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Total 1414 results found since Jan 2013.

SARS-CoV-2 infection increases risk of intracranial hemorrhage
We examined 21 patients suffering from stroke and intracranial hemorrhage (ICH) and 9 (43%) of them were male. We compared relative frequencies using Fisher’s exact test. As we had few observations and many variables, we used principal component analysis (PCA) to reduce data dimensionality. We trained a linear support vector machine (SVM) on the first two PCs of the laboratory data to predict COVID-19.ResultsPatients suffering from stroke had either hypertension or SARS-CoV-2 infection, but seldom both (OR = 0.05, p = 0.0075). The presence of SARS-CoV-2 infection was strongly associated with the logarithm of CRP (p = 1.4...
Source: Frontiers in Human Neuroscience - November 24, 2022 Category: Neuroscience Source Type: research

Repeated cardiopulmonary performance measurements in young competitive handball players with and without SARS-CoV-2 infection
ConclusionsThe physical performance of young athletes infected with SARS-CoV-2 was impaired. This decreased performance is probably due to cardiac and/or peripheral deconditioning. Studies with larger cohorts are needed to make more profound conclusions.
Source: BMC Sports Science, Medicine and Rehabilitation - November 23, 2022 Category: Sports Medicine Source Type: research

Incidence of acute symptomatic seizures  in patients with covid-19: a single-center study
Acta Clin Croat. 2021 Dec;60(Suppl 3):50-56. doi: 10.20471/acc.2021.60.s3.07.ABSTRACTThe most common neurological symptoms in patients with SARS-CoV-2 infection are headache, myalgia, encephalopathy, dizziness, dysgeusia and anosmia, making more than 90 percent of neurological manifestations of COVID-19. Other neurological manifestations such as stroke, movement disorder symptoms or epileptic seizures are rare but rather devastating, with possible lethal outcome. The primary aim of this study was to estimate the prevalence of acute symptomatic seizures among COVID-19 patients, while secondary aim was to determine their pos...
Source: Acta Clinica Croatica - November 21, 2022 Category: General Medicine Authors: Ivana Šušak Sporiš Davor Spori š Zrinka Čolak Romić Petra Bago Ro žanković Silvio Ba šić Source Type: research

Molecules, Vol. 27, Pages 8094: Neuropeptides, New Ligands of SARS-CoV-2 Nucleoprotein, a Potential Link between Replication, Inflammation and Neurotransmission
Slama Schwok This work identifies new ligands of the nucleoprotein N of SARS-CoV-2 by in silico screening, which used a new model of N, built from an Alphafold model refined by molecular dynamic simulations. The ligands were neuropeptides, such as substance P (1-7) and enkephalin, bound at a large site of the C-terminal or associated with the N-terminal &beta;&minus;sheet. The BA4 and BA5 Omicron variants of N also exhibited a large site as in wt N, and an increased flexibility of the BA5 variant, enabling substance P binding. The binding sites of some ligands deduced from modeling in wt N were assessed...
Source: Molecules - November 21, 2022 Category: Chemistry Authors: Julien Henri Laetitia Minder Kevin Mohanasundaram S ébastien Dilly Anne Goupil-Lamy Carmelo Di Primo Anny Slama Schwok Tags: Article Source Type: research

SARS-CoV-2 Infection and Increased Risk for Pediatric Stroke
There is an increased risk of stroke in adults with severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019 [COVID-19]) infection, but whether there is a similar association with stroke in children is unclear. Our objective was to determine whether there is a correlation between COVID-19 infection, multisystem inflammatory syndrome in children (MIS-C), and pediatric ischemic stroke.
Source: Pediatric Neurology - November 19, 2022 Category: Neurology Authors: MaryGlen J. Vielleux, Shanna Swartwood, Dan Nguyen, Karen E. James, Bree Barbeau, Joshua L. Bonkowsky Tags: Research Paper Source Type: research

A case report: Upper limb recovery from stroke related to SARS-CoV-2 infection during an intervention with a brain-computer interface
COVID-19 may increase the risk of acute ischemic stroke that can cause a loss of upper limb function, even in patients with low risk factors. However, only individual cases have been reported assessing different degrees of hospitalization outcomes. Therefore, outpatient recovery profiles during rehabilitation interventions are needed to better understand neuroplasticity mechanisms required for upper limb motor recovery. Here, we report the progression of physiological and clinical outcomes during upper limb rehabilitation of a 41-year-old patient, without any stroke risk factors, which presented a stroke on the same day as...
Source: Frontiers in Neurology - November 18, 2022 Category: Neurology Source Type: research

Glutathione: A Samsonian life-sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation
Front Nutr. 2022 Nov 1;9:1007816. doi: 10.3389/fnut.2022.1007816. eCollection 2022.ABSTRACTMany local and systemic diseases especially diseases that are leading causes of death globally like chronic obstructive pulmonary disease, atherosclerosis with ischemic heart disease and stroke, cancer and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 19 (COVID-19), involve both, (1) oxidative stress with excessive production of reactive oxygen species (ROS) that lower glutathione (GSH) levels, and (2) inflammation. The GSH tripeptide (γ- L-glutamyl-L-cysteinyl-glycine), the most abundant w...
Source: Atherosclerosis - November 17, 2022 Category: Cardiology Authors: Carlos A Labarrere Ghassan S Kassab Source Type: research

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