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Proliferation-Related Features of the Human Mesenchymal Stem Cells Derived from Palatine Tonsils, Adipose Tissues, and Bone Marrow
Conclusion:Our study compared MSCs of different origins to better understand the similarities and differences among these cell types.
Source: Tissue Engineering and Regenerative Medicine - August 18, 2023 Category: Biotechnology Source Type: research

BMSCs improve TNBS-induced colitis in rats by inducing Treg differentiation by expressing PD-L1
CONCLUSIONS: We found that BMSCs can induce Treg differentiation by inhibiting the Akt/mTOR pathway via PD-L1; this significantly improved symptoms and pathology in our ulcerative colitis rat models.PMID:36261682 | DOI:10.1007/s10529-022-03307-1
Source: Biotechnology Letters - October 19, 2022 Category: Biotechnology Authors: Fei Gao Dandan Cui Dongmei Zuo Zhexing Shou Jia Yang Ting Yu Yujin Liu Si Chu Feng Zhu Chunzhu Wei Source Type: research

Novel nanocarriers for silencing anti-phagocytosis CD47 marker in acute myeloid leukemia cells
Colloids Surf B Biointerfaces. 2022 Jun 1;217:112609. doi: 10.1016/j.colsurfb.2022.112609. Online ahead of print.ABSTRACTAcute myeloid leukemia (AML), a malignant disorder of Hematopoietic stem cells, can escape immunosurveillance by over expression of the cluster of differentiation 47 (CD47) marker, which functions as an inhibitory signal, suppressing phagocytosis by binding to signal regulatory protein α (SIRPα) on macrophages. AML is treated mainly by chemotherapy, which has drastic side effects and poor outcomes for the patients. Most AML patients develop drug resistance, so other methods to treat AML are highly requ...
Source: Colloids and Surfaces - June 6, 2022 Category: Biotechnology Authors: Eman M Hassan Shan Zou Source Type: research

Newly synthesized peptide, Ara ‐27, exhibits significant improvement in cell‐penetrating ability compared to conventional peptides
In conclusion, this study describes a novel CPP, Ara‐27, which exhibit significant improvement in intracellular uptake compared to conventional CPPs, without affecting cell viability. Thus, development of Ara‐27 based peptides may lead to imp roved delivery of functional cargo such as small molecules, siRNA, and drugs forin vivo studies.This article is protected by copyright. All rights reserved.
Source: Biotechnology Progress - May 5, 2020 Category: Biotechnology Authors: Sol Min, Kichul Kim, Seockmo Ku, Jeong ‐Yoon Park, Jeongmin Seo, Sangho Roh Tags: RESEARCH ARTICLE Source Type: research

Primary Cilia Mediate Wnt5a/ β-catenin Signaling to Regulate Adipogenic Differentiation of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Following Calcium Induction
Conclusion:Our data suggested that ciliogenesis was negatively regulated by Wnt5a/ β-catenin signaling during adipogenesis. Thus, we suggest that calcium induction triggers adipogenesis and ciliogenesis.
Source: Tissue Engineering and Regenerative Medicine - January 31, 2020 Category: Biotechnology Source Type: research

FAK mediates BMP9-induced osteogenic differentiation via Wnt and MAPK signaling pathway in synovial mesenchymal stem cells.
Conclusion: FAK plays a pivotal role in promoting BMP9-induced osteogenesis of SMSCs, which is probably via activating Wnt and MAPK pathway. PMID: 31240956 [PubMed - in process]
Source: Artificial Cells, Nanomedicine and Biotechnology - June 27, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Corin is a key regulator of endochondral ossification and bone development via modulation of vascular endothelial growth factor A expression
This study tested the hypothesis that, through modulation of angiogenic signalling pathways, corin is a critical regulator of osteogenic differentiation and endochondral ossification. In vitro, corin expression in hASC was suppressed via siRNA knockdown and vascular en dothelial growth factor A (VEGF‐A) expression was quantified via reverse transcription polymerase chain reaction. In vivo, a murine corin knockout model (female, 10 weeks) was used to determine the effect of corin deficiency on long bone development. Wild‐type and corin knockout long bones were compared via haematoxylin and eosin staining to assess tiss...
Source: Journal of Tissue Engineering and Regenerative Medicine - November 22, 2018 Category: Biotechnology Authors: Rachel C. Nordberg, Hao Wang, Qingyu Wu, Elizabeth G. Loboa Tags: RESEARCH ARTICLE Source Type: research

GM-CSF Enhances Mobilization of Bone Marrow Mesenchymal Stem Cells via a CXCR4-Medicated Mechanism
Conclusion:These results suggest that GM-CSF is a useful tool for mobilizing BM MSCs into the PB.
Source: Tissue Engineering and Regenerative Medicine - November 15, 2018 Category: Biotechnology Source Type: research

Graded functionalization of biomaterial surfaces using mussel-inspired adhesive coating of polydopamine.
In this study, by controlling oxidative polymerization of dopamine, we demonstrated universal techniques for generating chemical gradients on various materials with adaptability for secondary molecule immobilization. Diffusion-controlled oxygen supply was successfully exploited for coating of polydopamine (PD) in a gradient manner on different materials, regardless of their surface chemistry, which resulted in gradient in hydrophilicity and surface roughness. The PD gradient controlled graded adhesion and spreading of human mesenchymal stem cells (hMSCs) and endothelial cells. Furthermore, the PD gradient on these surfaces...
Source: Colloids and Surfaces - August 19, 2017 Category: Biotechnology Authors: Perikamana SKM, Shin YM, Lee JK, Lee YB, Heo Y, Ahmad T, Park SY, Shin J, Park KM, Jung HS, Cho SW, Shin H Tags: Colloids Surf B Biointerfaces Source Type: research

HMGB1 enhances embryonic neural stem cell proliferation by activating the MAPK signaling pathway.
Abstract Neural stem cells (NSCs) are involved in neural tube formation. As the high-mobility group box 1 (HMGB1) protein is involved in neurulation and is present at elevated levels in neural tube defects (NTDs) induced by hyperthermia, we have now investigated the effects of HMGB1 on proliferation, differentiation, and MAPK signaling pathways of NSCs in vitro. We constructed a lentivirus vector with HMGB1 siRNA and used it to infect NSCs. Down-regulation of HMGB1 expression was confirmed. Proliferation of NSCs was determined by MTS and nestin/BrdU double-labeling. Differentiation of NSCs was assessed using β-tu...
Source: Biotechnology Letters - April 19, 2014 Category: Biotechnology Authors: Wang L, Yu L, Zhang T, Wang L, Leng Z, Guan Y, Wang X Tags: Biotechnol Lett Source Type: research