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Cancer: Colorectal Cancer
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Total 470 results found since Jan 2013.
PARP14 regulates EP4 receptor expression in human colon cancer HCA-7 cells
Biochem Biophys Res Commun. 2022 Jul 19;623:133-139. doi: 10.1016/j.bbrc.2022.07.055. Online ahead of print.ABSTRACTE type prostanoid 4 (EP4) receptors and their signaling pathways have been implicated in the development and malignant transformation of colorectal cancer. We herein demonstrated that the mono(ADP-ribosyl)ation of histone deacetylase (HDAC)1 and HDAC2 by poly(ADP-ribose) polymerase 14 (PARP14) may be required to induce the expression of EP4 receptors. The suppression of PARP14 activity by siRNA and/or its inhibitors reduced the mRNA expression of EP4 receptors. Thus, the expression of their proteins to approx...
Source: Biochemical and Biophysical Research communications - August 1, 2022 Category: Biochemistry Authors: Masato Mashimo Asuka Shimizu Aimi Mori Ayaka Hamaguchi Keijo Fukushima Naofumi Seira Takeshi Fujii Hiromichi Fujino Source Type: research
E-164 Recurrent strokes as the initial presentation of colorectal adenocarcinoma
ConclusionCryptogenic strokes in patients with cancer are cardioembolic manifestations of cancer-mediated hypercoagulability such as NBTE, which consists of sterile, platelet-fibrin vegetations on cardiac valves. The mechanism of thromboembolism in patients with cancer is based on the interaction between tumor cells and leukocytes, which creates a thrombogenic vascular lining and induces the release of substances that activate the coagulation cascade. The diagnosis of NBTE should depend on the distribution of occluded vessels, identification of thrombus, and exclusion of other possible causes such as infective endocarditis...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Babici, D., Phillip Johansen, P., Rodriguez-Hernandez, A., Sommerville, S., Snelling, B., Miller, T. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research
Variable Clinical Features in a Large Family With Diamond Blackfan Anemia Caused by a Pathogenic Missense Mutation in RPS19
Discussion: This large family with DBA demonstrates the heterogeneity of phenotypes that can be seen within the same genotype. Most family members presented with steroid-responsive anemia in infancy and subtle congenital malformations, findings consistent with recent genotype-phenotype studies of RPS DBA. However, two family members were relatively unaffected, underscoring the importance of further studies to assess modifier genes, and epigenetic and/or environmental factors which may result in normal erythropoiesis despite underlying ribosome dysfunction. This large, multigenerational family highlights the need for indivi...
Source: Frontiers in Genetics - July 18, 2022 Category: Genetics & Stem Cells Source Type: research
Omega-3 polyunsaturated fatty acid biomarkers and risk of type 2 diabetes, cardiovascular disease, cancer, and mortality
CONCLUSIONS: Higher concentrations of marine-derived omega-3 PUFA biomarkers were associated with a significantly reduced risk of total CVD, CHD, and total mortality. Levels of ALA were inversely associated with a lower risk of T2D but not CVD-related outcomes. These data support the dietary recommendations advocating the role of omega-3 PUFAs in maintaining an overall lower risk of developing cardiovascular disease and premature deaths.PMID:35830775 | DOI:10.1016/j.clnu.2022.06.034
Source: Clinical Colorectal Cancer - July 13, 2022 Category: Cancer & Oncology Authors: Hong Jiang Lina Wang Duolao Wang Ni Yan Chao Li Min Wu Fan Wang Baibing Mi Fangyao Chen Wanru Jia Xi Liu Jiaxin Lv Yan Liu Jing Lin Le Ma Source Type: research
Intelligent Algorithm-Based Echocardiography to Evaluate the Effect of Lung Protective Ventilation Strategy on Cardiac Function and Hemodynamics in Patients Undergoing Laparoscopic Surgery
Comput Math Methods Med. 2022 Jun 30;2022:9349027. doi: 10.1155/2022/9349027. eCollection 2022.ABSTRACTThe aim of this study was to analyze the effect of optimal pulmonary compliance titration of PEEP regimen on cardiac function and hemodynamics in patients undergoing laparoscopic surgery. 120 patients undergoing elective laparoscopic radical resection of colorectal cancer were included as the study subjects and randomly divided into the experimental group (n = 60) and the control group (n = 60). The control group had a fixed positive end-expiratory pressure (PEEP) = 5 cmH2O. The experimental group had transesophageal ultr...
Source: Computational and Mathematical Methods in Medicine - July 11, 2022 Category: Statistics Authors: Huijuan Wang Chao Gong Yi Zhang Yun Wang Xiaoli Wang Xiao Zhao Lianhua Chen Shitong Li Source Type: research
Cardiovascular Disease Risk Among Cancer Survivors: The Atherosclerosis Risk In Communities (ARIC) Study
CONCLUSIONS: Compared with persons without cancer, adult cancer survivors have significantly higher risk of CVD, especially HF, independent of traditional cardiovascular risk factors. There is an unmet need to define strategies for CVD prevention in this high-risk population.PMID:35772913 | DOI:10.1016/j.jacc.2022.04.042
Source: Atherosclerosis - June 30, 2022 Category: Cardiology Authors: Roberta Florido Natalie R Daya Chiadi E Ndumele Silvia Koton Stuart D Russell Anna Prizment Roger S Blumenthal Kunihiro Matsushita Yejin Mok Ashley S Felix Josef Coresh Corinne E Joshu Elizabeth A Platz Elizabeth Selvin Source Type: research
Health benefits of astaxanthin against age-related diseases of multiple organs: A comprehensive review
Crit Rev Food Sci Nutr. 2022 Jun 16:1-66. doi: 10.1080/10408398.2022.2084600. Online ahead of print.ABSTRACTAge-related diseases are associated with increased morbidity in the past few decades and the cost associated with the treatment of these age-related diseases exerts a substantial impact on social and health care expenditure. Anti-aging strategies aim to mitigate, delay and reverse aging-associated diseases, thereby improving quality of life and reducing the burden of age-related pathologies. The natural dietary antioxidant supplementation offers substantial pharmacological and therapeutic effects against various dise...
Source: Atherosclerosis - June 16, 2022 Category: Cardiology Authors: Phaniendra Alugoju V K D Krishna Swamy Naga Venkata Anusha Anthikapalli Tewin Tencomnao Source Type: research
Incorrect Data
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Source: JAMA - June 14, 2022 Category: General Medicine Source Type: research
Impact of Comorbidities on Lung Cancer Screening Evaluation
CONCLUSION: Patient and procedure-level factors may alter the benefits of lung cancer screening. Data concerning individual risk factors and high-risk complications should therefore be incorporated into diagnostic algorithms to optimize clinical benefit and minimize harm. Further study and validation of the risk factors identified herein are warranted.PMID:35641376 | DOI:10.1016/j.cllc.2022.03.012
Source: Clinical Prostate Cancer - May 31, 2022 Category: Cancer & Oncology Authors: Eric M Robinson Benjamin Y Liu Keith Sigel Chung Yin Juan Wisnivesky Minal S Kale Source Type: research
Individual Benefits and Risks of Intravaginal Estrogen and Systemic Testosterone in the Management of Women in the Menopause, With a Discussion of Any Associated Risks for Cancer Development
Cancer J. 2022 May-Jun 01;28(3):196-203. doi: 10.1097/PPO.0000000000000598.ABSTRACTSeveral formulations of intravaginal oestrogen are available for the treatment of genitourinary syndrome of menopause (GSM). These are safe and effective treatments for the symptoms of GSM. Licensed doses of intravaginal oestrogen do not elevate systemic estradiol levels above the normal postmenopausal range with long term use and there is no evidence of an increased risk of coronary heart disease, stroke, thromboembolism, colorectal cancer, endometrial cancer, breast cancer or breast cancer recurrence with their use. This should reassure bo...
Source: Cancer Journal - May 20, 2022 Category: Cancer & Oncology Authors: Abbie J Laing Louise Newson James A Simon Source Type: research
