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Total 80202 results found since Jan 2013.

Regulatory T  cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration
Cell Metab. 2023 Sep 15:S1550-4131(23)00331-5. doi: 10.1016/j.cmet.2023.08.010. Online ahead of print.ABSTRACTMuscle-residing regulatory T cells (Tregs) control local tissue integrity and function. However, the molecular interface connecting Treg-based regulation with muscle function and regeneration remains largely unexplored. Here, we show that exercise fosters a stable induction of highly functional muscle-residing Tregs with increased expression of amphiregulin (Areg), EGFR, and ST2. Mechanistically, we find that mice lacking IL6Rα on T cells (TKO) harbor significant reductions in muscle Treg functionality and satelli...
Source: Cell Metabolism - September 21, 2023 Category: Cytology Authors: Maike Becker Sini S Joseph Francisco Garcia-Carrizo Robby Z Tom Daria Opaleva Isabelle Serr Matthias H Tsch öp Tim J Schulz Susanna M Hofmann Carolin Daniel Source Type: research

Development of a high-performance label-free electrochemical immunosensor for early cancer diagnosis using anti-CEA/Ag-MOF/GO/GCE nanocomposite
Environ Res. 2023 Sep 19:117178. doi: 10.1016/j.envres.2023.117178. Online ahead of print.ABSTRACTIn order to detect carcinoembryonic antigen (CEA) as a tumor marker in lung cancer for early cancer diagnosis, this study aimed to develop a label-free electrochemical immunosensor based on the immobilization of an Anti-CEA antibody on a metal-organic framework (MOF)-graphene oxide nanocomposite modified glassy carbon electrode (Anti-CEA/Ag-MOF/GO/GCE). Ag-MOF/GO nanocomposite was prepared on the GCE surface using the ultrasonic irradiation method, and Anti-CEA antibody was subsequently immobilized on the surface. Analysis of ...
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Peng Huang Lingzhang Meng Jun Pang Haiting Huang Jing Ma Linlin He Parnian Amani Source Type: research

Alzheimer's disease: The role of T lymphocytes in neuroinflammation and neurodegeneration
Brain Res. 2023 Sep 19:148589. doi: 10.1016/j.brainres.2023.148589. Online ahead of print.ABSTRACTAlzheimer's disease, the leading cause of progressive cognitive decline globally, has been reported to be enhanced by neuroinflammation. Brain-resident innate immune cells and adaptive immune cells work together to produce neuroinflammation. Studies over the past decade have established the neuroimmune axis present in Alzheimer's disease; the crosstalk between adaptive and innate immune cells within and outside the brain is crucial to the onset and progression of Alzheimer's disease. Although the role of the adaptive immune sy...
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Moses O Asamu Oladapo O Oladipo Oluseun A Abayomi Afeez A Adebayo Source Type: research

Brown adipocyte mineralocorticoid receptor deficiency impairs metabolic regulation in diet-induced obese mice
J Lipid Res. 2023 Sep 19:100449. doi: 10.1016/j.jlr.2023.100449. Online ahead of print.ABSTRACTActivation of brown adipose tissue (BAT) contributes to energy dissipation and metabolic health. Although mineralocorticoid receptor (MR) antagonists have been demonstrated to improve metabolism under obesity, the underlying mechanisms remain incompletely understood. We aimed to evaluate the role of BAT MR in metabolic regulation. After 8 weeks of high fat diet (HFD) feeding, BAT MR knockout (BMRKO) mice manifested significantly increased body weight, fat mass, serum fasting glucose and impaired glucose homeostasis compared to li...
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Chu-Mao Chen Xiao-Qian Meng Hong Zhu Ting Liu Yuan Liu Lu-Jun Zhou Guo-Dong Zhu Xiao-Bei Chen Xu-Guang Guo Sheng-Zhong Duan Source Type: research

Identification of γ-Fagarine as a novel antiviral agent against respiratory virus (hMPV) infection
In this study, we aim to investigate the effect of γ-Fagarine on hMPV infection and explore its underlying molecular mechanisms. Vero-E6 and 16HBE cells were used as cell models. Virus replication and microcosm character were explored in Vero-E6 cells. Then, the antiviral activities were investigated by quantitative real-time PCR (RT-qPCR), western blotting (WB), and indirect immunofluorescence assays (IFAs) in Vero-E6 and 16HBE. Potential mechanisms of γ-Fagarine related to HSPG and lysosome pH were assessed in 16HBE cells. Lastly, a virus-infected mouse model was established and antiviral assay in vivo was conducted. Î...
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Jinhua Li Yao Zhao Ying Dai Junning Zhao Source Type: research

Physical activity compensates for isoflurane-induced selective impairment of neuronal progenitor cell proliferation in the young adult hippocampus
In conclusion, isoflurane selectively impairs neuronal proliferation but not survival or neurogenesis-linked cognition in adult mice. The observed adverse effects can be attenuated by physical activity, a cost-effective means of preventing the neurogenic consequences of general anesthesia.PMID:37734489 | DOI:10.1016/j.bbr.2023.114675
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Saskia B öckmann Deetje Iggena Stefanie Schreyer Andr é Rex Barbara Steiner Source Type: research

Number of kinesins engaged in axonal cargo transport: A novel biomarker for neurological disorders
Neurosci Res. 2023 Sep 19:S0168-0102(23)00169-4. doi: 10.1016/j.neures.2023.09.004. Online ahead of print.ABSTRACTKinesin motor proteins play crucial roles in anterograde transport of cargo vesicles in neurons, moving them along axons from the cell body towards the synaptic region. Not only the transport force and velocity of single motor protein, but also the number of kinesin molecules involved in transporting a specific cargo, is pivotal for synapse formation. This collective transport by multiple kinesins ensures stable and efficient cargo transport in neurons. Abnormal increases or decreases in the number of engaged k...
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Kumiko Hayashi Kazuo Sasaki Source Type: research

Generation of two induced pluripotent stem cell lines from patients with Down syndrome
Stem Cell Res. 2023 Sep 14;72:103204. doi: 10.1016/j.scr.2023.103204. Online ahead of print.ABSTRACTDown syndrome (DS) is caused by trisomy of Homo sapiens chromosome 21 (HSA21) and is by far the most common chromosomal disorder accompanied by neurodevelopmental disorders and congenital heart disease. Here, we generated two induced pluripotent stem cell (iPSC) lines from two patients with DS. These two lines exhibited normal morphology, trisomy 21 karyotype, pluripotency and differentiation capability into derivatives of three germ layers. The patient-specific iPSC lines arean invaluable resource in research to model DS-re...
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Wenjuan Zhu Wenqiang Liu Rebecca Yu Melanie Manning Anitra Waran Romfh Joseph C Wu Source Type: research

Generation of an induced pluripotent stem cell line (ITXi012-A) from a patient with genetically determined high-lipoprotein(a) plasma levels
Stem Cell Res. 2023 Sep 15;72:103205. doi: 10.1016/j.scr.2023.103205. Online ahead of print.ABSTRACTElevated circulating lipoprotein(a) (Lp(a)) is a genetically determined risk factor for coronary artery disease and aortic valve stenosis (Tsimikas, 2017). Importantly, the LPA gene, which encodes the apolipoprotein(a) (protein-component of Lp(a)), is missing in most species, and human liver cell-lines do not secrete Lp(a). There is a need for the development of human in vitro models suitable for investigating biological mechanisms involved in Lp(a) metabolism. We here generated and characterized iPSCs from a patient with ex...
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Amandine Caillaud Lise Bray Aurore Girardeau Zo é Begué-Racapé Lucie Vince Murielle Patitucci C édric Le May Gilles Lambert Bertrand Cariou Antoine Rimbert Source Type: research

IL18R1-Related Molecules as Biomarkers for Asthma Severity and Prognostic Markers for Idiopathic Pulmonary Fibrosis
J Proteome Res. 2023 Sep 21. doi: 10.1021/acs.jproteome.3c00389. Online ahead of print.ABSTRACTTo determine the role of inflammation-related proteins in predicting asthma severity and outcome, 92 inflammation-related proteins were measured in the asthmatic serum using Olink analysis. Different bioinformatics algorithms were developed to cross analyze with the single-cell or transcriptome data sets from the Gene Expression Omnibus database to explore the role of IL18R1 and related genes in asthma and idiopathic pulmonary fibrosis (IPF). Olink identified 52 differentially expressed proteins in asthma. They were strongly link...
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Kun Lin Ting Wang Qingqin Tang Tingsang Chen Meishan Lin Jieyu Jin Jun Cao Sheng Zhang Yanru Xing Longwei Qiao Yuting Liang Source Type: research

PD-1 blockade induces reactivation of non-productive T cell responses characterized by NF-kB signaling in patients with pancreatic cancer
CONCLUSIONS: Cytotoxic T cells in the blood of PDAC patients remain sensitive to reinvigoration by PD-1 blockade and some have tumor-recognizing potential. Although these T cells proliferate and have a signature of IFN exposure, they also upregulate NF-κB signaling, which potentially counteracts the beneficial effects of anti-PD-1 reinvigoration and marks these T cells as non-productive contributors to anti-tumor immunity.PMID:37733830 | DOI:10.1158/1078-0432.CCR-23-1444
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Lestat R Ali Patrick J Lenehan Victoire Cardot-Ruffino Andressa Dias Costa Matthew H G Katz Todd W Bauer Jonathan A Nowak Brian M Wolpin Thomas A Abrams Anuj Patel Thomas E Clancy Jiping Wang Joseph D Mancias Matthew J Reilley Chee-Chee H Stucky Tanios S Source Type: research

Palbociclib releases the latent differentiation capacity of neuroblastoma cells
Dev Cell. 2023 Sep 9:S1534-5807(23)00443-4. doi: 10.1016/j.devcel.2023.08.028. Online ahead of print.ABSTRACTNeuroblastoma is the most common extracranial solid tumor in infants, arising from developmentally stalled neural crest-derived cells. Driving tumor differentiation is a promising therapeutic approach for this devastating disease. Here, we show that the CDK4/6 inhibitor palbociclib not only inhibits proliferation but induces extensive neuronal differentiation of adrenergic neuroblastoma cells. Palbociclib-mediated differentiation is manifested by extensive phenotypic and transcriptional changes accompanied by the es...
Source: Developmental Cell - September 21, 2023 Category: Cytology Authors: Kirsty M Ferguson Sarah L Gillen Lewis Chaytor Evon Poon Daniel Marcos Roshna Lawrence Gomez Laura M Woods Lidiya Mykhaylechko Louis Elfari Barbara Martins da Costa Yann Jamin Jason S Carroll Louis Chesler Fahad R Ali Anna Philpott Source Type: research

PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors
CONCLUSIONS: By disrupting an adaptive stress response evoked by VEGFR-TKIs, HC-5404 presents a clinical opportunity to improve the antitumor effects of well-established standard of care therapies in RCC.PMID:37733811 | DOI:10.1158/1078-0432.CCR-23-1182
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Michael E Stokes Veronica Calvo Sho Fujisawa Crissy Dudgeon Sharon Huang Nupur Ballal Leyi Shen Jennifer Gasparek Matthew Betzenhauser Simon J Taylor Kirk A Staschke Alan C Rigby Mark J Mulvihill Nandita Bose Eric S Lightcap David Surguladze Source Type: research

Differential benefit of metronomic chemotherapy among triple negative breast cancer subtypes treated in the IBCSG Trial 22-00
CONCLUSIONS: Our results show a differential benefit of low-dose CM therapy across different TNBC subtypes. Low-dose CM therapy could be considered as a potential immunomodulatory strategy for TNBC tumors with IM subtype in the early-disease setting.PMID:37733800 | DOI:10.1158/1078-0432.CCR-23-1267
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Andrea Joaquin Garcia Mattia Rediti David Venet Samira Majjaj Roswitha Kammler Elisabetta Munzone Lorenzo Gianni Beat Th ürlimann Istv án Láng Marco Colleoni Sherene Loi Giuseppe Viale Meredith M Regan Laurence Buisseret Fran çoise Rothé Christos Sot Source Type: research

ATM mutations associate with distinct co-mutational patterns and therapeutic vulnerabilities in NSCLC
CONCLUSIONS: ATM mutations define a distinct subset of NSCLC associated with KRAS mutations, increased TMB, decreased TP53 and EGFR co-occurrence, and potential increased sensitivity to ICIs in the context of DNA-damaging chemotherapy.PMID:37733794 | DOI:10.1158/1078-0432.CCR-23-1122
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Natalie I Vokes Ana Galan Cobo Margarita Fernandez-Chas David Molkentine Santiago Trevi ño Vitaly Druker Yu Qian Sonia Patel Stephanie Schmidt Lingzhi Hong Jeff Lewis Waree Rinsurongkawong Vadeerat Rinsurongkawong J Jack Lee Marcelo V Negrao Don L Gibbon Source Type: research