebrovascular disease/stroke, CT and MRI Brief Reports Source Type: research

Effects of Intravenous Solanezumab 400 mg q 4 Weeks vs. Placebo on Biomarkers in Patients with Mild to Moderate Alzheimer's Disease: Results of Two Phase 3 Studies (P01.011)
CONCLUSIONS: Solanezumab target engagement is associated with alteration of amyloid biology. There was a lack of apparent effect on markers of neurodegeneration. The overall findings lend support for the amyloid cascade hypothesis and suggest that various aspects of the cascade are viable targets for treatment of Alzheimer's disease.Supported by: Eli Lilly and Co.Disclosure: Dr. Hake has received personal compensation for activities with Eli Lilly and Company as an employee. Dr. Hake holds stock in Eli Lilly and Company. Dr. Siemers has received personal compensation for activities with Eli Lilly and Company as an employee...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Hake, A., Siemers, E., Carlson, C., Estergard, W., Sundell, K., Henley, D., Eads, J., Sexton, C., Liu-Seifert, H., Sethuraman, G., Chen, Y.-F., Mintun, M., Pontecorvo, M., Joshi, A., Dean, R., Willis, B., Demattos, R., Mohs, R. Tags: P01 Aging and Dementia: Therapeutics and Clinical Trials Source Type: research

Prevalence of Cerebrovascular Events in Extraluminal Protruding Intracranial Atherosclerotic Plaques: Analysis of Intracranial Vessels from the Nun Study (P03.009)
CONCLUSIONS: Outside protruding plaques without angiographic stenosis appear to be responsible for ischemic events in patients with cryptogenic stroke. Higher prevalence of stroke in these patients warrants the use of newer imaging modalities like high resolution magnetic resonance imaging to identify patients who are at high risk of cerebrovascular events.Disclosure: Dr. Semaan has nothing to disclose. Dr. Majidi has nothing to disclose. Dr. Chaudhry has nothing to disclose. Dr. Santa Cruz has nothing to disclose. Dr. Suri has nothing to disclose. Dr. ATACH Investigators has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Semaan, E., Majidi, S., Chaudhry, S., Santa Cruz, K., Suri, M. F., Qureshi, A. Tags: P03 Child Neurology II Source Type: research

A Novel Useful Tool of Computerized Touch Panel–Type Screening Test for Evaluating Cognitive Function of Chronic Ischemic Stroke Patients
Cognitive and affective impairments are important non-motor features of ischemic stroke (IS) related to white-matter hyperintensity, including periventricular hyperintensity (PVH). To confirm the usefulness of a novel computerized touch panel–type screening test, we investigated cognitive and affective functioning among 142 IS patients and 105 age-and gender-matched normal control subjects. Assessment using the mini-mental state examination, Hasegawa Dementia Scale-Revised, and frontal assessment battery revealed reduced cognitive function in IS patients, with the most severe reduction exhibited by cardiogenic embolism p...
Source: Journal of Stroke and Cerebrovascular Diseases - January 4, 2013 Category: Neurology Authors: Kentaro Deguchi, Syoichiro Kono, Shoko Deguchi, Nobutoshi Morimoto, Tomoko Kurata, Yoshio Ikeda, Koji Abe Tags: Original Articles Source Type: research

Apolipoprotein Epsilon 4 Allele Modifies Waist-to-Hip Ratio Effects on Cognition and Brain Structure
Conclusions: These findings suggest that associations between central adiposity and both neuropsychological performance and underlying brain structure are highly complex and must be considered in the context of possible modifying genetic influences.
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2011 Category: Neurology Authors: David Zade, Alexa Beiser, Regina McGlinchey, Rhoda Au, Sudha Seshadri, Carole Palumbo, Philip A. Wolf, Charles DeCarli, William Milberg Tags: Original Articles Source Type: research