Filtered By:
Specialty: Epidemiology

This page shows you your search results in order of date. This is page number 2.

Order by Relevance | Date

Total 51 results found since Jan 2013.

pH-sensitive, tail-modified, ester-linked ionizable cationic lipids for gene delivery
Biomater Adv. 2022 Jun 14;139:212984. doi: 10.1016/j.bioadv.2022.212984. Online ahead of print.ABSTRACTIonizable cationic lipids have great potential for gene delivery, yet the effect of the molecular structure of such lipids on gene delivery efficiency is an ongoing research challenge. To better understand corresponding structure-function activity relationships, we synthesized four ester-linked, pH-responsive, ionizable cationic lipids. The screened DEDM4 lipid, containing 2-ethylenedimethylamine in the headgroup and a branched-chain tail, exhibited a high delivery efficacy of plasmid DNA and siRNA in A549 cells, which wa...
Source: Adv Data - July 26, 2022 Category: Epidemiology Authors: Yu Zou Yuhong Zhen Yinan Zhao Huiying Chen Rui Wang Wei Wang Pengfei Ma Defu Zhi Benzhi Ju Shubiao Zhang Source Type: research

Colored petri net modeling of small interfering RNA-mediated messenger RNA degradation.
CONCLUSION: In previous studies, a network of stoichiometric equations was modeled. However, in this particular study, we modeled the mechanism behind the silencing process. Modeling this kind of mechanisms provides us with a tool to examine the effects of different factors such as mutation or drugs on the process. PMID: 27376039 [PubMed]
Source: Adv Data - July 6, 2016 Category: Epidemiology Authors: Nickaeen N, Moein S, Heidary Z, Ghaisari J Tags: Adv Biomed Res Source Type: research

Mismatch in epitope specificities between IFNγ inflamed and uninflamed conditions leads to escape from T lymphocyte killing in melanoma
Conclusions: Our results illustrate a little-studied mechanism of immune escape by tumor cells which, with appropriate understanding and treatment, may be reversible. These data have implications for the design of cancer vaccines and adoptive T cell therapies.
Source: Epidemiologic Perspectives and Innovations - February 16, 2016 Category: Epidemiology Authors: Katherine WoodsAshley J. KnightsMatthew AnakaRalf SchittenhelmAnthony PurcellAndreas BehrenJonathan Cebon Source Type: research

Urban traffic-derived nanoparticulate matter reduces neurite outgrowth via TNFα in vitro
Conclusions: These findings implicate microglia-derived TNFα as a mediator of nPM in air pollution-associated neurodegenerative changes which alter synaptic functions and neuronal growth.
Source: Epidemiologic Perspectives and Innovations - January 26, 2016 Category: Epidemiology Authors: Hank ChengDavid DavisSina HasheminassabConstantinos SioutasTodd MorganCaleb Finch Source Type: research

Aspirin inhibits epithelial-to-mesenchymal transition and migration of oncogenic K-ras-expressing non-small cell lung carcinoma cells by down-regulating E-cadherin repressor Slug
Conclusions: Cumulatively, these results signify a crucial role of the anti-inflammatory agent aspirin as a novel negative regulator of epithelial-to-mesenchymal transition thereby suggesting its candidature as a promising tool for deterring metastasis of highly invasive K-ras-expressing NSCLC cells.
Source: Epidemiologic Perspectives and Innovations - January 26, 2016 Category: Epidemiology Authors: Poulami KhanArgha MannaShilpi SahaSuchismita MohantyShravanti MukherjeeMinakshi MazumdarDeblina GuhaTanya Das Source Type: research

Analysis of the interaction between host factor Sam68 and viral elements during foot-and-mouth disease virus infections
Conclusion: We have found that Sam68 is a specific binding partner for FMDV non-structural proteins 3C pro and 3D pol and showed that mutations at RAAA motifs in IRES domains 3 and 4 cause a decrease in Sam68 affinity to these RNA elements and rendered the mutant RNA non-viable. Interestingly, in FMDV infected cells re-localized Sam68 was transiently detected along with SG markers in the cytoplasm. These results support the importance of Sam68 as a host factor co-opted by FMDV during infection and demonstrate that Sam68 interact with both, FMDV RNA motifs in the IRES and viral no...
Source: Epidemiologic Perspectives and Innovations - December 23, 2015 Category: Epidemiology Authors: Devendra RaiPaul LawrenceAnna KlocElizabeth SchaferElizabeth Rieder Source Type: research

ROS-p53-cyclophilin-D signaling mediates salinomycin-induced glioma cell necrosis
Conclusions: Thus, salinomycin mainly induces programmed necrosis in cultured glioma cells.
Source: Epidemiologic Perspectives and Innovations - May 29, 2015 Category: Epidemiology Authors: Li-sen QinPi-feng JiaZhi-qing ZhangShi-ming Zhang Source Type: research

Uterine NDRG2 expression is increased at implantation sites during early pregnancy in mice, and its down-regulation inhibits decidualization of mouse endometrial stromal cells
Conclusions: These results suggest that NDRG2 might play an important role in the process of decidualization during early pregnancy.
Source: Epidemiologic Perspectives and Innovations - May 26, 2015 Category: Epidemiology Authors: Yan GuXuan ZhangQian YangJian-mei WangYa-ping HeZhao-gui SunHui-qin ZhangJian Wang Source Type: research

Effects of hypoxia inducible factor-1α on apoptotic inhibition and glucocorticoid receptor downregulation by dexamethasone in AtT-20 cells
Conclusions: These findings strongly suggest that HIF-1α exerts an antiapoptotic role and participates in the downregulation of GR by dexamethasone in hypoxic AtT-20 cells.
Source: Epidemiologic Perspectives and Innovations - May 22, 2015 Category: Epidemiology Authors: Chenran ZhangQiang QiangYing JiangLiuhua HuXuehua DingYicheng LuGuohan Hu Source Type: research

Baicalein increases the expression and reciprocal interplay of RUNX3 and FOXO3a through crosstalk of AMPK¿ and MEK/ERK1/2 signaling pathways in human non-small cell lung cancer cells
Conclusion: Collectively, our results show that baicalein inhibits growth and induces apoptosis of NSCLC cells through AMPKα- and MEK/ERK1/2-mediated increase and interaction of FOXO3a and RUNX3 protein. The crosstalk between AMPKα and MEK/ERK1/2 signaling pathways, and the reciprocal interplay of FOXO3a and RUNX3 converge on the overall response of baicalein. This study reveals a novel mechanism for regulating FOXO3a and RUNX3 signaling axis in response to baicalein and suggests a new strategy for NSCLC associated targeted therapy.
Source: Epidemiologic Perspectives and Innovations - May 6, 2015 Category: Epidemiology Authors: Fang ZhengJingjing WuShunyu ZhaoQingmei LuoQing TangLiJun YangLiuning LiWanYing WuSwei Hann Source Type: research

Synergistic inhibition of avian leukosis virus subgroup J replication by miRNA-embedded siRNA interference of double-target
Conclusions: These data demonstrated that the miRNA-embedded siRNA interference is an efficient method for inhibition of ALV-J replication, especially double targets.
Source: Epidemiologic Perspectives and Innovations - March 21, 2015 Category: Epidemiology Authors: Rongrong WeiXiaoqian MaGuihua WangHuijun GuoJianzhu LiuLingxiao FanZiqiang Cheng Source Type: research

Involvement of ROS-alpha v beta 3 integrin-FAK/Pyk2 in the inhibitory effect of melatonin on U251 glioma cell migration and invasion under hypoxia
Conclusions: These results suggest that melatonin exerts anti-migratory and anti-invasive effects on glioma cells in response to hypoxia via ROS-αvβ3 integrin-FAK/Pyk2 signaling pathways. This provides evidence that melatonin may be a potential therapeutic molecule targeting the hypoxic microenvironment of glioma.
Source: Epidemiologic Perspectives and Innovations - March 20, 2015 Category: Epidemiology Authors: Cheng-Shi XuZe-Fen WangXiao-Dong HuangLi-Ming DaiChang-Jun CaoZhi-Qiang Li Source Type: research

Caspase-3-independent apoptotic pathways contribute to interleukin-32γ-mediated control of Mycobacterium tuberculosis infection in THP-1 cells
Conclusions: The anti-MTB effects of IL-32γ are mediated through classical caspase-3-dependent apoptosis as well as caspase-3-independent apoptosis.
Source: Epidemiologic Perspectives and Innovations - February 21, 2015 Category: Epidemiology Authors: Xiyuan BaiWilliam H KinneyWen-Lin SuAn BaiAlida R OvrutskyJennifer R HondaMihai G NeteaMarcela Henao-TamayoDiane J OrdwayCharles A DinarelloEdward D Chan Source Type: research

EpCAM aptamer mediated cancer cell specific delivery of EpCAM siRNA using polymeric nanocomplex
Conclusions: The PEI nanocomplex fabricated with EpApt and siEp was able to target EpCAM tumor cells, deliver the siRNA and silence the target gene. This nanocomplex exhibited decreased cell proliferation than the scrambled aptamer loaded nanocomplex in the EpCAM expressing cancer cells and may have potential for EpCAM targeting in vivo.
Source: Epidemiologic Perspectives and Innovations - January 9, 2015 Category: Epidemiology Authors: Nithya SubramanianJagat R KanwarPrasanna AthalyaNarayanan JanakiramanVikas KhetanRupinder K KanwarSailaja EluchuriSubramanian Krishnakumar Source Type: research

DEK is a potential marker for aggressive phenotype and irinotecan-based therapy response in metastatic colorectal cancer
Conclusions: These data suggest DEK overexpression as a crucial event for the emergence of an aggressive phenotype in colorectal cancer and its potential role as biomarker for irinotecan response in those patients with KRAS wild-type status.
Source: Epidemiologic Perspectives and Innovations - December 16, 2014 Category: Epidemiology Authors: Javier Martinez-UserosMaria Rodriguez-RemirezAurea Borrero-PalaciosIrene MorenoArancha CebrianTeresa Gomez del PulgarLaura del Puerto-NevadoRicardo Vega-BravoAlberto Puime-OtinNuria PerezSandra ZazoClara SeninMaria J Fernandez-AceñeroMaria S SoengasFeder Source Type: research