E-164 Recurrent strokes as the initial presentation of colorectal adenocarcinoma

ConclusionCryptogenic strokes in patients with cancer are cardioembolic manifestations of cancer-mediated hypercoagulability such as NBTE, which consists of sterile, platelet-fibrin vegetations on cardiac valves. The mechanism of thromboembolism in patients with cancer is based on the interaction between tumor cells and leukocytes, which creates a thrombogenic vascular lining and induces the release of substances that activate the coagulation cascade. The diagnosis of NBTE should depend on the distribution of occluded vessels, identification of thrombus, and exclusion of other possible causes such as infective endocarditis. Echocardiography is critical to diagnosing NBTE. Treatment of NBTE is poorly defined but should be directed at preventing systemic embolization and managing underlying malignancy, with long-term anticoagulation recommended by the American College of Chest Physicians. Unfractionated heparin is currently recommended to reduce rates of ischemic stroke in patients with cancer.>Disclosures D. Babici: None. P. Phillip Johansen: None. A. Rodriguez-Hernandez: None. S. Sommerville: None. B. Snelling: None. T. D. Miller: None.
Source: Journal of NeuroInterventional Surgery - Category: Neurosurgery Authors: Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research