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Specialty: Cytology
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Protein tyrosine phosphatase 1B is a regulator of alpha-actinin4 in the glomerular podocyte
This study aims to uncover novel substrates of PTP1B in podocytes and validate a leading candidate. To this end, using substrate-trapping and mass spectroscopy, we identified putative substrates of this phosphatase and investigated the actin cross-linking cytoskeletal protein alpha-actinin4. PTP1B and alpha-actinin4 co-localized in murine and human glomeruli and transiently transfected E11 podocyte cells. Additionally, podocyte PTP1B deficiency in vivo and culture was associated with elevated tyrosine phosphorylation of alpha-actinin4. Conversely, reconstitution of the knockdown cells with PTP1B attenuated alpha-actinin4 t...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Ming-Fo Hsu Yoshihiro Ito Jai Prakash Singh Shu-Fang Hsu Alan Wells Kuang-Yu Jen Tzu-Ching Meng Fawaz G Haj Source Type: research
Cisplatin-induced DNA crosslinks trigger neurotoxicity in C. elegans
Biochim Biophys Acta Mol Cell Res. 2023 Sep 18:119591. doi: 10.1016/j.bbamcr.2023.119591. Online ahead of print.ABSTRACTThe anticancer drug cisplatin (CisPt) injures post-mitotic neuronal cells, leading to neuropathy. Furthermore, CisPt triggers cell death in replicating cells. Here, we aim to unravel the relevance of different types of CisPt-induced DNA lesions for evoking neurotoxicity. To this end, we comparatively analyzed wild-type and loss of function mutants of C. elegans lacking key players of specific DNA repair pathways. Deficiency in ercc-1, which is essential for nucleotide excision repair (NER) and interstrand...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Fabian Wynen Johannes Krautstrunk Lisa Marie M üller Viktoria Graf Vanessa Brinkmann Gerhard Fritz Source Type: research
Coevolution-based computational approach to detect resistance mechanism of epidermal growth factor receptor
Biochim Biophys Acta Mol Cell Res. 2023 Sep 18:119592. doi: 10.1016/j.bbamcr.2023.119592. Online ahead of print.ABSTRACTTyrosine kinase epidermal growth factor receptor (EGFR) correlates the neoplastic cell metastasis, angiogenesis, neoplastic incursion, and apoptosis. Due to the involvement of EGFR in these biological processes, it becomes a most potent target for treating non-small cell lung cancer (NSCLC). The tyrosine kinase inhibitors (TKI) have endorsed high efficacy and anticipation to patients but unfortunately, within a year of treatment, drug targets develop resistance due to mutations. The present study detected...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Gyan Prakash Rai Asheesh Shanker Source Type: research
Noscapine alleviates unilateral ureteral obstruction-induced inflammation and fibrosis by regulating the TGF β1/Smads signaling pathways
Biochim Biophys Acta Mol Cell Res. 2023 Sep 18:119594. doi: 10.1016/j.bbamcr.2023.119594. Online ahead of print.ABSTRACTRenal fibrosis is a common pathway leading to progressive renal function loss in various forms of chronic kidney disease. Many fibrogenic factors regulate renal fibrosis; two key players are post-injury inflammation and transforming growth factor-β1 (TGF-β1)-induced myofibroblast differentiation. Myofibroblast differentiation is tightly regulated by the microtubule polymerization. Noscapine, an antitussive plant alkaloid, is a potent microtubule-interfering agent previously identified as a potential ant...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Cheng-Chieh Hung Kuan-Hsing Chen Hsiang-Hao Hsu Ming-Yang Chang Yi-Ching Ko Huang-Yu Yang Chih-Wei Yang Source Type: research
Single-cell RNA sequencing atlas of peripheral blood mononuclear cells from subjects with coronary artery disease
CONCLUSIONS: Our study offered a detailed profiling of single-cell RNA sequencing of PBMCs from subjects with CADs and controls. These data provide a line of evidence that the JUN signaling pathway may be a potential diagnostic and therapeutic molecule target for CAD.PMID:37730128 | DOI:10.1016/j.bbamcr.2023.119593
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Xiaolong Song Yahong Fu Chengcheng Li Qiaowei Jia Mengmeng Ren Xin Zhang Hengjie Bie Hanxiao Zhou Xiongkang Gan Shu He Yanjun Wang Sheng Zhang Renyou Pan Weixin Sun Haitang Zhou Qimeng Ni Jun Song Qian Zhang Xiumei Chen Enzhi Jia Source Type: research
Maresin-1 prevents blood-spinal cord barrier disruption associated with TRPV4 elevation in the experimental model of spinal cord injury
Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Sep 18:159395. doi: 10.1016/j.bbalip.2023.159395. Online ahead of print.ABSTRACTRecently, we reported the TRPV4 ion channel activation and its association with secondary damage after spinal cord injury (SCI). TRPV4 activation is linked with blood-spinal cord barrier (BSCB) disruption, endothelial damage, and inflammation after SCI. Specialized pro-resolving mediators (SPM) are endogenous lipid mediators released for inflammation resolution. Studies suggest that SPM could act as an endogenous antagonist of ion channels directly or indirectly at the plasma membrane. Herein, we ...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Zarna Pathak Tarang Jadav Abhishek Roy Manjeet Chopra Nidhi Singh Pinaki Sengupta Hemant Kumar Source Type: research
Targeting hnRNPC suppresses thyroid follicular epithelial cell apoptosis and necroptosis through m < sup > 6 < /sup > A-modified ATF4 in autoimmune thyroid disease
Pharmacol Res. 2023 Sep 18:106933. doi: 10.1016/j.phrs.2023.106933. Online ahead of print.ABSTRACTBoth environmental and genetic factors contribute to the etiology of autoimmune thyroid disease (AITD) including Graves' disease (GD) and Hashimoto's thyroiditis (HT). However, the exact pathogenesis and interactions that occur between environmental factors and genes remain unclear, and therapeutic targets require further investigation due to limited therapeutic options. To solve such problems, this study utilized single-cell transcriptome, whole transcriptome, full-length transcriptome (Oxford nanopore technology), and metabo...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Ke Mo Yongli Chu Yang Liu Guibin Zheng Kaiyu Song Qiong Song Haitao Zheng Yuxiao Tang Xinghan Tian Wenjie Yao Han Fang Kejian Wang Yongqiang Jiang Dengfeng Yang Yixuan Chen Chengyu Huang Ting Li Hongmei Qu Xicheng Song Jin Zhou Source Type: research
Effects of prolonged fluoride exposure on innate immunity, intestinal mechanical, and immune barriers in mice
Res Vet Sci. 2023 Sep 14;164:105019. doi: 10.1016/j.rvsc.2023.105019. Online ahead of print.ABSTRACTThe aim of this study is to explore the effects of fluoride on the innate immunity, intestinal mechanical barrier, and immune barrier of C57BL/6 mice, as well as to analyze the degree of structural and tissue damage, providing reference data for related research. Mice were randomly divided into four groups and then treated with 0 mg/L (control), 50 mg/L, 100 mg/L, 125 mg/L sodium fluoride solution, respectively, for 120 days. Histological technique, ELISA, MTT colorimetry methods were used to detect and analyze the effects o...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Yan Wang Jing Xu Hang Chen Yuanbin Shu Weiqi Peng Chunxiao Lai Ruiyang Kong Ruiyang Lan Lijing Huang Jinge Xin Ning Sun Xueqin Ni Yang Bai Bangyuan Wu Source Type: research
MEK inhibition induces expression of differentiation marker Keratin 10 in human keratinocytes
Pathol Res Pract. 2023 Sep 2;250:154788. doi: 10.1016/j.prp.2023.154788. Online ahead of print.ABSTRACTBRAF mutant metastatic melanoma was regularly treated in the past with a BRAF inhibitor (BRAFi) alone or in combination with inhibitors of the mitogen-activated protein kinase kinase (MEKi), which is still a common treatment. This combination therapy strongly reduced the occurrence of keratoacanthomas and squamous cell carcinoma, which was frequently seen when BRAFi was used as monotherapy. Here we addressed the question whether MEK inhibition counteracts squamous cell carcinoma development in part by promoting keratinocy...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: F Karras M Bonsack S Seifert L Friedrich M Kunz Source Type: research
Harnessing autologous immune effector mechanisms in acute myeloid leukemia: 2023 update of trials and tribulations
Leuk Res. 2023 Sep 14;134:107388. doi: 10.1016/j.leukres.2023.107388. Online ahead of print.ABSTRACTNumerous recent advances have been made in therapeutic approaches toward acute myeloid leukemia (AML). Since 2017, we have seen eleven novel Food & Drug Administration (FDA)-approved medications for AML, all of which extend beyond the classical cytarabine-based cytostatic chemotherapy. In the recent two decades, the role of immune surveillance in AML has been intensively investigated. The power of one's own innate and adaptive immunity has been harnessed pharmacologically toward the goal of clearance of AML cells. Specif...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Shyam A Patel Elisa Bello Andrew Wilks Jonathan M Gerber Narayanan Sadagopan Jan Cerny Source Type: research
Solar-driven strongly coupled plasmonic Au nanoarrays on mesoporous silica nanodisks enable selective fungal and bacterial inactivation in well water
This study provides a cost-effective and practical solution for efficient well water disinfection, which assists isolated rural areas in getting safe drinking water.PMID:37729695 | DOI:10.1016/j.watres.2023.120612
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Zhuoyun Tang Dingren Ma Jingling Yang Jinjuan Chen Zhuohang Lin Qiwen Liang Yimu Jiao Wei Qu Dehua Xia Source Type: research
The Pathogenesis of COVID-19-Related Taste Disorder and Treatments
J Dent Res. 2023 Sep 20:220345231182926. doi: 10.1177/00220345231182926. Online ahead of print.ABSTRACTCOVID-19, mainly manifested as acute respiratory distress syndrome, has afflicted millions of people worldwide since 2019. Taste dysfunction is a common early-stage symptom of COVID-19 infection that burdens patients for weeks or even permanently in some cases. Owing to its subjectivity and complexity, the mechanism of taste disorder is poorly studied. Previous studies have reported that the COVID-19 entry receptors are highly expressed in taste buds, thereby intensifying the cytocidal effect. Taste receptor cells are vul...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: J Wang R Liu H Ma W Zhang Source Type: research
Combinatorial treatment with PARP and MAPK inhibitors overcomes phenotype switch-driven drug resistance in advanced melanoma
Cancer Res. 2023 Sep 20. doi: 10.1158/0008-5472.CAN-23-0485. Online ahead of print.ABSTRACTMetastatic melanoma is either intrinsically resistant or rapidly acquires resistance to targeted therapy treatments, such as MAPK inhibitors. A leading cause of resistance to targeted therapy is a dynamic transition of melanoma cells from a proliferative to a highly invasive state, a phenomenon called phenotype switching. Mechanisms regulating phenotype switching represent potential targets for improving treatment of melanoma patients. Using a drug screen targeting chromatin regulators in patient-derived 3D MAPK inhibitor-resistant m...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Lorenza P Ferretti Flurina B öhi Deena M Leslie Pedrioli Phil F Cheng Elena Ferrari Petra Baumgaertner Abdiel Alvarado-Diaz Federica Sella Alessandra Cereghetti Patrick Turko Roni H Wright Katrien De Bock Daniel E Speiser Roberto Ferrari Mitchell P Leves Source Type: research
Fatty acid oxidation mediated by malonyl-CoA decarboxylase represses renal cell carcinoma progression
Cancer Res. 2023 Sep 20. doi: 10.1158/0008-5472.CAN-23-0969. Online ahead of print.ABSTRACTFatty acid metabolism reprogramming is a prominent feature of clear cell renal cell carcinoma (ccRCC). Increased lipid storage supports ccRCC progression, highlighting the importance of understanding the molecular mechanisms driving altered fatty acid synthesis in tumors. Here, we identified that malonyl-CoA decarboxylase (MLYCD), a key regulator of fatty acid anabolism, was downregulated in ccRCC, and low expression correlated with poor prognosis in patients. Restoring MLYCD expression in ccRCC cells decreased the content of malonyl...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Lijie Zhou Yongbo Luo Yuenan Liu Youmiao Zeng Junwei Tong Mengting Li Yaxin Hou Kaixuan Du Yabin Qi Wenbang Pan Yuanhao Liu Rongli Wang Fengyan Tian Chaohui Gu Ke Chen Source Type: research
Characterization of Proteoform Post-Translational Modifications by Top-Down and Bottom-Up Mass Spectrometry in Conjunction with Annotations
J Proteome Res. 2023 Sep 20. doi: 10.1021/acs.jproteome.3c00207. Online ahead of print.ABSTRACTMany proteoforms can be produced from a gene due to genetic mutations, alternative splicing, post-translational modifications (PTMs), and other variations. PTMs in proteoforms play critical roles in cell signaling, protein degradation, and other biological processes. Mass spectrometry (MS) is the primary technique for investigating PTMs in proteoforms, and two alternative MS approaches, top-down and bottom-up, have complementary strengths. The combination of the two approaches has the potential to increase the sensitivity and acc...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Wenrong Chen Zhengming Ding Yong Zang Xiaowen Liu Source Type: research
