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Source: International Journal of Oncology
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Total 2365 results found since Jan 2013.
Activated < em > KRAS < /em > reprograms neural progenitor cells to glioma stem cell ‑like phenotype
Int J Oncol. 2023 Jul;63(1):88. doi: 10.3892/ijo.2023.5536. Epub 2023 Jun 16.ABSTRACTGlioma is the most common primary brain tumor. Glioma stem cells (GSCs) are the origin of gliomagenesis and may develop from normal neural progenitor cells (NPCs). However, how neoplastic transformation occurs in normal NPCs and the role of the Ras/Raf/MAPK pathway in NPC transformation is unclear. The present study generated NPCs from human embryonic stem cells (ESCs) carrying gene alterations in the Ras/Raf/MAPK pathway. The CCK‑8 proliferation, single‑cell clonal expansion, cell migration, RT‑qPCR, immunofluorescence staining, wes...
Source: International Journal of Oncology - June 16, 2023 Category: Cancer & Oncology Authors: Zixi Qin Weiye Liang Zixuan Zhang Peiwen Li Tianyu Wang Qianyu Chen Baoyin Guo Ying Zhong Hui Kang Lihui Wang Source Type: research
New developments in the mechanism and application of immune checkpoint inhibitors in cancer therapy (Review)
Int J Oncol. 2023 Jul;63(1):86. doi: 10.3892/ijo.2023.5534. Epub 2023 Jun 16.ABSTRACTThe use of immune checkpoint inhibitors (ICIs) has been demonstrated in the treatment of numerous types of cancer and ICIs have remained a key focus of cancer research. However, improvements in survival rates only occur in a subset of patients, due to the complexity of drug resistance. Therefore, further investigations are required to identify predictive biomarkers that distinguish responders and non‑responders. Combined therapeutics involving ICIs and other modalities demonstrate potential in overcoming resistance to ICIs; however, furt...
Source: International Journal of Oncology - June 16, 2023 Category: Cancer & Oncology Authors: Yanjun Wang Shuo Yang Li Wan Wei Ling Hao Chen Jinghua Wang Source Type: research
Histone lysine demethylase 3B regulates autophagy via transcriptional regulation of < em > GABARAPL1 < /em > in acute myeloid leukemia cells
Int J Oncol. 2023 Jul;63(1):87. doi: 10.3892/ijo.2023.5535. Epub 2023 Jun 16.ABSTRACTMacroautophagy (hereafter referred to as autophagy) is a highly conserved self‑digestion process that is critical for maintaining homeostasis in response to various stresses. The autophagy‑related protein family, including the GABA type A receptor‑associated protein (GABARAP) and microtubule‑associated protein 1 light chain 3 subfamilies, is crucial for autophagosome biogenesis. Although the regulatory machinery of autophagy in the cytoplasm has been widely studied, its transcriptional and epigenetic regulatory mechanisms still req...
Source: International Journal of Oncology - June 16, 2023 Category: Cancer & Oncology Authors: Ying Song Jiaqi Zhang Haihua Wang Haiying Wang Yong Liu Zhenbo Hu Source Type: research
Corrigendum Curcumin reverses benzidine-induced epithelial-mesenchymal transition via suppression of ERK5/AP-1 in SV-40 immortalized human urothelial cells
Int J Oncol. 2023 Jul;63(1):85. doi: 10.3892/ijo.2023.5533. Epub 2023 Jun 16.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, for the Transwell invasion assays shown in Fig. 5D on p. 1326, the images selected for the '0 μM benzidine / 0 μM curcumin' and '0 μM benzidine / 1 μM curcumin' experiments were overlapping, such that these data appeared to have been derived from the same original source. After having consulted their original data, the authors have realized that the '0 μM benzidine / 1 μM curcumin' data panel was selected incorrectly. The revised...
Source: International Journal of Oncology - June 16, 2023 Category: Cancer & Oncology Authors: Zhiqi Liu Jie Liu Li Zhao Hao Geng Jiaxing Ma Zhiqiang Zhang Dexin Yu Caiyun Zhong Source Type: research
Activated < em > KRAS < /em > reprograms neural progenitor cells to glioma stem cell ‑like phenotype
Int J Oncol. 2023 Jul;63(1):88. doi: 10.3892/ijo.2023.5536. Epub 2023 Jun 16.ABSTRACTGlioma is the most common primary brain tumor. Glioma stem cells (GSCs) are the origin of gliomagenesis and may develop from normal neural progenitor cells (NPCs). However, how neoplastic transformation occurs in normal NPCs and the role of the Ras/Raf/MAPK pathway in NPC transformation is unclear. The present study generated NPCs from human embryonic stem cells (ESCs) carrying gene alterations in the Ras/Raf/MAPK pathway. The CCK‑8 proliferation, single‑cell clonal expansion, cell migration, RT‑qPCR, immunofluorescence staining, wes...
Source: International Journal of Oncology - June 16, 2023 Category: Cancer & Oncology Authors: Zixi Qin Weiye Liang Zixuan Zhang Peiwen Li Tianyu Wang Qianyu Chen Baoyin Guo Ying Zhong Hui Kang Lihui Wang Source Type: research
New developments in the mechanism and application of immune checkpoint inhibitors in cancer therapy (Review)
Int J Oncol. 2023 Jul;63(1):86. doi: 10.3892/ijo.2023.5534. Epub 2023 Jun 16.ABSTRACTThe use of immune checkpoint inhibitors (ICIs) has been demonstrated in the treatment of numerous types of cancer and ICIs have remained a key focus of cancer research. However, improvements in survival rates only occur in a subset of patients, due to the complexity of drug resistance. Therefore, further investigations are required to identify predictive biomarkers that distinguish responders and non‑responders. Combined therapeutics involving ICIs and other modalities demonstrate potential in overcoming resistance to ICIs; however, furt...
Source: International Journal of Oncology - June 16, 2023 Category: Cancer & Oncology Authors: Yanjun Wang Shuo Yang Li Wan Wei Ling Hao Chen Jinghua Wang Source Type: research
Histone lysine demethylase 3B regulates autophagy via transcriptional regulation of < em > GABARAPL1 < /em > in acute myeloid leukemia cells
Int J Oncol. 2023 Jul;63(1):87. doi: 10.3892/ijo.2023.5535. Epub 2023 Jun 16.ABSTRACTMacroautophagy (hereafter referred to as autophagy) is a highly conserved self‑digestion process that is critical for maintaining homeostasis in response to various stresses. The autophagy‑related protein family, including the GABA type A receptor‑associated protein (GABARAP) and microtubule‑associated protein 1 light chain 3 subfamilies, is crucial for autophagosome biogenesis. Although the regulatory machinery of autophagy in the cytoplasm has been widely studied, its transcriptional and epigenetic regulatory mechanisms still req...
Source: International Journal of Oncology - June 16, 2023 Category: Cancer & Oncology Authors: Ying Song Jiaqi Zhang Haihua Wang Haiying Wang Yong Liu Zhenbo Hu Source Type: research
Corrigendum Curcumin reverses benzidine-induced epithelial-mesenchymal transition via suppression of ERK5/AP-1 in SV-40 immortalized human urothelial cells
Int J Oncol. 2023 Jul;63(1):85. doi: 10.3892/ijo.2023.5533. Epub 2023 Jun 16.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, for the Transwell invasion assays shown in Fig. 5D on p. 1326, the images selected for the '0 μM benzidine / 0 μM curcumin' and '0 μM benzidine / 1 μM curcumin' experiments were overlapping, such that these data appeared to have been derived from the same original source. After having consulted their original data, the authors have realized that the '0 μM benzidine / 1 μM curcumin' data panel was selected incorrectly. The revised...
Source: International Journal of Oncology - June 16, 2023 Category: Cancer & Oncology Authors: Zhiqi Liu Jie Liu Li Zhao Hao Geng Jiaxing Ma Zhiqiang Zhang Dexin Yu Caiyun Zhong Source Type: research
Activated < em > KRAS < /em > reprograms neural progenitor cells to glioma stem cell ‑like phenotype
Int J Oncol. 2023 Jul;63(1):88. doi: 10.3892/ijo.2023.5536. Epub 2023 Jun 16.ABSTRACTGlioma is the most common primary brain tumor. Glioma stem cells (GSCs) are the origin of gliomagenesis and may develop from normal neural progenitor cells (NPCs). However, how neoplastic transformation occurs in normal NPCs and the role of the Ras/Raf/MAPK pathway in NPC transformation is unclear. The present study generated NPCs from human embryonic stem cells (ESCs) carrying gene alterations in the Ras/Raf/MAPK pathway. The CCK‑8 proliferation, single‑cell clonal expansion, cell migration, RT‑qPCR, immunofluorescence staining, wes...
Source: International Journal of Oncology - June 16, 2023 Category: Cancer & Oncology Authors: Zixi Qin Weiye Liang Zixuan Zhang Peiwen Li Tianyu Wang Qianyu Chen Baoyin Guo Ying Zhong Hui Kang Lihui Wang Source Type: research
New developments in the mechanism and application of immune checkpoint inhibitors in cancer therapy (Review)
Int J Oncol. 2023 Jul;63(1):86. doi: 10.3892/ijo.2023.5534. Epub 2023 Jun 16.ABSTRACTThe use of immune checkpoint inhibitors (ICIs) has been demonstrated in the treatment of numerous types of cancer and ICIs have remained a key focus of cancer research. However, improvements in survival rates only occur in a subset of patients, due to the complexity of drug resistance. Therefore, further investigations are required to identify predictive biomarkers that distinguish responders and non‑responders. Combined therapeutics involving ICIs and other modalities demonstrate potential in overcoming resistance to ICIs; however, furt...
Source: International Journal of Oncology - June 16, 2023 Category: Cancer & Oncology Authors: Yanjun Wang Shuo Yang Li Wan Wei Ling Hao Chen Jinghua Wang Source Type: research
Histone lysine demethylase 3B regulates autophagy via transcriptional regulation of < em > GABARAPL1 < /em > in acute myeloid leukemia cells
Int J Oncol. 2023 Jul;63(1):87. doi: 10.3892/ijo.2023.5535. Epub 2023 Jun 16.ABSTRACTMacroautophagy (hereafter referred to as autophagy) is a highly conserved self‑digestion process that is critical for maintaining homeostasis in response to various stresses. The autophagy‑related protein family, including the GABA type A receptor‑associated protein (GABARAP) and microtubule‑associated protein 1 light chain 3 subfamilies, is crucial for autophagosome biogenesis. Although the regulatory machinery of autophagy in the cytoplasm has been widely studied, its transcriptional and epigenetic regulatory mechanisms still req...
Source: International Journal of Oncology - June 16, 2023 Category: Cancer & Oncology Authors: Ying Song Jiaqi Zhang Haihua Wang Haiying Wang Yong Liu Zhenbo Hu Source Type: research
Corrigendum Curcumin reverses benzidine-induced epithelial-mesenchymal transition via suppression of ERK5/AP-1 in SV-40 immortalized human urothelial cells
Int J Oncol. 2023 Jul;63(1):85. doi: 10.3892/ijo.2023.5533. Epub 2023 Jun 16.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, for the Transwell invasion assays shown in Fig. 5D on p. 1326, the images selected for the '0 μM benzidine / 0 μM curcumin' and '0 μM benzidine / 1 μM curcumin' experiments were overlapping, such that these data appeared to have been derived from the same original source. After having consulted their original data, the authors have realized that the '0 μM benzidine / 1 μM curcumin' data panel was selected incorrectly. The revised...
Source: International Journal of Oncology - June 16, 2023 Category: Cancer & Oncology Authors: Zhiqi Liu Jie Liu Li Zhao Hao Geng Jiaxing Ma Zhiqiang Zhang Dexin Yu Caiyun Zhong Source Type: research
Corrigendum MicroRNA ‑133b targets TGFβ receptor I to inhibit TGF‑β‑induced epithelial‑to‑mesenchymal transition and metastasis by suppressing the TGF‑β/SMAD pathway in breast cancer
Int J Oncol. 2023 Jul;63(1):83. doi: 10.3892/ijo.2023.5531. Epub 2023 Jun 9.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, for the MCF‑7 cell migration assays shown in Fig. 3C on p. 1105, the representative images selected for the 'TGF‑β+ / miR‑NC' and 'TGF‑β1‑ / miR‑NC' experiments were found to be overlapping, such that the data appeared to have been derived from the same original source. After having consulted their original data, the authors noted that the error had arisen during the process of assembling this figure, and the data chosen f...
Source: International Journal of Oncology - June 9, 2023 Category: Cancer & Oncology Authors: Shengjie Wang Mingliang Huang Zichen Wang Wan Wang Zhiyuan Zhang Shuting Qu Chun Liu Source Type: research
Exosomes from PYCR1 knockdown bone marrow mesenchymal stem inhibits aerobic glycolysis and the growth of bladder cancer cells via regulation of the EGFR/PI3K/AKT pathway
Int J Oncol. 2023 Jul;63(1):84. doi: 10.3892/ijo.2023.5532. Epub 2023 Jun 9.ABSTRACTBladder cancer (BC) is a heterogeneous disease, and pyrroline‑5‑carboxylate reductase 1 (PYCR1) can promote the proliferation and invasion of BC cells and accelerate BC progression. In the present study, si‑PYCR1 was loaded into bone marrow mesenchymal stem cell (BMSC)‑derived exosomes (Exos) in BC. First, PYCR1 levels in BC tissues/cells were assessed, and cell proliferation, invasion, and migration were evaluated. Aerobic glycolysis levels (glucose uptake, lactate production, ATP production, and the expression of relevant enzymes)...
Source: International Journal of Oncology - June 9, 2023 Category: Cancer & Oncology Authors: Zhuo Li Ying Jiang Jian Liu Huifeng Fu Quan Yang Wei Song Yuanwei Li Source Type: research
Corrigendum MicroRNA ‑133b targets TGFβ receptor I to inhibit TGF‑β‑induced epithelial‑to‑mesenchymal transition and metastasis by suppressing the TGF‑β/SMAD pathway in breast cancer
Int J Oncol. 2023 Jul;63(1):83. doi: 10.3892/ijo.2023.5531. Epub 2023 Jun 9.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that, for the MCF‑7 cell migration assays shown in Fig. 3C on p. 1105, the representative images selected for the 'TGF‑β+ / miR‑NC' and 'TGF‑β1‑ / miR‑NC' experiments were found to be overlapping, such that the data appeared to have been derived from the same original source. After having consulted their original data, the authors noted that the error had arisen during the process of assembling this figure, and the data chosen f...
Source: International Journal of Oncology - June 9, 2023 Category: Cancer & Oncology Authors: Shengjie Wang Mingliang Huang Zichen Wang Wan Wang Zhiyuan Zhang Shuting Qu Chun Liu Source Type: research
