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Inhibition of heat shock protein 47 suppressed collagen production in Tenon's capsule fibroblasts
CONCLUSIONS: HSP47 siRNA inhibits the production of COLI in rat Tenon's fibroblasts, and may be the potential therapeutic method in bleb scarring after glaucoma filtration surgery.PMID:37724035 | DOI:10.5603/fhc.96514
Source: Folia Histochemica et Cytobiologica - September 19, 2023 Category: Cytology Authors: Weiwei Wang Haiyan lI Source Type: research
CSNK1A1/CK1 α suppresses autoimmunity by restraining the CGAS-STING1 signaling
Autophagy. 2023 Sep 18:1-18. doi: 10.1080/15548627.2023.2256135. Online ahead of print.ABSTRACTSTING1 (stimulator of interferon response cGAMP interactor 1) is the quintessential protein in the CGAS-STING1 signaling pathway, crucial for the induction of type I IFN (interferon) production and eliciting innate immunity. Nevertheless, the overactivation or sustained activation of STING1 has been closely associated with the onset of autoimmune disorders. Notably, the majority of these disorders manifest as an upregulated expression of type I interferons and IFN-stimulated genes (ISGs). Hence, strict regulation of STING1 activi...
Source: Autophagy - September 19, 2023 Category: Cytology Authors: Mingyu Pan Tongyu Hu Jiao Lyu Yue Yin Jing Sun Quanyi Wang Lingxiao Xu Haiyang Hu Chen Wang Source Type: research
High-Fat Ketogenic Diets and Ketone Monoester Supplements Differentially Affect Substrate Metabolism during Aerobic Exercise
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00359.2023. Online ahead of print.ABSTRACTChronically adhering to high-fat ketogenic diets or consuming ketone monoester supplements elicits ketosis. Resulting changes in substrate metabolism appear to be drastically different between ketogenic diets and ketone supplements. Consuming a ketogenic diet increases fatty acid oxidation with concomitant decreases in endogenous carbohydrate oxidation. Increased fat oxidation eventually results in an accumulation of circulating ketone bodies, which are metabolites of fatty acids that serve as an alternative source of fue...
Source: American Journal of Physiology. Cell Physiology - September 18, 2023 Category: Cytology Authors: Lee M Margolis Stefan M Pasiakos Emily E Howard Source Type: research
Signaling Circuits and the Apical Extracellular Matrix In Aging: Connections Identified in the Nematode < em > Caenorhabditis elegans < /em >
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00195.2023. Online ahead of print.ABSTRACTNumerous conserved signaling pathways play critical roles in aging, including insulin, TGF-β, Wnt, and autophagy pathways. Some of these pathways also play prominent roles in the formation and maintenance of the extracellular matrix. The nematode Caenorhabditis elegans has been an enduringly productive system for the identification of conserved mechanisms of biological aging. Recent studies in C. elegans highlight the regulatory circuits between conserved signaling pathways and the extracellular matrix, revealing a bidir...
Source: American Journal of Physiology. Cell Physiology - September 18, 2023 Category: Cytology Authors: Hannah Reich Cathy Savage-Dunn Source Type: research
Interleukin-6 and Epidermal Growth Factor as non-invasive biomarkers of progression in chronic glomerulonephritis
The objective of this study was to determine whether the urinary excretion of interleukin-6 (IL-6), transforming growth factor β1 (TGFβ1), monocytes chemoattractant protein (MCP-1), soluble tumor necrosis factor receptor 1 (sTNFR1) and epidermal growth factor (EGF) in patients with newly recognized CGN can serve as prognostic biomarkers in patients with newly recognized CGN and whether they can be effective in predicting a progressive reduction of renal function in prospective observation. The study included 150 Caucasian patients. UIL-6, UTGFβ1, UMCP-1 and UsTNFR1 and UEGF were measured using ELISA methods (Quantikine ...
Source: American Journal of Physiology. Cell Physiology - September 18, 2023 Category: Cytology Authors: Ilona Idasiak-Piechocka Mi łosz Miedziaszczyk Aldona Wo źniak El żbieta Pawliczak El żbieta Kaczmarek Andrzej Oko Source Type: research
CRISPR/Cas9-mediated deletion of adipocyte genes associated with NAFLD alters adipocyte lipid handling and reduces steatosis in hepatocytes < em > in vitro < /em >
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00291.2023. Online ahead of print.ABSTRACTObesity is a major risk factor for the development of non-alcoholic fatty liver disease (NAFLD) and the subcutaneous white adipose tissue (scWAT) is the primary lipid storage depot and regulates lipid fluxes to other organs. Our previous work identified genes up-regulated in scWAT of patients with NAFLD: SOCS3, DUSP1, and SIK1. Herein, we knocked down (KD) their expression in human adipose-derived mesenchymal stem cells (hADMSCs) using CRISPR/Cas9 technology and characterized their phenotype. We found that SOCS3, DUSP1, a...
Source: American Journal of Physiology. Cell Physiology - September 18, 2023 Category: Cytology Authors: Marta Lopez-Yus Scott Frendo-Cumbo Raquel Del Moral-Bergos Maria Pilar Garcia-Sobreviela Vanesa Bernal-Monterde Mikael Ryd én Silvia Lorente-Cebrian Jose M Arbones-Mainar Source Type: research
Regulation of mitochondrial calcium uniporter expression and calcium-dependent cell signalling by lncRNA < em > Tug1 < /em > in cardiomyocytes
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00339.2023. Online ahead of print.ABSTRACTCardiomyocyte calcium homeostasis is a tightly regulated process. The mitochondrial calcium uniporter (MCU) complex can buffer elevated cytosolic Ca2+ levels and consists of pore-forming proteins including MCU, and various regulatory proteins such as mitochondrial calcium uptake proteins 1 and 2 (MICU1/2). The stoichiometry of these proteins influences the sensitivity to Ca2+ and activity of the complex. However, the factors that regulate their gene expression remain incompletely understood. Long non-coding RNAs (lncRNAs)...
Source: American Journal of Physiology. Cell Physiology - September 18, 2023 Category: Cytology Authors: Adam J Trewin Kate L Weeks Glenn D Wadley S éverine Lamon Source Type: research
Tert-Butyl Hydroperoxide induces Ferroptosis of Bone Mesenchymal Stem cells by repressing the Prominin2/BACH1/ROS axis
CONCLUSION: Our findings revealed a mechanism that the prominin2/BACH1/ROS axis participates in BMSCs ferroptosis and the strengthening of this axis is promising to subsist BMSCs after explantation.PMID:37721001 | DOI:10.1152/ajpcell.00224.2023
Source: American Journal of Physiology. Cell Physiology - September 18, 2023 Category: Cytology Authors: Yuzhu Xu Pan Fan Xuanfei Xu Lei Liu Lele Zhang Xi Li Jiadong Wang Yuao Tao Xiaolong Li Dandan Xu Xiaohui Wang Yan Zhou Yuntao Wang Source Type: research
High-Fat Ketogenic Diets and Ketone Monoester Supplements Differentially Affect Substrate Metabolism during Aerobic Exercise
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00359.2023. Online ahead of print.ABSTRACTChronically adhering to high-fat ketogenic diets or consuming ketone monoester supplements elicits ketosis. Resulting changes in substrate metabolism appear to be drastically different between ketogenic diets and ketone supplements. Consuming a ketogenic diet increases fatty acid oxidation with concomitant decreases in endogenous carbohydrate oxidation. Increased fat oxidation eventually results in an accumulation of circulating ketone bodies, which are metabolites of fatty acids that serve as an alternative source of fue...
Source: Am J Physiol Cell Ph... - September 18, 2023 Category: Cytology Authors: Lee M Margolis Stefan M Pasiakos Emily E Howard Source Type: research
Signaling Circuits and the Apical Extracellular Matrix In Aging: Connections Identified in the Nematode < em > Caenorhabditis elegans < /em >
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00195.2023. Online ahead of print.ABSTRACTNumerous conserved signaling pathways play critical roles in aging, including insulin, TGF-β, Wnt, and autophagy pathways. Some of these pathways also play prominent roles in the formation and maintenance of the extracellular matrix. The nematode Caenorhabditis elegans has been an enduringly productive system for the identification of conserved mechanisms of biological aging. Recent studies in C. elegans highlight the regulatory circuits between conserved signaling pathways and the extracellular matrix, revealing a bidir...
Source: Am J Physiol Cell Ph... - September 18, 2023 Category: Cytology Authors: Hannah Reich Cathy Savage-Dunn Source Type: research
Interleukin-6 and Epidermal Growth Factor as non-invasive biomarkers of progression in chronic glomerulonephritis
The objective of this study was to determine whether the urinary excretion of interleukin-6 (IL-6), transforming growth factor β1 (TGFβ1), monocytes chemoattractant protein (MCP-1), soluble tumor necrosis factor receptor 1 (sTNFR1) and epidermal growth factor (EGF) in patients with newly recognized CGN can serve as prognostic biomarkers in patients with newly recognized CGN and whether they can be effective in predicting a progressive reduction of renal function in prospective observation. The study included 150 Caucasian patients. UIL-6, UTGFβ1, UMCP-1 and UsTNFR1 and UEGF were measured using ELISA methods (Quantikine ...
Source: Am J Physiol Cell Ph... - September 18, 2023 Category: Cytology Authors: Ilona Idasiak-Piechocka Mi łosz Miedziaszczyk Aldona Wo źniak El żbieta Pawliczak El żbieta Kaczmarek Andrzej Oko Source Type: research
CRISPR/Cas9-mediated deletion of adipocyte genes associated with NAFLD alters adipocyte lipid handling and reduces steatosis in hepatocytes < em > in vitro < /em >
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00291.2023. Online ahead of print.ABSTRACTObesity is a major risk factor for the development of non-alcoholic fatty liver disease (NAFLD) and the subcutaneous white adipose tissue (scWAT) is the primary lipid storage depot and regulates lipid fluxes to other organs. Our previous work identified genes up-regulated in scWAT of patients with NAFLD: SOCS3, DUSP1, and SIK1. Herein, we knocked down (KD) their expression in human adipose-derived mesenchymal stem cells (hADMSCs) using CRISPR/Cas9 technology and characterized their phenotype. We found that SOCS3, DUSP1, a...
Source: Am J Physiol Cell Ph... - September 18, 2023 Category: Cytology Authors: Marta Lopez-Yus Scott Frendo-Cumbo Raquel Del Moral-Bergos Maria Pilar Garcia-Sobreviela Vanesa Bernal-Monterde Mikael Ryd én Silvia Lorente-Cebrian Jose M Arbones-Mainar Source Type: research
Regulation of mitochondrial calcium uniporter expression and calcium-dependent cell signalling by lncRNA < em > Tug1 < /em > in cardiomyocytes
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00339.2023. Online ahead of print.ABSTRACTCardiomyocyte calcium homeostasis is a tightly regulated process. The mitochondrial calcium uniporter (MCU) complex can buffer elevated cytosolic Ca2+ levels and consists of pore-forming proteins including MCU, and various regulatory proteins such as mitochondrial calcium uptake proteins 1 and 2 (MICU1/2). The stoichiometry of these proteins influences the sensitivity to Ca2+ and activity of the complex. However, the factors that regulate their gene expression remain incompletely understood. Long non-coding RNAs (lncRNAs)...
Source: Am J Physiol Cell Ph... - September 18, 2023 Category: Cytology Authors: Adam J Trewin Kate L Weeks Glenn D Wadley S éverine Lamon Source Type: research
Tert-Butyl Hydroperoxide induces Ferroptosis of Bone Mesenchymal Stem cells by repressing the Prominin2/BACH1/ROS axis
CONCLUSION: Our findings revealed a mechanism that the prominin2/BACH1/ROS axis participates in BMSCs ferroptosis and the strengthening of this axis is promising to subsist BMSCs after explantation.PMID:37721001 | DOI:10.1152/ajpcell.00224.2023
Source: Am J Physiol Cell Ph... - September 18, 2023 Category: Cytology Authors: Yuzhu Xu Pan Fan Xuanfei Xu Lei Liu Lele Zhang Xi Li Jiadong Wang Yuao Tao Xiaolong Li Dandan Xu Xiaohui Wang Yan Zhou Yuntao Wang Source Type: research
ATP promotes resident CD34 < sup > + < /sup > cell migration mainly through P2Y2-Stim1-ERK/p38 pathway
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00048.2023. Online ahead of print.ABSTRACTExtracellular adenosine triphosphate (ATP) is one of the most abundant biochemical constitutes within the stem cell microenvironment and is postulated to play critical roles in cell migration. However, it is unclear whether ATP regulates the cell migration of CD34+ vascular wall-resident stem/progenitor cells (VW-SCs) and participates in angiogenesis. Therefore, the biological mechanisms of cell migration mediated by ATP was determined by in vivo subcutaneous matrigel plug assay, ex vivo aortic ring assay, in vitro transw...
Source: Am J Physiol Cell Ph... - September 18, 2023 Category: Cytology Authors: Ying Ma Chuting Han Cheng Xie Qingya Dang Liju Yang Yuan Li Min Zhang Jun Cheng Yan Yang Qingbo Xu Pengyun Li Source Type: research
