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Specialty: Epidemiology
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Total 51 results found since Jan 2013.
miRNA/siRNA-directed pathway to produce noncoding piRNAs from endogenous protein-coding regions ensures < em > Drosophila < /em > spermatogenesis
Sci Adv. 2023 Jul 21;9(29):eadh0397. doi: 10.1126/sciadv.adh0397. Epub 2023 Jul 19.ABSTRACTPIWI-interacting RNA (piRNA) pathways control transposable elements (TEs) and endogenous genes, playing important roles in animal gamete formation. However, the underlying piRNA biogenesis mechanisms remain elusive. Here, we show that endogenous protein coding sequences (CDSs), which are normally used for translation, serve as origins of noncoding piRNA biogenesis in Drosophila melanogaster testes. The product, namely, CDS-piRNAs, formed silencing complexes with Aubergine (Aub) in germ cells. Proximity proteome and functional analyse...
Source: Adv Data - July 19, 2023 Category: Epidemiology Authors: Taichiro Iki Shinichi Kawaguchi Toshie Kai Source Type: research
Remodeling Serine Synthesis and Metabolism via Nanoparticles (NPs)-Mediated CFL1 Silencing to Enhance the Sensitivity of Hepatocellular Carcinoma to Sorafenib
Adv Sci (Weinh). 2023 May 18:e2207118. doi: 10.1002/advs.202207118. Online ahead of print.ABSTRACTTyrosine kinase inhibitors represented by sorafenib are the first-line treatment for hepatocellular carcinoma (HCC), but the low response rate of HCC patient has become a clinical pain-point. Emerging evidences have revealed that metabolic reprogramming plays an important role in regulating the sensitivity of tumor cells to various chemotherapeutics including sorafenib. However, the underlying mechanisms are very complex and are not fully elucidated. By comparing the transcriptome sequencing data of sorafenib-sensitive and -in...
Source: Adv Data - May 19, 2023 Category: Epidemiology Authors: Senlin Li Lei Xu Guo Wu Ziqi Huang Linzhuo Huang Fengqian Zhang Chunfang Wei Qian Shen Rong Li Lei Zhang Xiaoding Xu Source Type: research
Uncovering Tumor-Promoting Roles of Activin A in Pancreatic Ductal Adenocarcinoma
Adv Sci (Weinh). 2023 Apr 21:e2207010. doi: 10.1002/advs.202207010. Online ahead of print.ABSTRACTPancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with high incidence rates of metastasis and cachexia. High circulating activin A, a homodimer of inhibin βA subunits that are encoded by INHBA gene, predicts poor survival among PDAC patients. However, it still raises the question of whether activin A suppression renders favorable PDAC outcomes. Here, the authors demonstrate that activin A is abundantly detected in tumor and stromal cells on PDAC tissue microarray and mouse PDAC sections. In orthotopic ...
Source: Adv Data - April 21, 2023 Category: Epidemiology Authors: Seok-Yeong Yu Yi Luan Siyuan Tang Amirhossein Abazarikia Rosemary Dong Thomas C Caffrey Michael A Hollingsworth David Oupicky So-Youn Kim Source Type: research
Persistent activation of Nrf2 in a p62-dependent non-canonical manner aggravates lead-induced kidney injury by promoting apoptosis and inhibiting autophagy
CONCLUSIONS: In conclusion, these findings highlight the dark side of persistent Nrf2 activation and potential crosstalk among Pb-induced persistent Nrf2 activation, apoptosis and autophagy blockage in Pb-triggered nephrotoxicity.PMID:37003700 | DOI:10.1016/j.jare.2022.04.016
Source: Adv Data - April 1, 2023 Category: Epidemiology Authors: Cai-Yu Lian Bing-Xin Chu Wei-Hao Xia Zhen-Yong Wang Rui-Feng Fan Lin Wang Source Type: research
Optimizing Lipid Nanoparticles for Delivery in Primates
This article is protected by copyright. All rights reserved.PMID:36972555 | DOI:10.1002/adma.202211420
Source: Adv Data - March 27, 2023 Category: Epidemiology Authors: Kieu Lam Petra Schreiner Ada Leung Paul Stainton Steve Reid Ed Yaworski Pete Lutwyche James Heyes Source Type: research
Enhancing the Management of Metastatic Tumors by Robust Co-delivery of 5-fluorouracil/microRNA-10b inhibitor Using EGFR-targeted Nanovehicles
This article is protected by copyright. All rights reserved.PMID:36740892 | DOI:10.1002/adhm.202202989
Source: Adv Data - February 6, 2023 Category: Epidemiology Authors: Di Wang Liwei Wang Liming Zheng Jiaxin Chen Wei Zhang Wei Zhou Xiaobo Yang Lifeng Jiang Xiaoqiang Jin Xiaohua Yu Xin Liu Heng Chen Jianbin Xu Source Type: research
Unsaturated, Trialkyl Ionizable Lipids are Versatile LNP Components for Therapeutic and Vaccine Applications
This article is protected by copyright. All rights reserved.PMID:36680477 | DOI:10.1002/adma.202209624
Source: Adv Data - January 21, 2023 Category: Epidemiology Authors: Kieu Lam Ada Leung Alan Martin Mark Wood Petra Schreiner Lorne Palmer Owen Daly Wenchen Zhao Kevin McClintock James Heyes Source Type: research
Targeting Ligand Independent Tropism of siRNA-LNP by Small Molecules for Directed Therapy of Liver or Myeloid Immune Cells
Adv Healthc Mater. 2023 Jan 8:e2202670. doi: 10.1002/adhm.202202670. Online ahead of print.ABSTRACTHepatic clearance of lipid nanoparticles (LNP) with encapsulated nucleic acids restricts their therapeutic applicability. Therefore, tools for regulating hepatic clearance are of high interest for nucleic acid delivery. To this end, this work employs wild-type (WT) and low-density lipoprotein receptor (Ldlr)-/- mice pretreated with either a leukotriene B4 receptor inhibitor (BLT1i) or a high-density lipoprotein receptor inhibitor (HDLRi) prior to the injection of siRNA-LNP. This work is able to demonstrate significantly incre...
Source: Adv Data - January 8, 2023 Category: Epidemiology Authors: Cheng Lin Asmaa Mostafa Alexander Jans Justina Clarinda Wolters Mohamed Ramadan Mohamed Emiel P C Van der Vorst Christian Trautwein Matthias Bartneck Source Type: research
Nanoneedles Induce Targeted siRNA Silencing of p16 in the Human Corneal Endothelium
Adv Sci (Weinh). 2022 Oct 17:e2203257. doi: 10.1002/advs.202203257. Online ahead of print.ABSTRACTNanoneedles can target nucleic acid transfection to primary cells at tissue interfaces with high efficiency and minimal perturbation. The corneal endothelium is an ideal target for nanoneedle-mediated RNA interference therapy aimed at enhancing its proliferative capacity, necessary for tissue regeneration. This work develops a strategy for siRNA nanoninjection to the human corneal endothelium. Nanoneedles can deliver p16-targeting siRNA to primary human corneal endothelial cells in vitro without toxicity. The nanoinjection of ...
Source: Adv Data - October 17, 2022 Category: Epidemiology Authors: Eleonora Maurizi Davide Alessandro Martella Davide Schiroli Alessia Merra Salman Ahmad Mustfa Graziella Pellegrini Claudio Macaluso Ciro Chiappini Source Type: research
Effect of the array of amines on the transfection efficiency of cationic peptidomimetic lipid molecules into neural cells
RSC Adv. 2022 Aug 3;12(33):21567-21573. doi: 10.1039/d2ra03347j. eCollection 2022 Jul 21.ABSTRACTThe amino groups in the head group of a cationic lipid play a determinative role regarding the nucleic acid delivery efficiency of the LNP formulated from lipids. Herein, we designed four types of lipid bearing different amine-containing branched head groups to investigate the influence of type and number of amines on the neural cell targeted nuclei acid delivery. Conjugation of an ethylamino group at selected positions of a lysine-based cationic lipid resulted in 4 distinct lipids with 3 (denoted N3 lipid), 4 (denoted N4 lipid...
Source: Adv Data - August 17, 2022 Category: Epidemiology Authors: Xiang Yu Hai Xiao Muqier Muqier Shuqin Han Huricha Baigude Source Type: research
