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Specialty: Neuroscience
Cancer: Brain Cancers

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Total 97 results found since Jan 2013.

The interaction between intestinal microenvironment and stroke
CONCLUSION: The structure and function of the intestinal environment can influence neurological function and cerebral ischemic outcome. Improving the intestinal microenvironment by targeting the gut microbiota may be a new direction in treating stroke.PMID:37309254 | DOI:10.1111/cns.14275
Source: CNS Neuroscience and Therapeutics - June 13, 2023 Category: Neuroscience Authors: Linna Zhao Jie Xiao Songlin Li Yuying Guo Rong Fu Shengyu Hua Yuzheng Du Shixin Xu Source Type: research

Astrocytic Chitinase ‐3‐like Protein 1 in Neurological Diseases: Potential Roles and Future Perspectives
AbstractChitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein characterized by its ability to regulate multiple biological processes, such as the inflammatory response and gene transcriptional signaling activation. Abnormal CHI3L1 expression has been associated with multiple neurological disorders and serves as a biomarker for the early detection of several neurodegenerative diseases. Aberrant CHI3L1 expression is also reportedly associated with brain tumor migration and metastasis, as well as contributions to immune escape, playing important roles in brain tumor progression. CHI3L1 is synthesized and secreted mai...
Source: Journal of Neurochemistry - April 7, 2023 Category: Neuroscience Authors: Fei Li, An Liu, Minggao Zhao, Lanxin Luo Tags: REVIEW Source Type: research

Transgenic animal models to explore and modulate the blood brain and blood retinal barriers of the CNS
AbstractThe unique environment of the brain and retina is tightly regulated by blood –brain barrier and the blood-retinal barrier, respectively, to ensure proper neuronal function. Endothelial cells within these tissues possess distinct properties that allow for controlled passage of solutes and fluids. Pericytes, glia cells and neurons signal to endothelial cells (ECs) to form an d maintain the barriers and control blood flow, helping to create the neurovascular unit. This barrier is lost in a wide range of diseases affecting the central nervous system (CNS) and retina such as brain tumors, stroke, dementia, and in the ...
Source: Fluids and Barriers of the CNS - November 1, 2022 Category: Neuroscience Source Type: research

Characterization of Astrocytes in the Minocycline-Administered Mouse Photothrombotic Ischemic Stroke Model
In this study, we used a mouse photothrombotic ischemic stroke model to examine the characteristics of astrocytes after the administration of minocycline during ischemic stroke. Minocycline increased astrocyte reactivity and affected the localization of astrocytes in the penumbra region. Molecular characterization revealed that the induced expression of mRNA encoding the fatty acid binding protein 7 (FABP7) by photothrombosis was enhanced by the minocycline administration. Meanwhile, minocycline did not significantly affect the phenotype or class of astrocytes. The expression of Fabp7 mRNA was well correlated with that of ...
Source: Neurochemical Research - July 30, 2022 Category: Neuroscience Authors: Mari Kondo Haruka Okazaki Kei Nakayama Hirofumi Hohjoh Kimie Nakagawa Eri Segi-Nishida Hiroshi Hasegawa Source Type: research

Non-coding RNAs in the regulation of blood –brain barrier functions in central nervous system disorders
AbstractThe blood –brain barrier (BBB) is an essential component of the neurovascular unit that controls the exchanges of various biological substances between the blood and the brain. BBB damage is a common feature of different central nervous systems (CNS) disorders and plays a vital role in the pathogenesis of t he diseases. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNA (lncRNAs), and circular RNAs (circRNAs), are important regulatory RNA molecules that are involved in almost all cellular processes in normal development and various diseases, including CNS diseases. Cumulative evi dences hav...
Source: Fluids and Barriers of the CNS - March 26, 2022 Category: Neuroscience Source Type: research

Long non-coding RNA H19 promotes leukocyte inflammation in ischemic stroke by targeting the miR-29b/C1QTNF6 axis
CONCLUSIONS: Our findings confirm that H19 promotes leukocyte inflammation by targeting the miR-29b/C1QTNF6 axis in cerebral ischemic injury.PMID:35322553 | DOI:10.1111/cns.13829
Source: CNS Neuroscience and Therapeutics - March 24, 2022 Category: Neuroscience Authors: Guangwen Li Xiaoqing Ma Haiping Zhao Junfen Fan Tianwei Liu Yumin Luo Yunliang Guo Source Type: research

Ying Yang 1 engagement in brain pathology
AbstractHerein, we discuss data concerning the involvement of transcription factor Yin Yang 1 (YY1) in the development of brain diseases, highlighting mechanisms of its pathological actions. YY1 plays an important role in the developmental and adult pathology of the nervous system. YY1 is essential for neurulation as well as maintenance and differentiation of neuronal progenitor cells and oligodendrocytes regulating both neural and glial tissues of the brain. Lack of a YY1 gene causes many developmental abnormalities and anatomical malformations of the central nervous system (CNS). Once dysregulated, YY1 exerts multiple ne...
Source: Journal of Neurochemistry - February 24, 2022 Category: Neuroscience Authors: Sylwia Pabian ‐Jewuła, Aneta Bragiel‐Pieczonka, Marcin Rylski Tags: SYSTEMATIC REVIEW Source Type: research

Understanding Language Reorganization With Neuroimaging: How Language Adapts to Different Focal Lesions and Insights Into Clinical Applications
When the language-dominant hemisphere is damaged by a focal lesion, the brain may reorganize the language network through functional and structural changes known as adaptive plasticity. Adaptive plasticity is documented for triggers including ischemic, tumoral, and epileptic focal lesions, with effects in clinical practice. Many questions remain regarding language plasticity. Different lesions may induce different patterns of reorganization depending on pathologic features, location in the brain, and timing of onset. Neuroimaging provides insights into language plasticity due to its non-invasiveness, ability to image the w...
Source: Frontiers in Human Neuroscience - February 18, 2022 Category: Neuroscience Source Type: research