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Total 28 results found since Jan 2013.
A measurement for chronic pain is a scientific holy grail – and we’re getting closer | Abdul-Ghaaliq Lalkhen
People who have chronic pain without a visible injury are often not believed, but new research can help visualise that painMost people, including doctors, do not appreciate that the organ that produces pain is the brain. A broken bone, damaged tissue or a bleeding wound is often the focus, but the experience of pain is the sum total of more than just the physical injury – it is the result of information sent from our nerves being filtered through an individual’s unique psychological makeup, genetics, gender, beliefs, expectations, motivations and emotional context. Pain is therefore an individual experience, and often ...
Source: Guardian Unlimited Science - May 25, 2023 Category: Science Authors: Abdul-Ghaaliq Lalkhen Tags: Medical research Health Science Neuroscience UK news Stroke Cancer Back pain Diabetes Source Type: news
Scientists tie third clinical trial death to experimental Alzheimer ’s drug
As enthusiasm mounts for a new experimental antibody that appears to slow cognitive decline in some Alzheimer’s patients, a third death linked to the drug during its clinical testing may amplify concerns about its safety.
Science
has obtained medical records showing a 79-year-old Florida woman participating in an ongoing trial of the antibody died in mid-September after experiencing extensive brain swelling and bleeding, as well as seizures. Multiple neuroscientists who reviewed the records at
Science
’s request believe her death was likely caused by the antibody, lecanemab.
“The brain swelling and t...
Source: ScienceNOW - December 21, 2022 Category: Science Source Type: news
Second death linked to potential antibody treatment for Alzheimer ’s disease
A 65-year-old woman who was receiving a promising experimental treatment to slow the cognitive decline caused by her early Alzheimer’s disease recently died from a massive brain hemorrhage that some researchers link to the drug. The clinical trial death, described in an unpublished case report
Science
has obtained, is the second thought to be associated with the antibody called lecanemab. The newly disclosed fatality intensifies questions about its safety and how widely lecanemab should be prescribed if ultimately approved by regulators.
The woman, who received infusions of the antibody as part of the trial, s...
Source: ScienceNOW - November 28, 2022 Category: Science Source Type: news
Cortical stimulation in aphasia following ischemic stroke: toward model-guided electrical neuromodulation.
Abstract
The aim of this paper is to integrate different bodies of research including brain traveling waves, brain neuromodulation, neural field modeling and post-stroke language disorders in order to explore the opportunity of implementing model-guided, cortical neuromodulation for the treatment of post-stroke aphasia. Worldwide according to WHO, strokes are the second leading cause of death and the third leading cause of disability. In ischemic stroke, there is not enough blood supply to provide enough oxygen and nutrients to parts of the brain, while in hemorrhagic stroke, there is bleeding within the enclosed ...
Source: Biological Cybernetics - February 3, 2020 Category: Science Authors: Beuter A, Balossier A, Vassal F, Hemm S, Volpert V Tags: Biol Cybern Source Type: research
Secondary prevention of acute coronary syndrome with antiplatelet agents in real life: a high-dimensional propensity score matched cohort study in the French National claims database
This study was done in a newly available large-scale claims database, which may differ from other population databases, by it size and exhaustiveness•The methods elaborate on standard high-dimensional propensity scores as adapted to this claims databaseGraphical abstract
Source: MethodsX - January 24, 2020 Category: Science Source Type: research
Metabolic benefits of rivaroxaban in non-valvular atrial fibrillation patients after radiofrequency catheter ablation.
CONCLUSIONS: Patients with NVAF receiving rivaroxaban after RFCA procedures appear to benefit from a metabolic perspective compared with warfarin, providing practical clinical reference for the choice of the anticoagulant. Rivaroxaban seems to be as safe and effective in preventing thromboembolic events as warfarin for these patients.
PMID: 29119732 [PubMed - in process]
Source: J Zhejiang Univ Sci ... - November 1, 2017 Category: Science Authors: Zhu J, Gao RJ, Liu Q, Jiang RH, Yu L, Sun YX, Zhang P, Lin JW, Ye Y, Zhang ZW, Chen SQ, Cheng H, Sheng X, Jiang CY Tags: J Zhejiang Univ Sci B Source Type: research
Risk of bleeds and death with daily aspirin use higher than thought
Research suggests 3,000 people die a year in UK from long-term use of aspirin or similar drugs, but also taking heartburn medication could help reduce riskThe risk of long-term aspirin use causing major bleeding and death is higher than previously thought, with over-75s particularly vulnerable, a study suggests.Around 40% of adults aged 75 or over in the UK take a daily aspirin and lifelong treatment is recommended for patients who have previously had a heart attack or stroke.Continue reading...
Source: Guardian Unlimited Science - June 14, 2017 Category: Science Authors: Haroon Siddique Tags: Aspirin Health Society Science Medical research Source Type: news
Researchers develop non-invasive deep brain stimulation method
Researchers at MIT have developed a new method of electrically stimulating deep brain tissues without opening the skullSince 1997, more than 100,000 Parkinson ’s Disease patients have been treated with deep brain stimulation (DBS), a surgical technique that involves theimplantation of ultra-thin wire electrodes. The implanted device, sometimes referred to as a ‘brain pacemaker’, delivers electrical pulses to a structure called the subthalamic nucleus, located near the centre of the brain, and effectively alleviates many of the physical symptoms of the disease, such as tremor, muscle rigidity, and slowed movements.DBS...
Source: Guardian Unlimited Science - June 1, 2017 Category: Science Authors: Mo Costandi Tags: Science Neuroscience Parkinson's disease Society Medical research Source Type: news
Coagulation This antiplatelet agent is just right
Antiplatelet drugs are commonly used to prevent stroke in high-risk patients. Unfortunately, a frequent side effect of these drugs is excessive bleeding. To improve the safety margin – [Read More]
Source: This Week in Science - January 5, 2017 Category: Science Authors: Yevgeniya Nusinovich Tags: Coagulation Source Type: research
New oral anticoagulants provide same stroke prevention as warfarin but cause less bleeding
The new oral anticoagulants provide the same stroke prevention as warfarin but cause less intracranial bleeding, reports an observational study in more than 43,000 patients.
Source: ScienceDaily Headlines - August 27, 2016 Category: Science Source Type: news
New imaging method may predict risk of post-treatment brain bleeding after stroke
In a study of stroke patients, investigators confirmed through MRI brain scans that there was an association between the extent of disruption to the brain's protective blood-brain barrier and the severity of bleeding following invasive stroke therapy. The results of the National Institutes of Health-funded study were published in Neurology.
Source: ScienceDaily Headlines - June 18, 2016 Category: Science Source Type: news
Poor patient warfarin knowledge may increase risk of deadly side effects
Patients have poor knowledge of warfarin which may increase their risk of serious side effects, according to research. Warfarin is given to patients at increased risk of blood clots from conditions such as atrial fibrillation or a mechanical heart valve. It 'thins the blood' by slowing down the anticoagulation effect of vitamin K, thereby increasing the time it takes blood to clot and reducing the risk of stroke. Taking too much warfain raises the risk of bleeding.
Source: ScienceDaily Headlines - April 15, 2016 Category: Science Source Type: news
Don't Forget To Brush Your Teeth. Seriously.
Brushing twice a day is good for your breath and gums and all, but it also helps out your whole body. Francesco D’Aiuto, senior lecturer at the Eastman Dental Institute in London, chatted with The Guardian about what he refers to as the the "mouth-body connection," or the idea that a healthy body is strongly correlated with good dental hygiene. “The mouth is not disconnected from the rest of the body,” he explained. "People should not underestimate what the body senses when the mouth is neglected." What exactly is D'Aiuto referring to when he talks about neglecting the mouth? Gum disease, for ...
Source: Science - The Huffington Post - July 20, 2015 Category: Science Source Type: news
How chickenpox virus can cause a stroke in an HIV patient
Varicella-zoster virus causes chickenpox in children and shingles in older adults. The virus typically remains dormant in patients with healthy immune systems, but can reactivate if the immune system is compromised. Patients infected with human immunodeficiency virus (HIV) can, in rare cases, experience bleeding on the brain that causes a type of stroke called intracerebral hemorrhage.
Source: ScienceDaily Headlines - May 4, 2015 Category: Science Source Type: news
The Science Behind Anti-Depressants May Be Completely 'Backwards'
Anti-depressants are the most commonly-prescribed medication in the U.S., with one in 10 Americans currently taking pills like Zoloft and Lexapro to treat depression. But these pharmaceuticals are only effective less than 30 percent of the time, and often come with troublesome side effects.
In a controversial new paper published in the journal Neuroscience & Biobehavioral Reviews, psychologist Paul Andrews of McMaster University in Ontario argues that this failure of medication may be based in a misunderstanding of the underlying chemistry related to depression.
Andrews surveyed 50 years' worth of research supporting t...
Source: Science - The Huffington Post - February 28, 2015 Category: Science Source Type: news
