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Source: International Journal of Oncology
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Total 2365 results found since Jan 2013.
Key role of exosomes derived from M2 macrophages in maintaining cancer cell stemness (Review)
Int J Oncol. 2023 Nov;63(5):126. doi: 10.3892/ijo.2023.5574. Epub 2023 Sep 15.ABSTRACTCancer stem cells (CSCs) constitute a specific subset of cells found within tumors that are responsible for initiating, advancing and resisting traditional cancer treatments. M2 macrophages, also known as alternatively activated macrophages, contribute to the development and progression of cancer through their involvement in promoting angiogenesis, suppressing the immune system, supporting tumor growth and facilitating metastasis. Exosomes, tiny vesicles released by cells, play a crucial role in intercellular communications and have been ...
Source: International Journal of Oncology - September 15, 2023 Category: Cancer & Oncology Authors: Weiqiong Zhang Ruiping Zhou Xin Liu Lin You Chang Chen Xiaoling Ye Jie Liu Youde Liang Source Type: research
Role of stress in the pathogenesis of cancer (Review)
Int J Oncol. 2023 Nov;63(5):124. doi: 10.3892/ijo.2023.5572. Epub 2023 Sep 15.ABSTRACTStress is a state of disrupted homeostasis, triggered by intrinsic or extrinsic factors, the stressors, which are counteracted by various physiological and behavioural adaptive responses. Stress has been linked to cancer development and incidence for decades; however, epidemiological studies and clinical trials have yielded contradictory results. The present review discusses the effects of stress on cancer development and the various underlying mechanisms. Animal studies have revealed a clear link between stress and cancer progression, re...
Source: International Journal of Oncology - September 15, 2023 Category: Cancer & Oncology Authors: Ioannis G Lempesis Vasiliki Epameinondas Georgakopoulou Petros Papalexis Georgios P Chrousos Demetrios A Spandidos Source Type: research
Anti ‑PD‑1/PD‑L1 and anti‑CTLA‑4 associated checkpoint inhibitor pneumonitis in non‑small cell lung cancer: Occurrence, pathogenesis and risk factors (Review)
Int J Oncol. 2023 Nov;63(5):122. doi: 10.3892/ijo.2023.5570. Epub 2023 Sep 8.ABSTRACTImmune checkpoint inhibitors (ICIs) play a significant anti‑tumor role in the management of non‑small cell lung cancer. The most broadly used ICIs are anti‑programmed death 1 (PD‑1), anti‑programmed cell death‑ligand 1, and anti‑cytotoxic T lymphocyte‑associated antigen‑4 monoclonal antibody. Compared with traditional chemotherapy, ICIs have the advantages of greater efficiency and more specific targeting. However, the resulting immune‑related adverse events limit the clinical application of ICIs, especially checkpoint ...
Source: International Journal of Oncology - September 8, 2023 Category: Cancer & Oncology Authors: Xiao Hu Jin Ren Qianfei Xue Rumei Luan Dongyan Ding Jie Tan Xin Su Junling Yang Source Type: research
Antimicrobial agent chloroxylenol targets β‑catenin‑mediated Wnt signaling and exerts anticancer activity in colorectal cancer
Int J Oncol. 2023 Nov;63(5):121. doi: 10.3892/ijo.2023.5569. Epub 2023 Sep 8.ABSTRACTChloroxylenol is the active ingredient of the antibacterial agent Dettol. The anticancer effect and underlying mechanisms of this compound and other common antimicrobial agents have not been clearly elucidated. In the present study, the effects of chloroxylenol, benzalkonium chloride, benzethonium chloride, triclosan and triclocarban on β‑catenin‑mediated Wnt signaling in colorectal cancer were evaluated using the SuperTOPFlash reporter assay. It was demonstrated that chloroxylenol, but not the other antimicrobial agents tested, inhib...
Source: International Journal of Oncology - September 8, 2023 Category: Cancer & Oncology Authors: Qi Sun Boxin Liu Quanxue Lan Zijie Su Qiuxia Fu Lian Wang Yingying Deng Chuanli Li Vivian Weiwen Xue Shanshan Liu Xianxiong Chen Guowu Yang Desheng Lu Source Type: research
Circular RNAs in osteosarcoma: An update of recent studies (Review)
Int J Oncol. 2023 Nov;63(5):123. doi: 10.3892/ijo.2023.5571. Epub 2023 Sep 8.ABSTRACTOsteosarcoma (OS) prevailing in children and adolescents mainly occurs at the metaphysis of long bones. As it is associated with a high invasive and metastatic ability, resistance to chemotherapy, and a low 5‑year survival rate, the diagnosis and treatment of OS post a global healthy issue. Over the past decades, RNA biology has shed new light onto the pathogenesis of OS. As a type of non‑coding RNAs, circular RNAs (circRNAs) have been found to play crucial roles in cellular activities. Recently, a large number of circRNAs have been id...
Source: International Journal of Oncology - September 8, 2023 Category: Cancer & Oncology Authors: Le Zeng Longzhou Liu Wen-Juan Ni Fuhua Xie Xiao-Min Leng Source Type: research
Anti ‑PD‑1/PD‑L1 and anti‑CTLA‑4 associated checkpoint inhibitor pneumonitis in non‑small cell lung cancer: Occurrence, pathogenesis and risk factors (Review)
Int J Oncol. 2023 Nov;63(5):122. doi: 10.3892/ijo.2023.5570. Epub 2023 Sep 8.ABSTRACTImmune checkpoint inhibitors (ICIs) play a significant anti‑tumor role in the management of non‑small cell lung cancer. The most broadly used ICIs are anti‑programmed death 1 (PD‑1), anti‑programmed cell death‑ligand 1, and anti‑cytotoxic T lymphocyte‑associated antigen‑4 monoclonal antibody. Compared with traditional chemotherapy, ICIs have the advantages of greater efficiency and more specific targeting. However, the resulting immune‑related adverse events limit the clinical application of ICIs, especially checkpoint ...
Source: International Journal of Oncology - September 8, 2023 Category: Cancer & Oncology Authors: Xiao Hu Jin Ren Qianfei Xue Rumei Luan Dongyan Ding Jie Tan Xin Su Junling Yang Source Type: research
Antimicrobial agent chloroxylenol targets β‑catenin‑mediated Wnt signaling and exerts anticancer activity in colorectal cancer
Int J Oncol. 2023 Nov;63(5):121. doi: 10.3892/ijo.2023.5569. Epub 2023 Sep 8.ABSTRACTChloroxylenol is the active ingredient of the antibacterial agent Dettol. The anticancer effect and underlying mechanisms of this compound and other common antimicrobial agents have not been clearly elucidated. In the present study, the effects of chloroxylenol, benzalkonium chloride, benzethonium chloride, triclosan and triclocarban on β‑catenin‑mediated Wnt signaling in colorectal cancer were evaluated using the SuperTOPFlash reporter assay. It was demonstrated that chloroxylenol, but not the other antimicrobial agents tested, inhib...
Source: International Journal of Oncology - September 8, 2023 Category: Cancer & Oncology Authors: Qi Sun Boxin Liu Quanxue Lan Zijie Su Qiuxia Fu Lian Wang Yingying Deng Chuanli Li Vivian Weiwen Xue Shanshan Liu Xianxiong Chen Guowu Yang Desheng Lu Source Type: research
Circular RNAs in osteosarcoma: An update of recent studies (Review)
Int J Oncol. 2023 Nov;63(5):123. doi: 10.3892/ijo.2023.5571. Epub 2023 Sep 8.ABSTRACTOsteosarcoma (OS) prevailing in children and adolescents mainly occurs at the metaphysis of long bones. As it is associated with a high invasive and metastatic ability, resistance to chemotherapy, and a low 5‑year survival rate, the diagnosis and treatment of OS post a global healthy issue. Over the past decades, RNA biology has shed new light onto the pathogenesis of OS. As a type of non‑coding RNAs, circular RNAs (circRNAs) have been found to play crucial roles in cellular activities. Recently, a large number of circRNAs have been id...
Source: International Journal of Oncology - September 8, 2023 Category: Cancer & Oncology Authors: Le Zeng Longzhou Liu Wen-Juan Ni Fuhua Xie Xiao-Min Leng Source Type: research
Anti ‑PD‑1/PD‑L1 and anti‑CTLA‑4 associated checkpoint inhibitor pneumonitis in non‑small cell lung cancer: Occurrence, pathogenesis and risk factors (Review)
Int J Oncol. 2023 Nov;63(5):122. doi: 10.3892/ijo.2023.5570. Epub 2023 Sep 8.ABSTRACTImmune checkpoint inhibitors (ICIs) play a significant anti‑tumor role in the management of non‑small cell lung cancer. The most broadly used ICIs are anti‑programmed death 1 (PD‑1), anti‑programmed cell death‑ligand 1, and anti‑cytotoxic T lymphocyte‑associated antigen‑4 monoclonal antibody. Compared with traditional chemotherapy, ICIs have the advantages of greater efficiency and more specific targeting. However, the resulting immune‑related adverse events limit the clinical application of ICIs, especially checkpoint ...
Source: International Journal of Oncology - September 8, 2023 Category: Cancer & Oncology Authors: Xiao Hu Jin Ren Qianfei Xue Rumei Luan Dongyan Ding Jie Tan Xin Su Junling Yang Source Type: research
Antimicrobial agent chloroxylenol targets β‑catenin‑mediated Wnt signaling and exerts anticancer activity in colorectal cancer
Int J Oncol. 2023 Nov;63(5):121. doi: 10.3892/ijo.2023.5569. Epub 2023 Sep 8.ABSTRACTChloroxylenol is the active ingredient of the antibacterial agent Dettol. The anticancer effect and underlying mechanisms of this compound and other common antimicrobial agents have not been clearly elucidated. In the present study, the effects of chloroxylenol, benzalkonium chloride, benzethonium chloride, triclosan and triclocarban on β‑catenin‑mediated Wnt signaling in colorectal cancer were evaluated using the SuperTOPFlash reporter assay. It was demonstrated that chloroxylenol, but not the other antimicrobial agents tested, inhib...
Source: International Journal of Oncology - September 8, 2023 Category: Cancer & Oncology Authors: Qi Sun Boxin Liu Quanxue Lan Zijie Su Qiuxia Fu Lian Wang Yingying Deng Chuanli Li Vivian Weiwen Xue Shanshan Liu Xianxiong Chen Guowu Yang Desheng Lu Source Type: research
Circular RNAs in osteosarcoma: An update of recent studies (Review)
Int J Oncol. 2023 Nov;63(5):123. doi: 10.3892/ijo.2023.5571. Epub 2023 Sep 8.ABSTRACTOsteosarcoma (OS) prevailing in children and adolescents mainly occurs at the metaphysis of long bones. As it is associated with a high invasive and metastatic ability, resistance to chemotherapy, and a low 5‑year survival rate, the diagnosis and treatment of OS post a global healthy issue. Over the past decades, RNA biology has shed new light onto the pathogenesis of OS. As a type of non‑coding RNAs, circular RNAs (circRNAs) have been found to play crucial roles in cellular activities. Recently, a large number of circRNAs have been id...
Source: International Journal of Oncology - September 8, 2023 Category: Cancer & Oncology Authors: Le Zeng Longzhou Liu Wen-Juan Ni Fuhua Xie Xiao-Min Leng Source Type: research
Anti ‑PD‑1/PD‑L1 and anti‑CTLA‑4 associated checkpoint inhibitor pneumonitis in non‑small cell lung cancer: Occurrence, pathogenesis and risk factors (Review)
Int J Oncol. 2023 Nov;63(5):122. doi: 10.3892/ijo.2023.5570. Epub 2023 Sep 8.ABSTRACTImmune checkpoint inhibitors (ICIs) play a significant anti‑tumor role in the management of non‑small cell lung cancer. The most broadly used ICIs are anti‑programmed death 1 (PD‑1), anti‑programmed cell death‑ligand 1, and anti‑cytotoxic T lymphocyte‑associated antigen‑4 monoclonal antibody. Compared with traditional chemotherapy, ICIs have the advantages of greater efficiency and more specific targeting. However, the resulting immune‑related adverse events limit the clinical application of ICIs, especially checkpoint ...
Source: International Journal of Oncology - September 8, 2023 Category: Cancer & Oncology Authors: Xiao Hu Jin Ren Qianfei Xue Rumei Luan Dongyan Ding Jie Tan Xin Su Junling Yang Source Type: research
Antimicrobial agent chloroxylenol targets β‑catenin‑mediated Wnt signaling and exerts anticancer activity in colorectal cancer
Int J Oncol. 2023 Nov;63(5):121. doi: 10.3892/ijo.2023.5569. Epub 2023 Sep 8.ABSTRACTChloroxylenol is the active ingredient of the antibacterial agent Dettol. The anticancer effect and underlying mechanisms of this compound and other common antimicrobial agents have not been clearly elucidated. In the present study, the effects of chloroxylenol, benzalkonium chloride, benzethonium chloride, triclosan and triclocarban on β‑catenin‑mediated Wnt signaling in colorectal cancer were evaluated using the SuperTOPFlash reporter assay. It was demonstrated that chloroxylenol, but not the other antimicrobial agents tested, inhib...
Source: International Journal of Oncology - September 8, 2023 Category: Cancer & Oncology Authors: Qi Sun Boxin Liu Quanxue Lan Zijie Su Qiuxia Fu Lian Wang Yingying Deng Chuanli Li Vivian Weiwen Xue Shanshan Liu Xianxiong Chen Guowu Yang Desheng Lu Source Type: research
Circular RNAs in osteosarcoma: An update of recent studies (Review)
Int J Oncol. 2023 Nov;63(5):123. doi: 10.3892/ijo.2023.5571. Epub 2023 Sep 8.ABSTRACTOsteosarcoma (OS) prevailing in children and adolescents mainly occurs at the metaphysis of long bones. As it is associated with a high invasive and metastatic ability, resistance to chemotherapy, and a low 5‑year survival rate, the diagnosis and treatment of OS post a global healthy issue. Over the past decades, RNA biology has shed new light onto the pathogenesis of OS. As a type of non‑coding RNAs, circular RNAs (circRNAs) have been found to play crucial roles in cellular activities. Recently, a large number of circRNAs have been id...
Source: International Journal of Oncology - September 8, 2023 Category: Cancer & Oncology Authors: Le Zeng Longzhou Liu Wen-Juan Ni Fuhua Xie Xiao-Min Leng Source Type: research
Anti ‑PD‑1/PD‑L1 and anti‑CTLA‑4 associated checkpoint inhibitor pneumonitis in non‑small cell lung cancer: Occurrence, pathogenesis and risk factors (Review)
Int J Oncol. 2023 Nov;63(5):122. doi: 10.3892/ijo.2023.5570. Epub 2023 Sep 8.ABSTRACTImmune checkpoint inhibitors (ICIs) play a significant anti‑tumor role in the management of non‑small cell lung cancer. The most broadly used ICIs are anti‑programmed death 1 (PD‑1), anti‑programmed cell death‑ligand 1, and anti‑cytotoxic T lymphocyte‑associated antigen‑4 monoclonal antibody. Compared with traditional chemotherapy, ICIs have the advantages of greater efficiency and more specific targeting. However, the resulting immune‑related adverse events limit the clinical application of ICIs, especially checkpoint ...
Source: International Journal of Oncology - September 8, 2023 Category: Cancer & Oncology Authors: Xiao Hu Jin Ren Qianfei Xue Rumei Luan Dongyan Ding Jie Tan Xin Su Junling Yang Source Type: research
