Heparin, grad students, a clinical revolution and giving credit where it's due
The story of a grad student who overcame remarkable odds only to be denied his moment of glory, or a tale of dark deceit and devilish doings? The story of heparin is as complicated as the chemistry itselfBlood is remarkable.A liquid that carries nutrients, waste products and the ever-vigilant cells of the immune system around the body, blood rapidly turns into a solid when it leaves its veins and arteries and becomes exposed to bodily tissues or the air outside. This process of solidification – clotting, or coagulation – is executed and controlled by a complex set of reactions and interactions primarily involving the enzyme thrombin and the surface of platelets. The 'coagulation cascade' was first elucidated and described in the 1960s, but continues to surprise us even today.As with any biological process, coagulation can and does go wrong. If one of the factors in the cascade is missing, or inactive, or present only at very low levels, then you end up with a bleeding condition such as von Willebrand Disease or haemophilia. If, on the other hand, your blood clots where it shouldn't – while still in the veins and arteries – then you have a thrombotic condition. Depending on where the clot forms and what it does next this can manifest as deep vein thrombosis, a pulmonary embolism, a stroke or a myocardial infarction (heart attack). These are all pretty serious events and will cause you a great deal of grief – if they don't kill you immediately.Fort...
Conclusion: FN made in the 4:3:3 ratio of powder of corn, powder of bean cake defatted and powder of peeled whole potato is more effective to decrease the levels of postprandial 2h-blood glucose. FN is a staple type of functional food that could be used for the treatment of IGT.
The article Intracerebral haemorrhage on the acute stroke unit
A new study estimates that more than five million American workers lost their insurance this spring, a number higher than those in any full year of insurance losses.
Conclusion Studies on metacognition in BD are scarce, but the existing literature indicates potential clinical and sociodemographic factors associated with poorer metacognition in the disorder, also suggesting that metacognitive therapeutic interventions may be clinically relevant for the management of BD.
Publication date: Available online 13 July 2020Source: The Annals of Thoracic SurgeryAuthor(s): Feifei Z. Williams, Amy Clampitt-Holsenbeck, Alex Lopilato, Ramin Nazari, Matthew E. Zussman, Aurelio Reyes, Frank A. Pigula
Although patients with bipolar disorder commonly experience depressive symptoms, clinicians should be very cautious about treating them with antidepressants, especially as monotherapy.Medscape Medical News
Dr Christoph Diener on the six recent neurology studies with potential impact on the field.Medscape Neurology
ConclusionThe results do not support a cardioprotective effect of bisphosphonates regardless of the duration of treatment, age, sex or background cardiovascular risk. However, a small protective effect could have been masked if patients with osteoporosis have had a background higher risk of AMI.
Background: Technology platforms that afford biomarker discovery in patients suffering from traumatic brain injury (TBI) remain an unmet medical need. Here, we describe an observational pilot study to explore the utility of an alternating current electrokinetic (ACE) microchip device in this context.Methods: Blood samples were collected from participating subjects with and without minor TBI. Plasma levels of glial fibrillary acidic protein (GFAP), Tau, ubiquitin C-terminal hydrolase L1 (UCH-L1), and cell-free DNA (cfDNA) were determined in subjects with and without minor TBI using ACE microchip device followed by on-chip i...
AbstractIn silico analysis is the most important approach to understand protein structure and functions, and the most important problem for designing and producing a fusion construct is producing large amounts of functional protein.Clostridium perfringens type A andClostridium septicum produce alpha (plc) and alpha toxins respectively.C. perfringens can cause gas gangrene and gastrointestinal diseases.C. septicum can cause traumatic and non-traumatic gas gangrene. The aim of current research was in silico analysis of a chimeric fusion protein againstC. perfringens type A andC. septicum alpha toxins. Firstly, the chimeric f...
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