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Condition: Bleeding
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Total 136 results found since Jan 2013.

Clinical features, sex differences and outcomes of myocardial infarction with nonobstructive coronary arteries: a registry analysis
Conclusion The incidence of MINOCA was 9.5%. Compared to OACD-MI, patients with MINOCA have less cardiac risk factors. In-hospital outcomes of patients diagnosed with MINOCA were better than OACD-MI.
Source: Coronary Artery Disease - December 23, 2020 Category: Cardiology Tags: Acute Coronary Syndromes Source Type: research

Robot-assisted coronary artery bypass surgery: a systematic review and meta-analysis of comparative studies.
CONCLUSION: Although the findings from this review of comparative studies of RCAB appear promising and suggest that RCAB may offer some benefits to patients, in the absence of randomized controlled trials, these results should be interpreted cautiously. PMID: 33155975 [PubMed - in process]
Source: Canadian Journal of Surgery - November 1, 2020 Category: Surgery Authors: Hammal F, Nagase F, Menon D, Ali I, Nagendran J, Stafinski T Tags: Can J Surg Source Type: research

Protamine Reduces Serious Bleeding Complications Associated with Carotid Endarterectomy in Asymptomatic Patients without Increasing the Risk of Stroke, Myocardial Infarction, or Death in a Large National Analysis.
CONCLUSION: Protamine reduces serious bleeding complications at the time of CEA without increasing the risk of MI, stroke, or death, in this large North American analysis. Based on this and previous regional work regarding protamine use in CEA, it is believed that there is now sufficient evidence to support its routine use, and it should be considered as a benchmark for quality during CEA. PMID: 33127243 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - October 27, 2020 Category: Surgery Authors: Stone DH, Giles KA, Kubilis P, Suckow BD, Goodney PP, Huber TS, Powell RJ, Cronenwett JL, Scali ST Tags: Eur J Vasc Endovasc Surg Source Type: research

Biased signalling in platelet G-protein-coupled receptors.
Abstract Platelets are small megakaryocyte-derived, anucleate, disk-like structures that play an outsized role in human health and disease. Both a decrease in the number of platelets, as well as a variety of platelet function disorders, result in petechiae or bleeding which can be life threatening. Conversely, the inappropriate activation of platelets, within diseased blood vessels, remains the leading cause of death and morbidity through affecting heart attacks and stroke. The fine balance of the platelet state in healthy individuals is controlled by a number of receptor-mediated signalling pathways that allow th...
Source: Canadian Journal of Physiology and Pharmacology - August 25, 2020 Category: Drugs & Pharmacology Authors: Thibeault PE, Ramachrandran R Tags: Can J Physiol Pharmacol Source Type: research

Mitral valve prosthesis choice in patients < 70 years: A systematic review and meta ‐analysis of 20 219 patients
ConclusionMechanical MVR in patients aged less than 70 years is associated with a lower risk of operative mortality as well as a 20% lower risk of long ‐term death and 65% lower risk of mitral valve reoperation but 60% greater risk of bleeding compared with bioMVR in matched or adjusted data.
Source: Journal of Cardiac Surgery - February 27, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Bobby Yanagawa, Jessica Lee, Maral Ouzounian, Akshay Bagai, Asim Cheema, Subodh Verma, Jan O. Friedrich, on behalf of the Canadian Cardiovascular Surgery Meta ‐Analysis Working Group Tags: ORIGINAL ARTICLE Source Type: research

Oral Anticoagulants and Antiplatelet Agents in Atrial Fibrillation Patients with Concomitant Critical Limb Ischemia: A nationwide cohort study
ConclusionsDOAC was associated with a significantly lower risk of composite net-clinical-benefit outcome than either warfarin or APT in AF patients with concomitant CLI. Further prospective study is necessary to validate the findings in the future.
Source: Canadian Journal of Cardiology - February 19, 2020 Category: Cardiology Source Type: research

Status, Indications, and Use of Cardiac Replacement Therapy in the Era of Multimodal Mechanical Approaches to Circulatory Support: A Scoping Review
In conclusion, the Syncardia temporary TAH is a reasonable bridge-to-transplant option for selected patients with either biventricular failure or special anatomic conditions.RésuméLes auteurs décrivent l’utilisation, les indications et les résultats actuels du cœur artificiel total (CAT) temporaire Syncardia (Syncardia Systems, Tucson, AZ, États-Unis), le seul CAT actuellement approuvé comme stratégie de transition vers une transplantation au Canada, aux États-Unis et en Europe. Implanté chez plus de 1 700 patients dans le monde, le CAT temporaire Syncardia est la pompe la plus utilisée. À l’échelle mondia...
Source: Canadian Journal of Cardiology - February 7, 2020 Category: Cardiology Source Type: research

Medical Management of Left Ventricular Assist Device Patients: A Practical Guide for the Nonexpert Clinician
This article provides a concise overview of the medical management of LVAD patients for nonexpert clinicians. Our presentation includes the basics of LVAD physiology, design, and operation, patient selection and assessment, medical management, adverse event identification and management, multidisciplinary care, and management of special circumstances, such as noncardiac surgery, cardiac arrest, and end-of-life care. The clinical examination of LVAD patients is unique in terms of blood pressure and heart rate assessment, LVAD “hum” auscultation, driveline and insertion site inspection, and device parameter recording. Im...
Source: Canadian Journal of Cardiology - February 7, 2020 Category: Cardiology Source Type: research

Short- and long-term outcomes in dialysis patients undergoing transcatheter aortic valve implantation: a systematic review and meta-analysis
ConclusionDialysis patients had significantly higher rates of short- and long-term mortality, short-term life threatening and/or major bleeding, permanent pacemaker implantation, and device failure compared to non-dialysis patients. Careful patient selection who would benefit from TAVI in patients with ESRD requiring dialysis, is necessary to prevent high-rates of post-procedural complications.
Source: Canadian Journal of Cardiology - January 25, 2020 Category: Cardiology Source Type: research

Valve-Sparing Root Replacement vs Composite Valve Grafting in Aortic Root Dilation: A Meta-Analysis
ConclusionsAortic valve sparing appears to be safe, and associated with reduced late mortality, thromboembolism/stroke and bleeding compared with composite valve grafting. Late durability is equivalent. Aortic valve sparing should be considered in patients with favorable aortic valve morphology.Graphical abstract
Source: The Annals of Thoracic Surgery - January 23, 2020 Category: Cardiovascular & Thoracic Surgery Source Type: research

Valve-Sparing Root Replacement vs Composite Valve Grafting in Aortic Root Dilation: A Meta-Analysis.
CONCLUSIONS: Aortic valve sparing appears to be safe, and associated with reduced late mortality, thromboembolism/stroke and bleeding compared with composite valve grafting. Late durability is equivalent. Aortic valve sparing should be considered in patients with favorable aortic valve morphology. PMID: 31981499 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - January 21, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Elbatarny M, Tam DY, Edelman JJ, Rocha RV, Chu MWA, Peterson MD, El-Hamamsy I, Appoo JJ, Friedrich JO, Boodhwani M, Yanagawa B, Ouzounian M, Canadian Thoracic Aortic Collaborative (CTAC) Investigators Tags: Ann Thorac Surg Source Type: research

Dual-Antithrombotic Therapy With DOACs After Acute Coronary Syndrome or Percutaneous Coronary Intervention in Atrial Fibrillation: A Meta-analysis of Randomized Controlled Trials
ConclusionsIn patients with AF and recent ACS or PCI, the use of dual-antithrombotic therapy with DOACs was associated with less major bleeding and less major bleeding or clinically relevant nonmajor bleeding compared with triple therapy. The use of dual therapy also showed nonsignificantly higher composite of death and ischemic events but no difference in mortality.RésuméContexteIl est difficile de choisir un traitement antithrombotique en cas de fibrillation auriculaire (FA) chez les patients ayant subi un syndrome coronarien aigu (SCA) ou une intervention coronarienne percutanée (ICP). Nous avons comparé les résult...
Source: Canadian Journal of Cardiology - December 24, 2019 Category: Cardiology Source Type: research

Prescribing of oral anticoagulants in the emergency department and subsequent long-term use by older adults with atrial fibrillation.
Authors: Atzema CL, Jackevicius CA, Chong A, Dorian P, Ivers NM, Parkash R, Austin PC Abstract BACKGROUND: Patients with atrial fibrillation frequently seek emergency care. Rates of guideline-concordant oral anticoagulant therapy for stroke prevention are suboptimal in the community. We assessed the association between prescribing of oral anticoagulants in the emergency department (relative to referral to a longitudinal care provider for treatment initiation) and long-term use of oral anticoagulants. METHODS: This retrospective cohort study performed at 15 hospitals in Ontario, Canada, involved patients aged 65...
Source: Canadian Medical Association Journal - December 11, 2019 Category: General Medicine Tags: CMAJ Source Type: research

Status, Indications and Use of Cardiac Replacement Therapy in the Era of Multimodal Mechanical Approaches to Circulatory Support: A Scoping Review
In conclusion, the SynCardia temporary TAH is a reasonable bridge-to-transplant option for selected patients with either biventricular failure or special anatomical conditions.
Source: Canadian Journal of Cardiology - November 30, 2019 Category: Cardiology Source Type: research

Dual antithrombotic therapy with DOACs after ACS or PCI in Atrial Fibrillation: A meta-analysis of Randomized Controlled Trials
ConclusionsIn patients with AF and recent ACS or PCI, the use of dual antithrombotic therapy with DOACs was associated with less major bleeding, and major bleeding or clinically relevant non-major bleeding, compared to triple therapy. The use of dual therapy also shows non-significantly higher composite of death/ischemic events but no difference in mortality.
Source: Canadian Journal of Cardiology - November 14, 2019 Category: Cardiology Source Type: research