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Protein quality control: from molecular mechanisms to therapeutic intervention-EMBO workshop, May 21-26 2023, Srebreno, Croatia
This report summarizes the workshop and highlights selected presentations.PMID:37731161 | DOI:10.1007/s12192-023-01383-4
Source: Cell Stress and Chaperones - September 21, 2023 Category: Cytology Authors: Christian M ünch Janine Kirstein Source Type: research
Unveiling the anti-cancer mechanisms of calotropin: Insights into cell growth inhibition, cell cycle arrest, and metabolic regulation in human oral squamous carcinoma cells (HSC-3)
CONCLUSION: Overall, our findings shed an experimental evidence on how calotropin inhibits the HSC-3 oral squamous cancer cell growth, highlighting the drug's potential as a treatment for oral cancer. Further, investigation on in-vivo experiment is warranted to explore its potential mechanism of action and to develop a novel drug towards clinical trial.PMID:37731845 | PMC:PMC10507650 | DOI:10.1016/j.jobcr.2023.09.002
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Selvaraj Jayaraman Sathan Raj Natarajan Vishnu Priya Veeraraghavan Sharmila Jasmine Source Type: research
Kinesin Superfamily Member 18B (KIF18B) Promotes Cell Proliferation in Colon Adenocarcinoma Retraction
Cancer Manag Res. 2023 Sep 15;15:1011-1012. doi: 10.2147/CMAR.S440061. eCollection 2023.ABSTRACT[This retracts the article DOI: 10.2147/CMAR.S261894.].PMID:37731840 | PMC:PMC10508229 | DOI:10.2147/CMAR.S440061
Source: Cell Research - September 21, 2023 Category: Cytology Source Type: research
Recent developments in membrane targeting antifungal agents to mitigate antifungal resistance
RSC Med Chem. 2023 Jun 26;14(9):1603-1628. doi: 10.1039/d3md00151b. eCollection 2023 Sep 19.ABSTRACTFungal infections cause severe and life-threatening complications especially in immunocompromised individuals. Antifungals targeting cellular machinery and cell membranes including azoles are used in clinical practice to manage topical to systemic fungal infections. However, continuous exposure to clinically used antifungal agents in managing the fungal infections results in the development of multi-drug resistance via adapting different kinds of intrinsic and extrinsic mechanisms. The unique chemical composition of fungal m...
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Devashish Mehta Varsha Saini Avinash Bajaj Source Type: research
Subtype of SCLC Is an Intrinsic and Persistent Feature Through Systemic Treatment
CONCLUSIONS: Subtype of SCLC generally remains the same after acquiring chemotherapy resistance. Plasticity was observed with rare cases switching from NEUROD1-predominant to ASC1-predominant SCLC. Resubtyping is unnecessary for the consideration of novel subtype-specific targeted agents, except cases with NEUROD1-predominant subtype.PMID:37731627 | PMC:PMC10507151 | DOI:10.1016/j.jtocrr.2023.100561
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Ying-Chun Lo Joel Rivera-Concepcion George Vasmatzis Marie-Christine Aubry Konstantinos Leventakos Source Type: research
Biogeographical Impacts of Dental, Oral, and Craniofacial Microbial Reservoirs
J Dent Res. 2023 Sep 20:220345231191115. doi: 10.1177/00220345231191115. Online ahead of print.ABSTRACTThe human mouth, or oral cavity, is at the crossroads of our external and internal environments, and it is increasingly evident that local colonization of dental, oral, and craniofacial (DOC) tissues and cells by bacteria and viruses may also have systemic effects across myriad diseases and disorders. Better understanding of this phenomenon will require a holistic understanding of host-microbial interactions in both spatiotemporal and biogeographical contexts while also considering person-, organ-, tissue-, cell-, and mol...
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Q T Easter B Fernandes Matuck B M Warner K M Byrd Source Type: research
The protective effect of apigenin against inorganic arsenic salt-induced toxicity in PC12 cells
In conclusion, the obtained results of the present study have clinical significance and indicate that apigenin is a promising candidate for shielding the nervous system from toxic effects caused by arsenic. These findings require further investigation using in vivo experimental models.PMID:37730986 | DOI:10.1007/s11356-023-29884-w
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Rafa Almeer Nouf M Alyami Source Type: research
Learning human liver biology in humanized mice
Cell Res. 2023 Sep 20. doi: 10.1038/s41422-023-00877-1. Online ahead of print.NO ABSTRACTPMID:37730939 | DOI:10.1038/s41422-023-00877-1
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Brandon M Lehrich Satdarshan P Monga Source Type: research
LICOB: a powerful organoid platform for drug discovery
Cell Res. 2023 Sep 20. doi: 10.1038/s41422-023-00878-0. Online ahead of print.NO ABSTRACTPMID:37730938 | DOI:10.1038/s41422-023-00878-0
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Haojie Jin Zhen Sun Ren é Bernards Source Type: research
AZI2 mediates TBK1 activation at unresolved selective autophagy cargo receptor complexes with implications for CD8 T-cell infiltration in breast cancer
Autophagy. 2023 Sep 21. doi: 10.1080/15548627.2023.2259775. Online ahead of print.ABSTRACTMost breast cancers do not respond to immune checkpoint inhibitors and there is an urgent need to identify novel sensitization strategies. Herein, we uncovered that activation of the TBK-IFN pathway that is mediated by the TBK1 adapter protein AZI2 is a potent strategy for this purpose. Our initial observations showed that RB1CC1 depletion leads to accumulation of AZI2, in puncta along with selective macroautophagy/autophagy cargo receptors, which are both required for TBK1 activation. Specifically, disrupting the selective autophagy ...
Source: Autophagy - September 21, 2023 Category: Cytology Authors: Syn Kok Yeo Michael Haas Kanakaraju Manupati Mingang Hao Fuchun Yang Song Chen Jun-Lin Guan Source Type: research
Artesunate Sensitizes Human hepatocellular carcinoma to sorafenib via exacerbating AFAP1L2-SRC-FUNDC1 axis-dependent mitophagy
In conclusion, artesunate may be a promising strategy to mitigate sorafenib resistance in HCC via exacerbating AFAP1L2-SRC-FUNDC1 axis-dependent mitophagy.PMID:37733919 | DOI:10.1080/15548627.2023.2261758
Source: Autophagy - September 21, 2023 Category: Cytology Authors: Zhaochen Ma Wenjia Chen Yudong Liu Lingxiang Yu Xia Mao Xiaodong Guo Funeng Jiang Qiuyan Guo Na Lin Yanqiong Zhang Source Type: research
ER stress elicits non-canonical CASP8 (caspase 8) activation on autophagosomal membranes to induce apoptosis
Autophagy. 2023 Sep 21. doi: 10.1080/15548627.2023.2258701. Online ahead of print.ABSTRACTThe VPS37A gene encodes a subunit of the endosomal sorting complex required for transport (ESCRT)-I complex that is frequently lost in a wide variety of human solid cancers. We have previously demonstrated the role of VPS37A in directing the ESCRT membrane scission machinery to seal the phagophore for autophagosome completion. Here, we report that VPS37A-deficient cells exhibit an accumulation of the apoptotic initiator CASP8 (caspase 8) on the phagophore and are primed to undergo rapid apoptosis through the intracellular death-induci...
Source: Autophagy - September 21, 2023 Category: Cytology Authors: Tatsuya Hattori Kevin A Fundora Kouta Hamamoto David M Opozda Xinwen Liang Xiaoming Liu Jiawen Zhang Yasin Uzun Yoshinori Takahashi Hong-Gang Wang Source Type: research
Inhibition of PRKAA/AMPK (Ser485/491) phosphorylation by crizotinib induces cardiotoxicity via perturbing autophagosome-lysosome fusion
Autophagy. 2023 Sep 21. doi: 10.1080/15548627.2023.2259216. Online ahead of print.ABSTRACTCrizotinib, a small-molecule tyrosine kinase inhibitor targeting ALK, MET and ROS1, is the first-line drug for ALK-positive metastatic non-small cell lung cancer and is associated with severe, sometimes fatal, cases of cardiac failure, which increases the risk of mortality. However, the underlying mechanism remains unclear, which causes the lack of therapeutic strategy. We established in vitro and in vivo models for crizotinib-induced cardiotoxicity and found that crizotinib caused left ventricular dysfunction, myocardial injury and p...
Source: Autophagy - September 21, 2023 Category: Cytology Authors: Zhifei Xu Zezheng Pan Ying Jin Zizheng Gao Feng Jiang Huangxi Fu Xueqin Chen Xiaochen Zhang Hao Yan Xiaochun Yang Bo Yang Qiaojun He Peihua Luo Source Type: research
Ksp1 is an autophagic receptor protein for the Snx4-assisted autophagy of Ssn2/Med13
Autophagy. 2023 Sep 21. doi: 10.1080/15548627.2023.2259708. Online ahead of print.ABSTRACTKsp1 is a casein II-like kinase whose activity prevents aberrant macroautophagy/autophagy induction in nutrient-rich conditions in yeast. Here, we describe a kinase-independent role of Ksp1 as a novel autophagic receptor protein for Ssn2/Med13, a known cargo of Snx4-assisted autophagy of transcription factors. In this pathway, a subset of conserved transcriptional regulators, Ssn2/Med13, Rim15, and Msn2, are selectively targeted for vacuolar proteolysis following nitrogen starvation, assisted by the sorting nexin heterodimer Snx4-Atg2...
Source: Autophagy - September 21, 2023 Category: Cytology Authors: Sara E Hanley Stephen D Willis Steven J Doyle Randy Strich Katrina F Cooper Source Type: research
Protein quality control: from molecular mechanisms to therapeutic intervention-EMBO workshop, May 21-26 2023, Srebreno, Croatia
This report summarizes the workshop and highlights selected presentations.PMID:37731161 | DOI:10.1007/s12192-023-01383-4
Source: Cell Stress and Chaperones - September 21, 2023 Category: Cytology Authors: Christian M ünch Janine Kirstein Source Type: research
