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Liver Fibrosis is Associated with Ischemic Stroke Risk in Women but not Men: The REGARDS Study
Nonalcoholic fatty liver disease is inconsistently associated with ischemic stroke, with one study suggesting an association in women and not men. The relative importance of liver fibrosis, as opposed to fatty liver, for cardiovascular risk is increasingly appreciated. We hypothesized that advanced liver fibrosis is associated with incident ischemic stroke risk, and especially in women.
Source: Journal of Stroke and Cerebrovascular Diseases - April 16, 2021 Category: Neurology Authors: Neal S. Parikh, Insu Koh, Lisa B. VanWagner, Mitchell S.V. Elkind, Neil A. Zakai, Mary Cushman Source Type: research

Nonalcoholic fatty liver disease with advanced fibrosis, stroke and cardiovascular disease
Parikh et al. conducted a cross-sectional study on the relationship of nonalcoholic fatty liver disease with advanced fibrosis (NAFLD-fibrosis) with stroke, heart disease, and major cardiovascular disease [1]. As indicators of NAFLD-fibrosis, the Fibrosis-4 Score (FIB-4) and NAFLD Fibrosis Score (NFS) were used for the analysis. Adjusted odds ratio (OR) (95% confidence interval [CI]) of the FIB-4 for stroke was 1.87 (1.00 –3.50). In addition, adjusted ORs of NAFLD-fibrosis for heart disease and major cardiovascular disease significantly increased.
Source: Journal of the Neurological Sciences - November 6, 2019 Category: Neurology Authors: Tomoyuki Kawada Tags: Letter to the Editor Source Type: research

Response to letter to the editor by Kawada on “Association between nonalcoholic fatty liver disease with advanced fibrosis and stroke”
We thank Dr. Kawada for their interest [1] in our recent publication [2], in which we reported on the association between nonalcoholic fatty liver disease (NAFLD) fibrosis indices and stroke. In a large, nationally representative sample of Americans, we demonstrated a cross-sectional relationship between NAFLD-advanced fibrosis and prevalent, self-reported stroke, with variability in our findings depending on the liver fibrosis score used.
Source: Journal of the Neurological Sciences - November 6, 2019 Category: Neurology Authors: NealS. Parikh, Jose Gutierrez Tags: Letter to the Editor Source Type: research

Association between nonalcoholic fatty liver disease with advanced fibrosis and stroke
There is an increasing appreciation of the cardiovascular implications of nonalcoholic fatty liver disease with advanced fibrosis (NAFLD-fibrosis). However, data regarding stroke risk are limited. We sought to investigate whether NAFLD-fibrosis is associated with stroke in addition to heart disease.
Source: Journal of the Neurological Sciences - October 12, 2019 Category: Neurology Authors: Neal S. Parikh, Lisa B. VanWagner, Mitchell S.V. Elkind, Jose Gutierrez Source Type: research

The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke
Conclusions: Our study shows that a higher burden of liver steatosis seems to be associated with less severe stroke and better functional outcome after ischemic stroke or TIA. Introduction Non-alcoholic fatty liver disease (NAFLD) is a spectrum of diseases from simple steatosis to steatohepatitis with varying degree of fibrosis, and liver cirrhosis (1, 2). NAFLD is becoming the most common chronic liver disease worldwide including Korea, affecting approximately 25% of the general population (3, 4). NAFLD is closely associated with obesity, insulin resistance, and type 2 diabetes mellitus, and is even recognized as ...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

The Influence of Abdominal and Ectopic Fat Accumulation on Carotid Intima-Media Thickness: A Chongqing Study
To investigate the effects of abdominal obesity (AO) and nonalcoholic fatty liver disease (NAFLD) with or without AO on carotid arteries by determining carotid intima-media thickness (CIMT).
Source: Journal of Stroke and Cerebrovascular Diseases - April 16, 2018 Category: Neurology Authors: Xu Yi, Yu-Hui Liu, Xin-Fu Zhou, Yan-Jiang Wang, Juan Deng, Juan Liu, Hong-Bo He, Zhi-Qiang Xu Source Type: research

Nonalcoholic fatty liver disease: an emerging predictor of stroke risk, severity and outcome
This article is protected by copyright. All rights reserved.
Source: European Journal of Neurology - January 25, 2018 Category: Neurology Authors: Marianthi Papagianni, Konstantinos Tziomalos Tags: Editorials Source Type: research

Non ‐alcoholic Fatty Liver Disease is associated with stroke severity and progression of brainstem infarctions
ConclusionThese results suggest that NAFLD is a potential risk factor when evaluating the severity and progression of acute BSIs. This relationship is independent of classic risk factors and metabolic syndrome features.This article is protected by copyright. All rights reserved.
Source: European Journal of Neurology - December 27, 2017 Category: Neurology Authors: Haiyan Li, Biao Hu, Wei Lei, Li Zhou, Lei Zhang, Yinyao Lin, Bing Qin, Yongqiang Dai, Zhengqi Lu Tags: Original Article Source Type: research