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Therapy: Gene Therapy

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Total 490 results found since Jan 2013.

Characterization of PDL1 enhanced siRNA/albumin liposome for effective therapeutic function in lung cancer
CONCLUSION: The results showed that the PDL1-targeted albumin liposome could be used as a high efficient delivery vector of siRNA, and was a high efficient and safe nano vector for tumor targeted gene therapy.PMID:35997823 | DOI:10.1007/s00432-022-04298-2
Source: Cell Research - August 23, 2022 Category: Cytology Authors: Liming Zhang Guangke Xie Xin Xiao Chao Cheng Source Type: research

Suppression of mTOR expression by siRNA leads to cell cycle arrest and apoptosis induction in MDA-MB-231 breast cancer cells
CONCLUSION: With these results, we can conclude that mTOR-siRNA exerts direct 'anti-breast cancer' activity propagated by the S6K-GSK-3β- caspase 3 mediated apoptosis and by inducing cell cycle arrest.PMID:36999418 | DOI:10.2174/1566523223666230329085606
Source: Current Gene Therapy - March 31, 2023 Category: Genetics & Stem Cells Authors: Roja Sahu Shivesh Jha Shakti Pattanayak Source Type: research

Characterization of PDL1 enhanced siRNA/albumin liposome for effective therapeutic function in lung cancer
ConclusionThe results showed that the PDL1-targeted albumin liposome could be used as a high efficient delivery vector of siRNA, and was a high efficient and safe nano vector for tumor targeted gene therapy.
Source: Journal of Cancer Research and Clinical Oncology - July 1, 2023 Category: Cancer & Oncology Source Type: research

A review of the current status of siRNA nanomedicines in the treatment of cancer.
Abstract RNA interference currently offers new opportunities for gene therapy by the specific extinction of targeted gene(s) in cancer diseases. However, the main challenge for nucleic acid delivery still remains its efficacy through intravenous administration. Over the last decade, many delivery systems have been developed and optimized to encapsulate siRNA and to specifically promote their delivery into tumor cells and improve their pharmacokinetics for anti-cancer purposes. This review aims to sum up the potential targets in numerous pathways and the properties of recently optimized siRNA synthetic nanomedicine...
Source: Biomaterials - May 30, 2013 Category: Materials Science Authors: Resnier P, Montier T, Mathieu V, Benoit JP, Passirani C Tags: Biomaterials Source Type: research

Application of Target Peptide in siRNA Delivery 
for the Research of Lung Cancer Therapy
This article will make a brief overview of target peptides applying in siRNA dilivery for the research of lung cancer treatment. DOI: 10.3779/j.issn.1009-3419.2014.09.06
Source: Chinese Journal of Lung Cancer - September 19, 2014 Category: Cancer & Oncology Source Type: research

Anticancer siRNA cocktails as a novel tool to treat cancer cells. Part (B). Efficiency of pharmacological action
Publication date: 15 May 2015 Source:International Journal of Pharmaceutics, Volume 485, Issues 1–2 Author(s): Volha Dzmitruk , Aleksandra Szulc , Dzmitry Shcharbin , Anna Janaszewska , Natallia Shcharbina , Joanna Lazniewska , Darya Novopashina , Marina Buyanova , Maksim Ionov , Barbara Klajnert-Maculewicz , Rafael Gómez-Ramirez , Serge Mignani , Jean-Pierre Majoral , Maria Angeles Muñoz-Fernández , Maria Bryszewska This paper examines a perspective to use newly engineered nanomaterials as effective and safe carriers for gene therapy of cancer. Three different groups of cationic dendrimers (PAMAM, phosphorus, and c...
Source: International Journal of Pharmaceutics - March 27, 2015 Category: Drugs & Pharmacology Source Type: research

Gold nanorod delivery of LSD1 siRNA induces human mesenchymal stem cell differentiation.
In this study, we have developed poly-sodium 4-styrenesulfonate (PSS) and poly-allylamine hydrochloride (PAH) coated AuNR-based nanocarriers, which are capable of delivering small interfering RNA (siRNA) against LSD1 to induce the differentiation of human mesenchymal stem cells. To further study the mechanism, we tested the stemness and differentiation genes and found that they have been changed with LSD1 down-regulation. In addition, with the hepatocyte growth factor (HGF), LSD1 siRNA delivery by AuNRs could promote the differentiation of the human mesenchymal stem cells (human MSCs) into a hepatocyte lineage in vitro. Ou...
Source: Appl Human Sci - June 7, 2015 Category: Physiology Authors: Zhao X, Huang Q, Jin Y Tags: Mater Sci Eng C Mater Biol Appl Source Type: research