Link between indigestion drugs and dementia 'inconclusive'

Conclusion This study found people taking PPIs had a 44% higher risk of developing dementia in a seven-year period compared with those not taking the drugs. However, it's not accurate to say this was down to the PPIs – the study couldn't prove this, and there are many possible explanations. For a start, the groups weren't very similar. Those taking PPIs had poorer health, and were more likely to be taking a number of medicines and have conditions linked to a higher risk of dementia, such as diabetes and heart disease. After taking these factors into account in the analysis, the link between PPIs and dementia reduced from 66% to 44%. It's possible this adjustment wasn't complete (residual confounding), or that many other factors not measured in this study could further explain the remaining risk increase (bias). A study where the characteristics of the two groups are more closely matched would be a positive next step for this research area.  The study also focused solely on PPIs, which are mainly prescribed for the protection and management of stomach ulcers. It does not apply to indigestion treatments like over-the-counter antacid treatments you might take for heartburn or indigestion, which work in a different way by neutralising excess stomach acid. These limitations mean you should not stop taking prescribed PPIs. The link with dementia is uncertain, and is likely to be outweighed by the benefit of protecting the stomach&n...
Source: NHS News Feed - Category: Consumer Health News Tags: Medication Neurology Older people Source Type: news

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Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Depression subscribers-only Source Type: blogs
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Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 wire Source Type: news
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Source: Guardian Unlimited Science - Category: Science Authors: Tags: Mental health Drugs Alcoholism Methamphetamine (crystal meth) Society Life and style World news Christianity Religion Psychology Source Type: news
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Source: Dimensions of Critical Care Nursing - Category: Nursing Tags: Leadership DIMENSION Source Type: research
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Source: CNS Neuroscience and Therapeutics - Category: Neuroscience Authors: Source Type: research
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Source: CNS Neuroscience and Therapeutics - Category: Neuroscience Authors: Source Type: research
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