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Source: International Journal of Oncology
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Corrigendum Dexamethasone-induced inhibition of miR-132 via methylation promotes TGF- β-driven progression of pancreatic cancer
Int J Oncol. 2023 Aug;63(2):95. doi: 10.3892/ijo.2023.5543. Epub 2023 Jul 7.ABSTRACTSubsequently to the publication of the above article, an interested reader drew to the authors' attention that two pairs of the culture plate images in Fig. 4A-C on p. 60 appeared to be the same, although the images were shown in different orientations; moreover, the 'NC/0 and DEX+miR132' and 'DEX and miR132' pairings of images in the scratch-wound assay experiments shown in Fig. 4B also appeared to be overlapping, such that these were apparently derived from the same original source where the results of differently performed experiments we...
Source: International Journal of Oncology - July 7, 2023 Category: Cancer & Oncology Authors: Alia Abukiwan Clifford C Nwaeburu Nathalie Bauer Zhefu Zhao Li Liu Jury Gladkich Wolfgang Gross Axel Benner Oliver Strobel J örg Fellenberg Ingrid Herr Source Type: research
Overexpression of SERPINA3 suppresses tumor progression by modulating SPOP/NF ‑κB in lung cancer
Int J Oncol. 2023 Aug;63(2):96. doi: 10.3892/ijo.2023.5544. Epub 2023 Jul 7.ABSTRACTThe pathogenesis mechanism of lung cancer is very complex, with high incidence and mortality. Serpin family A member 3 (SERPINA3) expression levels were reduced in the sera of patients with lung cancer and may be a candidate diagnostic and prognostic survival biomarker in lung cancer, as previously reported. However, the detailed biological functions of SERPINA3 in the pathogenesis of lung cancer remain unknown. In the present study, it was aimed to explore the effects of SERPINA3 on the occurrence of lung cancer. SERPINA3 expression was as...
Source: International Journal of Oncology - July 7, 2023 Category: Cancer & Oncology Authors: Yanxia Jin Yueyang Zhang Ankang Huang Ying Chen Jinsong Wang Na Liu Xianping Wang Yongsheng Gong Weidong Wang Jicheng Pan Source Type: research
Immunotherapy for nasopharyngeal carcinoma: Current status and prospects (Review)
Int J Oncol. 2023 Aug;63(2):97. doi: 10.3892/ijo.2023.5545. Epub 2023 Jul 7.ABSTRACTNasopharyngeal carcinoma (NPC) is an epithelial tumor located in the nasopharynx and is highly associated with Epstein‑Barr virus (EBV) infection. Although radiotherapy alone can cure ~90% of patients with early‑stage disease, >70% of patients with NPC have locoregionally advanced or metastatic disease at the first diagnosis due to the insidious and aggressive nature of NPC. After comprehensive radiochemotherapy, 20‑30% of patients with advanced NPC still fail treatment, mainly due to recurrence and/or metastasis (R/M). Conventiona...
Source: International Journal of Oncology - July 7, 2023 Category: Cancer & Oncology Authors: Huageng Huang Yuyi Yao Xinyi Deng Zongyao Huang Yungchang Chen Zhao Wang Huangming Hong He Huang Tongyu Lin Source Type: research
Corrigendum Dexamethasone-induced inhibition of miR-132 via methylation promotes TGF- β-driven progression of pancreatic cancer
Int J Oncol. 2023 Aug;63(2):95. doi: 10.3892/ijo.2023.5543. Epub 2023 Jul 7.ABSTRACTSubsequently to the publication of the above article, an interested reader drew to the authors' attention that two pairs of the culture plate images in Fig. 4A-C on p. 60 appeared to be the same, although the images were shown in different orientations; moreover, the 'NC/0 and DEX+miR132' and 'DEX and miR132' pairings of images in the scratch-wound assay experiments shown in Fig. 4B also appeared to be overlapping, such that these were apparently derived from the same original source where the results of differently performed experiments we...
Source: International Journal of Oncology - July 7, 2023 Category: Cancer & Oncology Authors: Alia Abukiwan Clifford C Nwaeburu Nathalie Bauer Zhefu Zhao Li Liu Jury Gladkich Wolfgang Gross Axel Benner Oliver Strobel J örg Fellenberg Ingrid Herr Source Type: research
Overexpression of SERPINA3 suppresses tumor progression by modulating SPOP/NF ‑κB in lung cancer
Int J Oncol. 2023 Aug;63(2):96. doi: 10.3892/ijo.2023.5544. Epub 2023 Jul 7.ABSTRACTThe pathogenesis mechanism of lung cancer is very complex, with high incidence and mortality. Serpin family A member 3 (SERPINA3) expression levels were reduced in the sera of patients with lung cancer and may be a candidate diagnostic and prognostic survival biomarker in lung cancer, as previously reported. However, the detailed biological functions of SERPINA3 in the pathogenesis of lung cancer remain unknown. In the present study, it was aimed to explore the effects of SERPINA3 on the occurrence of lung cancer. SERPINA3 expression was as...
Source: International Journal of Oncology - July 7, 2023 Category: Cancer & Oncology Authors: Yanxia Jin Yueyang Zhang Ankang Huang Ying Chen Jinsong Wang Na Liu Xianping Wang Yongsheng Gong Weidong Wang Jicheng Pan Source Type: research
Immunotherapy for nasopharyngeal carcinoma: Current status and prospects (Review)
Int J Oncol. 2023 Aug;63(2):97. doi: 10.3892/ijo.2023.5545. Epub 2023 Jul 7.ABSTRACTNasopharyngeal carcinoma (NPC) is an epithelial tumor located in the nasopharynx and is highly associated with Epstein‑Barr virus (EBV) infection. Although radiotherapy alone can cure ~90% of patients with early‑stage disease, >70% of patients with NPC have locoregionally advanced or metastatic disease at the first diagnosis due to the insidious and aggressive nature of NPC. After comprehensive radiochemotherapy, 20‑30% of patients with advanced NPC still fail treatment, mainly due to recurrence and/or metastasis (R/M). Conventiona...
Source: International Journal of Oncology - July 7, 2023 Category: Cancer & Oncology Authors: Huageng Huang Yuyi Yao Xinyi Deng Zongyao Huang Yungchang Chen Zhao Wang Huangming Hong He Huang Tongyu Lin Source Type: research
Corrigendum Dexamethasone-induced inhibition of miR-132 via methylation promotes TGF- β-driven progression of pancreatic cancer
Int J Oncol. 2023 Aug;63(2):95. doi: 10.3892/ijo.2023.5543. Epub 2023 Jul 7.ABSTRACTSubsequently to the publication of the above article, an interested reader drew to the authors' attention that two pairs of the culture plate images in Fig. 4A-C on p. 60 appeared to be the same, although the images were shown in different orientations; moreover, the 'NC/0 and DEX+miR132' and 'DEX and miR132' pairings of images in the scratch-wound assay experiments shown in Fig. 4B also appeared to be overlapping, such that these were apparently derived from the same original source where the results of differently performed experiments we...
Source: International Journal of Oncology - July 7, 2023 Category: Cancer & Oncology Authors: Alia Abukiwan Clifford C Nwaeburu Nathalie Bauer Zhefu Zhao Li Liu Jury Gladkich Wolfgang Gross Axel Benner Oliver Strobel J örg Fellenberg Ingrid Herr Source Type: research
Overexpression of SERPINA3 suppresses tumor progression by modulating SPOP/NF ‑κB in lung cancer
Int J Oncol. 2023 Aug;63(2):96. doi: 10.3892/ijo.2023.5544. Epub 2023 Jul 7.ABSTRACTThe pathogenesis mechanism of lung cancer is very complex, with high incidence and mortality. Serpin family A member 3 (SERPINA3) expression levels were reduced in the sera of patients with lung cancer and may be a candidate diagnostic and prognostic survival biomarker in lung cancer, as previously reported. However, the detailed biological functions of SERPINA3 in the pathogenesis of lung cancer remain unknown. In the present study, it was aimed to explore the effects of SERPINA3 on the occurrence of lung cancer. SERPINA3 expression was as...
Source: International Journal of Oncology - July 7, 2023 Category: Cancer & Oncology Authors: Yanxia Jin Yueyang Zhang Ankang Huang Ying Chen Jinsong Wang Na Liu Xianping Wang Yongsheng Gong Weidong Wang Jicheng Pan Source Type: research
Immunotherapy for nasopharyngeal carcinoma: Current status and prospects (Review)
Int J Oncol. 2023 Aug;63(2):97. doi: 10.3892/ijo.2023.5545. Epub 2023 Jul 7.ABSTRACTNasopharyngeal carcinoma (NPC) is an epithelial tumor located in the nasopharynx and is highly associated with Epstein‑Barr virus (EBV) infection. Although radiotherapy alone can cure ~90% of patients with early‑stage disease, >70% of patients with NPC have locoregionally advanced or metastatic disease at the first diagnosis due to the insidious and aggressive nature of NPC. After comprehensive radiochemotherapy, 20‑30% of patients with advanced NPC still fail treatment, mainly due to recurrence and/or metastasis (R/M). Conventiona...
Source: International Journal of Oncology - July 7, 2023 Category: Cancer & Oncology Authors: Huageng Huang Yuyi Yao Xinyi Deng Zongyao Huang Yungchang Chen Zhao Wang Huangming Hong He Huang Tongyu Lin Source Type: research
Corrigendum Dexamethasone-induced inhibition of miR-132 via methylation promotes TGF- β-driven progression of pancreatic cancer
Int J Oncol. 2023 Aug;63(2):95. doi: 10.3892/ijo.2023.5543. Epub 2023 Jul 7.ABSTRACTSubsequently to the publication of the above article, an interested reader drew to the authors' attention that two pairs of the culture plate images in Fig. 4A-C on p. 60 appeared to be the same, although the images were shown in different orientations; moreover, the 'NC/0 and DEX+miR132' and 'DEX and miR132' pairings of images in the scratch-wound assay experiments shown in Fig. 4B also appeared to be overlapping, such that these were apparently derived from the same original source where the results of differently performed experiments we...
Source: International Journal of Oncology - July 7, 2023 Category: Cancer & Oncology Authors: Alia Abukiwan Clifford C Nwaeburu Nathalie Bauer Zhefu Zhao Li Liu Jury Gladkich Wolfgang Gross Axel Benner Oliver Strobel J örg Fellenberg Ingrid Herr Source Type: research
Overexpression of SERPINA3 suppresses tumor progression by modulating SPOP/NF ‑κB in lung cancer
Int J Oncol. 2023 Aug;63(2):96. doi: 10.3892/ijo.2023.5544. Epub 2023 Jul 7.ABSTRACTThe pathogenesis mechanism of lung cancer is very complex, with high incidence and mortality. Serpin family A member 3 (SERPINA3) expression levels were reduced in the sera of patients with lung cancer and may be a candidate diagnostic and prognostic survival biomarker in lung cancer, as previously reported. However, the detailed biological functions of SERPINA3 in the pathogenesis of lung cancer remain unknown. In the present study, it was aimed to explore the effects of SERPINA3 on the occurrence of lung cancer. SERPINA3 expression was as...
Source: International Journal of Oncology - July 7, 2023 Category: Cancer & Oncology Authors: Yanxia Jin Yueyang Zhang Ankang Huang Ying Chen Jinsong Wang Na Liu Xianping Wang Yongsheng Gong Weidong Wang Jicheng Pan Source Type: research
Immunotherapy for nasopharyngeal carcinoma: Current status and prospects (Review)
Int J Oncol. 2023 Aug;63(2):97. doi: 10.3892/ijo.2023.5545. Epub 2023 Jul 7.ABSTRACTNasopharyngeal carcinoma (NPC) is an epithelial tumor located in the nasopharynx and is highly associated with Epstein‑Barr virus (EBV) infection. Although radiotherapy alone can cure ~90% of patients with early‑stage disease, >70% of patients with NPC have locoregionally advanced or metastatic disease at the first diagnosis due to the insidious and aggressive nature of NPC. After comprehensive radiochemotherapy, 20‑30% of patients with advanced NPC still fail treatment, mainly due to recurrence and/or metastasis (R/M). Conventiona...
Source: International Journal of Oncology - July 7, 2023 Category: Cancer & Oncology Authors: Huageng Huang Yuyi Yao Xinyi Deng Zongyao Huang Yungchang Chen Zhao Wang Huangming Hong He Huang Tongyu Lin Source Type: research
RPL27 contributes to colorectal cancer proliferation and stemness via PLK1 signaling
Int J Oncol. 2023 Aug;63(2):93. doi: 10.3892/ijo.2023.5541. Epub 2023 Jun 30.ABSTRACTAlthough expression of ribosomal protein L27 (RPL27) is upregulated in clinical colorectal cancer (CRC) tissue, to the best of our knowledge, the oncogenic role of RPL27 has not yet been defined. The present study aimed to investigate whether targeting RPL27 could alter CRC progression and determine whether RPL27 gains an extra‑ribosomal function during CRC development. Human CRC cell lines HCT116 and HT29 were transfected with RPL27‑specific small interfering RNA and proliferation was assessed in vitro and in vivo using proliferation ...
Source: International Journal of Oncology - June 30, 2023 Category: Cancer & Oncology Authors: So-Young Park Daekwan Seo Eun-Hye Jeon Jee Young Park Byeong-Churl Jang Jee In Kim Seung-Soon Im Jae-Ho Lee Shin Kim Chi Heum Cho Yun-Han Lee Source Type: research
DYRK1A-mediated PLK2 phosphorylation regulates the proliferation and invasion of glioblastoma cells
Int J Oncol. 2023 Aug;63(2):94. doi: 10.3892/ijo.2023.5542. Epub 2023 Jun 30.ABSTRACTPolo-like kinases (PLKs) are a family of serine-threonine kinases that exert regulatory effects on diverse cellular processes. Dysregulation of PLKs has been implicated in multiple cancers, including glioblastoma (GBM). Notably, PLK2 expression in GBM tumor tissue is lower than that in normal brains. Notably, high PLK2 expression is significantly correlated with poor prognosis. Thus, it can be inferred that PLK2 expression alone may not be sufficient for accurate prognosis evaluation, and there are unknown mechanisms underlying PLK2 regula...
Source: International Journal of Oncology - June 30, 2023 Category: Cancer & Oncology Authors: Shichuan Tan Juan Zhao Pin Wang Source Type: research
Deactivation of glycogen synthase kinase-3 β by heat shock‑inducible tumor small protein attenuates hyperthermia‑induced pro‑migratory activity in colorectal cancer cells
Int J Oncol. 2023 Aug;63(2):92. doi: 10.3892/ijo.2023.5540. Epub 2023 Jun 30.ABSTRACTHyperthermia is a promising approach for improving cancer treatment in combination with chemotherapy, radiotherapy and/or immunotherapy; however, its molecular mechanisms remain unclear. Although heat shock proteins (HSPs) are involved in hyperthermia via antigen presentation and immune activation, major HSPs including HSP90 are associated with cancer progression via tumor cell migration and metastasis. The present study showed that heat shock‑inducible tumor small protein (HITS) could counteract the pro‑migratory effects of HSPs in co...
Source: International Journal of Oncology - June 30, 2023 Category: Cancer & Oncology Authors: Keita Koizumi Takahiro Domoto Toshinari Minamoto Kazuhito Satomura Hideo Nakajima Source Type: research
