VWF linkage and GWAS [Genetics]

The plasma glycoprotein von Willebrand factor (VWF) exhibits fivefold antigen level variation across the normal human population determined by both genetic and environmental factors. Low levels of VWF are associated with bleeding and elevated levels with increased risk for thrombosis, myocardial infarction, and stroke. To identify additional genetic determinants of...

Source: Proceedings of the National Academy of Sciences - January 8, 2013 Category: Science Authors: Desch, K. C., Ozel, A. B., Siemieniak, D., Kalish, Y., Shavit, J. A., Thornburg, C. D., Sharathkumar, A. A., McHugh, C. P., Laurie, C. C., Crenshaw, A., Mirel, D. B., Kim, Y., Cropp, C. D., Molloy, A. M., Kirke, P. N., Bailey-Wilson, J. E., Wilson, A. F., Tags: Biological Sciences Source Type: research