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Anti-tumor activity of olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, in cultured endometrial carcinoma cells
Conclusions: Our results suggest that olaparib, a PARP inhibitor, is effective on certain endometrial cancer cell lines. Inactivation of PTEN might not affect the DNA repair function. Predictive biomarkers are warranted to utilize olaparib in endometrial cancer.
Source: Epidemiologic Perspectives and Innovations - March 13, 2014 Category: Epidemiology Authors: Aki MiyasakaKatsutoshi OdaYuji IkedaOsamu Wada-HiraikeTomoko KashiyamaAtsushi EnomotoNoriko HosoyaTakahiro KosoTomohiko FukudaKanako InabaKenbun SoneYuriko UeharaReiko KurikawaKazunori NagasakaYoko MatsumotoTakahide ArimotoShunsuke NakagawaHiroyuki Kuramo Source Type: research

TGFbetaR2 is a major target of miR-93 in nasopharyngeal carcinoma aggressiveness
Conclusion: The present study reports an involvement of miR-93-mediated TGFbetaR2 down-regulation in NPC aggressiveness, thus giving extended insights into molecular mechanisms underlying cancer aggressiveness. Approaches aimed at blocking miR-93 may serve as a promising therapeutic strategy for treating NPC patients.
Source: Epidemiologic Perspectives and Innovations - March 8, 2014 Category: Epidemiology Authors: Xiaoming LyuWeiyi FangHang ZhengLongmei CaiYanfen YeLan ZhangJinbang liHong PengWilliam C ChoEna WangFrancesco M MarincolaKaitai YaoHongbing CaiJiliang LiXin Li Source Type: research

Peptide deformylase inhibitor actinonin reduces celastrol's HSP70 induction while synergizing proliferation inhibition in tumor cells
Conclusions: Concurrent use of the chemical agent actinonin could reduce celastrol's HSP70 elevation and also enhance proliferation inhibition by celastrol. This combination presents a novel alternative to siRNA technology and is worth further investigation for its potentially effective anti-tumor action.
Source: Epidemiologic Perspectives and Innovations - March 4, 2014 Category: Epidemiology Authors: Bin PengXue ZhangFanfan CaoYing WangLimin XuLu CaoChunxin YangMaoquan LiGeorges UzanDenghai Zhang Source Type: research

Zyflamend, a polyherbal mixture, down regulates class I and class II histone deacetylases and increases p21 levels in castrate-resistant prostate cancer cells
Conclusions: Our results suggest that the extracts of this polyherbal combination increase histone 3 acetylation, inhibit the expression of class I and class II histone deacetylases, increase the activation of CBP/p300 and inhibit cell proliferation, in part, by up regulating p21 expression.
Source: Epidemiologic Perspectives and Innovations - February 21, 2014 Category: Epidemiology Authors: E-Chu HuangYi ZhaoGuoxun ChenSeung Joon BaekMichael F McEnteeSteven MinkinJohn P BiggerstaffJay Whelan Source Type: research

CRTC2 enhances HBV transcription and replication by inducing PGC1alpha expression
Conclusions: Our results clearly indicate that non-phosphorylated CRTC2 strongly enhances HBV biosynthesis through inducing PGC1alpha expression. Further study of the mechanisms will elucidate the importance of metabolic signals on HBV transcription and replication, and offer insight into potential targets for developing anti-HBV agents.
Source: Epidemiologic Perspectives and Innovations - February 14, 2014 Category: Epidemiology Authors: Xiaohui TianFei ZhaoWeihua SunXiaoguang ZhiZhikui ChengMing ZhouKanghong Hu Source Type: research

The novel IGF-IR/Akt-dependent anticancer activities of glucosamine
Conclusions: Taken together, our results suggest that targeting the IGF-1R/Akt pathway with glucosamine may be an effective therapeutic strategy for treating some type of cancer.
Source: Epidemiologic Perspectives and Innovations - January 20, 2014 Category: Epidemiology Authors: Ki-Hoon SongJu-Hee KangJong-Kyu WooJeong-Seok NamHye-Young MinHo-Young LeeSoo-Youl KimSeung-Hyun Oh Source Type: research

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