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Total 28 results found since Jan 2013.
Why The Science Behind Anti-Depressants May Be Completely 'Backwards'
Anti-depressants are the most commonly-prescribed medication in the U.S., with one in 10 Americans currently taking pills like Zoloft and Lexapro to treat depression. But these pharmaceuticals are only fully effective roughly 30 percent of the time, and often come with troublesome side effects.
In a controversial new paper published in the journal Neuroscience & Biobehavioral Reviews, psychologist Paul Andrews of McMaster University in Ontario argues that this failure of medication may be based in a misunderstanding of the underlying chemistry related to depression.
Andrews surveyed 50 years' worth of research supporti...
Source: Science - The Huffington Post - February 28, 2015 Category: Science Source Type: news
Taking NSAIDs with anti-clotting medications, risk of bleeding, cv events
Among patients receiving antithrombotic therapy (to prevent the formation of blood clots) after a heart attack, the use of nonsteroidal anti-inflammatory drugs (NSAIDs) was associated with an increased risk of bleeding and events such as heart attack, stroke or cardiovascular death, even after short-term treatment, according to a study.
Source: ScienceDaily Headlines - February 24, 2015 Category: Science Source Type: news
Development of apixaban: a novel anticoagulant for prevention of stroke in patients with atrial fibrillation
The factor Xa inhibitor apixaban is one of the novel anticoagulants to emerge as alternatives to long‐standing standards of care that include low‐molecular‐weight heparin and warfarin. The development of apixaban reflects a strategy to optimize the clinical pharmacology profile, dosing posology, trial designs, and statistical analyses across multiple indications, and to seek alignment with global health authorities. The primary objective of dose selection was to maintain balance between efficacy and bleeding risk. Twice‐daily dosing of apixaban, rather than once daily, was chosen to lower peak concentrations and re...
Source: Annals of the New York Academy of Sciences - November 5, 2014 Category: Science Authors: Michael S. Hanna, Puneet Mohan, Robert Knabb, Elora Gupta, Charles Frost, John H. Lawrence Tags: Original Article Source Type: research
Costs to treat bleeding strokes increases 10 years later
Costs to treat strokes caused by bleeding in the brain increased about 31 percent from five years after stroke to 10 years. Medication, nursing home and informal care expenses accounted for some of the increases.
Source: ScienceDaily Headlines - October 23, 2014 Category: Science Source Type: news
Protein in plasma may one day change transfusions
When someone is bleeding, a blood clot is a positive response -- the body forms the clot as a plug to stop bleeding. But when blood clots form in the absence of an injury, those clots can be life-threatening. Excessive blood clots in arteries and the brain are the main cause of heart attack and stroke. Researchers found that fibronectin can actually switch its function from stopping bleeding to stopping overactive blood clots.
Source: ScienceDaily Headlines - September 3, 2014 Category: Science Source Type: news
Systolic, diastolic blood pressures predict risk of different cardiovascular diseases
Raised systolic and diastolic blood pressures may have different effects on different types of cardiovascular diseases and at different ages, according to new research involving 1.25 million patients from primary care practices. The new findings suggest that individuals with higher systolic blood pressures have a greater risk of intracerebral haemorrhage (stroke caused by bleeding within the brain tissue), subarachnoid haemorrhage (the deadliest form of stroke), and stable angina, whereas raised diastolic blood pressure is a better indicator of abdominal aortic aneurysm risk.
Source: ScienceDaily Headlines - May 30, 2014 Category: Science Source Type: news
New cause of brain bleeding immediately after stroke identified
By discovering a new mechanism that allows blood to enter the brain immediately after a stroke, researchers have opened the door to new therapies that may limit or prevent stroke-induced brain damage. A complex and devastating neurological condition, stroke is the fourth-leading cause of death and primary reason for disability in the U.S. The blood-brain barrier is severely damaged in a stroke and lets blood-borne material into the brain, causing the permanent deficits in movement and cognition seen in stroke patients.
Source: ScienceDaily Headlines - April 17, 2014 Category: Science Source Type: news
Book reviews roundup: Catastrophe, Bleeding Edge and An Appetite for Wonder
What the critics thought of Catastrophe by Max Hastings, Bleeding Edge by Thomas Pynchon and An Appetite for Wonder by Richard Dawkins"Hastings hates British complacency about her military past, he hates British chauvinism, he hates Britain's patronising attitudes towards her allies, he hates Britain's love of turning retreats – Corunna, Dunkirk, Mons – into moral victories, he hates her continuing penchant for 'gesture politics', and he is damned sure that he is going to leave no treasured national myth unexploded." David Crane in the Spectator was taken aback by Max Hastings's Catastrophe, which c...
Source: Guardian Unlimited Science - September 20, 2013 Category: Science Tags: The Guardian History Culture Fiction Thomas Pynchon Books Richard Dawkins Features Science and nature Source Type: news
Heparin, grad students, a clinical revolution and giving credit where it's due
The story of a grad student who overcame remarkable odds only to be denied his moment of glory, or a tale of dark deceit and devilish doings? The story of heparin is as complicated as the chemistry itselfBlood is remarkable.A liquid that carries nutrients, waste products and the ever-vigilant cells of the immune system around the body, blood rapidly turns into a solid when it leaves its veins and arteries and becomes exposed to bodily tissues or the air outside. This process of solidification – clotting, or coagulation – is executed and controlled by a complex set of reactions and interactions primarily involving the e...
Source: Guardian Unlimited Science - September 4, 2013 Category: Science Authors: Richard P Grant Tags: theguardian.com Blogposts Science Source Type: news
Rivaroxaban: a novel oral anticoagulant for the prevention and treatment of several thrombosis‐mediated conditions
The development of rivaroxaban (XARELTO®) is an important new medical advance in the field of oral anticoagulation. Thrombosis‐mediated conditions constitute a major burden for patients, healthcare systems, and society. For more than 60 years, the prevention and treatment of these conditions have been dominated by oral vitamin K antagonists (such as warfarin) and the injectable heparins. Thrombosis can lead to several conditions, including deep vein thrombosis, pulmonary embolism, myocardial infarction, stroke, and/or death. Prevention and treatment of thrombosis with an effective, convenient‐to‐use oral anticoagula...
Source: Annals of the New York Academy of Sciences - May 23, 2013 Category: Science Authors: Troy C. Sarich, Gary Peters, Scott D. Berkowitz, Frank Misselwitz, Christopher C. Nessel, Paul Burton, Nancy Cook‐Bruns, Anthonie W.A. Lensing, Lloyd Haskell, Elisabeth Perzborn, Dagmar Kubitza, Kenneth T. Moore, Sanjay Jalota, Juergen Weber, Guohua Pan Tags: Original Article Source Type: research
Humble Aspirin could cut risk of heart attack - from Guardian archive, 28 Jan 1988
Twenty-five years ago, a study claimed that heart problems could be avoided by taking tablets designed for mild pain reliefMen with outwardly healthy hearts can cut the future risk of heart attacks by 47 per cent if they take an aspirin every two days, a United States study claims today.Advance word of its publication in the New England Journal of Medicine brought warnings from specialists about the danger to stomach linings of a rush to the aspirin bottle by either sex.Work in Europe and the US over the past two years has commended aspirin as an anti-blood clotting agent for heart and stroke sufferers. Advice on dosage we...
Source: Guardian Unlimited Science - January 28, 2013 Category: Science Tags: Heart attack Pharmaceuticals industry Health guardian.co.uk Medical research Aspirin Editorial From the Guardian Source Type: news
Gene breakthrough boosts hope of drug for blood diseases
Discovery could prevent lethal blood clots and help children with rare platelet function disorderNoah Edwards is four years old and suffers from a disorder that prevents his blood from clotting. He bleeds profusely when cut and his face and body are easily bruised.His condition, called platelet function disorder, is a constant worry for his mother, Ruby. However, thanks to Noah's involvement in a remarkable project, funded by the British Heart Foundation, his prospects of leading a normal life have received a major boost.Researchers at Birmingham University have uncovered the genetic roots of platelet function disorder, a ...
Source: Guardian Unlimited Science - January 13, 2013 Category: Science Authors: Robin McKie Tags: University of Birmingham Genetics Biology News Medical research Higher education UK news The Observer Science Source Type: news
VWF linkage and GWAS Genetics
The plasma glycoprotein von Willebrand factor (VWF) exhibits fivefold antigen level variation across the normal human population determined by both genetic and environmental factors. Low levels of VWF are associated with bleeding and elevated levels with increased risk for thrombosis, myocardial infarction, and stroke. To identify additional genetic determinants of...
Source: Proceedings of the National Academy of Sciences - January 8, 2013 Category: Science Authors: Desch, K. C., Ozel, A. B., Siemieniak, D., Kalish, Y., Shavit, J. A., Thornburg, C. D., Sharathkumar, A. A., McHugh, C. P., Laurie, C. C., Crenshaw, A., Mirel, D. B., Kim, Y., Cropp, C. D., Molloy, A. M., Kirke, P. N., Bailey-Wilson, J. E., Wilson, A. F., Tags: Biological Sciences Source Type: research
