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Source: International Journal of Oncology
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Total 2365 results found since Jan 2013.
Emerging proteins involved in castration ‑resistant prostate cancer via the AR‑dependent and AR‑independent pathways (Review)
Int J Oncol. 2023 Nov;63(5):127. doi: 10.3892/ijo.2023.5575. Epub 2023 Sep 21.ABSTRACTDespite achieving optimal initial responses to androgen deprivation therapy, most patients with prostate cancer eventually progress to a poor prognosis state known as castration‑resistant prostate cancer (CRPC). Currently, there is a notable absence of reliable early warning biomarkers and effective treatment strategies for these patients. Although androgen receptor (AR)‑independent pathways have been discovered and acknowledged in recent years, the AR signaling pathway continues to play a pivotal role in the progression of CRPC. The ...
Source: International Journal of Oncology - September 21, 2023 Category: Cancer & Oncology Authors: Kangle Feng Chunhua Liu Weixi Wang Piaoping Kong Zhihua Tao Weiwei Liu Source Type: research
Calcium signals and potential therapy targets in ovarian cancer (Review)
Int J Oncol. 2023 Nov;63(5):125. doi: 10.3892/ijo.2023.5573. Epub 2023 Sep 15.ABSTRACTOvarian cancer (OC) is a deadly disease. The poor prognosis and high lethality of OC are attributed to its high degrees of aggressiveness, resistance to chemotherapy and recurrence rates. Calcium ion (Ca2+) signaling has received attention in recent years, as it appears to form an essential part of various aspects of cancer pathophysiology and is a potential therapeutic target for OC treatment. Disruption of normal Ca2+ signaling pathways can induce changes in cell cycle progression, apoptosis, proliferation and migration and invasion, le...
Source: International Journal of Oncology - September 15, 2023 Category: Cancer & Oncology Authors: Fengying Deng Mengyu Fu Chenxuan Zhao Jiahui Lei Ting Xu Bingyu Ji Hongmei Ding Yueming Zhang Jie Chen Junlan Qiu Qinqin Gao Source Type: research
Key role of exosomes derived from M2 macrophages in maintaining cancer cell stemness (Review)
Int J Oncol. 2023 Nov;63(5):126. doi: 10.3892/ijo.2023.5574. Epub 2023 Sep 15.ABSTRACTCancer stem cells (CSCs) constitute a specific subset of cells found within tumors that are responsible for initiating, advancing and resisting traditional cancer treatments. M2 macrophages, also known as alternatively activated macrophages, contribute to the development and progression of cancer through their involvement in promoting angiogenesis, suppressing the immune system, supporting tumor growth and facilitating metastasis. Exosomes, tiny vesicles released by cells, play a crucial role in intercellular communications and have been ...
Source: International Journal of Oncology - September 15, 2023 Category: Cancer & Oncology Authors: Weiqiong Zhang Ruiping Zhou Xin Liu Lin You Chang Chen Xiaoling Ye Jie Liu Youde Liang Source Type: research
Role of stress in the pathogenesis of cancer (Review)
Int J Oncol. 2023 Nov;63(5):124. doi: 10.3892/ijo.2023.5572. Epub 2023 Sep 15.ABSTRACTStress is a state of disrupted homeostasis, triggered by intrinsic or extrinsic factors, the stressors, which are counteracted by various physiological and behavioural adaptive responses. Stress has been linked to cancer development and incidence for decades; however, epidemiological studies and clinical trials have yielded contradictory results. The present review discusses the effects of stress on cancer development and the various underlying mechanisms. Animal studies have revealed a clear link between stress and cancer progression, re...
Source: International Journal of Oncology - September 15, 2023 Category: Cancer & Oncology Authors: Ioannis G Lempesis Vasiliki Epameinondas Georgakopoulou Petros Papalexis Georgios P Chrousos Demetrios A Spandidos Source Type: research
Calcium signals and potential therapy targets in ovarian cancer (Review)
Int J Oncol. 2023 Nov;63(5):125. doi: 10.3892/ijo.2023.5573. Epub 2023 Sep 15.ABSTRACTOvarian cancer (OC) is a deadly disease. The poor prognosis and high lethality of OC are attributed to its high degrees of aggressiveness, resistance to chemotherapy and recurrence rates. Calcium ion (Ca2+) signaling has received attention in recent years, as it appears to form an essential part of various aspects of cancer pathophysiology and is a potential therapeutic target for OC treatment. Disruption of normal Ca2+ signaling pathways can induce changes in cell cycle progression, apoptosis, proliferation and migration and invasion, le...
Source: International Journal of Oncology - September 15, 2023 Category: Cancer & Oncology Authors: Fengying Deng Mengyu Fu Chenxuan Zhao Jiahui Lei Ting Xu Bingyu Ji Hongmei Ding Yueming Zhang Jie Chen Junlan Qiu Qinqin Gao Source Type: research
Key role of exosomes derived from M2 macrophages in maintaining cancer cell stemness (Review)
Int J Oncol. 2023 Nov;63(5):126. doi: 10.3892/ijo.2023.5574. Epub 2023 Sep 15.ABSTRACTCancer stem cells (CSCs) constitute a specific subset of cells found within tumors that are responsible for initiating, advancing and resisting traditional cancer treatments. M2 macrophages, also known as alternatively activated macrophages, contribute to the development and progression of cancer through their involvement in promoting angiogenesis, suppressing the immune system, supporting tumor growth and facilitating metastasis. Exosomes, tiny vesicles released by cells, play a crucial role in intercellular communications and have been ...
Source: International Journal of Oncology - September 15, 2023 Category: Cancer & Oncology Authors: Weiqiong Zhang Ruiping Zhou Xin Liu Lin You Chang Chen Xiaoling Ye Jie Liu Youde Liang Source Type: research
Role of stress in the pathogenesis of cancer (Review)
Int J Oncol. 2023 Nov;63(5):124. doi: 10.3892/ijo.2023.5572. Epub 2023 Sep 15.ABSTRACTStress is a state of disrupted homeostasis, triggered by intrinsic or extrinsic factors, the stressors, which are counteracted by various physiological and behavioural adaptive responses. Stress has been linked to cancer development and incidence for decades; however, epidemiological studies and clinical trials have yielded contradictory results. The present review discusses the effects of stress on cancer development and the various underlying mechanisms. Animal studies have revealed a clear link between stress and cancer progression, re...
Source: International Journal of Oncology - September 15, 2023 Category: Cancer & Oncology Authors: Ioannis G Lempesis Vasiliki Epameinondas Georgakopoulou Petros Papalexis Georgios P Chrousos Demetrios A Spandidos Source Type: research
Calcium signals and potential therapy targets in ovarian cancer (Review)
Int J Oncol. 2023 Nov;63(5):125. doi: 10.3892/ijo.2023.5573. Epub 2023 Sep 15.ABSTRACTOvarian cancer (OC) is a deadly disease. The poor prognosis and high lethality of OC are attributed to its high degrees of aggressiveness, resistance to chemotherapy and recurrence rates. Calcium ion (Ca2+) signaling has received attention in recent years, as it appears to form an essential part of various aspects of cancer pathophysiology and is a potential therapeutic target for OC treatment. Disruption of normal Ca2+ signaling pathways can induce changes in cell cycle progression, apoptosis, proliferation and migration and invasion, le...
Source: International Journal of Oncology - September 15, 2023 Category: Cancer & Oncology Authors: Fengying Deng Mengyu Fu Chenxuan Zhao Jiahui Lei Ting Xu Bingyu Ji Hongmei Ding Yueming Zhang Jie Chen Junlan Qiu Qinqin Gao Source Type: research
Key role of exosomes derived from M2 macrophages in maintaining cancer cell stemness (Review)
Int J Oncol. 2023 Nov;63(5):126. doi: 10.3892/ijo.2023.5574. Epub 2023 Sep 15.ABSTRACTCancer stem cells (CSCs) constitute a specific subset of cells found within tumors that are responsible for initiating, advancing and resisting traditional cancer treatments. M2 macrophages, also known as alternatively activated macrophages, contribute to the development and progression of cancer through their involvement in promoting angiogenesis, suppressing the immune system, supporting tumor growth and facilitating metastasis. Exosomes, tiny vesicles released by cells, play a crucial role in intercellular communications and have been ...
Source: International Journal of Oncology - September 15, 2023 Category: Cancer & Oncology Authors: Weiqiong Zhang Ruiping Zhou Xin Liu Lin You Chang Chen Xiaoling Ye Jie Liu Youde Liang Source Type: research
Role of stress in the pathogenesis of cancer (Review)
Int J Oncol. 2023 Nov;63(5):124. doi: 10.3892/ijo.2023.5572. Epub 2023 Sep 15.ABSTRACTStress is a state of disrupted homeostasis, triggered by intrinsic or extrinsic factors, the stressors, which are counteracted by various physiological and behavioural adaptive responses. Stress has been linked to cancer development and incidence for decades; however, epidemiological studies and clinical trials have yielded contradictory results. The present review discusses the effects of stress on cancer development and the various underlying mechanisms. Animal studies have revealed a clear link between stress and cancer progression, re...
Source: International Journal of Oncology - September 15, 2023 Category: Cancer & Oncology Authors: Ioannis G Lempesis Vasiliki Epameinondas Georgakopoulou Petros Papalexis Georgios P Chrousos Demetrios A Spandidos Source Type: research
Calcium signals and potential therapy targets in ovarian cancer (Review)
Int J Oncol. 2023 Nov;63(5):125. doi: 10.3892/ijo.2023.5573. Epub 2023 Sep 15.ABSTRACTOvarian cancer (OC) is a deadly disease. The poor prognosis and high lethality of OC are attributed to its high degrees of aggressiveness, resistance to chemotherapy and recurrence rates. Calcium ion (Ca2+) signaling has received attention in recent years, as it appears to form an essential part of various aspects of cancer pathophysiology and is a potential therapeutic target for OC treatment. Disruption of normal Ca2+ signaling pathways can induce changes in cell cycle progression, apoptosis, proliferation and migration and invasion, le...
Source: International Journal of Oncology - September 15, 2023 Category: Cancer & Oncology Authors: Fengying Deng Mengyu Fu Chenxuan Zhao Jiahui Lei Ting Xu Bingyu Ji Hongmei Ding Yueming Zhang Jie Chen Junlan Qiu Qinqin Gao Source Type: research
Key role of exosomes derived from M2 macrophages in maintaining cancer cell stemness (Review)
Int J Oncol. 2023 Nov;63(5):126. doi: 10.3892/ijo.2023.5574. Epub 2023 Sep 15.ABSTRACTCancer stem cells (CSCs) constitute a specific subset of cells found within tumors that are responsible for initiating, advancing and resisting traditional cancer treatments. M2 macrophages, also known as alternatively activated macrophages, contribute to the development and progression of cancer through their involvement in promoting angiogenesis, suppressing the immune system, supporting tumor growth and facilitating metastasis. Exosomes, tiny vesicles released by cells, play a crucial role in intercellular communications and have been ...
Source: International Journal of Oncology - September 15, 2023 Category: Cancer & Oncology Authors: Weiqiong Zhang Ruiping Zhou Xin Liu Lin You Chang Chen Xiaoling Ye Jie Liu Youde Liang Source Type: research
Role of stress in the pathogenesis of cancer (Review)
Int J Oncol. 2023 Nov;63(5):124. doi: 10.3892/ijo.2023.5572. Epub 2023 Sep 15.ABSTRACTStress is a state of disrupted homeostasis, triggered by intrinsic or extrinsic factors, the stressors, which are counteracted by various physiological and behavioural adaptive responses. Stress has been linked to cancer development and incidence for decades; however, epidemiological studies and clinical trials have yielded contradictory results. The present review discusses the effects of stress on cancer development and the various underlying mechanisms. Animal studies have revealed a clear link between stress and cancer progression, re...
Source: International Journal of Oncology - September 15, 2023 Category: Cancer & Oncology Authors: Ioannis G Lempesis Vasiliki Epameinondas Georgakopoulou Petros Papalexis Georgios P Chrousos Demetrios A Spandidos Source Type: research
