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Condition: Dementia
Drug: Proton Pump Inhibitors PPIs

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Total 16 results found since Jan 2013.

Fast Heartburn Relief Without Deadly Drugs
Since gastroesophageal reflux disease (GERD) was first identified in the early 1930s, the number of people experiencing heartburn has increased substantially. In fact, one study shows that in just 10 years, the number of people experiencing:1 Any GERD symptoms increased by 30% Symptoms at least once a week increased by 47% Severe GERD increased by 24% While these numbers are concerning, I’ll admit they’re not surprising considering the typical American diet. Our nutrition-less, grain-based diet of carbohydrates and starches has wrecked our health and made our bodies behave in ways nature never intended. This has led ...
Source: Al Sears, MD Natural Remedies - August 28, 2023 Category: Complementary Medicine Authors: Jacob Tags: Health Heart Health Natural Cures Nutrition Source Type: news

Electrophilic and Drug-Induced Stimulation of NOTCH3 N-terminal Fragment Oligomerization in Cerebrovascular Pathology
AbstractSmall vessel disease is a prevalent age-related condition linked to increased risk of dementia and stroke. We investigate the most commonly inherited form, CADASIL, caused by cysteine-involving mutations inNOTCH3. Recent studies highlight accumulation of NOTCH3 N-terminal fragmentation product (NTF) in disease. In vitro, NTF is capable of both spontaneous and catecholamine-enhanced cysteine-mediated oligomerization. Despite well-characterized genetic influence on CADASIL, environmental effects, including medication usage, on disease remain unclear. We studied effects of assorted electrophilic compounds and drugs on...
Source: Translational Stroke Research - May 3, 2021 Category: Neurology Source Type: research

Acetylcholinesterase inhibitors are associated with reduced fracture risk among older Veterans with dementia
This article is protected by copyright. All rights reserved.
Source: Journal of Bone and Mineral Research - November 10, 2019 Category: Orthopaedics Authors: Abayomi N. Ogunwale, Cathleen S. Colon ‐Emeric, Richard Sloane, Robert A. Adler, Kenneth W. Lyles, Richard H. Lee Tags: Original Article Source Type: research

PFO Closure Reduces Strokes, and PPIs Increase Dementia Risk? PFO Closure Reduces Strokes, and PPIs Increase Dementia Risk?
New research suggests that reducing patent foramen ovale size could lessen stroke risk, while other work explores the role that PPIs might play in causing dementia.Medscape Neurology
Source: Medscape Today Headlines - October 17, 2017 Category: Consumer Health News Tags: Neurology & Neurosurgery Commentary Source Type: news

Chronic use of proton pump inhibitors, adverse events and potential biological mechanisms: A translational analysis.
Abstract Proton pump inhibitors (PPIs) are among the most frequently prescribed drugs. Even if PPI are usually considered as safe, there is a growing concern for a range of adverse effects of chronic PPI therapy often in the absence of appropriate indications. We propose, after a summary of renal, cardiovascular and neurological complications (dementia, chronic kidney disease, myocardial infarction and stroke), an integrative overview of the potential biological mechanisms involved. Eleven positive pharmacoepidemiological studies, mainly based on health insurance database linkage to hospital database, reported an ...
Source: Therapie - October 14, 2017 Category: Psychiatry & Psychology Authors: Kheloufi F, Frankel D, Kaspi E, Lepelley M, Mallaret M, Boucherie Q, Roll P, Micallef J Tags: Therapie Source Type: research

Heartburn drugs linked to premature death
Conclusion This larger set of observational data finds that PPI drugs are associated with an increase in the risk of early death compared with either H2 blockers or no acid suppression drugs. This was the case for participants both with and without gastrointestinal problems. It also appears as though the longer the PPIs drugs are taken, the greater the risk of death. Considering that these drugs are widely used in the UK, these findings may cause concern. But the research has a number of important limitations: The study was conducted in a population of mostly white, older US male veterans, which might limit the ability...
Source: NHS News Feed - July 4, 2017 Category: Consumer Health News Tags: Medication Source Type: news

This Popular Kind Of Heartburn Medicine Can Increase Stroke Risk
This study further questions the cardiovascular safety of these drugs,” Sehested said. Although the study found an association between PPIs and stroke risk, it does not prove cause and effect. More studies are needed, and doctors should consider if and for how long patients should take these drugs, the researchers said. [7 Bizarre Drug Side Effects] PPIs are not the only medicines available to treat heartburn. The researchers noted that another type of heartburn medication, called a histamine H2 antagonist, was found to have no association with stroke risk in the study. Histamine H2 antagonists include famotidine (Pe...
Source: Science - The Huffington Post - November 21, 2016 Category: Science Source Type: news

Proton Pump Inhibitors and Dementia Incidence
To the Editor I read with interest the article by Gomm and colleagues, which examined the association between the use of proton pump inhibitors (PPIs) and incident dementia in elderly individuals in a prospective study. The authors adopted time-dependent Cox regression analysis, and the time-dependent covariates were polypharmacy and the comorbidities of depression, diabetes, ischemic heart disease, and stroke. Age and sex were also used as confounding factors. The hazard ratio of PPIs for incident dementia was 1.44 (95% CI, 1.36-1.52), and the authors recommended randomized clinical trials to confirm the causal associatio...
Source: JAMA Neurology - June 20, 2016 Category: Neurology Source Type: research

PPI Side Effects Destroying Your Blood Vessels
It seems whenever I turn on my TV these days, there’s Larry the Cable Guy with a quick fix for heartburn. He makes it sound so simple. Just pop a pill, eat all the chili dogs you want, and no more heartburn… at least for a couple of weeks. What Is Heartburn? Heartburn is an irritation of the esophagus that is caused by stomach acid. It has nothing to do with the heart. But a new study has found a link between proton-pump inhibitors (PPIs) — heartburn drugs — and the premature aging of blood vessels. Heartburn Drugs PPI Side Effects Researchers focused on the effects of two PPIs, one of which is Nexium. They...
Source: Al Sears, MD Natural Remedies - June 16, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Heart Health Source Type: news

3 Surprising Things That Increase Your Dementia Risk
SPECIAL FROM “As many as five million Americans age 65 and older may have Alzheimer’s Disease, and that number is expected to double for every five-year interval beyond age 65.” — the National Institute of Neurologic Disorders and Stroke. While Alzheimer’s is the most common form of dementia, it is not the only form. Risk factors for all kinds of dementia include, age, alcohol use, smoking, atherosclerosis, diabetes, hypertension, and genetics. However, researchers have found some startling connections that show other surprising factors that can heighten your risk: Risk Factor #1: Anticho...
Source: Healthy Living - The Huffington Post - May 6, 2016 Category: Consumer Health News Source Type: news

Link between indigestion drugs and dementia 'inconclusive'
Conclusion This study found people taking PPIs had a 44% higher risk of developing dementia in a seven-year period compared with those not taking the drugs. However, it's not accurate to say this was down to the PPIs – the study couldn't prove this, and there are many possible explanations. For a start, the groups weren't very similar. Those taking PPIs had poorer health, and were more likely to be taking a number of medicines and have conditions linked to a higher risk of dementia, such as diabetes and heart disease. After taking these factors into account in the analysis, the link between PPIs and dementia reduc...
Source: NHS News Feed - February 16, 2016 Category: Consumer Health News Tags: Medication Neurology Older people Source Type: news

Management of acid-related disorders in patients with dysphagia
Publication date: 6 September 2004 Source:The American Journal of Medicine Supplements, Volume 117, Issue 5, Supplement 1 Author(s): Colin W. Howden Dysphagia affects a large and growing number of individuals in the United States, particularly the elderly and those who are neurologically impaired. Swallowing difficulties may be due to age-related changes in oropharyngeal and esophageal functioning as well as central nervous system diseases such as stroke, Parkinson disease, and dementia. Among institutionalized individuals, dysphagia is associated with increased morbidity and mortality. An appreciation of the physiology ...
Source: The American Journal of Medicine Supplements - November 6, 2014 Category: Drugs & Pharmacology Source Type: research

Risk of dementia in elderly patients with the use of proton pump inhibitors.
Authors: Haenisch B, von Holt K, Wiese B, Prokein J, Lange C, Ernst A, Brettschneider C, König HH, Werle J, Weyerer S, Luppa M, Riedel-Heller SG, Fuchs A, Pentzek M, Weeg D, Bickel H, Broich K, Jessen F, Maier W, Scherer M Abstract Drugs that modify the risk of dementia in the elderly are of potential interest for dementia prevention. Proton pump inhibitors (PPIs) are widely used to reduce gastric acid production, but information on the risk of dementia is lacking. We assessed association between the use of PPIs and the risk of dementia in elderly people. Data were derived from a longitudinal, multicenter cohort s...
Source: European Archives of Psychiatry and Clinical Neuroscience - October 25, 2014 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research