Heparin, grad students, a clinical revolution and giving credit where it's due

The story of a grad student who overcame remarkable odds only to be denied his moment of glory, or a tale of dark deceit and devilish doings? The story of heparin is as complicated as the chemistry itselfBlood is remarkable.A liquid that carries nutrients, waste products and the ever-vigilant cells of the immune system around the body, blood rapidly turns into a solid when it leaves its veins and arteries and becomes exposed to bodily tissues or the air outside. This process of solidification – clotting, or coagulation – is executed and controlled by a complex set of reactions and interactions primarily involving the enzyme thrombin and the surface of platelets. The 'coagulation cascade' was first elucidated and described in the 1960s, but continues to surprise us even today.As with any biological process, coagulation can and does go wrong. If one of the factors in the cascade is missing, or inactive, or present only at very low levels, then you end up with a bleeding condition such as von Willebrand Disease or haemophilia. If, on the other hand, your blood clots where it shouldn't – while still in the veins and arteries – then you have a thrombotic condition. Depending on where the clot forms and what it does next this can manifest as deep vein thrombosis, a pulmonary embolism, a stroke or a myocardial infarction (heart attack). These are all pretty serious events and will cause you a great deal of grief – if they don't kill you immediately.Fort...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: theguardian.com Blogposts Science Source Type: news

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Conclusion: EBD for small-bowel strictures demonstrated good clinical outcomes in non-CD patients. PMID: 31198420 [PubMed]
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
The objective of the study was to investigate the antidiabetic and antioxidant effects of Foeniculum vulgare in streptozotocin-induced diabetic rat. METHODS: The effects of the leaves aqueous extract (LAE) of Foeniculum vulgare (F. vulgare) at a dose of 10 mg/kg on blood glucose levels were evaluated in normal and streptozotocin (STZ)-induced diabetic rats. Histopathological changes were also evaluated in liver in STZ-induced rats. RESULTS: Single oral administration of F. vulgare LAE reduced blood glucose levels 6 h after administration in STZ diabetic rats (p
Source: Cardiovascular and Hematological Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research
Conclusion: This review has shown that D. kotschyi is an important medicinal plant with a large number of active constituents and great potential to safeguard human and animal health in Iran. However, over utilization of the D. kotschyi plant is already endangering its existence. Nevertheless, more studies need be conducted across the country. PMID: 31198431 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Currently have been scribing at an urban ED, privately owned level 3 trauma center. I love my coworkers, doctors, boss, and job as a whole. I've worked 12 hours shifts until 3AM and I come home exhausted but ultimately so happy with my job. Currently have almost 1000 hours at this location under my belt over the past year. Here's my dilemma: I likely will not go for a chief scribe position as I will never be able to commit to working full time at the facility so having another year... ED Scribing Dilemma, opinions needed.
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pre-Medical - MD Source Type: forums
In this study, predictors of LOS were identified using a survival model that considered age as a continuous variable, separate comorbidities, and the discharge destination. Our findings are consistent with earlier reports and confirm the strong associations linking LOS to diabetes, day of surgery, and discharge destination in France. We also identified predictors of discharge to rehabilitation and of readmission within 30 days.Level of evidenceIV, retrospective observational cohort study.
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
Publication date: Available online 14 June 2019Source: Orthopaedics &Traumatology: Surgery &ResearchAuthor(s): D. Saragaglia, B. Rubens-Duval, R. PailhéAbstractExtra- and intra-articular proximal tibia malunion is not uncommon. Functional impact is variable but may lead to almost total impotence. The present study aimed to provide a review on malunion, answering 5 questions: (1) How should malunion be classified, and with what pathogenicity? Malunion results from reduction defect and/or secondary displacement in tibial plateau fracture (A2, A3, B, C on the AO classification), but also from previous epiphysio...
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
Publication date: Available online 14 June 2019Source: Neurología (English Edition)Author(s): F. López Espuela, J.C. Portilla Cuenca, C. Leno Díaz, J.M. Párraga Sánchez, G. Gamez-Leyva, I. Casado NaranjoAbstractObjectiveTo evaluate long-term quality of life (QoL) in patients who have experienced a stroke and to analyse differences in QoL between sexes.MethodsWe conducted a descriptive, cross-sectional, observational study to gather sociodemographic variables and risk factors; data were also obtained on QoL, mood, and functional status using validated scales. The study was approved by our ...
Source: Neurologia - Category: Neurology Source Type: research
Publication date: Available online 14 June 2019Source: Brain, Behavior, and ImmunityAuthor(s): Alessandra Borsini, Carmine M. Pariante, Patricia A. Zunszain, Nilay Hepgul, Alice Russell, Zuzanna Zajkowska, Valeria Mondelli, S. Sandrine ThuretAbstractInterferon (IFN)-α treatment for hepatitis C virus (HCV) is a well-recognized clinical model for inflammation-induced depression, but the brain cellular mechanisms underlying these effects are still not clear. Previous data reported an alteration in peripheral levels of inflammatory and neuroplasticity markers in the blood of depressed versus non-depressed patients. We in...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Conclusion: Mirt2 was elevated in IFN-γ-treated SGECs and then up-regulated miR-377 in response to inflammatory lesions. Mechanically, in synergy with miR-377 Mirt2 blocked IFN-γ-evoked activation of NF-κB and JAK/STAT signalling pathway. PMID: 31198060 [PubMed - in process]
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
In New York, the NYPD is a police force shaken by suicide. The death of an officer yesterday is the third suspected suicide in just 10 days. It's a growing problem — not just in New York — but nationwide. Kenneth Craig reports.
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news
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