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Source: International Journal of Oncology
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Total 2365 results found since Jan 2013.
A potential tumor marker: Chaperonin containing TCP ‑1 controls the development of malignant tumors (Review)
Int J Oncol. 2023 Sep;63(3):106. doi: 10.3892/ijo.2023.5554. Epub 2023 Aug 4.ABSTRACTDue to concealment, high invasiveness and a lack of indicators, malignant tumors have emerged as one of the deadliest diseases worldwide and their incidence is rising yearly. Research has revealed that the chaperonin family member, chaperonin containing TCP‑1 (CCT), serves a crucial role in malignant tumors. CCT is involved in the growth of numerous malignant tumors such as lung cancer, breast cancer, hepatocellular carcinoma and colorectal cancer and assists the folding of a number of proteins linked to cancer, such as KRAS, p53 and STA...
Source: International Journal of Oncology - August 4, 2023 Category: Cancer & Oncology Authors: Liming Zheng Xingyue Chen Li Zhang Nannan Qin Jiaxing An Jiaxing Zhu Hai Jin Biguang Tuo Source Type: research
Retracted SB-T-121205, a next-generation taxane, enhances apoptosis and inhibits migration/invasion in MCF-7/PTX cells
Int J Oncol. 2023 Sep;63(3):104. doi: 10.3892/ijo.2023.5552. Epub 2023 Aug 4.ABSTRACTFollowing the publication of this paper, and subsequently to a corrigendum that was published to take account of errors that had been made concerning the Transwell invasion assay data in Fig. 4B (doi: 10.3892/ijo.2022.5463), it was drawn to the Editor's attention by a concerned reader that the western blots shown in Figs. 3C and 6B shared the same control data; moreover, potential anomalies were identified in the flow cytometric plots shown in Fig. 2A. Although the authors proposed to publish a corrigendum to account for these errors, incl...
Source: International Journal of Oncology - August 4, 2023 Category: Cancer & Oncology Authors: Xiaowei Zheng Changwei Wang Yuanming Xing Siying Chen Ti Meng Haisheng You Iwao Ojima Yalin Dong Source Type: research
Artificial intelligence in cancer pathology: Challenge to meet increasing demands of precision medicine
Int J Oncol. 2023 Sep;63(3):107. doi: 10.3892/ijo.2023.5555. Epub 2023 Aug 4.ABSTRACTClinical efforts on precision medicine are driving the need for accurate diagnostic, new prognostic and novel drug predictive assays to inform patient selection and stratification for disease treatment. Accumulating evidence suggests that a combination of cancer pathology and artificial intelligence (AI) can meet this requirement. In the present review, the past, present and emerging integrations of AI into cancer pathology were comprehensively reviewed, which were divided into four main groups to highlight the roles of AI‑integrated can...
Source: International Journal of Oncology - August 4, 2023 Category: Cancer & Oncology Authors: Boan Lai Jianjiang Fu Qingxin Zhang Nan Deng Qingping Jiang Juan Peng Source Type: research
Role of miR ‑181a‑5p in cancer (Review)
Int J Oncol. 2023 Oct;63(4):108. doi: 10.3892/ijo.2023.5556. Epub 2023 Aug 4.ABSTRACTMicroRNAs (miRNAs) are non‑coding RNAs (ncRNAs) that can post‑transcriptionally suppress targeted genes. Dysregulated miRNAs are associated with a variety of diseases. MiR‑181a‑5p is a conserved miRNA with the ability to regulate pathological processes, such as angiogenesis, inflammatory response and obesity. Numerous studies have demonstrated that miR‑181a‑5p exerts regulatory influence on cancer development and progression, acting as an oncomiR or tumor inhibitor in various cancer types by impacting multiple hallmarks of tumo...
Source: International Journal of Oncology - August 4, 2023 Category: Cancer & Oncology Authors: Junxin Li Jing Shen Yueshui Zhao Fukuan Du Mingxing Li Xu Wu Yu Chen Shurong Wang Zhangang Xiao Zhigui Wu Source Type: research
IGJ suppresses breast cancer growth and metastasis by inhibiting EMT via the NF ‑κB signaling pathway
Int J Oncol. 2023 Sep;63(3):105. doi: 10.3892/ijo.2023.5553. Epub 2023 Aug 4.ABSTRACTBreast cancer metastasis is the primary cause of mortality of patients with breast cancer. The present study aimed to explore the role and underlying mechanisms of IGJ in the invasion and metastasis of breast cancer. The Cancer Genome Atlas database was utilized to analyze the differential gene expression profiles in patients with breast cancer with or without metastasis; the target gene, joining chain of multimeric IgA and IgM (JCHAIN, also known as IGJ, as referred to herein), with significant expression and with prognostic value was scr...
Source: International Journal of Oncology - August 4, 2023 Category: Cancer & Oncology Authors: Mengxue Wang Yushen Wu Xunjia Li Meng Dai Shengwei Li Source Type: research
A potential tumor marker: Chaperonin containing TCP ‑1 controls the development of malignant tumors (Review)
Int J Oncol. 2023 Sep;63(3):106. doi: 10.3892/ijo.2023.5554. Epub 2023 Aug 4.ABSTRACTDue to concealment, high invasiveness and a lack of indicators, malignant tumors have emerged as one of the deadliest diseases worldwide and their incidence is rising yearly. Research has revealed that the chaperonin family member, chaperonin containing TCP‑1 (CCT), serves a crucial role in malignant tumors. CCT is involved in the growth of numerous malignant tumors such as lung cancer, breast cancer, hepatocellular carcinoma and colorectal cancer and assists the folding of a number of proteins linked to cancer, such as KRAS, p53 and STA...
Source: International Journal of Oncology - August 4, 2023 Category: Cancer & Oncology Authors: Liming Zheng Xingyue Chen Li Zhang Nannan Qin Jiaxing An Jiaxing Zhu Hai Jin Biguang Tuo Source Type: research
Retracted SB-T-121205, a next-generation taxane, enhances apoptosis and inhibits migration/invasion in MCF-7/PTX cells
Int J Oncol. 2023 Sep;63(3):104. doi: 10.3892/ijo.2023.5552. Epub 2023 Aug 4.ABSTRACTFollowing the publication of this paper, and subsequently to a corrigendum that was published to take account of errors that had been made concerning the Transwell invasion assay data in Fig. 4B (doi: 10.3892/ijo.2022.5463), it was drawn to the Editor's attention by a concerned reader that the western blots shown in Figs. 3C and 6B shared the same control data; moreover, potential anomalies were identified in the flow cytometric plots shown in Fig. 2A. Although the authors proposed to publish a corrigendum to account for these errors, incl...
Source: International Journal of Oncology - August 4, 2023 Category: Cancer & Oncology Authors: Xiaowei Zheng Changwei Wang Yuanming Xing Siying Chen Ti Meng Haisheng You Iwao Ojima Yalin Dong Source Type: research
Artificial intelligence in cancer pathology: Challenge to meet increasing demands of precision medicine
Int J Oncol. 2023 Sep;63(3):107. doi: 10.3892/ijo.2023.5555. Epub 2023 Aug 4.ABSTRACTClinical efforts on precision medicine are driving the need for accurate diagnostic, new prognostic and novel drug predictive assays to inform patient selection and stratification for disease treatment. Accumulating evidence suggests that a combination of cancer pathology and artificial intelligence (AI) can meet this requirement. In the present review, the past, present and emerging integrations of AI into cancer pathology were comprehensively reviewed, which were divided into four main groups to highlight the roles of AI‑integrated can...
Source: International Journal of Oncology - August 4, 2023 Category: Cancer & Oncology Authors: Boan Lai Jianjiang Fu Qingxin Zhang Nan Deng Qingping Jiang Juan Peng Source Type: research
Role of miR ‑181a‑5p in cancer (Review)
Int J Oncol. 2023 Oct;63(4):108. doi: 10.3892/ijo.2023.5556. Epub 2023 Aug 4.ABSTRACTMicroRNAs (miRNAs) are non‑coding RNAs (ncRNAs) that can post‑transcriptionally suppress targeted genes. Dysregulated miRNAs are associated with a variety of diseases. MiR‑181a‑5p is a conserved miRNA with the ability to regulate pathological processes, such as angiogenesis, inflammatory response and obesity. Numerous studies have demonstrated that miR‑181a‑5p exerts regulatory influence on cancer development and progression, acting as an oncomiR or tumor inhibitor in various cancer types by impacting multiple hallmarks of tumo...
Source: International Journal of Oncology - August 4, 2023 Category: Cancer & Oncology Authors: Junxin Li Jing Shen Yueshui Zhao Fukuan Du Mingxing Li Xu Wu Yu Chen Shurong Wang Zhangang Xiao Zhigui Wu Source Type: research
A potential tumor marker: Chaperonin containing TCP ‑1 controls the development of malignant tumors (Review)
Int J Oncol. 2023 Sep;63(3):106. doi: 10.3892/ijo.2023.5554. Epub 2023 Aug 4.ABSTRACTDue to concealment, high invasiveness and a lack of indicators, malignant tumors have emerged as one of the deadliest diseases worldwide and their incidence is rising yearly. Research has revealed that the chaperonin family member, chaperonin containing TCP‑1 (CCT), serves a crucial role in malignant tumors. CCT is involved in the growth of numerous malignant tumors such as lung cancer, breast cancer, hepatocellular carcinoma and colorectal cancer and assists the folding of a number of proteins linked to cancer, such as KRAS, p53 and STA...
Source: International Journal of Oncology - August 4, 2023 Category: Cancer & Oncology Authors: Liming Zheng Xingyue Chen Li Zhang Nannan Qin Jiaxing An Jiaxing Zhu Hai Jin Biguang Tuo Source Type: research
Retracted SB-T-121205, a next-generation taxane, enhances apoptosis and inhibits migration/invasion in MCF-7/PTX cells
Int J Oncol. 2023 Sep;63(3):104. doi: 10.3892/ijo.2023.5552. Epub 2023 Aug 4.ABSTRACTFollowing the publication of this paper, and subsequently to a corrigendum that was published to take account of errors that had been made concerning the Transwell invasion assay data in Fig. 4B (doi: 10.3892/ijo.2022.5463), it was drawn to the Editor's attention by a concerned reader that the western blots shown in Figs. 3C and 6B shared the same control data; moreover, potential anomalies were identified in the flow cytometric plots shown in Fig. 2A. Although the authors proposed to publish a corrigendum to account for these errors, incl...
Source: International Journal of Oncology - August 4, 2023 Category: Cancer & Oncology Authors: Xiaowei Zheng Changwei Wang Yuanming Xing Siying Chen Ti Meng Haisheng You Iwao Ojima Yalin Dong Source Type: research
Artificial intelligence in cancer pathology: Challenge to meet increasing demands of precision medicine
Int J Oncol. 2023 Sep;63(3):107. doi: 10.3892/ijo.2023.5555. Epub 2023 Aug 4.ABSTRACTClinical efforts on precision medicine are driving the need for accurate diagnostic, new prognostic and novel drug predictive assays to inform patient selection and stratification for disease treatment. Accumulating evidence suggests that a combination of cancer pathology and artificial intelligence (AI) can meet this requirement. In the present review, the past, present and emerging integrations of AI into cancer pathology were comprehensively reviewed, which were divided into four main groups to highlight the roles of AI‑integrated can...
Source: International Journal of Oncology - August 4, 2023 Category: Cancer & Oncology Authors: Boan Lai Jianjiang Fu Qingxin Zhang Nan Deng Qingping Jiang Juan Peng Source Type: research
Role of miR ‑181a‑5p in cancer (Review)
Int J Oncol. 2023 Oct;63(4):108. doi: 10.3892/ijo.2023.5556. Epub 2023 Aug 4.ABSTRACTMicroRNAs (miRNAs) are non‑coding RNAs (ncRNAs) that can post‑transcriptionally suppress targeted genes. Dysregulated miRNAs are associated with a variety of diseases. MiR‑181a‑5p is a conserved miRNA with the ability to regulate pathological processes, such as angiogenesis, inflammatory response and obesity. Numerous studies have demonstrated that miR‑181a‑5p exerts regulatory influence on cancer development and progression, acting as an oncomiR or tumor inhibitor in various cancer types by impacting multiple hallmarks of tumo...
Source: International Journal of Oncology - August 4, 2023 Category: Cancer & Oncology Authors: Junxin Li Jing Shen Yueshui Zhao Fukuan Du Mingxing Li Xu Wu Yu Chen Shurong Wang Zhangang Xiao Zhigui Wu Source Type: research
IGJ suppresses breast cancer growth and metastasis by inhibiting EMT via the NF ‑κB signaling pathway
Int J Oncol. 2023 Sep;63(3):105. doi: 10.3892/ijo.2023.5553. Epub 2023 Aug 4.ABSTRACTBreast cancer metastasis is the primary cause of mortality of patients with breast cancer. The present study aimed to explore the role and underlying mechanisms of IGJ in the invasion and metastasis of breast cancer. The Cancer Genome Atlas database was utilized to analyze the differential gene expression profiles in patients with breast cancer with or without metastasis; the target gene, joining chain of multimeric IgA and IgM (JCHAIN, also known as IGJ, as referred to herein), with significant expression and with prognostic value was scr...
Source: International Journal of Oncology - August 4, 2023 Category: Cancer & Oncology Authors: Mengxue Wang Yushen Wu Xunjia Li Meng Dai Shengwei Li Source Type: research
