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Specialty: Cytology
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Multidimensional Analysis of a Cell-Free DNA Whole Methylome Sequencing Assay for Early Detection of Gastric Cancer: Protocol for an Observational Case-Control Study
CONCLUSIONS: This is the first registered case-control study designed to investigate a stacked ensemble model integrating several cfDNA features generated from a bisulfite-free whole methylome sequencing assay. These features include methylation patterns, fragmentation profiles, and chromosomal copy number changes, with the aim of identifying the GC population. This study will determine whether multidimensional analysis of cfDNA will prove to be an effective strategy for distinguishing patients with GC from nonmalignant individuals within the Chinese population. We anticipate the THEMIS model will complement the standard-o...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Yongjun Han Jiangpeng Wei Weidong Wang Ruiqi Gao Ning Shen Xiaofeng Song Yang Ni Yulong Li Li-Di Xu Weizhi Chen Xiaohua Li Source Type: research
Tumor-infiltrating normal B cells revealed by immunoglobulin repertoire clonotype analysis are highly prognostic and crucial for antitumor immune responses in DLBCL
CONCLUSIONS: TIL-B frequency is a significant prognostic factor in DLBCL and plays a crucial role in antitumor immune responses. This study provides novel insights into the prognostic determinants in DLBCL and TIL-B functions with important therapeutic implications.PMID:37728879 | DOI:10.1158/1078-0432.CCR-23-1554
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Zijun Y Xu-Monette Yong Li Thomas Snyder Tiantian Yu Tingxun Lu Alexandar Tzankov Carlo Visco Govind Bhagat Wenbin Qian Karen Dybkaer April Chiu Wayne Tam Youli Zu Eric D Hsi Fredrick B Hagemeister Yingjun Wang Heounjeong Go Maurilio Ponzoni Andr és J M Source Type: research
Nontraditional Approaches To Enable High-Energy and Long-Life Lithium-Sulfur Batteries
Acc Chem Res. 2023 Sep 20. doi: 10.1021/acs.accounts.3c00400. Online ahead of print.ABSTRACTConspectusLithium-sulfur (Li-S) batteries are promising for automotive applications due to their high theoretical energy density (2600 Wh/kg). In addition, the natural abundance of sulfur could mitigate the global raw material supply chain challenge of commercial lithium-ion batteries that use critical elements, such as nickel and cobalt. However, due to persistent polysulfide shuttling and uncontrolled lithium dendrite growth, Li-S batteries using nonencapsulated sulfur cathodes and conventional ether-based electrolytes suffer from...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Chen Zhao Khalil Amine Gui-Liang Xu Source Type: research
Synthesis of Peptidyl-tRNA Mimics for Structural Biology Applications
Acc Chem Res. 2023 Sep 20. doi: 10.1021/acs.accounts.3c00412. Online ahead of print.ABSTRACTConspectusProtein biosynthesis is a central process in all living cells that is catalyzed by a complex molecular machine─the ribosome. This process is termed translation because the language of nucleotides in mRNAs is translated into the language of amino acids in proteins. Transfer RNA (tRNA) molecules charged with amino acids serve as adaptors and recognize codons of mRNA in the decoding center while simultaneously the individual amino acids are assembled into a peptide chain in the peptidyl transferase center (PTC). As the nasc...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Yury S Polikanov M élanie Etheve-Quelquejeu Ronald Micura Source Type: research
Downregulated BIRC5 inhibits proliferation and metastasis of melanoma through the β-catenin/HIF-1α/VEGF/MMPs pathway
CONCLUSION: Our findings revealed that ZWZ-3 could downregulate BIRC5 and inhibit melanoma proliferation and metastasis through the β-catenin/HIF-1α/VEGF/MMPs pathway. Therefore, BIRC5 represents a promising therapeutic target for the treatment of melanoma.PMID:37728702 | DOI:10.1007/s00432-023-05425-3
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Qingqing He Yijing He Changqiang Li Jianv Wang Tong Xia Xia Xiong Jixiang Xu Li Liu Source Type: research
The inherited KRAS-variant as a biomarker of Cetuximab Response in NSCLC
CONCLUSIONS/DISCUSSION: Although an overall survival advantage was not achieved in KRAS-variant patients, there is potential impact of cetuximab for this genetic subset of patients. In contrast, cetuximab seems to harm non-variant patients. These findings further support the importance of genetic patient selection in trials studying the addition of systemic agents to radiotherapy.PMID:37728512 | DOI:10.1158/2767-9764.CRC-23-0084
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Joanne B Weidhaas Chen Hu Ritsuko Komaki Gregory A Masters George R Blumenschein Joe Y Chang Bo Lu Adam P Dicker Jeffrey A Bogart Yolanda I Garces Samir Narayan Clifford G Robinson Vivek S Kavadi Joel S Greenberger Christopher D Koprowski James W Welsh El Source Type: research
Metastatic competency and tumor spheroid formation are independent cell states governed by RB in lung adenocarcinoma
Cancer Res Commun. 2023 Sep 20. doi: 10.1158/2767-9764.CRC-23-0172. Online ahead of print.ABSTRACTInactivation of the retinoblastoma (RB) tumor suppressor in lung adenocarcinoma is associated with the rapid acquisition of metastatic ability and the loss of lung cell lineage commitment. We previously showed that restoration of RB in advanced lung adenocarcinomas in the mouse was correlated with a decreased frequency of lineage de-committed tumors and overt metastases. To identify a causal relationship for RB and its role in reprogramming lineage commitment and reducing metastatic competency in lung adenocarcinoma, we develo...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Nelson F Freeburg Nia Peterson Dain A Ruiz Amy C Gladstein David M Feldser Source Type: research
EDIL3 as an angiogenic target of immune exclusion following checkpoint blockade
Cancer Immunol Res. 2023 Sep 20. doi: 10.1158/2326-6066.CIR-23-0171. Online ahead of print.ABSTRACTImmune checkpoint blockade (ICB) has become the standard of care for several solid tumors. Multiple combinatorial approaches have been studied to improve therapeutic efficacy. The combination of anti-angiogenesis agents and ICB has demonstrated efficacy in several cancers. To improve the mechanistic understanding of synergies with these treatment modalities, we performed serologic screens of human protein array using sera from long-term responding patients treated with ipilimumab and bevacizumab. We discovered a high-titer an...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Saba Tabasum Dinesh Thapa Anita Giobbie-Hurder Jason L Weirather Marco Campisi Pieter J Schol Xiaoyu Li Jingjing Li Charles H Yoon Michael P Manos David A Barbie F Stephen Hodi Source Type: research
Investigation of conditioned medium properties obtained from human umbilical cord mesenchymal stem/stromal cells preconditioned with dimethyloxalylglycine in a correlation with ultrastructural changes
Microsc Res Tech. 2023 Sep 20. doi: 10.1002/jemt.24420. Online ahead of print.ABSTRACTMesenchymal stem/stromal cells (MSCs) hold significant therapeutic value due to their regeneration abilities, migration capacity, and immunosuppressive and immunomodulatory properties. These cells secrete soluble and insoluble factors, and this complex secretome contributes to their therapeutic effect. Furthermore, stimulation of cells by various external stimuli lead to secretome modifications that can increase the therapeutic efficacy. So, this study examined the effect of dimethyloxalylglycine (DMOG), a hypoxia-mimetic agent, on secret...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Hanife Nurdan Olcar Basak Isildar Serbay Ozkan Merve Ercin Selda Gezginci-Oktayoglu Meral Koyuturk Source Type: research
Effect of Chemotherapeutics on In Vitro Immune Checkpoint Expression in Non-Small Cell Lung Cancer
Conclusion: Chemotherapy agents have different effects on the expression of ICP ligands in tumor cells with different pathological types, and this may affect the efficacy of combined immunotherapy. These results provide a theoretical basis for further selection and optimization of the combination of chemotherapy and immunotherapy.PMID:37728201 | DOI:10.1177/15330338231202307
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Yu Zhao Zhe Wang Xiuhuan Shi Ting Liu Wenwen Yu Xiubao Ren Hua Zhao Source Type: research
Cytocompatibility, antibacterial, and corrosion properties of chitosan/polymethacrylates and chitosan/poly(4-vinylpyridine) smart coatings, electrophoretically deposited on nanosilver-decorated titania nanotubes
This study involved different surface treatments of titanium surface, mainly by electrochemical oxidation to produce a nanotubular oxide layer (TNTs), a subsequent electrochemical reduction of silver nitrate and decoration of a nanotubular surface with silver nanoparticles (AgNPs), and finally electrophoretic deposition (EPD) of a composite of chitosan (CS) and either polymethacrylate-based copolymer Eudragit E 100 (EE100) or poly(4-vinylpyridine) (P4VP) coating. The effects of each stage of this multi-step modification were examined in terms of morphology, roughness, wettability, corrosion resistance, coating-substrate ad...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Łukasz Pawłowski Micha ł Bartmański Anna Ronowska Adrianna Banach-Kope ć Szymon Mania Bart łomiej Michał Cieślik Aleksandra Mielewczyk-Gry ń Jakub Karczewski Andrzej Zieli ński Source Type: research
Machine learning-based mortality prediction in hip fracture patients using biomarkers
J Orthop Res. 2023 Sep 20. doi: 10.1002/jor.25675. Online ahead of print.ABSTRACTThe purpose of this retrospective study was to assess whether mortality following a hip fracture can be predicted by a machine learning model trained on basic blood and lab test data as well as basic demographic data. Additionally, the purpose was to identify the key variables most associated with 1-, 5-, and 10-year mortality and investigate their clinical significance. Input data included 3751 hip fracture patient records sourced from the Medical Information Mart for Intensive Care IV database, which provided records from in-hospital databas...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: George Asrian Abhinav Suri Chamith Rajapakse Source Type: research
The Emerging Roles of Ferroptosis in Pathophysiology and Treatment of Acute Lung Injury
J Inflamm Res. 2023 Sep 14;16:4073-4085. doi: 10.2147/JIR.S420676. eCollection 2023.ABSTRACTFerroptosis, a programmed cell death discovered in recent years, is an iron-dependent lipid peroxidation accumulation. Unlike other modes of cell death (autophagy, necroptosis, pyroptosis, cuproptosis, etc.), ferroptosis has unique morphological characteristics and plays an important role in a variety of diseases. In recent years, there has been great progress in the study of ferroptosis. Studies have found that ferroptosis is associated with acute lung injury (ALI), a condition with a high mortality rate and limited treatment optio...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Yufei Wang Zijun Zhao Zhaoyang Xiao Source Type: research
Integrated Analysis of Immune Infiltration and Hub Pyroptosis-Related Genes for Multiple Sclerosis
CONCLUSION: MS was associated with immune infiltration. CASP4 and NLRC4 were key biomarkers of pyroptosis in MS.PMID:37727371 | PMC:PMC10505586 | DOI:10.2147/JIR.S422189
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Shaoru Zhang Yue Ma Xiaoqin Luo Hongmei Xiao Ruiqi Cheng Anan Jiang Xinyue Qin Source Type: research
Twenty years of research in melanoma therapy-From "nothing works" to cures: A personal account
Pigment Cell Melanoma Res. 2023 Sep 19. doi: 10.1111/pcmr.13133. Online ahead of print.NO ABSTRACTPMID:37726985 | DOI:10.1111/pcmr.13133
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Meenhard Herlyn Jessie Villanueva Source Type: research
