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Total 416 results found since Jan 2013.
Background free in vivo29Si MR imaging with hyperpolarized PEGylated silicon nanoparticles
This study demonstrated the potential of 50 nm PEGylated Si NPs for high-resolutionin vivo29Si MR imaging, emphasizing their biocompatibility and water dispersibility. The acquisition of in vivo Si... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - September 23, 2023 Category: Chemistry Authors: Seung-Hyun Yang Source Type: research
Oktoberfest: Open ‐source spectral library generation and rescoring pipeline based on Prosit
AbstractMachine learning (ML) and deep learning (DL) models for peptide property prediction such as Prosit have enabled the creation of high quality in silico reference libraries. These libraries are used in various applications, ranging from data-independent acquisition (DIA) data analysis to data-driven rescoring of search engine results. Here, we present Oktoberfest, an open source Python package of our spectral library generation and rescoring pipeline originally only available online via ProteomicsDB. Oktoberfest is largely search engine agnostic and provides access to online peptide property predictions, promoting th...
Source: Proteomics - September 7, 2023 Category: Biochemistry Authors: Mario Picciani,
Wassim Gabriel,
Victor ‐George Giurcoiu,
Omar Shouman,
Firas Hamood,
Ludwig Lautenbacher,
Cecilia Bang Jensen,
Julian Müller,
Mostafa Kalhor,
Armin Soleymaniniya,
Bernhard Kuster,
Matthew The,
Mathias Wilhelm Tags: TECHNICAL BRIEF Source Type: research
Towards the Regrowth of Lost Sensory Hair Cells in the Inner Ear
Age-related deafness arises from some combination of (a) the loss of sensory hair cells in the inner ear, and (b) the loss of connections between those cells and the brain. There is some disagreement in the literature as to which of these mechanisms is the most relevant, but most recent efforts in the field are focused on trying to coerce the body into producing new hair cells. If that production of new hair cells in the inner ear follows the normal developmental processes, then it might solve both of the above mentioned issues, providing both cells and connections to the brain.
Today's research materials illustrate...
Source: Fight Aging! - August 23, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Bioactivity-guided isolation of anti-acetylcholinesterase compounds from Odontites vulgaris Moench
This study aimed to separate the anti-acetylcholinesterase (anti-AChE) compounds fromOdontites vulgaris Moench, a member of the Orobanchaceae famly, using a bioactivity-guided isolation strategy. Active fractions were selected according to the results of AChE-inhibitory activities. Then, various chromatographic packings were performed to separate the compounds from the active fractions, followed by identifying their structures using 1D NMR and HR –ESI–MS analyses. In addition, the isolated compounds were tested for their AChE-inhibitory activities. As a result, the bioactivity-guided isolation ofO. vulgaris resulted in...
Source: Medicinal Chemistry Research - August 19, 2023 Category: Chemistry Source Type: research
Assessing Medicaid Coverage for Hematopoietic Cell Transplantation and Chimeric Antigen Receptor T Cell Therapy: A Project from the American Society for Transplantation and Cellular Therapy and the National Marrow Donor Program ACCESS Initiative
The American Society for Transplantation and Cellular Therapy (ASTCT) and the National Marrow Donor Program (NMDP) formed the ACCESS Initiative to address and reduce barriers to hematopoietic cell transplantation (HCT) and cellular therapy (CT) to ensure equal access and outcomes for all patients in need. The 3 committees, addressing awareness, poverty, and racial and ethnic inequity, defined pilot projects focusing on addressing relevant barriers to HCT/CT. Because many socioeconomically disadvantaged HCT/CT recipients receive care through state Medicaid programs, the Poverty Committee conducted a Medicaid scan of all 50 ...
Source: Biology of Blood and Marrow Transplantation - August 12, 2023 Category: Hematology Authors: Jeffery J. Auletta, Nandita Khera, Patrick DeMartino, Amar H. Kelkar, Rafeek A. Yusuf, Stella M. Davies, Jessica Knutson, Ellie Beaver, Alycia Maloney, Navneet S. Majhail Source Type: research
Assessing Medicaid coverage for hematopoietic cell transplantation and chimeric antigen receptor T-cell therapy: A project from the ASTCT-NMDP ACCESS Initiative
The American Society for Transplantation and Cellular Therapy (ASTCT) and the National Marrow Donor Program (NMDP) formed the ACCESS Initiative to address and reduce barriers to hematopoietic cell transplantation and cellular therapy (HCT/CT) in order to ensure equal access and outcomes for all patients in need. The three committees include awareness, poverty, and racial and ethnic inequity and each has defined pilot projects focusing on addressing relevant barriers to HCT/CT. Since many socioeconomically disadvantaged HCT/CT recipients receive care through state Medicaid programs, the poverty committee conducted a Medicai...
Source: Biology of Blood and Marrow Transplantation - August 12, 2023 Category: Hematology Authors: Jeffery J. Auletta, Nandita Khera, Patrick DeMartino, Amar H. Kelkar, Rafeek A. Yusuf, Stella M. Davies, Jessica Knutson, Ellie Beaver, Alycia Maloney, Navneet S. Majhail Source Type: research
A scientometric analysis of research trends on targeting mTOR in breast cancer from 2012 to 2022
Over the past decade, thousands of articles have been published on the mechanistic target of rapamycin (mTOR) and its role in breast cancer. However, the variability and heterogeneity of academic data may impact the acquisition of published research information. Due to the large number, heterogeneity, and varying quality of publications related to mTOR and breast cancer, sorting out the present state of the research in this area is critical for both researchers and clinicians. Therefore, scientometric techniques and visualization tools were employed to analyze the large number of bibliographic metadata related to the resea...
Source: Frontiers in Oncology - August 10, 2023 Category: Cancer & Oncology Source Type: research
Will Vince McMahon ’s legal woes kill the WWE-Endeavor Merger?
Vince McMahon’s legal problems could kill the WWE-Endeavor merger. McMahon is facing a federal criminal investigation. “Federal law enforcement agents executed a search warrant and served a federal grand jury subpoena on Mr. McMahon,” WWE’s 28 July 2023 Quarterly Report admits. Mr. McMahon is…#vincemcmahon #wwe #vincentkmcmahonjr #mcmahon #trumpinvestigation #donaldjtrump #florida #lindamcmahon #smallbusiness
Source: Reuters: Health - August 8, 2023 Category: Consumer Health News Source Type: news
Kaiser-Geisinger vs. Amazon, Walmart, CVS: Who will reign supreme?
For decades, research studies and news stories have concluded the American system is ineffective, too expensive and falling further behind its international peers in important measures of performance: life expectancy, chronic-disease management and incidence of medical error. As patients and health care professionals search for viable alternatives to the status quo, a recent mega-merger is
Read more…
Kaiser-Geisinger vs. Amazon, Walmart, CVS: Who will reign supreme? originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - August 6, 2023 Category: General Medicine Authors: Robert Pearl, MD Tags: Policy Public Health & Policy Source Type: blogs
Novartis builds on neuroscience pipeline and xRNA platform capabilities with acquisition of DTx Pharma
Novartis has acquired DTx Pharma, a San-Diego based, preclinical stage biotechnology company focused on leveraging its proprietary FALCON platform to develop siRNA therapies for neuroscience indications.
DTx’s lead program, DTx-1252 targets the root cause of CMT1A - the overexpression of PMP22, a protein that causes the myelin sheath that supports and insulates nerves in the peripheral nervous system to function abnormally.
Source: World Pharma News - July 19, 2023 Category: Pharmaceuticals Tags: Featured Novartis Business and Industry Source Type: news
Single Cell ICP-MS as a powerful analytical tool to determine metal content in individual pollen cells
J. Anal. At. Spectrom., 2023, Accepted Manuscript DOI: 10.1039/D3JA00140G, Technical NoteJavier Jim énez-Lamana, Katarzyna Bierla, Alexandra Leskova, Catherine Curie, Joanna Szpunar, Stephane Mari The acquisition and storage of essential metals (Fe, Cu, Zn, Mn …) is considered to be crucial for the quality of pollen grains. It is therefore strategic to develop analytical approaches... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - J. Anal. At. Spectrom. latest articles - July 10, 2023 Category: Chemistry Authors: Javier Jim énez-Lamana Source Type: research
An optimized PDMS microfluidic device for ultra-fast and high-throughput imaging flow cytometry
Lab Chip, 2023, Accepted Manuscript DOI: 10.1039/D3LC00237C, PaperXun Liu, jiehua Zhou, Ruopeng Yan, Tao Tang, Shubin Wei, Rubing Li, Dan Hou, Yueyun Weng, Du Wang, Hui Shen, Fuling Zhou, Yo Tanaka, Ming Li, Yoichiroh Hosokawa, Yaxiaer Yalikun, Cheng Lei Imaging flow cytometry (IFC) is a powerful tool for cell detection and analysis due to its high throughput and compatibility of image acquisition. Optical time-stretch (OTS) imaging is considered as... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Lab Chip latest articles - June 26, 2023 Category: Chemistry Authors: Xun Liu Source Type: research
High-field EPR of copper(II) –nitroxide compound exhibiting three-step phase transition: structural insights from the field-induced sample orientation
Dalton Trans., 2023, Advance Article DOI: 10.1039/D3DT01297B, PaperSergey V. Tumanov, Alexey N. Ponomaryov, Kseniya Yu. Maryunina, Artem S. Bogomyakov, Victor I. Ovcharenko, Sergei A. Zvyagin, Matvey V. Fedin, Sergey L. Veber Partial alignment of a polycrystalline paramagnetic sample in a high magnetic field enables the acquisition of important structural information inaccessible otherwise. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - June 23, 2023 Category: Chemistry Authors: Sergey V. Tumanov Source Type: research
CEO of Ground-Breaking DNA Sequencing Company Illumina Resigns Amid Pressure From Investor Carl Icahn
Gene sequencing test maker Illumina Inc. said Sunday that its board has accepted the resignation of its CEO and director, Francis deSouza, effective immediately.
Charles Dadswell, senior vice president and general counsel, has been named interim CEO, while the board conducts a search for a new CEO. Illumina said deSouza, who has been with the company since 2013 and was named CEO three years later, will stay on in an advisory capacity until July 31.
“Illumina’s technology remains at the forefront of DNA sequencing and has continued to set the pace for the industry,” Illumina’s board chair, Stephen P....
Source: TIME: Health - June 11, 2023 Category: Consumer Health News Authors: Associated Press Tags: Uncategorized wire Source Type: news
Why the CEO of Ground-Breaking DNA Sequencing Company Illumina Resigned
Gene sequencing test maker Illumina Inc. said Sunday that its board has accepted the resignation of its CEO and director, Francis deSouza, effective immediately.
Charles Dadswell, senior vice president and general counsel, has been named interim CEO, while the board conducts a search for a new CEO. Illumina said deSouza, who has been with the company since 2013 and was named CEO three years later, will stay on in an advisory capacity until July 31.
“Illumina’s technology remains at the forefront of DNA sequencing and has continued to set the pace for the industry,” Illumina’s board chair, Stephen P....
Source: TIME: Health - June 11, 2023 Category: Consumer Health News Authors: Associated Press Tags: Uncategorized healthscienceclimate wire Source Type: news
