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N-hydroxy-N'-(4-butyl-2-methylphenyl)-formamidine attenuates oxygen-glucose deprivation and reoxygenation-induced cerebral ischemia-reperfusion injury via regulation of microRNAs.
Abstract Cerebral ischemia-reperfusion injury is a common complication that occurs during stroke treatment. Increasingly, microRNAs have been found to participate in the modulation of neuron function; however, the role of microRNAs in cerebral ischemia-reperfusion injury remains unclear. We developed a mechanism of cerebral ischemia-reperfusion injury using a cellular model of oxygen-glucose deprivation and reoxygenation-induced injury in human neuroblastoma SH-SY5Y cells. We found that treatment of oxygen-glucose deprivation and reoxygenation promoted the apoptosis of SH-SY5Y cells. Analysis of microRNAs sequenci...
Source: Journal of Integrative Neuroscience - June 29, 2020 Category: Neuroscience Authors: Yang T, Wang D, Qu Y, Wang Y, Feng Y, Yang Y, Luo Q, Sun X, Yu G, He J, Sun Z, Zhu Y Tags: J Integr Neurosci Source Type: research

Levetiracetam, an antiepileptic drug has neuroprotective effects on intracranial hemorrhage injury
Publication date: Available online 11 February 2020Source: NeuroscienceAuthor(s): Takahiko Imai, Tomoki Sugiyama, Sena Iwata, Shinsuke Nakamura, Masamitsu Shimazawa, Hideaki HaraAbstractIntracranial hemorrhage (ICH) is a devastating disease that induces hematoma formation with poor neuronal outcome. Levetiracetam (LEV) has been approval for epilepsy seizures. In a previous study, LEV exerted protective effects on cerebral ischemia models; however, the detail effects and the influence of LEV on ICH are still unknown. The aim of this study was to investigate whether oral administration of LEV (50 or 150 mg/kg) has protective...
Source: Neuroscience - February 13, 2020 Category: Neuroscience Source Type: research

Protective effect of gastrodin against methamphetamine-induced autophagy in human dopaminergic neuroblastoma SH-SY5Y cells via the AKT/mTOR signaling pathway
This study investigates whether METH induces autophagy in the human dopaminergic neuroblastoma cell line SH-SY5Y, then examines the neuroprotective effects of gastrodin against autophagy in METH-treated SH-SY5Y cells. The effects of METH on the protein expressions of autophagy-related genes (LC3B and Beclin-1) were evaluated with and without gastrodin. The presence of autophagosomes in the METH-induced treatment with and without gastrodin is revealed through transmission electron microscopy. Pharmacological intervention was employed to study the role of the AKT/mTOR signaling pathway in the gastrodin-mediated neuroprotecti...
Source: Neuroscience Letters - May 24, 2019 Category: Neuroscience Source Type: research

Neuroprotective potential of adenosine A1 receptor partial agonists in experimental models of cerebral ischemia
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - January 7, 2019 Category: Neuroscience Authors: Alberto Martire, Catia Lambertucci, Rita Pepponi, Antonella Ferrante, Nicholas Benati, Michela Buccioni, Diego Dal Ben, Gabriella Marucci, Karl ‐Norbert Klotz, Rosaria Volpini, Patrizia Popoli Tags: Original Article Source Type: research

Sirtuin 6 protects the brain from cerebral ischemia/reperfusion injury through NRF2 activation
In this study, we investigated the effects of SIRT6 overexpression in regulating I/R injury in a mouse cerebral I/R model in vivo and in oxygen-glucose-deprivation/reoxygenation (OGD/R)-stimulated neuro-2a neuroblastoma cells in vitro. We found that cerebral I/R (1 h/24 h) resulted in decreased SIRT6 expression in the cerebral cortex (P < 0.01). SIRT6 overexpression in the brain by in vivo gene transfer enhanced the antioxidant NRF2 signaling (P < 0.05), reduced oxidative stress (P < 0.05), and attenuated cerebral I/R-induced brain tissue damage and neurological deficits (P <�...
Source: Neuroscience - November 15, 2017 Category: Neuroscience Source Type: research

Neuroprotective activity of (1S,2E,4R,6R,-7E,11E)-2,7,11-cembratriene-4,6-diol (4R) in vitro and in vivo in rodent models of brain ischemia
In conclusion, the present study indicates that 4R has a protective effect in rodent ischemic stroke models. Inhibition of ICAM-1 expression and restoration of Akt phosphorylation are the possible mechanisms involved in cellular protection by 4R.
Source: Neuroscience - March 5, 2015 Category: Neuroscience Source Type: research

Endothelial Nitric Oxide Synthase Protects Neurons against Ischemic Injury through Regulation of Brain-Derived Neurotrophic Factor Expression.
CONCLUSION: Collectively, our results indicate that the neuroprotection of neuron-derived eNOS against the cerebral ischemia was mediated through the regulation of BDNF secretion. In conclusion, our discovery provides a novel explanation for the neuroprotective effect of eNOS under pathological ischemic conditions such as stroke. PMID: 24397751 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - January 8, 2014 Category: Neuroscience Authors: Li ST, Pan J, Hua XM, Liu H, Shen S, Liu JF, Li B, Tao BB, Ge XL, Wang XH, Shi JH, Wang XQ Tags: CNS Neurosci Ther Source Type: research