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Source: International Journal of Oncology
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Total 2365 results found since Jan 2013.
Roles of salt ‑inducible kinases in cancer (Review)
Int J Oncol. 2023 Nov;63(5):118. doi: 10.3892/ijo.2023.5566. Epub 2023 Sep 1.ABSTRACTSalt inducible kinases (SIKs) with three subtypes SIK1, SIK2 and SIK3, belong to the AMP‑activated protein kinase family. They are expressed ubiquitously in humans. Under normal circumstances, SIK1 regulates adrenocortical function in response to high salt or adrenocorticotropic hormone stimulation, SIK2 is involved in cell metabolism, controlling insulin signaling and gluconeogenesis and SIK3 coordinates with the mTOR complex, promoting cancer. The dysregulation of SIKs has been widely detected in various types of cancers. Based on most...
Source: International Journal of Oncology - September 1, 2023 Category: Cancer & Oncology Authors: Shenghui Feng Fangyi Wei Haoran Shi Shen Chen Bangqi Wang Deqiang Huang Lingyu Luo Source Type: research
RYBP contributes to improved prognosis in colorectal cancer via regulation of cell cycle, apoptosis and oxaliplatin sensitivity
Int J Oncol. 2023 Nov;63(5):120. doi: 10.3892/ijo.2023.5568. Epub 2023 Sep 1.ABSTRACTRing1 and YY‑1 binding protein (RYBP) is a member of the polycomb repressive complex 1 and serves as a transcriptional suppressor via epigenetic modification. RYBP has a tumour‑suppressive role in solid tumours, but its function in colorectal cancer (CRC) remains unknown. The present study evaluated the expression of RYBP using immunohistochemistry in 140 cases of primary CRC and 11 patient‑matched cases of liver metastases. Using CRC cell lines with different TP53 gene status such as HCT116 (TP53wt/wt), HCT116 (TP53‑/‑), SW48 an...
Source: International Journal of Oncology - September 1, 2023 Category: Cancer & Oncology Authors: Takashi Morinaka Nozomu Sakai Tsukasa Takayashiki Satoshi Kuboki Shigetsugu Takano Gaku Ohira Hisahiro Matsubara Masayuki Ohtsuka Source Type: research
Human cytomegalovirus infection enhances 5 ‑lipoxygenase and cycloxygenase‑2 expression in colorectal cancer
Int J Oncol. 2023 Nov;63(5):116. doi: 10.3892/ijo.2023.5564. Epub 2023 Sep 1.ABSTRACTColorectal cancer (CRC) is one of the most common and fatal types of cancer. Inflammation promotes CRC development, however, the underlying etiological factors are unknown. Human cytomegalovirus (HCMV), a virus that induces inflammation and other cancer hallmarks, has been detected in several types of malignancy, including CRC. The present study investigated whether HCMV infection was associated with expression of the pro‑inflammatory enzymes 5‑lipoxygenase (5‑LO) and cyclooxygenase‑2 (COX‑2) and other molecular, genetic and clin...
Source: International Journal of Oncology - September 1, 2023 Category: Cancer & Oncology Authors: Mattia Russel Pantalone Nerea Martin Almazan Rossano Lattanzio Chato Taher Simone De Fabritiis Silvia Valentinuzzi Faraz Bishehsari Mahboobeh Mahdavinia Fabio Verginelli Afsar Rahbar Renato Mariani-Costantini Cecilia S öderberg-Naucler Source Type: research
CHCHD2 mediates glioblastoma cell proliferation, mitochondrial metabolism, hypoxia ‑induced invasion and therapeutic resistance
Int J Oncol. 2023 Nov;63(5):117. doi: 10.3892/ijo.2023.5565. Epub 2023 Sep 1.ABSTRACTGlioblastoma (GBM) is the most common and malignant primary brain tumor affecting adults and remains incurable. The mitochondrial coiled‑coil‑helix‑coiled‑coil‑helix domain‑containing protein 2 (CHCHD2) has been demonstrated to mediate mitochondrial respiration, nuclear gene expression and cell migration; however, evidence of this in GBM is lacking. In the present study, it was hypothesized that CHCHD2 may play a functional role in U87 GBM cells expressing the constitutively active epidermal growth factor receptor variant III (...
Source: International Journal of Oncology - September 1, 2023 Category: Cancer & Oncology Authors: Jan C Lumibao Payton L Haak Vladimir L Kolossov Jee-Wei Emily Chen Jeremy Stutchman Alejandra Ruiz Mayandi Sivaguru Jann N Sarkaria Brendan A C Harley Andrew J Steelman H Rex Gaskins Source Type: research
Mechanism of multidrug resistance to chemotherapy mediated by P ‑glycoprotein (Review)
Int J Oncol. 2023 Nov;63(5):119. doi: 10.3892/ijo.2023.5567. Epub 2023 Sep 1.ABSTRACTMultidrug resistance (MDR) seriously limits the clinical application of chemotherapy. A mechanism underlying MDR is the overexpression of efflux transporters associated with chemotherapeutic drugs. P‑glycoprotein (P‑gp) is an ATP‑binding cassette (ABC) transporter, which promotes MDR by pumping out chemotherapeutic drugs and reducing their intracellular concentration. To date, overexpression of P‑gp has been detected in various types of chemoresistant cancer and inhibiting P‑gp‑related MDR has been suggested. The present review...
Source: International Journal of Oncology - September 1, 2023 Category: Cancer & Oncology Authors: Yichen Tian Yongrong Lei Yani Wang Jiejuan Lai Jianhua Wang Feng Xia Source Type: research
Tumour follower cells: A novel driver of leader cells in collective invasion (Review)
Int J Oncol. 2023 Oct;63(4):115. doi: 10.3892/ijo.2023.5563. Epub 2023 Aug 24.ABSTRACTCollective cellular invasion in malignant tumours is typically characterized by the cooperative migration of multiple cells in close proximity to each other. Follower cells are led away from the tumour by specialized leader cells, and both cell populations play a crucial role in collective invasion. Follower cells form the main body of the migration system and depend on intercellular contact for migration, whereas leader cells indicate the direction for the entire cell population. Although collective invasion can occur in epithelial and n...
Source: International Journal of Oncology - August 24, 2023 Category: Cancer & Oncology Authors: Xiao-Chen Wang Ya-Ling Tang Xin-Hua Liang Source Type: research
Lnc ‑RGS5 sponges miR‑542‑5p to promote FoxM1/VEGFA signaling and breast cancer cell proliferation
Int J Oncol. 2023 Oct;63(4):111. doi: 10.3892/ijo.2023.5559. Epub 2023 Aug 18.ABSTRACTBreast cancer (BRCA) exhibits a high incidence rate among women worldwide. LOC127814295 (ENSG00000232995), termed long non‑coding (lnc)‑regulator of G protein signaling 5 (RGS5), is a novel lncRNA with a genomic region overlapping with protein‑coding gene RGS5. Results obtained using The Cancer Genome Atlas demonstrated that lnc‑RGS5 was deregulated in diverse cancer types, including BRCA; however, the functional role of lnc‑RGS5 remains unclear. Results of the present study demonstrated that lnc‑RGS5 was upregulated in BRCA t...
Source: International Journal of Oncology - August 18, 2023 Category: Cancer & Oncology Authors: Jing Song Yongyao Tang Fangzhou Song Source Type: research
RNA binding proteins in extracellular vesicles and their potential value for cancer diagnosis and treatment (Review)
Int J Oncol. 2023 Oct;63(4):114. doi: 10.3892/ijo.2023.5562. Epub 2023 Aug 18.ABSTRACTExtracellular vesicles (EVs) are spherical bilayer membrane vesicles released by cells into extracellular spaces and body fluids, including plasma and synovial fluid. EV cargo comprises various biomolecules, such as proteins, DNA, mRNAs, non‑coding RNAs, lipids and metabolites. By delivering these bioactive molecules to recipient cells, EVs mediate intercellular communications and play a critical role in maintaining cellular homeostasis and promoting pathological progression. Of note, cells can selectively sort these bioactive molecules...
Source: International Journal of Oncology - August 18, 2023 Category: Cancer & Oncology Authors: Weichao Sun Hanwei Cui Tianhao Xu Jiaji Yue Jianhui Liang Wei You Wei Sun Qian Yi Source Type: research
USP35 promotes hepatocellular carcinoma progression by protecting PKM2 from ubiquitination ‑mediated degradation
Int J Oncol. 2023 Oct;63(4):113. doi: 10.3892/ijo.2023.5561. Epub 2023 Aug 18.ABSTRACTHepatocellular carcinoma (HCC) is the most frequently diagnosed primary liver cancer with a high mortality rate and imposes a huge burden on patients and society. Recently, ubiquitin‑specific protease 35 (USP35) was found to be involved in cell proliferation and mitosis, but its role in HCC remains largely unknown. The expression of USP35 in HCC and its association with patient prognosis in the study cohort and public databases was analyzed in the present study. The effects of USP35 on the malignant biological behavior of HCC were analy...
Source: International Journal of Oncology - August 18, 2023 Category: Cancer & Oncology Authors: Tao Lv Bo Zhang Chenghao Jiang Qiwen Zeng Jiayin Yang Yongjie Zhou Source Type: research
RBM15 ‑mediating MDR1 mRNA m < sup > 6 < /sup > A methylation regulated by the TGF ‑β signaling pathway in paclitaxel‑resistant ovarian cancer
Int J Oncol. 2023 Oct;63(4):112. doi: 10.3892/ijo.2023.5560. Epub 2023 Aug 18.ABSTRACTOvarian cancer (OC) lacks effective biomarkers for diagnosis at an early stage and often develops chemoresistance after the initial treatment at an advanced stage. RNA‑binding motif protein 15 (RBM15) is an RNA m6A methylation mediator that serves an oncogenic role in some cancers. However, the function and molecular mechanisms of RBM15 in ovarian tumorigenesis and chemoresistance remain to be elucidated. The present study identified the overexpression of RBM15 in OC tissues and paclitaxel (PTX)‑resistant cells using reverse transcrip...
Source: International Journal of Oncology - August 18, 2023 Category: Cancer & Oncology Authors: Jia Yuan Wencai Guan Xin Li Fanchen Wang Huiqiang Liu Guoxiong Xu Source Type: research
